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Items: 1 to 50 of 210

1.

A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection.

Bazzone LE, King M, MacKay CR, Kyawe PP, Meraner P, Lindstrom D, Rojas-Quintero J, Owen CA, Wang JP, Brass AL, Kurt-Jones EA, Finberg RW.

MBio. 2019 Feb 5;10(1). pii: e02734-18. doi: 10.1128/mBio.02734-18.

2.

Gαs-coupled GPCRs GPR65 and GPR174. Downers for immune responses.

Robert R, Mackay CR.

Immunol Cell Biol. 2018 Apr;96(4):341-343. doi: 10.1111/imcb.12027. Epub 2018 Mar 14.

PMID:
29542190
3.

The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung.

Galvão I, Tavares LP, Corrêa RO, Fachi JL, Rocha VM, Rungue M, Garcia CC, Cassali G, Ferreira CM, Martins FS, Oliveira SC, Mackay CR, Teixeira MM, Vinolo MAR, Vieira AT.

Front Immunol. 2018 Feb 20;9:142. doi: 10.3389/fimmu.2018.00142. eCollection 2018.

4.

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis.

Dick J, Gan PY, Ford SL, Odobasic D, Alikhan MA, Loosen SH, Hall P, Westhorpe CL, Li A, Ooi JD, Woodruff TM, Mackay CR, Kitching AR, Hickey MJ, Holdsworth SR.

Kidney Int. 2018 Mar;93(3):615-625. doi: 10.1016/j.kint.2017.09.018. Epub 2017 Dec 12.

PMID:
29241626
5.

Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.

Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR.

Nat Immunol. 2017 Oct 18;18(11):1271. doi: 10.1038/ni1117-1271c.

PMID:
29044240
6.

A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6.

Robert R, Juglair L, Lim EX, Ang C, Wang CJH, Ebert G, Dolezal O, Mackay CR.

PLoS One. 2017 Sep 5;12(9):e0184278. doi: 10.1371/journal.pone.0184278. eCollection 2017.

7.

Beyond gut feelings: how the gut microbiota regulates blood pressure.

Marques FZ, Mackay CR, Kaye DM.

Nat Rev Cardiol. 2018 Jan;15(1):20-32. doi: 10.1038/nrcardio.2017.120. Epub 2017 Aug 24. Review.

PMID:
28836619
8.

Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice.

Robert R, Ang C, Sun G, Juglair L, Lim EX, Mason LJ, Payne NL, Bernard CC, Mackay CR.

JCI Insight. 2017 Aug 3;2(15). pii: 94821. doi: 10.1172/jci.insight.94821. eCollection 2017 Aug 3.

9.

Erratum: Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.

Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR.

Nat Immunol. 2017 Jul 19;18(8):951. doi: 10.1038/ni0817-951c. No abstract available.

PMID:
28722715
10.

The nutrition-gut microbiome-physiology axis and allergic diseases.

McKenzie C, Tan J, Macia L, Mackay CR.

Immunol Rev. 2017 Jul;278(1):277-295. doi: 10.1111/imr.12556. Review.

PMID:
28658542
11.

Metabolite-Sensing G Protein-Coupled Receptors-Facilitators of Diet-Related Immune Regulation.

Tan JK, McKenzie C, Mariño E, Macia L, Mackay CR.

Annu Rev Immunol. 2017 Apr 26;35:371-402. doi: 10.1146/annurev-immunol-051116-052235. Review.

PMID:
28446062
12.

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses.

Piovesan D, Tempany J, Di Pietro A, Baas I, Yiannis C, O'Donnell K, Chen Y, Peperzak V, Belz GT, Mackay CR, Smyth GK, Groom JR, Tarlinton DM, Good-Jacobson KL.

Cell Rep. 2017 Apr 18;19(3):461-470. doi: 10.1016/j.celrep.2017.03.060.

13.

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes.

Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR.

Nat Immunol. 2017 May;18(5):552-562. doi: 10.1038/ni.3713. Epub 2017 Mar 27. Erratum in: Nat Immunol. 2017 Oct 18;18(11):1271. Nat Immunol. 2017 Jul 19;18(8):951.

PMID:
28346408
14.

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety.

Brooks L, Viardot A, Tsakmaki A, Stolarczyk E, Howard JK, Cani PD, Everard A, Sleeth ML, Psichas A, Anastasovskaj J, Bell JD, Bell-Anderson K, Mackay CR, Ghatei MA, Bloom SR, Frost G, Bewick GA.

