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Items: 23

1.

African isolates show a high proportion of multiple copies of the Plasmodium falciparum plasmepsin-2 gene, a piperaquine resistance marker.

Leroy D, Macintyre F, Adoke Y, Ouoba S, Barry A, Mombo-Ngoma G, Ndong Ngomo JM, Varo R, Dossou Y, Tshefu AK, Duong TT, Phuc BQ, Laurijssens B, Klopper R, Khim N, Legrand E, Ménard D.

Malar J. 2019 Apr 10;18(1):126. doi: 10.1186/s12936-019-2756-4.

2.

A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria.

Burrows J, Slater H, Macintyre F, Rees S, Thomas A, Okumu F, Hooft van Huijsduijnen R, Duparc S, Wells TNC.

Malar J. 2018 Dec 10;17(1):462. doi: 10.1186/s12936-018-2598-5. Review.

3.

Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria.

Macintyre F, Ramachandruni H, Burrows JN, Holm R, Thomas A, Möhrle JJ, Duparc S, Hooft van Huijsduijnen R, Greenwood B, Gutteridge WE, Wells TNC, Kaszubska W.

Malar J. 2018 Nov 1;17(1):402. doi: 10.1186/s12936-018-2549-1. Review.

4.

A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria.

Macintyre F, Adoke Y, Tiono AB, Duong TT, Mombo-Ngoma G, Bouyou-Akotet M, Tinto H, Bassat Q, Issifou S, Adamy M, Demarest H, Duparc S, Leroy D, Laurijssens BE, Biguenet S, Kibuuka A, Tshefu AK, Smith M, Foster C, Leipoldt I, Kremsner PG, Phuc BQ, Ouedraogo A, Ramharter M; OZ-Piperaquine Study Group.

BMC Med. 2017 Oct 9;15(1):181. doi: 10.1186/s12916-017-0940-3.

5.

Erratum to: New developments in anti-malarial target candidate and product profiles.

Burrows JN, Duparc S, Gutteridge WE, van Huijsduijnen RH, Kaszubska W, Macintyre F, Mazzuri S, Möhrle JJ, Wells TNC.

Malar J. 2017 Apr 18;16(1):151. doi: 10.1186/s12936-017-1809-9. No abstract available.

6.

New developments in anti-malarial target candidate and product profiles.

Burrows JN, Duparc S, Gutteridge WE, Hooft van Huijsduijnen R, Kaszubska W, Macintyre F, Mazzuri S, Möhrle JJ, Wells TNC.

Malar J. 2017 Jan 13;16(1):26. doi: 10.1186/s12936-016-1675-x. Review. Erratum in: Malar J. 2017 Apr 18;16(1):151.

7.

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial.

Phyo AP, Jittamala P, Nosten FH, Pukrittayakamee S, Imwong M, White NJ, Duparc S, Macintyre F, Baker M, Möhrle JJ.

Lancet Infect Dis. 2016 Jan;16(1):61-69. doi: 10.1016/S1473-3099(15)00320-5. Epub 2015 Oct 5.

8.

Evaluation of the QT effect of a combination of piperaquine and a novel anti-malarial drug candidate OZ439, for the treatment of uncomplicated malaria.

Darpo B, Ferber G, Siegl P, Laurijssens B, Macintyre F, Toovey S, Duparc S.

Br J Clin Pharmacol. 2015 Oct;80(4):706-15. doi: 10.1111/bcp.12680. Epub 2015 Jul 14.

9.

SAR of a series of inhaled A(2A) agonists and comparison of inhaled pharmacokinetics in a preclinical model with clinical pharmacokinetic data.

Mantell SJ, Stephenson PT, Monaghan SM, Maw GN, Trevethick MA, Yeadon M, Walker DK, Selby MD, Batchelor DV, Rozze S, Chavaroche H, Lemaitre A, Wright KN, Whitlock L, Stuart EF, Wright PA, Macintyre F.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4471-5. doi: 10.1016/j.bmcl.2009.05.027. Epub 2009 May 12.

PMID:
19501510
10.

Role of mechanistically-based pharmacokinetic/pharmacodynamic models in drug development : a case study of a therapeutic protein.

Marshall S, Macintyre F, James I, Krams M, Jonsson NE.

Clin Pharmacokinet. 2006;45(2):177-97.

PMID:
16485916
11.
12.

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

Obach RS, Baxter JG, Liston TE, Silber BM, Jones BC, MacIntyre F, Rance DJ, Wastall P.

J Pharmacol Exp Ther. 1997 Oct;283(1):46-58.

PMID:
9336307
13.

Some comments on the thermodynamics of sonoluminescence--a personal view.

MacIntyre F.

Ultrason Sonochem. 1997 Apr;4(2):85-93.

PMID:
11237049
14.

Diversity of eukaryotic microorganisms: computer-based resources, "The Handbook of Protoctista" and its "Glossary".

Margulis L, Olendzenski L, Dolan M, MacIntyre F.

Microbiologia. 1996 Mar;12(1):29-42.

PMID:
9019132
15.

Sperm competition and the persistence of genes for male homosexuality.

MacIntyre F, Estep KW.

Biosystems. 1993;31(2-3):223-33.

PMID:
8155854
16.

Plasma bromine concentrations and lipid profiles.

Corrigan FM, Skinner ER, MacIntyre F, Ijomah G, Holliday J, Horrobin DF, Ward NI.

Clin Chim Acta. 1991 Dec 31;204(1-3):301-4. No abstract available.

PMID:
1819471
17.

Plasma lipoprotein profiles and the distribution of high-density lipoprotein subfractions in the elderly: the effect of Alzheimer's disease and multi-infarct dementia.

Van Rhijn A, Macintyre F, Corrigan FM, Watt C, Ijomah G, Skinner ER.

Biochem Soc Trans. 1990 Apr;18(2):324. No abstract available.

PMID:
2379739
18.

The use of metabolic inhibitors in the analysis of eukaryotic DNA repair.

Collins A, Macintyre F, Gedik C.

Acta Biol Hung. 1990;41(1-3):65-75. Review.

PMID:
2094131
19.

Serum cyclosporin levels, hepatic drug metabolism and renal tubulotoxicity.

Cunningham C, Gavin MP, Whiting PH, Burke MD, Macintyre F, Thomson AW, Simpson JG.

Biochem Pharmacol. 1984 Sep 15;33(18):2857-61.

PMID:
6477645
20.

Carbon-13 in tree rings indicates no record of sea-surface temperature.

Macintyre F.

Science. 1979 Sep 14;205(4411):1127-9.

PMID:
17735048
21.

Accumulation of radioiodine in staff members.

Jackson GL, MacIntyre F.

J Nucl Med. 1979 Sep;20(9):995. No abstract available.

22.

Experimental studies of renal function in acute urethral obstruction.

DOMINGUEZ R, ADAMS RB, MACINTYRE F.

Postgrad Semin Am Urol Assoc North Cent. 1956-1957:28-30. No abstract available.

PMID:
13567629
23.

Effect of stress, TSH and ACTH on the level of hormonal I131 of serum.

SHIPLEY RA, MACINTYRE FH.

J Clin Endocrinol Metab. 1954 Mar;14(3):309-17. No abstract available.

PMID:
13143066

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