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Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab.

Bellier J, Nokin MJ, Caprasse M, Tiamiou A, Blomme A, Scheijen JL, Koopmansch B, MacKay GM, Chiavarina B, Costanza B, Rademaker G, Durieux F, Agirman F, Maloujahmoum N, Cusumano PG, Lovinfosse P, Leung HY, Lambert F, Bours V, Schalkwijk CG, Hustinx R, Peulen O, Castronovo V, Bellahcène A.

Cell Rep. 2020 Feb 4;30(5):1400-1416.e6. doi: 10.1016/j.celrep.2020.01.012.


Effect of preoperative oral antibiotics in combination with mechanical bowel preparation on inflammatory response and short-term outcomes following left-sided colonic and rectal resections.

Golder AM, Steele CW, Conn D, MacKay GJ, McMillan DC, Horgan PG, Roxburgh CS, McSorley ST.

BJS Open. 2019 Oct 16;3(6):830-839. doi: 10.1002/bjs5.50224. eCollection 2019 Dec.


All-Inside Arthroscopic Meniscal Repair with the Arthrex Meniscal Cinch™ II.

Jenkins JM, Hopper GP, Mackay GM.

Surg Technol Int. 2019 Dec 12;36. pii: sti36/1225. [Epub ahead of print]


Autoimmune encephalitis.

Goodfellow JA, Mackay GA.

J R Coll Physicians Edinb. 2019 Dec;49(4):287-294. doi: 10.4997/JRCPE.2019.407. Review.


Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer.

Patel R, Brzezinska EA, Repiscak P, Ahmad I, Mui E, Gao M, Blomme A, Harle V, Tan EH, Malviya G, Mrowinska A, Loveridge CJ, Rushworth LK, Edwards J, Ntala C, Nixon C, Hedley A, Mackay G, Tardito S, Sansom OJ, Leung HY.

Cancer Res. 2020 Feb 1;80(3):576-590. doi: 10.1158/0008-5472.CAN-19-1684. Epub 2019 Nov 12.


N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis.

Juin A, Spence HJ, Martin KJ, McGhee E, Neilson M, Cutiongco MFA, Gadegaard N, Mackay G, Fort L, Lilla S, Kalna G, Thomason P, Koh YWH, Norman JC, Insall RH, Machesky LM.

Dev Cell. 2019 Nov 18;51(4):431-445.e7. doi: 10.1016/j.devcel.2019.09.018. Epub 2019 Oct 24.


Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response.

McGregor GH, Campbell AD, Fey SK, Tumanov S, Sumpton D, Blanco GR, Mackay G, Nixon C, Vazquez A, Sansom OJ, Kamphorst JJ.

Cancer Res. 2020 Jan 15;80(2):175-188. doi: 10.1158/0008-5472.CAN-19-0644. Epub 2019 Sep 27.


Reversible tongue atrophy in Lambert-Eaton myasthenic syndrome.

Cammaert LA, Macleod AD, Mackay GA, Duncan CW.

Neurology. 2019 Sep 3;93(10):459-460. doi: 10.1212/WNL.0000000000008076. No abstract available.


Re-evaluation of the causes of variation among mouse aggregation chimaeras.

West JD, Tang PC, Everett CA, MacKay GE, Flockhart JH, Keighren MA.

Biol Open. 2019 May 30;8(5). pii: bio042804. doi: 10.1242/bio.042804.


Possible dose dependent effect of perioperative dexamethasone and laparoscopic surgery on the postoperative systemic inflammatory response and complications following surgery for colon cancer.

McSorley ST, Dolan RD, Roxburgh CS, Horgan PG, MacKay GJ, McMillan DC.

Eur J Surg Oncol. 2019 Sep;45(9):1613-1618. doi: 10.1016/j.ejso.2019.05.020. Epub 2019 May 20.


Fibrin-thrombin sealant does not reduce lymphocele formation in patients with inguinofemoral lymphadenectomy for vulvar cancer.

Saner FA, Schötzau A, Mackay G, Heinzelmann-Schwarz V, Montavon Sartorius C.

Cancer Manag Res. 2019 Apr 30;11:3575-3582. doi: 10.2147/CMAR.S197143. eCollection 2019.


Stratification of cancer and diabetes based on circulating levels of formate and glucose.