Mol Metab. 2016 Nov 4;6(1):48-60. doi: 10.1016/j.molmet.2016.10.011. eCollection 2017 Jan.

15.

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells.

Goverse G, Molenaar R, Macia L, Tan J, Erkelens MN, Konijn T, Knippenberg M, Cook EC, Hanekamp D, Veldhoen M, Hartog A, Roeselers G, Mackay CR, Mebius RE.

J Immunol. 2017 Mar 1;198(5):2172-2181. doi: 10.4049/jimmunol.1600165. Epub 2017 Jan 18.

16.

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.

Marques FZ, Nelson E, Chu PY, Horlock D, Fiedler A, Ziemann M, Tan JK, Kuruppu S, Rajapakse NW, El-Osta A, Mackay CR, Kaye DM.

Circulation. 2017 Mar 7;135(10):964-977. doi: 10.1161/CIRCULATIONAHA.116.024545. Epub 2016 Dec 7.

PMID:
27927713
17.

G Protein-Coupled Receptor 43 Modulates Neutrophil Recruitment during Acute Inflammation.

Kamp ME, Shim R, Nicholls AJ, Oliveira AC, Mason LJ, Binge L, Mackay CR, Wong CH.

PLoS One. 2016 Sep 22;11(9):e0163750. doi: 10.1371/journal.pone.0163750. eCollection 2016.

18.

Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice.

Vieira AT, Galvão I, Macia LM, Sernaglia ÉM, Vinolo MA, Garcia CC, Tavares LP, Amaral FA, Sousa LP, Martins FS, Mackay CR, Teixeira MM.

J Leukoc Biol. 2017 Jan;101(1):275-284. doi: 10.1189/jlb.3A1015-453RRR. Epub 2016 Aug 5.

PMID:
27496979
19.

Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges.

Chevalier N, Tan JK, Mason LJ, Robert R, McKenzie CI, Lim F, Wong CH, Macia L, Thorburn AN, Russ BE, Masters SL, Mackay CR.

J Autoimmun. 2016 Sep;73:120-9. doi: 10.1016/j.jaut.2016.06.018. Epub 2016 Jul 12.

PMID:
27427404
20.

Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases.

Richards JL, Yap YA, McLeod KH, Mackay CR, Mariño E.

Clin Transl Immunology. 2016 May 13;5(5):e82. doi: 10.1038/cti.2016.29. eCollection 2016 May. Review.

21.

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways.

Tan J, McKenzie C, Vuillermin PJ, Goverse G, Vinuesa CG, Mebius RE, Macia L, Mackay CR.

Cell Rep. 2016 Jun 21;15(12):2809-24. doi: 10.1016/j.celrep.2016.05.047.

22.

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.

Lassen KG, McKenzie CI, Mari M, Murano T, Begun J, Baxt LA, Goel G, Villablanca EJ, Kuo SY, Huang H, Macia L, Bhan AK, Batten M, Daly MJ, Reggiori F, Mackay CR, Xavier RJ.

Immunity. 2016 Jun 21;44(6):1392-405. doi: 10.1016/j.immuni.2016.05.007. Epub 2016 Jun 7.

23.

The Role of Follicular Helper T Cell Molecules and Environmental Influences in Autoantibody Production and Progression to Inflammatory Arthritis in Mice.

Chevalier N, Macia L, Tan JK, Mason LJ, Robert R, Thorburn AN, Wong CH, Tsai LM, Bourne K, Brink R, Yu D, Mackay CR.

Arthritis Rheumatol. 2016 Apr;68(4):1026-38. doi: 10.1002/art.39481.

24.

GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases.

McKenzie CI, Mackay CR, Macia L.

Trends Endocrinol Metab. 2015 Oct;26(10):511-512. doi: 10.1016/j.tem.2015.07.009. Review.

PMID:
26412151
25.

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites.

Thorburn AN, McKenzie CI, Shen S, Stanley D, Macia L, Mason LJ, Roberts LK, Wong CH, Shim R, Robert R, Chevalier N, Tan JK, Mariño E, Moore RJ, Wong L, McConville MJ, Tull DL, Wood LG, Murphy VE, Mattes J, Gibson PG, Mackay CR.

Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.

PMID:
26102221
26.

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.

Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT.

