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Items: 1 to 50 of 53

1.

One-year efficacy and safety of prasugrel and ticagrelor in patients with Acute Coronary Syndromes: results from a prospective and multicenter ACHILLES Registry.

Ruiz-Nodar JM, Esteve-Pastor MA, Rivera-Caravaca JM, Sandín M, Lozano T, Vicente-Ibarra N, Orenes-Piñero E, Macías MJ, Pernías V, Carrillo L, Candela E, Veliz A, Tello-Montoliu A, Martínez JGM, Marín F.

Br J Clin Pharmacol. 2020 Jan 8. doi: 10.1111/bcp.14213. [Epub ahead of print]

PMID:
31912949
2.

Binding site plasticity in viral PPxY Late domain recognition by the third WW domain of human NEDD4.

Iglesias-Bexiga M, Palencia A, Corbi-Verge C, Martin-Malpartida P, Blanco FJ, Macias MJ, Cobos ES, Luque I.

Sci Rep. 2019 Oct 21;9(1):15076. doi: 10.1038/s41598-019-50701-3.

3.

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling.

Aragón E, Wang Q, Zou Y, Morgani SM, Ruiz L, Kaczmarska Z, Su J, Torner C, Tian L, Hu J, Shu W, Agrawal S, Gomes T, Márquez JA, Hadjantonakis AK, Macias MJ, Massagué J.

Genes Dev. 2019 Nov 1;33(21-22):1506-1524. doi: 10.1101/gad.330837.119. Epub 2019 Oct 3.

4.

Conservatively managed patients with non-ST-segment elevation acute coronary syndrome are undertreated with indicated medicines.

Candela E, Marín F, Rivera-Caravaca JM, Vicente Ibarra N, Carrillo L, Esteve-Pastor MA, Lozano T, Macías MJ, Pernias V, Sandín M, Orenes-Piñero E, Quintana-Giner M, Hortelano I, Villamía B, Veliz A, Valdés M, Martínez-Martínez JG, Ruiz-Nodar JM.

PLoS One. 2018 Nov 28;13(11):e0208069. doi: 10.1371/journal.pone.0208069. eCollection 2018.

5.

TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling.

Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ.

Nucleic Acids Res. 2018 Sep 28;46(17):9220-9235. doi: 10.1093/nar/gky680.

6.

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors.

Martin-Malpartida P, Batet M, Kaczmarska Z, Freier R, Gomes T, Aragón E, Zou Y, Wang Q, Xi Q, Ruiz L, Vea A, Márquez JA, Massagué J, Macias MJ.

Nat Commun. 2017 Dec 12;8(1):2070. doi: 10.1038/s41467-017-02054-6.

7.

The synthesis of an EDTA-like chelating peptidomimetic building block suitable for solid-phase peptide synthesis.

Spengler J, Barker M, Schelhorn C, García J, Macias MJ, Albericio F.

Chem Commun (Camb). 2017 Feb 23;53(17):2634-2636. doi: 10.1039/c6cc10203d.

PMID:
28198898
8.

Peptide aromatic interactions modulated by fluorinated residues: Synthesis, structure and biological activity of Somatostatin analogs containing 3-(3',5'difluorophenyl)-alanine.

Martín-Gago P, Rol Á, Todorovski T, Aragón E, Martin-Malpartida P, Verdaguer X, Vallès Miret M, Fernández-Carneado J, Ponsati B, Macias MJ, Riera A.

Sci Rep. 2016 Jun 7;6:27285. doi: 10.1038/srep27285.

9.

ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.

Wright RH, Lioutas A, Le Dily F, Soronellas D, Pohl A, Bonet J, Nacht AS, Samino S, Font-Mateu J, Vicent GP, Wierer M, Trabado MA, Schelhorn C, Carolis C, Macias MJ, Yanes O, Oliva B, Beato M.

Science. 2016 Jun 3;352(6290):1221-5. doi: 10.1126/science.aad9335.

10.

Preventing fibril formation of a protein by selective mutation.

Maisuradze GG, Medina J, Kachlishvili K, Krupa P, Mozolewska MA, Martin-Malpartida P, Maisuradze L, Macias MJ, Scheraga HA.

Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13549-54. doi: 10.1073/pnas.1518298112. Epub 2015 Oct 19.

