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Items: 1 to 50 of 86

1.

MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling.

Baturcam E, Vollmer S, Schlüter H, Maciewicz RA, Kurian N, Vaarala O, Ludwig S, Cunoosamy DM.

Cell Commun Signal. 2019 Jul 18;17(1):78. doi: 10.1186/s12964-019-0378-7.

2.

Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases.

Fujino N, Brand OJ, Morgan DJ, Fujimori T, Grabiec AM, Jagger CP, Maciewicz RA, Yamada M, Itakura K, Sugiura H, Ichinose M, Hussell T.

J Exp Med. 2019 Sep 2;216(9):2184-2201. doi: 10.1084/jem.20171978. Epub 2019 Jul 9.

PMID:
31289116
3.

Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing.

Khoo SK, Read J, Franks K, Zhang G, Bizzintino J, Coleman L, McCrae C, Öberg L, Troy NM, Prastanti F, Everard J, Oo S, Borland ML, Maciewicz RA, Le Souëf PN, Laing IA, Bosco A.

J Immunol. 2019 Mar 15;202(6):1845-1858. doi: 10.4049/jimmunol.1800178. Epub 2019 Feb 11.

PMID:
30745463
4.

Phenotypic screening identifies Axl kinase as a negative regulator of an alveolar epithelial cell phenotype.

Fujino N, Kubo H, Maciewicz RA.

Lab Invest. 2017 Sep;97(9):1047-1062. doi: 10.1038/labinvest.2017.52. Epub 2017 May 29.

5.

Pain in knee osteoarthritis is associated with variation in the neurokinin 1/substance P receptor (TACR1) gene.

Warner SC, Walsh DA, Laslett LL, Maciewicz RA, Soni A, Hart DJ, Zhang W, Muir KR, Dennison EM, Leaverton P, Rampersaud E, Cooper C, Spector TD, Cicuttini FM, Arden NK, Jones G, Doherty M, Valdes AM.

Eur J Pain. 2017 Aug;21(7):1277-1284. doi: 10.1002/ejp.1027. Epub 2017 May 11.

6.

Bone Area Provides a Responsive Outcome Measure for Bone Changes in Short-term Knee Osteoarthritis Studies.

Bowes MA, Maciewicz RA, Waterton JC, Hunter DJ, Conaghan PG.

J Rheumatol. 2016 Dec;43(12):2179-2182. Epub 2016 Oct 1.

7.

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.

Castaño-Betancourt MC, Evans DS, Ramos YF, Boer CG, Metrustry S, Liu Y, den Hollander W, van Rooij J, Kraus VB, Yau MS, Mitchell BD, Muir K, Hofman A, Doherty M, Doherty S, Zhang W, Kraaij R, Rivadeneira F, Barrett-Connor E, Maciewicz RA, Arden N, Nelissen RG, Kloppenburg M, Jordan JM, Nevitt MC, Slagboom EP, Hart DJ, Lafeber F, Styrkarsdottir U, Zeggini E, Evangelou E, Spector TD, Uitterlinden AG, Lane NE, Meulenbelt I, Valdes AM, van Meurs JB.

PLoS Genet. 2016 Oct 4;12(10):e1006260. doi: 10.1371/journal.pgen.1006260. eCollection 2016 Oct.

8.

Association of Beta-Blocker Use With Less Prevalent Joint Pain and Lower Opioid Requirement in People With Osteoarthritis.

Valdes AM, Abhishek A, Muir K, Zhang W, Maciewicz RA, Doherty M.

Arthritis Care Res (Hoboken). 2017 Jul;69(7):1076-1081. doi: 10.1002/acr.23091. Epub 2017 Jun 7.

9.

Does Chondrocalcinosis Associate With a Distinct Radiographic Phenotype of Osteoarthritis in Knees and Hips? A Case-Control Study.

Abhishek A, Doherty S, Maciewicz RA, Muir K, Zhang W, Doherty M.

Arthritis Care Res (Hoboken). 2016 Feb;68(2):211-6. doi: 10.1002/acr.22652.

10.

Beer and wine consumption and risk of knee or hip osteoarthritis: a case control study.

Muthuri SG, Zhang W, Maciewicz RA, Muir K, Doherty M.

Arthritis Res Ther. 2015 Feb 5;17:23. doi: 10.1186/s13075-015-0534-4.

