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Items: 36


Dual dependence on BCL2 and MCL1 in T-cell prolymphocytic leukemia.

Smith VM, Lomas O, Constantine D, Palmer L, Schuh AH, Bruce D, Gonchar O, Macip S, Jayne S, Dyer MJS, Eyre TA.

Blood Adv. 2020 Feb 11;4(3):525-529. doi: 10.1182/bloodadvances.2019000917. No abstract available.


Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition.

Ekpenyong-Akiba AE, Poblocka M, Althubiti M, Rada M, Jurk D, Germano S, Kocsis-Fodor G, Shi Y, Canales JJ, Macip S.

Aging Cell. 2020 Jan;19(1):e13079. doi: 10.1111/acel.13079. Epub 2019 Nov 17.


Specific interactions of BCL-2 family proteins mediate sensitivity to BH3-mimetics in diffuse large B-cell lymphoma.

Smith VM, Dietz A, Henz K, Bruecher D, Jackson R, Kowald L, van Wijk SJL, Jayne S, Macip S, Fulda S, Dyer MJS, Vogler M.

Haematologica. 2019 Oct 10. pii: haematol.2019.220525. doi: 10.3324/haematol.2019.220525. [Epub ahead of print]


Radiotherapy-Induced Senescence and its Effects on Responses to Treatment.

Tabasso AFS, Jones DJL, Jones GDD, Macip S.

Clin Oncol (R Coll Radiol). 2019 May;31(5):283-289. doi: 10.1016/j.clon.2019.02.003. Epub 2019 Feb 27.


CUDC-907 blocks multiple pro-survival signals and abrogates microenvironment protection in CLL.

Chen Y, Peubez C, Smith V, Xiong S, Kocsis-Fodor G, Kennedy B, Wagner S, Balotis C, Jayne S, Dyer MJS, Macip S.

J Cell Mol Med. 2019 Jan;23(1):340-348. doi: 10.1111/jcmm.13935. Epub 2018 Oct 24.


BTK: a two-faced effector in cancer and tumour suppression.

Rada M, Barlev N, Macip S.

Cell Death Dis. 2018 Oct 18;9(11):1064. doi: 10.1038/s41419-018-1122-8.


BTK modulates p73 activity to induce apoptosis independently of p53.

Rada M, Barlev N, Macip S.

Cell Death Discov. 2018 Sep 11;4:30. doi: 10.1038/s41420-018-0097-7. eCollection 2018. Erratum in: Cell Death Discov. 2019 Jul 10;5:116.


Racial differences in endometrial cancer molecular portraits in The Cancer Genome Atlas.

Guttery DS, Blighe K, Polymeros K, Symonds RP, Macip S, Moss EL.

Oncotarget. 2018 Mar 30;9(24):17093-17103. doi: 10.18632/oncotarget.24907. eCollection 2018 Mar 30.


Differential activation of pro-survival pathways in response to CD40LG/IL4 stimulation in chronic lymphocytic leukaemia cells.

Chen Y, Peubez C, Jayne S, Kocsis-Fodor G, Dyer MJS, Macip S.

Br J Haematol. 2019 Mar;184(5):867-869. doi: 10.1111/bjh.15197. Epub 2018 Apr 20. No abstract available.


BTK blocks the inhibitory effects of MDM2 on p53 activity.

Rada M, Althubiti M, Ekpenyong-Akiba AE, Lee KG, Lam KP, Fedorova O, Barlev NA, Macip S.

Oncotarget. 2017 Nov 20;8(63):106639-106647. doi: 10.18632/oncotarget.22543. eCollection 2017 Dec 5.


Paradoxical activation of alternative pro-survival pathways determines resistance to MEK inhibitors in chronic lymphocytic leukaemia.

Chen Y, Germano S, Shelmani G, Kluczna D, Jayne S, Dyer MJS, Macip S.

Br J Haematol. 2018 Sep;182(6):921-924. doi: 10.1111/bjh.14880. Epub 2017 Aug 2. No abstract available.


Long-term follow-up of patients with CLL treated with the selective Bruton's tyrosine kinase inhibitor ONO/GS-4059.

Walter HS, Jayne S, Rule SA, Cartron G, Morschhauser F, Macip S, Karlin L, Jones C, Herbaux C, Quittet P, Shah N, Hutchinson CV, Fegan C, Yang Y, Mitra S, Salles G, Dyer MJS.

Blood. 2017 May 18;129(20):2808-2810. doi: 10.1182/blood-2017-02-765115. Epub 2017 Apr 4. No abstract available.


Detection of Senescent Cells by Extracellular Markers Using a Flow Cytometry-Based Approach.

Althubiti M, Macip S.

Methods Mol Biol. 2017;1534:147-153.


Posttranscriptional Upregulation of p53 by Reactive Oxygen Species in Chronic Lymphocytic Leukemia.

Samuel J, Jayne S, Chen Y, Majid A, Wignall A, Wormull T, Najeeb H, Luo JL, Jones GD, Macip S, Dyer MJ.

Cancer Res. 2016 Nov 1;76(21):6311-6319. Epub 2016 Sep 7.


BTK Modulates p53 Activity to Enhance Apoptotic and Senescent Responses.

Althubiti M, Rada M, Samuel J, Escorsa JM, Najeeb H, Lee KG, Lam KP, Jones GD, Barlev NA, Macip S.

Cancer Res. 2016 Sep 15;76(18):5405-14. doi: 10.1158/0008-5472.CAN-16-0690. Epub 2016 Jul 26.


Pro-survival signal inhibition by CDK inhibitor dinaciclib in Chronic Lymphocytic Leukaemia.