Pietzke M, Arroyo SF, Sumpton D, Mackay GM, Martin-Castillo B, Camps J, Joven J, Menendez JA, Vazquez A; METTEN study group.

Cancer Metab. 2019 Apr 24;7:3. doi: 10.1186/s40170-019-0195-x. eCollection 2019.


Posterior Cruciate Ligament Repair With Suture Tape Augmentation.

Hopper GP, Heusdens CHW, Dossche L, Mackay GM.

Arthrosc Tech. 2018 Dec 3;8(1):e7-e10. doi: 10.1016/j.eats.2018.08.022. eCollection 2019 Jan.


Medial Patellofemoral Ligament Repair With Suture Tape Augmentation.

Hopper GP, Heusdens CHW, Dossche L, Mackay GM.

Arthrosc Tech. 2018 Dec 3;8(1):e1-e5. doi: 10.1016/j.eats.2018.08.021. eCollection 2019 Jan.


Cancer and motor neuron disease-causal or coincidental? Two contrasting cases.

Goodfellow J, Gorrie G, Leach V, Patel S, Mackay G.

Neurol Sci. 2019 Jul;40(7):1461-1463. doi: 10.1007/s10072-019-03784-9. Epub 2019 Mar 6.


Prehabilitation is feasible in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy and may minimize physical deterioration: results from the REx trial.

Moug SJ, Mutrie N, Barry SJE, Mackay G, Steele RJC, Boachie C, Buchan C, Anderson AS.

Colorectal Dis. 2019 May;21(5):548-562. doi: 10.1111/codi.14560. Epub 2019 Feb 16.


Improving the metabolic fidelity of cancer models with a physiological cell culture medium.

Vande Voorde J, Ackermann T, Pfetzer N, Sumpton D, Mackay G, Kalna G, Nixon C, Blyth K, Gottlieb E, Tardito S.

Sci Adv. 2019 Jan 2;5(1):eaau7314. doi: 10.1126/sciadv.aau7314. eCollection 2019 Jan.


Anterolateral Ligament Repair With Suture Tape Augmentation.

Heusdens CHW, Hopper GP, Dossche L, Mackay GM.

Arthrosc Tech. 2018 Nov 26;7(12):e1311-e1314. doi: 10.1016/j.eats.2018.08.016. eCollection 2018 Dec.


Posterolateral Corner Repair With Suture Tape Augmentation.

Hopper GP, Heusdens CHW, Dossche L, Mackay GM.

Arthrosc Tech. 2018 Nov 26;7(12):e1299-e1303. doi: 10.1016/j.eats.2018.08.018. eCollection 2018 Dec.


Repair of the ulnar collateral ligament of the elbow with internal brace augmentation: a 5-year follow-up.

Wilson WT, Hopper GP, Byrne PA, MacKay GM.

BMJ Case Rep. 2018 Dec 19;11(1). pii: e227113. doi: 10.1136/bcr-2018-227113.


Mannose impairs tumour growth and enhances chemotherapy.

Gonzalez PS, O'Prey J, Cardaci S, Barthet VJA, Sakamaki JI, Beaumatin F, Roseweir A, Gay DM, Mackay G, Malviya G, Kania E, Ritchie S, Baudot AD, Zunino B, Mrowinska A, Nixon C, Ennis D, Hoyle A, Millan D, McNeish IA, Sansom OJ, Edwards J, Ryan KM.

Nature. 2018 Nov;563(7733):719-723. doi: 10.1038/s41586-018-0729-3. Epub 2018 Nov 21.


Impact of the new FIGO 2013 classification on prognosis of stage I epithelial ovarian cancers.

Montavon Sartorius C, Mirza U, Schötzau A, Mackay G, Fink D, Hacker NF, Heinzelmann-Schwarz V.

Cancer Manag Res. 2018 Oct 17;10:4709-4718. doi: 10.2147/CMAR.S174777. eCollection 2018.


Anterior cruciate ligament repair with Independent Suture Tape Reinforcement: a case series with 2-year follow-up.

Heusdens CHW, Hopper GP, Dossche L, Roelant E, Mackay GM.

Knee Surg Sports Traumatol Arthrosc. 2019 Jan;27(1):60-67. doi: 10.1007/s00167-018-5239-1. Epub 2018 Oct 31.


The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1.

