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Items: 1 to 50 of 61

1.

The evolutionary history of 2,658 cancers.

Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S, Rosebrock D, Mitchell TJ, Rubanova Y, Anur P, Yu K, Tarabichi M, Deshwar A, Wintersinger J, Kleinheinz K, Vázquez-García I, Haase K, Jerman L, Sengupta S, Macintyre G, Malikic S, Donmez N, Livitz DG, Cmero M, Demeulemeester J, Schumacher S, Fan Y, Yao X, Lee J, Schlesner M, Boutros PC, Bowtell DD, Zhu H, Getz G, Imielinski M, Beroukhim R, Sahinalp SC, Ji Y, Peifer M, Markowetz F, Mustonen V, Yuan K, Wang W, Morris QD; PCAWG Evolution & Heterogeneity Working Group, Spellman PT, Wedge DC, Van Loo P; PCAWG Consortium.

Nature. 2020 Feb;578(7793):122-128. doi: 10.1038/s41586-019-1907-7. Epub 2020 Feb 6.

PMID:
32025013
2.

Inferring structural variant cancer cell fraction.

Cmero M, Yuan K, Ong CS, Schröder J; PCAWG Evolution and Heterogeneity Working Group, Corcoran NM, Papenfuss T, Hovens CM, Markowetz F, Macintyre G; PCAWG Consortium.

Nat Commun. 2020 Feb 5;11(1):730. doi: 10.1038/s41467-020-14351-8.

3.

Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis.

Lodhi RJ, Wang Y, Macintyre G, Crocker C, Loverock A, Henriques BC, Heywood B, Sivapalan S, Bowker A, Majeau B, Bolt C, Bugbee D, Newton V, Tibbo P, Purdon SE, Aitchison KJ.

Psychiatry Res. 2019 Oct;280:112500. doi: 10.1016/j.psychres.2019.112500. Epub 2019 Aug 8.

PMID:
31445421
4.

The double-edged sword of vulnerability: Explaining the persistent challenges for practitioners in supporting parents with intellectual disabilities.

MacIntyre G, Stewart A, McGregor S.

J Appl Res Intellect Disabil. 2019 Nov;32(6):1523-1534. doi: 10.1111/jar.12647. Epub 2019 Jul 18.

PMID:
31318123
5.

Correction: Safety and utility of image-guided research biopsies in relapsed high-grade serous ovarian carcinoma-experience of the BriTROC consortium.

Goranova T, Ennis D, Piskorz AM, Macintyre G, Lewsley LA, Stobo J, Wilson C, Kay D, Glasspool RM, Lockley M, Brockbank E, Montes A, Walther A, Sundar S, Edmondson R, Hall GD, Clamp A, Gourley C, Hall M, Fotopoulou C, Gabra H, Freeman S, Moore L, Jimenez-Linan M, Paul J, Brenton JD, McNeish IA; BriTROC investigators.

Br J Cancer. 2019 Apr;120(8):868. doi: 10.1038/s41416-019-0433-6.

6.

Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use.

Lodhi RJ, Wang Y, Rossolatos D, MacIntyre G, Bowker A, Crocker C, Ren H, Dimitrijevic A, Bugbee DA, Loverock A, Majeau B, Sivapalan S, Newton VM, Tibbo P, Purdon SE, Aitchison KJ.

Brain Behav. 2018 Sep;8(9):e01120. doi: 10.1002/brb3.1120. No abstract available.

7.

Copy number signatures and mutational processes in ovarian carcinoma.

Macintyre G, Goranova TE, De Silva D, Ennis D, Piskorz AM, Eldridge M, Sie D, Lewsley LA, Hanif A, Wilson C, Dowson S, Glasspool RM, Lockley M, Brockbank E, Montes A, Walther A, Sundar S, Edmondson R, Hall GD, Clamp A, Gourley C, Hall M, Fotopoulou C, Gabra H, Paul J, Supernat A, Millan D, Hoyle A, Bryson G, Nourse C, Mincarelli L, Sanchez LN, Ylstra B, Jimenez-Linan M, Moore L, Hofmann O, Markowetz F, McNeish IA, Brenton JD.