11.

Structural Analysis of the Pin1-CPEB1 interaction and its potential role in CPEB1 degradation.

Schelhorn C, Martín-Malpartida P, Suñol D, Macias MJ.

Sci Rep. 2015 Oct 12;5:14990. doi: 10.1038/srep14990.

12.

Addition of HOBt improves the conversion of thioester-Amine chemical ligation.

Todorovski T, Suñol D, Riera A, Macias MJ.

Biopolymers. 2015 Nov;104(6):693-702. doi: 10.1002/bip.22745.

PMID:
26396113
13.

Structural determinants of Smad function in TGF-β signaling.

Macias MJ, Martin-Malpartida P, Massagué J.

Trends Biochem Sci. 2015 Jun;40(6):296-308. doi: 10.1016/j.tibs.2015.03.012. Epub 2015 Apr 29. Review.

14.

Structure of the N-terminal domain of the protein Expansion: an 'Expansion' to the Smad MH2 fold.

Beich-Frandsen M, Aragón E, Llimargas M, Benach J, Riera A, Pous J, Macias MJ.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):844-53. doi: 10.1107/S1399004715001443. Epub 2015 Mar 26.

15.

Folding kinetics of WW domains with the united residue force field for bridging microscopic motions and experimental measurements.

Zhou R, Maisuradze GG, Suñol D, Todorovski T, Macias MJ, Xiao Y, Scheraga HA, Czaplewski C, Liwo A.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18243-8. doi: 10.1073/pnas.1420914111. Epub 2014 Dec 8.

16.

Structural basis of the activation and degradation mechanisms of the E3 ubiquitin ligase Nedd4L.

Escobedo A, Gomes T, Aragón E, Martín-Malpartida P, Ruiz L, Macias MJ.

Structure. 2014 Oct 7;22(10):1446-57. doi: 10.1016/j.str.2014.08.016.

17.

RNA recognition and self-association of CPEB4 is mediated by its tandem RRM domains.

Schelhorn C, Gordon JM, Ruiz L, Alguacil J, Pedroso E, Macias MJ.

Nucleic Acids Res. 2014 Sep;42(15):10185-95. doi: 10.1093/nar/gku700. Epub 2014 Jul 31.

18.

Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation.

Fernandez-Chamorro J, Piñeiro D, Gordon JM, Ramajo J, Francisco-Velilla R, Macias MJ, Martinez-Salas E.

Nucleic Acids Res. 2014 May;42(9):5742-54. doi: 10.1093/nar/gku177. Epub 2014 Mar 5.

19.

A tetradecapeptide somatostatin dicarba-analog: Synthesis, structural impact and biological activity.

Martín-Gago P, Ramón R, Aragón E, Fernández-Carneado J, Martin-Malpartida P, Verdaguer X, López-Ruiz P, Colás B, Cortes MA, Ponsati B, Macias MJ, Riera A.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):103-7. doi: 10.1016/j.bmcl.2013.11.065. Epub 2013 Dec 3.

PMID:
24342240
20.

Insights into structure-activity relationships of somatostatin analogs containing mesitylalanine.

Martín-Gago P, Aragón E, Gomez-Caminals M, Fernández-Carneado J, Ramón R, Martin-Malpartida P, Verdaguer X, López-Ruiz P, Colás B, Cortes MA, Ponsati B, Macias MJ, Riera A.

Molecules. 2013 Nov 25;18(12):14564-84. doi: 10.3390/molecules181214564.

21.

Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways.

Aragón E, Goerner N, Xi Q, Gomes T, Gao S, Massagué J, Macias MJ.

Structure. 2012 Oct 10;20(10):1726-36. doi: 10.1016/j.str.2012.07.014. Epub 2012 Aug 23.

22.

DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.

Sancho A, Duran J, García-España A, Mauvezin C, Alemu EA, Lamark T, Macias MJ, DeSalle R, Royo M, Sala D, Chicote JU, Palacín M, Johansen T, Zorzano A.

PLoS One. 2012;7(3):e34034. doi: 10.1371/journal.pone.0034034. Epub 2012 Mar 28. Erratum in: PLoS One. 2012 May;7(5): doi/10.1371/annotation/f2e121d7-0878-44b1-a5c2-994231626fe1. PLoS One. 2012;7(6): doi/0.1371/annotation/4d84cc19-b887-4c1e-a26f-1968819f8c70.