Anania JC, Trist HM, Palmer CS, Tan PS, Kouskousis BP, Chenoweth AM, Kent SJ, Mackay GA, Hoi A, Koelmeyer R, Slade C, Bryant VL, Hodgkin PD, Aui PM, van Zelm MC, Wines BD, Hogarth PM.

Front Immunol. 2018 Aug 20;9:1809. doi: 10.3389/fimmu.2018.01809. eCollection 2018.


Anterior Cruciate Ligament Repair Using Independent Suture Tape Reinforcement.

Heusdens CHW, Hopper GP, Dossche L, Mackay GM.

Arthrosc Tech. 2018 Jun 18;7(7):e747-e753. doi: 10.1016/j.eats.2018.03.007. eCollection 2018 Jul.


Acromioclavicular Joint Stabilisation Using the Internal Brace Principle.

Byrne PA, Hopper GP, Wilson WT, Mackay GM.

Surg Technol Int. 2018 Nov 11;33:294-298.


Ultrasound-Guided Suture Tape Augmentation and Stabilization of the Medial Collateral Ligament.

Hirahara AM, Mackay G, Andersen WJ.

Arthrosc Tech. 2018 Feb 5;7(3):e205-e210. doi: 10.1016/j.eats.2017.08.069. eCollection 2018 Mar.


Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth.

Rath N, Munro J, Cutiongco MF, Jagiełło A, Gadegaard N, McGarry L, Unbekandt M, Michalopoulou E, Kamphorst JJ, Sumpton D, Mackay G, Vennin C, Pajic M, Timpson P, Olson MF.

Cancer Res. 2018 Jun 15;78(12):3321-3336. doi: 10.1158/0008-5472.CAN-17-1339. Epub 2018 Apr 18.


Increased formate overflow is a hallmark of oxidative cancer.

Meiser J, Schuster A, Pietzke M, Vande Voorde J, Athineos D, Oizel K, Burgos-Barragan G, Wit N, Dhayade S, Morton JP, Dornier E, Sumpton D, Mackay GM, Blyth K, Patel KJ, Niclou SP, Vazquez A.

Nat Commun. 2018 Apr 10;9(1):1368. doi: 10.1038/s41467-018-03777-w.


Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1.

Patel R, Fleming J, Mui E, Loveridge C, Repiscak P, Blomme A, Harle V, Salji M, Ahmad I, Teo K, Hamdy FC, Hedley A, van den Broek N, Mackay G, Edwards J, Sansom OJ, Leung HY.

EMBO Mol Med. 2018 Apr;10(4). pii: e8347. doi: 10.15252/emmm.201708347.


Identification of an Immortalized Human Airway Epithelial Cell Line with Dyskinetic Cilia.

Kuek LE, Griffin P, Martinello P, Graham AN, Kalitsis P, Robinson PJ, Mackay GA.

Am J Respir Cell Mol Biol. 2018 Sep;59(3):375-382. doi: 10.1165/rcmb.2017-0188OC.


Selection against BALB/c strain cells in mouse chimaeras.

Tang PC, MacKay GE, Flockhart JH, Keighren MA, Kopakaki A, West JD.

Biol Open. 2018 Jan 12;7(1). pii: bio030189. doi: 10.1242/bio.030189.


Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.

Dornier E, Rabas N, Mitchell L, Novo D, Dhayade S, Marco S, Mackay G, Sumpton D, Pallares M, Nixon C, Blyth K, Macpherson IR, Rainero E, Norman JC.

Nat Commun. 2017 Dec 21;8(1):2255. doi: 10.1038/s41467-017-02101-2.


Sacral neuromodulation for faecal incontinence - 10 years' experience at a Scottish tertiary centre.

Koh H, McSorley S, Hunt S, Quinn M, MacKay G, Anderson J.

Surgeon. 2018 Aug;16(4):207-213. doi: 10.1016/j.surge.2017.08.006. Epub 2017 Oct 26.


LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells.

Susanto O, Koh YWH, Morrice N, Tumanov S, Thomason PA, Nielson M, Tweedy L, Muinonen-Martin AJ, Kamphorst JJ, Mackay GM, Insall RH.

J Cell Sci. 2017 Oct 15;130(20):3455-3466. doi: 10.1242/jcs.207514. Epub 2017 Sep 4.


Corrigendum: Modulating the therapeutic response of tumours to dietary serine and glycine starvation.

Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH.

Nature. 2017 Aug 2;548(7665):122. doi: 10.1038/nature23471.