11.

The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung.

Fujimori T, Grabiec AM, Kaur M, Bell TJ, Fujino N, Cook PC, Svedberg FR, MacDonald AS, Maciewicz RA, Singh D, Hussell T.

Mucosal Immunol. 2015 Sep;8(5):1021-1030. doi: 10.1038/mi.2014.129. Epub 2015 Jan 21.

12.

Lower leptin/adiponectin ratio and risk of rapid lung function decline in chronic obstructive pulmonary disease.

Suzuki M, Makita H, Östling J, Thomsen LH, Konno S, Nagai K, Shimizu K, Pedersen JH, Ashraf H, Bruijnzeel PL, Maciewicz RA, Nishimura M; Hokkaido COPD Cohort Study; Danish Lung Cancer Screening Trial Investigators.

Ann Am Thorac Soc. 2014 Dec;11(10):1511-9. doi: 10.1513/AnnalsATS.201408-351OC.

PMID:
25372271
13.

Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study.

McWilliams DF, Muthuri S, Muir KR, Maciewicz RA, Zhang W, Doherty M.

BMC Musculoskelet Disord. 2014 Sep 20;15:308. doi: 10.1186/1471-2474-15-308.

14.

Evidence of changes to skeletal muscle contractile properties during the initiation of disease in the ageing guinea pig model of osteoarthritis.

Tonge DP, Bardsley RG, Parr T, Maciewicz RA, Jones SW.

Longev Healthspan. 2013 Dec 1;2(1):15. doi: 10.1186/2046-2395-2-15.

15.

Use of statins is associated with a lower prevalence of generalised osteoarthritis.

Valdes AM, Zhang W, Muir K, Maciewicz RA, Doherty S, Doherty M.

Ann Rheum Dis. 2014 May;73(5):943-5. doi: 10.1136/annrheumdis-2013-204382. Epub 2013 Dec 17. No abstract available.

16.

The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study.

Panoutsopoulou K, Metrustry S, Doherty SA, Laslett LL, Maciewicz RA, Hart DJ, Zhang W, Muir KR, Wheeler M, Cooper C, Spector TD, Cicuttini FM, Jones G, Arden NK, Doherty M, Zeggini E, Valdes AM; arcOGEN Consortium.

Ann Rheum Dis. 2014 Dec;73(12):2082-6. doi: 10.1136/annrheumdis-2013-203772. Epub 2013 Aug 6.

17.

Contribution of the COMT Val158Met variant to symptomatic knee osteoarthritis.

Neogi T, Soni A, Doherty SA, Laslett LL, Maciewicz RA, Hart DJ, Zhang W, Muir KR, Wheeler M, Cooper C, Spector TD, Cicuttini F, Jones G, Nevitt M, Liu Y, Arden NK, Doherty M, Valdes AM.

Ann Rheum Dis. 2014 Jan;73(1):315-7. doi: 10.1136/annrheumdis-2013-203836. Epub 2013 Jul 13. No abstract available.

18.

Hydantoin based inhibitors of MMP13--discovery of AZD6605.

De Savi C, Waterson D, Pape A, Lamont S, Hadley E, Mills M, Page KM, Bowyer J, Maciewicz RA.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4705-12. doi: 10.1016/j.bmcl.2013.05.089. Epub 2013 Jun 10.

PMID:
23810497
19.

Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis.

Muthuri SG, Doherty S, Zhang W, Maciewicz RA, Muir KR, Doherty M.

Arthritis Res Ther. 2013 Apr 18;15(2):R52. doi: 10.1186/ar4214.

20.

The genetic contribution to severe post-traumatic osteoarthritis.

Valdes AM, Doherty SA, Muir KR, Wheeler M, Maciewicz RA, Zhang W, Doherty M.

Ann Rheum Dis. 2013 Oct;72(10):1687-90. doi: 10.1136/annrheumdis-2012-202562. Epub 2013 Jan 26.

21.

Genetic contribution to radiographic severity in osteoarthritis of the knee.

Valdes AM, Doherty S, Muir KR, Zhang W, Maciewicz RA, Wheeler M, Arden N, Cooper C, Doherty M.

Ann Rheum Dis. 2012 Sep;71(9):1537-40. doi: 10.1136/annrheumdis-2012-201382. Epub 2012 May 21.

22.