23.

The FF4 and FF5 domains of transcription elongation regulator 1 (TCERG1) target proteins to the periphery of speckles.

Sánchez-Hernández N, Ruiz L, Sánchez-Álvarez M, Montes M, Macias MJ, Hernández-Munain C, Suñé C.

J Biol Chem. 2012 May 18;287(21):17789-800. doi: 10.1074/jbc.M111.304782. Epub 2012 Mar 27.

24.

Fine-tuning the π-π aromatic interactions in peptides: somatostatin analogues containing mesityl alanine.

Martín-Gago P, Gomez-Caminals M, Ramón R, Verdaguer X, Martin-Malpartida P, Aragón E, Fernández-Carneado J, Ponsati B, López-Ruiz P, Cortes MA, Colás B, Macias MJ, Riera A.

Angew Chem Int Ed Engl. 2012 Feb 20;51(8):1820-5. doi: 10.1002/anie.201106406. Epub 2011 Dec 9. No abstract available.

PMID:
22162246
25.

A Smad action turnover switch operated by WW domain readers of a phosphoserine code.

Aragón E, Goerner N, Zaromytidou AI, Xi Q, Escobedo A, Massagué J, Macias MJ.

Genes Dev. 2011 Jun 15;25(12):1275-88. doi: 10.1101/gad.2060811.

26.

SSTR1- and SSTR3-selective somatostatin analogues.

Ramón R, Martín-Gago P, Verdaguer X, Macias MJ, Martin-Malpartida P, Fernández-Carneado J, Gomez-Caminals M, Ponsati B, López-Ruiz P, Cortés MA, Colás B, Riera A.

Chembiochem. 2011 Mar 7;12(4):625-32. doi: 10.1002/cbic.201000597. Epub 2011 Jan 21.

PMID:
21259412
27.

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling.

Gao S, Alarcón C, Sapkota G, Rahman S, Chen PY, Goerner N, Macias MJ, Erdjument-Bromage H, Tempst P, Massagué J.

Mol Cell. 2009 Nov 13;36(3):457-68. doi: 10.1016/j.molcel.2009.09.043.

28.

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.

Alarcón C, Zaromytidou AI, Xi Q, Gao S, Yu J, Fujisawa S, Barlas A, Miller AN, Manova-Todorova K, Macias MJ, Sapkota G, Pan D, Massagué J.

Cell. 2009 Nov 13;139(4):757-69. doi: 10.1016/j.cell.2009.09.035.

29.

Solution structure of the fourth FF domain of yeast Prp40 splicing factor.

Bonet R, Ruiz L, Morales B, Macias MJ.

Proteins. 2009 Dec;77(4):1000-3. doi: 10.1002/prot.22547. No abstract available.

PMID:
19722265
30.

NMR structural studies on human p190-A RhoGAPFF1 revealed that domain phosphorylation by the PDGF-receptor alpha requires its previous unfolding.

Bonet R, Ruiz L, Aragón E, Martín-Malpartida P, Macias MJ.

J Mol Biol. 2009 Jun 5;389(2):230-7. doi: 10.1016/j.jmb.2009.04.035. Epub 2009 Apr 22.

PMID:
19393245
31.
32.

Structural characterization of a new binding motif and a novel binding mode in group 2 WW domains.

Ramirez-Espain X, Ruiz L, Martin-Malpartida P, Oschkinat H, Macias MJ.

J Mol Biol. 2007 Nov 9;373(5):1255-68. Epub 2007 Aug 29.

PMID:
17915251
33.

NMR structural studies of the ItchWW3 domain reveal that phosphorylation at T30 inhibits the interaction with PPxY-containing ligands.

Morales B, Ramirez-Espain X, Shaw AZ, Martin-Malpartida P, Yraola F, Sánchez-Tilló E, Farrera C, Celada A, Royo M, Macias MJ.

Structure. 2007 Apr;15(4):473-83.

34.

Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains.

Brucet M, Querol-Audí J, Serra M, Ramirez-Espain X, Bertlik K, Ruiz L, Lloberas J, Macias MJ, Fita I, Celada A.