Comparison of two related lines of tauGFP transgenic mice designed for lineage tracing.

Sharp L, Pratt T, MacKay GE, Keighren MA, Flockhart JH, Chandler EJ, Price DJ, Mason JO, West JD.

BMC Dev Biol. 2017 Jun 29;17(1):8. doi: 10.1186/s12861-017-0149-x.


Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells.

Dolfi SC, Medina DJ, Kareddula A, Paratala B, Rose A, Dhami J, Chen S, Ganesan S, Mackay G, Vazquez A, Hirshfield KM.

Oncotarget. 2017 Jul 4;8(27):44639-44653. doi: 10.18632/oncotarget.17961.


Syndesmotic InternalBraceTM for anatomic distal tibiofibular ligament augmentation.

Regauer M, Mackay G, Lange M, Kammerlander C, Böcker W.

World J Orthop. 2017 Apr 18;8(4):301-309. doi: 10.5312/wjo.v8.i4.301. eCollection 2017 Apr 18.


Modulating the therapeutic response of tumours to dietary serine and glycine starvation.

Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH.

Nature. 2017 Apr 19;544(7650):372-376. doi: 10.1038/nature22056. Erratum in: Nature. 2017 Aug 2;548(7665):122.


Antenatal dexamethasone before asphyxia promotes cystic neural injury in preterm fetal sheep by inducing hyperglycemia.

Lear CA, Davidson JO, Mackay GR, Drury PP, Galinsky R, Quaedackers JS, Gunn AJ, Bennet L.

J Cereb Blood Flow Metab. 2018 Apr;38(4):706-718. doi: 10.1177/0271678X17703124. Epub 2017 Apr 7.


Examination of a CRP first approach for the detection of postoperative complications in patients undergoing surgery for colorectal cancer: A pragmatic study.

McSorley ST, Khor BY, MacKay GJ, Horgan PG, McMillan DC.

Medicine (Baltimore). 2017 Feb;96(7):e6133. doi: 10.1097/MD.0000000000006133.


A 50-year-old with rapid neuropsychiatric deterioration and choreiform movements.

Mackay GA, Campbell S, Jampana R, Cavanagh J.

Pract Neurol. 2017 Jun;17(3):237-240. doi: 10.1136/practneurol-2016-001481. Epub 2017 Jan 24. No abstract available.


Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation.

Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Vande Voorde J, Blyth K, Gottlieb E, Vazquez A, Kamphorst JJ.

Cell Rep. 2017 Jan 17;18(3):647-658. doi: 10.1016/j.celrep.2016.12.055.


Achilles Tendon Repair Using the InternalBrace™ Principle.

Hopper GP, Mackay GM.

Surg Technol Int. 2017 Jun;30:325-328. Epub 2017 Jan 10.


Analysis of lesion localisation at colonoscopy: outcomes from a multi-centre U.K. study.

Moug SJ, Fountas S, Johnstone MS, Bryce AS, Renwick A, Chisholm LJ, McCarthy K, Hung A, Diament RH, McGregor JR, Khine M, Saldanha JD, Khan K, Mackay G, Leitch EF, McKee RF, Anderson JH, Griffiths B, Horgan A, Lockwood S, Bisset C, Molloy R, Vella M.

Surg Endosc. 2017 Jul;31(7):2959-2967. doi: 10.1007/s00464-016-5313-z. Epub 2016 Nov 8.


Serine one-carbon catabolism with formate overflow.

Meiser J, Tumanov S, Maddocks O, Labuschagne CF, Athineos D, Van Den Broek N, Mackay GM, Gottlieb E, Blyth K, Vousden K, Kamphorst JJ, Vazquez A.

Sci Adv. 2016 Oct 28;2(10):e1601273. eCollection 2016 Oct.


Anterior Cruciate Ligament Repair with Internal Brace Ligament Augmentation.

Wilson WT, Hopper GP, Byrne PA, MacKay GM.

Surg Technol Int. 2016 Oct 26;29:273-278.


Knotless Repair of Achilles Tendon Rupture in an Elite Athlete: Return to Competition in 18 Weeks.

Byrne PA, Hopper GP, Wilson WT, Mackay GM.

J Foot Ankle Surg. 2017 Jan - Feb;56(1):121-124. doi: 10.1053/j.jfas.2016.07.007. Epub 2016 Aug 21. Review.


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