Nat Genet. 2018 Sep;50(9):1262-1270. doi: 10.1038/s41588-018-0179-8. Epub 2018 Aug 13.

8.

NPAS3 exonic SNP genotype is linked to working memory performance in healthy young adults.

Luoma LM, Macintyre G, Tibbo PG, Wild TC, Colman I, Purdon SE.

Psychiatry Res. 2018 Jul;265:263-264. doi: 10.1016/j.psychres.2018.04.063. Epub 2018 May 7. No abstract available.

PMID:
29763846
9.

Periprostatic fat tissue transcriptome reveals a signature diagnostic for high-risk prostate cancer.

Mangiola S, Stuchbery R, Macintyre G, Clarkson MJ, Peters JS, Costello AJ, Hovens CM, Corcoran NM.

Endocr Relat Cancer. 2018 May;25(5):569-581. doi: 10.1530/ERC-18-0058. Epub 2018 Mar 28.

PMID:
29592867
10.

Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use.

Lodhi RJ, Wang Y, Rossolatos D, MacIntyre G, Bowker A, Crocker C, Ren H, Dimitrijevic A, Bugbee DA, Loverock A, Majeau B, Sivapalan S, Newton VM, Tibbo P, Purdon SE, Aitchison KJ.

Brain Behav. 2017 Oct 6;7(11):e00850. doi: 10.1002/brb3.850. eCollection 2017 Nov. Erratum in: Brain Behav. 2018 Sep;8(9):e01120.

11.

Safety and utility of image-guided research biopsies in relapsed high-grade serous ovarian carcinoma-experience of the BriTROC consortium.

Goranova T, Ennis D, Piskorz AM, Macintyre G, Lewsley LA, Stobo J, Wilson C, Kay D, Glasspool RM, Lockley M, Brockbank E, Montes A, Walther A, Sundar S, Edmondson R, Hall GD, Clamp A, Gourley C, Hall M, Fotopoulou C, Gabra H, Freeman S, Moore L, Jimenez-Linan M, Paul J, Brenton JD, McNeish IA.

Br J Cancer. 2017 May 9;116(10):1294-1301. doi: 10.1038/bjc.2017.86. Epub 2017 Mar 30. Erratum in: Br J Cancer. 2019 Apr;120(8):868.

12.

How Subclonal Modeling Is Changing the Metastatic Paradigm.

Macintyre G, Van Loo P, Corcoran NM, Wedge DC, Markowetz F, Hovens CM.

Clin Cancer Res. 2017 Feb 1;23(3):630-635. doi: 10.1158/1078-0432.CCR-16-0234. Epub 2016 Nov 18. Review.

13.

Comparing nodal versus bony metastatic spread using tumour phylogenies.

Mangiola S, Hong MK, Cmero M, Kurganovs N, Ryan A, Costello AJ, Corcoran NM, Macintyre G, Hovens CM.

Sci Rep. 2016 Sep 22;6:33918. doi: 10.1038/srep33918.

14.

Sequencing Structural Variants in Cancer for Precision Therapeutics.

Macintyre G, Ylstra B, Brenton JD.

Trends Genet. 2016 Sep;32(9):530-542. doi: 10.1016/j.tig.2016.07.002. Epub 2016 Jul 29. Review.

PMID:
27478068
15.

Reduction in expression of the benign AR transcriptome is a hallmark of localised prostate cancer progression.

Stuchbery R, Macintyre G, Cmero M, Harewood LM, Peters JS, Costello AJ, Hovens CM, Corcoran NM.

Oncotarget. 2016 May 24;7(21):31384-92. doi: 10.18632/oncotarget.8915.

16.

The tandem duplicator phenotype as a distinct genomic configuration in cancer.