Mol Endocrinol. 2015 Jul;29(7):1055-66. doi: 10.1210/me.2015-1007. Epub 2015 Jun 15. Erratum in: Mol Endocrinol. 2016 Jul;30(7):826.

27.

Delayed consent: will there be a shift in approach for US primary percutaneous coronary intervention trials?

MacKay CR, Torguson R, Waksman R.

Lancet. 2015 Aug 15;386(9994):714-6. doi: 10.1016/S0140-6736(15)60077-0. Epub 2015 May 7. Review. No abstract available.

PMID:
25960111
28.

Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model.

Atkinson SM, Nansen A, Usher PA, Sondergaard BC, Mackay CR, Friedrichsen B, Chang CC, Tang R, Skov S, Haase C, Hornum L.

Autoimmunity. 2015;48(7):460-70. doi: 10.3109/08916934.2015.1031888. Epub 2015 Apr 27.

PMID:
25915570
29.

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout.

Vieira AT, Macia L, Galvão I, Martins FS, Canesso MC, Amaral FA, Garcia CC, Maslowski KM, De Leon E, Shim D, Nicoli JR, Harper JL, Teixeira MM, Mackay CR.

Arthritis Rheumatol. 2015 Jun;67(6):1646-56. doi: 10.1002/art.39107.

30.

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.

Macia L, Tan J, Vieira AT, Leach K, Stanley D, Luong S, Maruya M, Ian McKenzie C, Hijikata A, Wong C, Binge L, Thorburn AN, Chevalier N, Ang C, Marino E, Robert R, Offermanns S, Teixeira MM, Moore RJ, Flavell RA, Fagarasan S, Mackay CR.

Nat Commun. 2015 Apr 1;6:6734. doi: 10.1038/ncomms7734.

PMID:
25828455
31.

Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion.

Chevalier N, Thorburn AN, Macia L, Tan J, Juglair L, Yagita H, Yu D, Hansbro PM, Mackay CR.

J Immunol. 2014 Nov 15;193(10):4845-58. doi: 10.4049/jimmunol.1302966. Epub 2014 Oct 22.

32.

Short-term global health education programs abroad: disease patterns observed in Haitian migrant worker communities around La Romana, Dominican Republic.

Ferrara BJ, Townsley E, MacKay CR, Lin HC, Loh LC.

Am J Trop Med Hyg. 2014 Nov;91(5):871-5. doi: 10.4269/ajtmh.14-0012. Epub 2014 Sep 8.

33.

CXCR3⁺CCR5⁺ T cells and autoimmune diseases: guilty as charged?

Mackay CR.

J Clin Invest. 2014 Sep;124(9):3682-4. doi: 10.1172/JCI77837. Epub 2014 Sep 2.

34.

TRIL is involved in cytokine production in the brain following Escherichia coli infection.

Wochal P, Rathinam VA, Dunne A, Carlson T, Kuang W, Seidl KJ, Hall JP, Lin LL, Collins M, Schattgen SA, MacKay CR, Fagundes CT, Carpenter S, Fitzgerald KA, O'Neill LA.

J Immunol. 2014 Aug 15;193(4):1911-9. doi: 10.4049/jimmunol.1302392. Epub 2014 Jul 11.

35.

Diet, metabolites, and "western-lifestyle" inflammatory diseases.

Thorburn AN, Macia L, Mackay CR.

Immunity. 2014 Jun 19;40(6):833-42. doi: 10.1016/j.immuni.2014.05.014. Review.

36.

Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis.

Koupenova M, Vitseva O, MacKay CR, Beaulieu LM, Benjamin EJ, Mick E, Kurt-Jones EA, Ravid K, Freedman JE.

Blood. 2014 Jul 31;124(5):791-802. doi: 10.1182/blood-2013-11-536003. Epub 2014 Apr 22.

37.

Dicer's role as an antiviral: still an enigma.

MacKay CR, Wang JP, Kurt-Jones EA.

Curr Opin Immunol. 2014 Feb;26:49-55. doi: 10.1016/j.coi.2013.10.015. Epub 2013 Nov 22. Review.

38.

BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice.

Mariño E, Walters SN, Villanueva JE, Richards JL, Mackay CR, Grey ST.

Eur J Immunol. 2014 Apr;44(4):983-93. doi: 10.1002/eji.201344186. Epub 2014 Feb 16.

39.

The role of short-chain fatty acids in health and disease.

Tan J, McKenzie C, Potamitis M, Thorburn AN, Mackay CR, Macia L.