Chen Y, Germano S, Clements C, Samuel J, Shelmani G, Jayne S, Dyer MJ, Macip S.

Br J Haematol. 2016 Nov;175(4):641-651. doi: 10.1111/bjh.14285. Epub 2016 Jul 29.


Human EHMT2/G9a activates p53 through methylation-independent mechanism.

Rada M, Vasileva E, Lezina L, Marouco D, Antonov AV, Macip S, Melino G, Barlev NA.

Oncogene. 2017 Feb 16;36(7):922-932. doi: 10.1038/onc.2016.258. Epub 2016 Jul 25.


Characterization of novel markers of senescence and their prognostic potential in cancer.

Althubiti M, Lezina L, Carrera S, Jukes-Jones R, Giblett SM, Antonov A, Barlev N, Saldanha GS, Pritchard CA, Cain K, Macip S.

Cell Death Dis. 2014 Nov 20;5:e1528. doi: 10.1038/cddis.2014.489.


The role of the HIF-1α transcription factor in increased cell division at physiological oxygen tensions.

Carrera S, Senra J, Acosta MI, Althubiti M, Hammond EM, de Verdier PJ, Macip S.

PLoS One. 2014 May 16;9(5):e97938. doi: 10.1371/journal.pone.0097938. eCollection 2014.


Efficacy of vemurafenib in hairy-cell leukemia.

Samuel J, Macip S, Dyer MJ.

N Engl J Med. 2014 Jan 16;370(3):286-8. doi: 10.1056/NEJMc1310849. No abstract available.


Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage.

Carrera S, Cuadrado-Castano S, Samuel J, Jones GD, Villar E, Lee SW, Macip S.

Cell Death Differ. 2013 Jul;20(7):910-9. doi: 10.1038/cdd.2013.14. Epub 2013 Mar 1.


Precision medicines for B-cell leukaemias and lymphomas; progress and potential pitfalls.

Dyer MJ, Vogler M, Samuel J, Jayne S, Wagner S, Pritchard C, Macip S.

Br J Haematol. 2013 Mar;160(6):725-33. doi: 10.1111/bjh.12219. Epub 2013 Jan 24.


Reactive oxygen species and mitochondrial sensitivity to oxidative stress determine induction of cancer cell death by p21.

Masgras I, Carrera S, de Verdier PJ, Brennan P, Majid A, Makhtar W, Tulchinsky E, Jones GD, Roninson IB, Macip S.

J Biol Chem. 2012 Mar 23;287(13):9845-54. doi: 10.1074/jbc.M111.250357. Epub 2012 Feb 6.


Protection of cells in physiological oxygen tensions against DNA damage-induced apoptosis.

Carrera S, de Verdier PJ, Khan Z, Zhao B, Mahale A, Bowman KJ, Zainol M, Jones GD, Lee SW, Aaronson SA, Macip S.

J Biol Chem. 2010 Apr 30;285(18):13658-65. doi: 10.1074/jbc.M109.062562. Epub 2010 Mar 12.


Transcriptional role of p53 in interferon-mediated antiviral immunity.

Muñoz-Fontela C, Macip S, Martínez-Sobrido L, Brown L, Ashour J, García-Sastre A, Lee SW, Aaronson SA.

J Exp Med. 2008 Aug 4;205(8):1929-38. doi: 10.1084/jem.20080383. Epub 2008 Jul 28.


Loss of polycystin-1 causes centrosome amplification and genomic instability.

Battini L, Macip S, Fedorova E, Dikman S, Somlo S, Montagna C, Gusella GL.

Hum Mol Genet. 2008 Sep 15;17(18):2819-33. doi: 10.1093/hmg/ddn180. Epub 2008 Jun 19.


Entertaining science: I forgot to learn to forget.

Macip S.

Lancet Neurol. 2007 Feb;6(2):112. No abstract available.


Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance.

Battini L, Fedorova E, Macip S, Li X, Wilson PD, Gusella GL.

J Am Soc Nephrol. 2006 Nov;17(11):3049-58. Epub 2006 Sep 27.


Characterization of human metapneumovirus infection of myeloid dendritic cells.

Tan MC, Battini L, Tuyama AC, Macip S, Melendi GA, Horga MA, Gusella GL.

Virology. 2007 Jan 5;357(1):1-9. Epub 2006 Sep 7.


Oxidative stress induces a prolonged but reversible arrest in p53-null cancer cells, involving a Chk1-dependent G2 checkpoint.

Macip S, Kosoy A, Lee SW, O'Connell MJ, Aaronson SA.

Oncogene. 2006 Oct 5;25(45):6037-47. Epub 2006 May 1.


Human parainfluenza virus 3 neuraminidase activity contributes to dendritic cell maturation.

Horga MA, Macip S, Tuyama AC, Tan MC, Gusella GL.

Viral Immunol. 2005;18(3):523-33.


HB-EGF is a potent inducer of tumor growth and angiogenesis.

Ongusaha PP, Kwak JC, Zwible AJ, Macip S, Higashiyama S, Taniguchi N, Fang L, Lee SW.

Cancer Res. 2004 Aug 1;64(15):5283-90.


ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.

Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Nakayama KI, Aaronson SA, Lee SW.

Nat Cell Biol. 2004 Feb;6(2):121-8. Epub 2004 Jan 18.


Influence of induced reactive oxygen species in p53-mediated cell fate decisions.

Macip S, Igarashi M, Berggren P, Yu J, Lee SW, Aaronson SA.

Mol Cell Biol. 2003 Dec;23(23):8576-85.


Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence.

Macip S, Igarashi M, Fang L, Chen A, Pan ZQ, Lee SW, Aaronson SA.

EMBO J. 2002 May 1;21(9):2180-8.

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