J Biol Chem. 2007 May 11;282(19):14547-57. Epub 2007 Mar 13.

35.

Myotonia-related mutations in the distal C-terminus of ClC-1 and ClC-0 chloride channels affect the structure of a poly-proline helix.

Macías MJ, Teijido O, Zifarelli G, Martin P, Ramirez-Espain X, Zorzano A, Palacín M, Pusch M, Estévez R.

Biochem J. 2007 Apr 1;403(1):79-87.

36.

The structure of Prp40 FF1 domain and its interaction with the crn-TPR1 motif of Clf1 gives a new insight into the binding mode of FF domains.

Gasch A, Wiesner S, Martin-Malpartida P, Ramirez-Espain X, Ruiz L, Macias MJ.

J Biol Chem. 2006 Jan 6;281(1):356-64. Epub 2005 Oct 27.

37.

Phosphorylation of either Ser16 or Thr30 does not disrupt the structure of the Itch E3 ubiquitin ligase third WW domain.

Shaw AZ, Martin-Malpartida P, Morales B, Yraola F, Royo M, Macias MJ.

Proteins. 2005 Aug 15;60(3):558-60. No abstract available.

PMID:
15971201
38.

Structure and dynamics of the human pleckstrin DEP domain: distinct molecular features of a novel DEP domain subfamily.

Civera C, Simon B, Stier G, Sattler M, Macias MJ.

Proteins. 2005 Feb 1;58(2):354-66.

PMID:
15573383
39.

Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40.

Wiesner S, Stier G, Sattler M, Macias MJ.

J Mol Biol. 2002 Dec 6;324(4):807-22.

PMID:
12460579
40.

WW and SH3 domains, two different scaffolds to recognize proline-rich ligands.

Macias MJ, Wiesner S, Sudol M.

FEBS Lett. 2002 Feb 20;513(1):30-7. Review.

41.

Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope.

Pires JR, Taha-Nejad F, Toepert F, Ast T, Hoffmüller U, Schneider-Mergener J, Kühne R, Macias MJ, Oschkinat H.

J Mol Biol. 2001 Dec 14;314(5):1147-56.

PMID:
11743730
42.

Synthesis and properties of oligonucleotides containing 8-bromo-2'-deoxyguanosine.

Fàbrega C, Macías MJ, Eritja R.

Nucleosides Nucleotides Nucleic Acids. 2001 Mar;20(3):251-60.

PMID:
11393401
43.

Structural analysis of WW domains and design of a WW prototype.

Macias MJ, Gervais V, Civera C, Oschkinat H.

Nat Struct Biol. 2000 May;7(5):375-9.

PMID:
10802733
44.

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.

Liu Z, Macias MJ, Bottomley MJ, Stier G, Linge JP, Nilges M, Bork P, Sattler M.

Structure. 1999 Dec 15;7(12):1557-66.

45.

A tale of two secondary structure elements: when a beta-hairpin becomes an alpha-helix.

Cregut D, Civera C, Macias MJ, Wallon G, Serrano L.

J Mol Biol. 1999 Sep 17;292(2):389-401.

PMID:
10493883
46.

A novel NMR experiment for the sequential assignment of proline residues and proline stretches in 13C/15N-labeled proteins.

Bottomley MJ, Macias MJ, Liu Z, Sattler M.

J Biomol NMR. 1999 Apr;13(4):381-5.

PMID:
10353197
47.

Theoretical calculations, synthesis and base pairing properties of oligonucleotides containing 8-amino-2'-deoxyadenosine.

García RG, Ferrer E, Macías MJ, Eritja R, Orozco M.

Nucleic Acids Res. 1999 May 1;27(9):1991-8.

48.

Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels.

Schultz J, Hoffmüller U, Krause G, Ashurst J, Macias MJ, Schmieder P, Schneider-Mergener J, Oschkinat H.

Nat Struct Biol. 1998 Jan;5(1):19-24.

PMID:
9437424
49.
50.

Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide.

Macias MJ, Hyvönen M, Baraldi E, Schultz J, Sudol M, Saraste M, Oschkinat H.

Nature. 1996 Aug 15;382(6592):646-9.

PMID:
8757138

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