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.

Castaño Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, Metrustry S, Muir K, Peters MJ, Rivadeneira F, Wheeler M, Zhang W, Arden N, Spector TD, Uitterlinden AG, Doherty M, Lories RJ, Valdes AM, van Meurs JB.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8218-23. doi: 10.1073/pnas.1119899109. Epub 2012 May 7.

23.

A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.

Malfait AM, Seymour AB, Gao F, Tortorella MD, Le Graverand-Gastineau MP, Wood LS, Doherty M, Doherty S, Zhang W, Arden NK, Vaughn FL, Leaverton PE, Spector TD, Hart DJ, Maciewicz RA, Muir KR, Das R, Sorge RE, Sotocinal SG, Schorscher-Petcu A, Valdes AM, Mogil JS.

Ann Rheum Dis. 2012 Jun;71(6):1042-8. doi: 10.1136/annrheumdis-2011-200300. Epub 2012 Mar 22.

24.

Self-reported knee malalignment in early adult life as an independent risk for knee chondrocalcinosis.

Abhishek A, Doherty S, Maciewicz RA, Muir KR, Zhang W, Doherty M.

Arthritis Care Res (Hoboken). 2011 Nov;63(11):1550-7. doi: 10.1002/acr.20593.

25.

A variant in MCF2L is associated with osteoarthritis.

Day-Williams AG, Southam L, Panoutsopoulou K, Rayner NW, Esko T, Estrada K, Helgadottir HT, Hofman A, Ingvarsson T, Jonsson H, Keis A, Kerkhof HJ, Thorleifsson G, Arden NK, Carr A, Chapman K, Deloukas P, Loughlin J, McCaskie A, Ollier WE, Ralston SH, Spector TD, Wallis GA, Wilkinson JM, Aslam N, Birell F, Carluke I, Joseph J, Rai A, Reed M, Walker K; arcOGEN Consortium, Doherty SA, Jonsdottir I, Maciewicz RA, Muir KR, Metspalu A, Rivadeneira F, Stefansson K, Styrkarsdottir U, Uitterlinden AG, van Meurs JB, Zhang W, Valdes AM, Doherty M, Zeggini E.

Am J Hum Genet. 2011 Sep 9;89(3):446-50. doi: 10.1016/j.ajhg.2011.08.001. Epub 2011 Aug 25.

26.

Inverse relationship between preoperative radiographic severity and postoperative pain in patients with osteoarthritis who have undergone total joint arthroplasty.

Valdes AM, Doherty SA, Zhang W, Muir KR, Maciewicz RA, Doherty M.

Semin Arthritis Rheum. 2012 Feb;41(4):568-75. doi: 10.1016/j.semarthrit.2011.07.002. Epub 2011 Aug 24.

PMID:
21868060
27.

Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations.

Valdes AM, Styrkarsdottir U, Doherty M, Morris DL, Mangino M, Tamm A, Doherty SA, Kisand K, Kerna I, Tamm A, Wheeler M, Maciewicz RA, Zhang W, Muir KR, Dennison EM, Hart DJ, Metrustry S, Jonsdottir I, Jonsson GF, Jonsson H, Ingvarsson T, Cooper C, Vyse TJ, Spector TD, Stefansson K, Arden NK.

PLoS One. 2011;6(8):e23371. doi: 10.1371/journal.pone.0023371. Epub 2011 Aug 10.

28.

The Ile585Val TRPV1 variant is involved in risk of painful knee osteoarthritis.

Valdes AM, De Wilde G, Doherty SA, Lories RJ, Vaughn FL, Laslett LL, Maciewicz RA, Soni A, Hart DJ, Zhang W, Muir KR, Dennison EM, Wheeler M, Leaverton P, Cooper C, Spector TD, Cicuttini FM, Chapman V, Jones G, Arden NK, Doherty M.

Ann Rheum Dis. 2011 Sep;70(9):1556-61. doi: 10.1136/ard.2010.148122. Epub 2011 May 25.

29.

Temporal relationship between serum adipokines, biomarkers of bone and cartilage turnover, and cartilage volume loss in a population with clinical knee osteoarthritis.

Berry PA, Jones SW, Cicuttini FM, Wluka AE, Maciewicz RA.

Arthritis Rheum. 2011 Mar;63(3):700-7. doi: 10.1002/art.30182.