Menghi F, Inaki K, Woo X, Kumar PA, Grzeda KR, Malhotra A, Yadav V, Kim H, Marquez EJ, Ucar D, Shreckengast PT, Wagner JP, MacIntyre G, Murthy Karuturi KR, Scully R, Keck J, Chuang JH, Liu ET.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):E2373-82. doi: 10.1073/pnas.1520010113. Epub 2016 Apr 7.

17.

A urinary microRNA signature can predict the presence of bladder urothelial carcinoma in patients undergoing surveillance.

Sapre N, Macintyre G, Clarkson M, Naeem H, Cmero M, Kowalczyk A, Anderson PD, Costello AJ, Corcoran NM, Hovens CM.

Br J Cancer. 2016 Feb 16;114(4):454-62. doi: 10.1038/bjc.2015.472. Epub 2016 Jan 26.

18.

Methanol-based fixation is superior to buffered formalin for next-generation sequencing of DNA from clinical cancer samples.

Piskorz AM, Ennis D, Macintyre G, Goranova TE, Eldridge M, Segui-Gracia N, Valganon M, Hoyle A, Orange C, Moore L, Jimenez-Linan M, Millan D, McNeish IA, Brenton JD.

Ann Oncol. 2016 Mar;27(3):532-9. doi: 10.1093/annonc/mdv613. Epub 2015 Dec 17.

19.

Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.

Hong MK, Macintyre G, Wedge DC, Van Loo P, Patel K, Lunke S, Alexandrov LB, Sloggett C, Cmero M, Marass F, Tsui D, Mangiola S, Lonie A, Naeem H, Sapre N, Phal PM, Kurganovs N, Chin X, Kerger M, Warren AY, Neal D, Gnanapragasam V, Rosenfeld N, Pedersen JS, Ryan A, Haviv I, Costello AJ, Corcoran NM, Hovens CM.

Nat Commun. 2015 Apr 1;6:6605. doi: 10.1038/ncomms7605.

20.

Associating disease-related genetic variants in intergenic regions to the genes they impact.

Macintyre G, Jimeno Yepes A, Ong CS, Verspoor K.

PeerJ. 2014 Oct 23;2:e639. doi: 10.7717/peerj.639. eCollection 2014.

21.

Establishing and managing a global student network.

Shanmugam A, Macintyre G.

PLoS Comput Biol. 2014 Oct 30;10(10):e1003920. doi: 10.1371/journal.pcbi.1003920. eCollection 2014 Oct. No abstract available.

22.

Paving the way towards a successful and fulfilling career in computational biology.

Oluwagbemi O, Adebiyi M, Fatumo S, Macintyre G.

PLoS Comput Biol. 2014 May 1;10(5):e1003593. doi: 10.1371/journal.pcbi.1003593. eCollection 2014 May. No abstract available.

23.

Canonical androstenedione reduction is the predominant source of signaling androgens in hormone-refractory prostate cancer.

Fankhauser M, Tan Y, Macintyre G, Haviv I, Hong MK, Nguyen A, Pedersen JS, Costello AJ, Hovens CM, Corcoran NM.

Clin Cancer Res. 2014 Nov 1;20(21):5547-57. doi: 10.1158/1078-0432.CCR-13-3483. Epub 2014 Apr 25.

24.

Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads.

Schröder J, Hsu A, Boyle SE, Macintyre G, Cmero M, Tothill RW, Johnstone RW, Shackleton M, Papenfuss AT.

Bioinformatics. 2014 Apr 15;30(8):1064-1072. Epub 2014 Jan 2.

25.

Curated microRNAs in urine and blood fail to validate as predictive biomarkers for high-risk prostate cancer.

Sapre N, Hong MK, Macintyre G, Lewis H, Kowalczyk A, Costello AJ, Corcoran NM, Hovens CM.

PLoS One. 2014 Apr 4;9(4):e91729. doi: 10.1371/journal.pone.0091729. eCollection 2014.

26.

NPAS3 variants in schizophrenia: a neuroimaging study.

Bernier D, Macintyre G, Bartha R, Hanstock CC, McAllindon D, Cox D, Purdon S, Aitchison KJ, Rusak B, Tibbo PG.