Adv Immunol. 2014;121:91-119. doi: 10.1016/B978-0-12-800100-4.00003-9. Review.

PMID:
24388214
40.

Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d) -specific CD8+ T cells.

Rahir G, Wathelet N, Hanoteau A, Henin C, Oldenhove G, Galuppo A, Lanaya H, Colau D, Mackay CR, Van den Eynde B, Moser M.

Int J Cancer. 2014 Jun 15;134(12):2841-52. doi: 10.1002/ijc.28617. Epub 2013 Nov 29.

41.

Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure.

He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N, Sun X, Vandenberg K, Rockman S, Ding Y, Zhu L, Wei W, Wang C, Karnowski A, Belz GT, Ghali JR, Cook MC, Riminton DS, Veillette A, Schwartzberg PL, Mackay F, Brink R, Tangye SG, Vinuesa CG, Mackay CR, Li Z, Yu D.

Immunity. 2013 Oct 17;39(4):770-81. doi: 10.1016/j.immuni.2013.09.007.

42.

Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice.

Chtanova T, Hampton HR, Waterhouse LA, Wood K, Tomura M, Miwa Y, Mackay CR, Brink R, Phan TG.

J Biophotonics. 2014 Jun;7(6):425-33. doi: 10.1002/jbio.201200175. Epub 2012 Nov 26.

PMID:
23184395
43.

CD200R1 supports HSV-1 viral replication and licenses pro-inflammatory signaling functions of TLR2.

Soberman RJ, MacKay CR, Vaine CA, Ryan GB, Cerny AM, Thompson MR, Nikolic B, Primo V, Christmas P, Sheiffele P, Aronov L, Knipe DM, Kurt-Jones EA.

PLoS One. 2012;7(10):e47740. doi: 10.1371/journal.pone.0047740. Epub 2012 Oct 17.

44.

Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice.

Starkey MR, Kim RY, Beckett EL, Schilter HC, Shim D, Essilfie AT, Nguyen DH, Beagley KW, Mattes J, Mackay CR, Horvat JC, Hansbro PM.

PLoS One. 2012;7(8):e42588. doi: 10.1371/journal.pone.0042588. Epub 2012 Aug 1.

45.

B-cell cross-presentation of autologous antigen precipitates diabetes.

Mariño E, Tan B, Binge L, Mackay CR, Grey ST.

Diabetes. 2012 Nov;61(11):2893-905. doi: 10.2337/db12-0006. Epub 2012 Jul 24. Erratum in: Diabetes. 2013 Feb;62(2):662.

46.

Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling.

Gunton JE, Sisavanh M, Stokes RA, Satin J, Satin LS, Zhang M, Liu SM, Cai W, Cheng K, Cooney GJ, Laybutt DR, So T, Molero JC, Grey ST, Andres DA, Rolph MS, Mackay CR.

PLoS One. 2012;7(6):e39462. doi: 10.1371/journal.pone.0039462. Epub 2012 Jun 28.

47.

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases.

Macia L, Thorburn AN, Binge LC, Marino E, Rogers KE, Maslowski KM, Vieira AT, Kranich J, Mackay CR.

Immunol Rev. 2012 Jan;245(1):164-76. doi: 10.1111/j.1600-065X.2011.01080.x. Review.

PMID:
22168419
48.

IL-21 enhances the potential of human γδ T cells to provide B-cell help.

Bansal RR, Mackay CR, Moser B, Eberl M.

Eur J Immunol. 2012 Jan;42(1):110-9. doi: 10.1002/eji.201142017. Epub 2011 Dec 12.

49.

Protection against Nippostrongylus brasiliensis infection in mice is independent of GM-CSF.

Shim DS, Schilter HC, Knott ML, Almeida RA, Short RP, Mackay CR, Dent LA, Sewell WA.

Immunol Cell Biol. 2012 May;90(5):553-8. doi: 10.1038/icb.2011.69. Epub 2011 Aug 16.

PMID:
21844882
50.

Specific expression of GPR56 by human cytotoxic lymphocytes.

Peng YM, van de Garde MD, Cheng KF, Baars PA, Remmerswaal EB, van Lier RA, Mackay CR, Lin HH, Hamann J.

J Leukoc Biol. 2011 Oct;90(4):735-40. doi: 10.1189/jlb.0211092. Epub 2011 Jul 1.

PMID:
21724806

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