30.

Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.

Kerkhof HJ, Doherty M, Arden NK, Abramson SB, Attur M, Bos SD, Cooper C, Dennison EM, Doherty SA, Evangelou E, Hart DJ, Hofman A, Javaid K, Kerna I, Kisand K, Kloppenburg M, Krasnokutsky S, Maciewicz RA, Meulenbelt I, Muir KR, Rivadeneira F, Samuels J, Sezgin M, Slagboom E, Smith AJ, Spector TD, Tamm A, Tamm A, Uitterlinden AG, Wheeler M, Zhai G, Zhang W, van Meurs JB, Valdes AM.

Osteoarthritis Cartilage. 2011 Mar;19(3):265-71. doi: 10.1016/j.joca.2010.12.003. Epub 2010 Dec 10. Review.

31.

Lifetime body mass index, other anthropometric measures of obesity and risk of knee or hip osteoarthritis in the GOAL case-control study.

Holliday KL, McWilliams DF, Maciewicz RA, Muir KR, Zhang W, Doherty M.

Osteoarthritis Cartilage. 2011 Jan;19(1):37-43. doi: 10.1016/j.joca.2010.10.014. Epub 2010 Oct 31.

32.

Role of the Nav1.7 R1150W amino acid change in susceptibility to symptomatic knee osteoarthritis and multiple regional pain.

Valdes AM, Arden NK, Vaughn FL, Doherty SA, Leaverton PE, Zhang W, Muir KR, Rampersaud E, Dennison EM, Edwards MH, Jameson KA, Javaid MK, Spector TD, Cooper C, Maciewicz RA, Doherty M.

Arthritis Care Res (Hoboken). 2011 Mar;63(3):440-4. doi: 10.1002/acr.20375. Epub 2010 Oct 28.

33.

The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance.

Valdes AM, Evangelou E, Kerkhof HJ, Tamm A, Doherty SA, Kisand K, Tamm A, Kerna I, Uitterlinden A, Hofman A, Rivadeneira F, Cooper C, Dennison EM, Zhang W, Muir KR, Ioannidis JP, Wheeler M, Maciewicz RA, van Meurs JB, Arden NK, Spector TD, Doherty M.

Ann Rheum Dis. 2011 May;70(5):873-5. doi: 10.1136/ard.2010.134155. Epub 2010 Sep 24. No abstract available.

34.

Relationship of serum markers of cartilage metabolism to imaging and clinical outcome measures of knee joint structure.

Berry PA, Maciewicz RA, Wluka AE, Downey-Jones MD, Forbes A, Hellawell CJ, Cicuttini FM.

Ann Rheum Dis. 2010 Oct;69(10):1816-22. doi: 10.1136/ard.2009.124420. Epub 2010 Jun 15.

PMID:
20551154
35.

Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes.

Valdes AM, McWilliams D, Arden NK, Doherty SA, Wheeler M, Muir KR, Zhang W, Cooper C, Maciewicz RA, Doherty M.

Arthritis Rheum. 2010 Sep;62(9):2688-95. doi: 10.1002/art.27574.

36.

Mild acetabular dysplasia and risk of osteoarthritis of the hip: a case-control study.

McWilliams DF, Doherty SA, Jenkins WD, Maciewicz RA, Muir KR, Zhang W, Doherty M.

Ann Rheum Dis. 2010 Oct;69(10):1774-8. doi: 10.1136/ard.2009.127076. Epub 2010 May 14.

PMID:
20472600
37.

Markers of bone formation and resorption identify subgroups of patients with clinical knee osteoarthritis who have reduced rates of cartilage loss.

Berry PA, Maciewicz RA, Cicuttini FM, Jones MD, Hellawell CJ, Wluka AE.

J Rheumatol. 2010 Jun;37(6):1252-9. doi: 10.3899/jrheum.091055. Epub 2010 Apr 15.

PMID:
20395641
38.

Self-reported knee and foot alignments in early adult life and risk of osteoarthritis.

McWilliams DF, Doherty S, Maciewicz RA, Muir KR, Zhang W, Doherty M.

Arthritis Care Res (Hoboken). 2010 Apr;62(4):489-95. doi: 10.1002/acr.20169.

39.

Anatomically corresponded regional analysis of cartilage in asymptomatic and osteoarthritic knees by statistical shape modelling of the bone.