BMC Med Genet. 2014 Mar 27;15:37. doi: 10.1186/1471-2350-15-37.

27.

Workshops: a great way to enhance and supplement a degree.

Fatumo S, Shome S, Macintyre G.

PLoS Comput Biol. 2014 Feb 27;10(2):e1003497. doi: 10.1371/journal.pcbi.1003497. eCollection 2014 Feb.

28.

Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array.

Naeem H, Wong NC, Chatterton Z, Hong MK, Pedersen JS, Corcoran NM, Hovens CM, Macintyre G.

BMC Genomics. 2014 Jan 22;15:51. doi: 10.1186/1471-2164-15-51.

29.

Breaking the ice and forging links: the importance of socializing in research.

Stobbe M, Mishra T, Macintyre G.

PLoS Comput Biol. 2013;9(11):e1003355. doi: 10.1371/journal.pcbi.1003355. Epub 2013 Nov 21.

30.

Ten simple rules for starting a regional student group.

Shanmugam AK, Macintyre G, Michaut M, Abeel T.

PLoS Comput Biol. 2013;9(11):e1003340. doi: 10.1371/journal.pcbi.1003340. Epub 2013 Nov 21. No abstract available.

31.

The young PI buzz: learning from the organizers of the Junior Principal Investigator Meeting at ISMB-ECCB 2013.

de Ridder J, Bromberg Y, Michaut M, Satagopam VP, Corpas M, MacIntyre G, Alexandrov T.

PLoS Comput Biol. 2013;9(11):e1003350. doi: 10.1371/journal.pcbi.1003350. Epub 2013 Nov 7. No abstract available.

32.

The regional student group program of the ISCB student council: stories from the road.

Macintyre G, Michaut M, Abeel T.

PLoS Comput Biol. 2013;9(9):e1003241. doi: 10.1371/journal.pcbi.1003241. Epub 2013 Sep 26.

33.

Percutaneous image-guided biopsy of prostate cancer metastases yields samples suitable for genomics and personalised oncology.

Hong MK, Sapre N, Phal PM, Macintyre G, Chin X, Pedersen JS, Ryan A, Kerger M, Costello AJ, Corcoran NM, Hovens CM.

Clin Exp Metastasis. 2014 Feb;31(2):159-67. doi: 10.1007/s10585-013-9617-2. Epub 2013 Oct 2.

PMID:
24085599
34.

ISCB computational biology Wikipedia competition.

Bateman A, Kelso J, Mietchen D, Macintyre G, Di Domenico T, Abeel T, Logan DW, Radivojac P, Rost B.

PLoS Comput Biol. 2013;9(9):e1003242. doi: 10.1371/journal.pcbi.1003242. Epub 2013 Sep 19. No abstract available.

35.

Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics.

Choudhury S, Almendro V, Merino VF, Wu Z, Maruyama R, Su Y, Martins FC, Fackler MJ, Bessarabova M, Kowalczyk A, Conway T, Beresford-Smith B, Macintyre G, Cheng YK, Lopez-Bujanda Z, Kaspi A, Hu R, Robens J, Nikolskaya T, Haakensen VD, Schnitt SJ, Argani P, Ethington G, Panos L, Grant M, Clark J, Herlihy W, Lin SJ, Chew G, Thompson EW, Greene-Colozzi A, Richardson AL, Rosson GD, Pike M, Garber JE, Nikolsky Y, Blum JL, Au A, Hwang ES, Tamimi RM, Michor F, Haviv I, Liu XS, Sukumar S, Polyak K.

Cell Stem Cell. 2013 Jul 3;13(1):117-30. doi: 10.1016/j.stem.2013.05.004. Epub 2013 Jun 13.

36.

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells.

Pirola L, Balcerczyk A, Tothill RW, Haviv I, Kaspi A, Lunke S, Ziemann M, Karagiannis T, Tonna S, Kowalczyk A, Beresford-Smith B, Macintyre G, Kelong M, Hongyu Z, Zhu J, El-Osta A.

Genome Res. 2011 Oct;21(10):1601-15. doi: 10.1101/gr.116095.110. Epub 2011 Sep 2.

37.

A bi-ordering approach to linking gene expression with clinical annotations in gastric cancer.

Shi F, Leckie C, MacIntyre G, Haviv I, Boussioutas A, Kowalczyk A.

BMC Bioinformatics. 2010 Sep 23;11:477. doi: 10.1186/1471-2105-11-477.

38.

is-rSNP: a novel technique for in silico regulatory SNP detection.

Macintyre G, Bailey J, Haviv I, Kowalczyk A.

Bioinformatics. 2010 Sep 15;26(18):i524-30. doi: 10.1093/bioinformatics/btq378.

39.

Association of NPAS3 exonic variation with schizophrenia.

Macintyre G, Alford T, Xiong L, Rouleau GA, Tibbo PG, Cox DW.

Schizophr Res. 2010 Jul;120(1-3):143-9. doi: 10.1016/j.schres.2010.04.002. Epub 2010 May 14.

PMID:
20466522
40.

Functional analysis of mutations in the ATP loop of the Wilson disease copper transporter, ATP7B.

Luoma LM, Deeb TM, Macintyre G, Cox DW.

Hum Mutat. 2010 May;31(5):569-77. doi: 10.1002/humu.21228.

PMID:
20333758
41.

A degree of success? Messages from the new social work degree in England for nurse education.

Moriarty J, Manthorpe J, Stevens M, Hussein S, Macintyre G, Orme J, Green Lister P, Sharpe E, Crisp B.

Nurse Educ Today. 2010 Jul;30(5):443-7. doi: 10.1016/j.nedt.2009.10.003. Epub 2009 Nov 3.

PMID:
19889483
42.

A minigene approach for analysis of ATP7B splice variants in patients with Wilson disease.

Wilson AM, Schlade-Bartusiak K, Tison JL, Macintyre G, Cox DW.

Biochimie. 2009 Oct;91(10):1342-5. doi: 10.1016/j.biochi.2009.06.008. Epub 2009 Jun 21.

PMID:
19540904
43.

A voting approach to identify a small number of highly predictive genes using multiple classifiers.

Hassan MR, Hossain MM, Bailey J, Macintyre G, Ho JW, Ramamohanarao K.

BMC Bioinformatics. 2009 Jan 30;10 Suppl 1:S19. doi: 10.1186/1471-2105-10-S1-S19.

44.

New mutations in the Wilson disease gene, ATP7B: implications for molecular testing.

Davies LP, Macintyre G, Cox DW.

Genet Test. 2008 Mar;12(1):139-45. doi: 10.1089/gte.2007.0072.

PMID:
18373411
45.

Sequence variation in the ATP-binding domain of the Wilson disease transporter, ATP7B, affects copper transport in a yeast model system.

Hsi G, Cullen LM, Macintyre G, Chen MM, Glerum DM, Cox DW.

Hum Mutat. 2008 Apr;29(4):491-501. doi: 10.1002/humu.20674.

PMID:
18203200
46.

A child with deletion (14)(q24.3q32.13) and auditory neuropathy.

Schlade-Bartusiak K, Macintyre G, Zunich J, Cox DW.

Am J Med Genet A. 2008 Jan 1;146A(1):117-23.

PMID:
18074379
47.

Value of an enzymatic assay for the determination of serum ceruloplasmin.

Macintyre G, Gutfreund KS, Martin WR, Camicioli R, Cox DW.

J Lab Clin Med. 2004 Dec;144(6):294-301.

PMID:
15614251
48.

Lowering S-adenosylmethionine levels in Escherichia coli modulates C-to-T transition mutations.

Macintyre G, Atwood CV, Cupples CG.

J Bacteriol. 2001 Feb;183(3):921-7.

49.

The E. coli Vsr endonuclease. Assaying activity in vitro and in vivo.

Cupples CG, Macintyre G.

Methods Mol Biol. 2000;152:63-73. No abstract available.

PMID:
10957969
50.

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