Williams TG, Holmes AP, Waterton JC, Maciewicz RA, Hutchinson CE, Moots RJ, Nash AF, Taylor CJ.

IEEE Trans Med Imaging. 2010 Aug;29(8):1541-59. doi: 10.1109/TMI.2010.2047653. Epub 2010 Apr 8.

PMID:
20378463
40.

Measurement and visualisation of focal cartilage thickness change by MRI in a study of knee osteoarthritis using a novel image analysis tool.

Williams TG, Holmes AP, Bowes M, Vincent G, Hutchinson CE, Waterton JC, Maciewicz RA, Taylor CJ.

Br J Radiol. 2010 Nov;83(995):940-8. doi: 10.1259/bjr/68875123. Epub 2010 Mar 11.

41.

Can cartilage loss be detected in knee osteoarthritis (OA) patients with 3-6 months' observation using advanced image analysis of 3T MRI?

Hunter DJ, Bowes MA, Eaton CB, Holmes AP, Mann H, Kwoh CK, Maciewicz RA, Samuels J, Waterton JC.

Osteoarthritis Cartilage. 2010 May;18(5):677-83. doi: 10.1016/j.joca.2010.02.010. Epub 2010 Feb 26.

42.

A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis.

Valdes AM, Arden NK, Tamm A, Kisand K, Doherty S, Pola E, Cooper C, Tamm A, Muir KR, Kerna I, Hart D, O'Neil F, Zhang W, Spector TD, Maciewicz RA, Doherty M.

Osteoarthritis Cartilage. 2010 May;18(5):699-704. doi: 10.1016/j.joca.2009.12.012. Epub 2010 Feb 6.

43.

Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis.

Mapp PI, Walsh DA, Bowyer J, Maciewicz RA.

Osteoarthritis Cartilage. 2010 Apr;18(4):593-600. doi: 10.1016/j.joca.2009.12.006. Epub 2010 Jan 7.

44.

Beta2-adrenergic agonist-induced hypertrophy of the quadriceps skeletal muscle does not modulate disease severity in the rodent meniscectomy model of osteoarthritis.

Tonge DP, Jones SW, Parr T, Bardsley R, Doherty M, Maciewicz RA.

Osteoarthritis Cartilage. 2010 Apr;18(4):555-62. doi: 10.1016/j.joca.2009.11.014. Epub 2009 Dec 21.

45.

Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease?

Maciewicz RA, Warburton D, Rennard SI.

Proc Am Thorac Soc. 2009 Dec 1;6(7):614-7. doi: 10.1513/pats.200908-094RM. Review.

PMID:
19934358
46.

Characterization of fibrodysplasia in the dog following inhibition of metalloproteinases.

Westwood R, Scott RC, Somers RL, Coulson M, Maciewicz RA.

Toxicol Pathol. 2009 Dec;37(7):860-72. doi: 10.1177/0192623309347909.

PMID:
19801504
47.

Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig.

Bowyer J, Heapy CG, Flannelly JK, Waterton JC, Maciewicz RA.

Int J Exp Pathol. 2009 Apr;90(2):174-81. doi: 10.1111/j.1365-2613.2008.00634.x.

48.

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized.

Hunter DJ, Gerstenfeld L, Bishop G, Davis AD, Mason ZD, Einhorn TA, Maciewicz RA, Newham P, Foster M, Jackson S, Morgan EF.

Arthritis Res Ther. 2009;11(1):R11. doi: 10.1186/ar2601. Epub 2009 Jan 26.

49.

Attempt to replicate published genetic associations in a large, well-defined osteoarthritis case-control population (the GOAL study).

Limer KL, Tosh K, Bujac SR, McConnell R, Doherty S, Nyberg F, Zhang W, Doherty M, Muir KR, Maciewicz RA.

Osteoarthritis Cartilage. 2009 Jun;17(6):782-9. doi: 10.1016/j.joca.2008.09.019. Epub 2008 Nov 1.

50.

Nonspherical femoral head shape (pistol grip deformity), neck shaft angle, and risk of hip osteoarthritis: a case-control study.

Doherty M, Courtney P, Doherty S, Jenkins W, Maciewicz RA, Muir K, Zhang W.

Arthritis Rheum. 2008 Oct;58(10):3172-82. doi: 10.1002/art.23939.

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