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Items: 25


Editorial: Biology and Pathogenesis of Legionella.

Newton HJ, Hartland EL, Machner MP.

Front Cell Infect Microbiol. 2018 Sep 19;8:328. doi: 10.3389/fcimb.2018.00328. eCollection 2018. No abstract available.


The Legionella Effector Kinase LegK7 Hijacks the Host Hippo Pathway to Promote Infection.

Lee PC, Machner MP.

Cell Host Microbe. 2018 Sep 12;24(3):429-438.e6. doi: 10.1016/j.chom.2018.08.004.


Legionella effector AnkX interacts with host nuclear protein PLEKHN1.

Yu X, Noll RR, Romero Dueñas BP, Allgood SC, Barker K, Caplan JL, Machner MP, LaBaer J, Qiu J, Neunuebel MR.

BMC Microbiol. 2018 Jan 5;18(1):5. doi: 10.1186/s12866-017-1147-7.


RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases.

Lin YH, Lucas M, Evans TR, Abascal-Palacios G, Doms AG, Beauchene NA, Rojas AL, Hierro A, Machner MP.

PLoS Pathog. 2018 Feb 7;14(2):e1006897. doi: 10.1371/journal.ppat.1006897. eCollection 2018 Feb.


Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL.

Romano-Moreno M, Rojas AL, Williamson CD, Gershlick DC, Lucas M, Isupov MN, Bonifacino JS, Machner MP, Hierro A.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11151-E11160. doi: 10.1073/pnas.1715361115. Epub 2017 Dec 11.


Exploitation of the host cell ubiquitin machinery by microbial effector proteins.

Lin YH, Machner MP.

J Cell Sci. 2017 Jun 15;130(12):1985-1996. doi: 10.1242/jcs.188482. Epub 2017 May 5. Review.


Infection biology: Small RNA with a large impact.

Machner MP, Storz G.

Nature. 2016 Jan 28;529(7587):472-3. doi: 10.1038/nature16872. Epub 2016 Jan 20. No abstract available.


Host Cell-catalyzed S-Palmitoylation Mediates Golgi Targeting of the Legionella Ubiquitin Ligase GobX.

Lin YH, Doms AG, Cheng E, Kim B, Evans TR, Machner MP.

J Biol Chem. 2015 Oct 16;290(42):25766-81. doi: 10.1074/jbc.M115.637397. Epub 2015 Aug 27.


Ingenious strategies of microbial pathogens.

Morrissette NS, Machner MP.

Mol Biol Cell. 2015 Mar 15;26(6):1007. doi: 10.1091/mbc.E15-01-0011. No abstract available.


Host-pathogen interaction profiling using self-assembling human protein arrays.

Yu X, Decker KB, Barker K, Neunuebel MR, Saul J, Graves M, Westcott N, Hang H, LaBaer J, Qiu J, Machner MP.

J Proteome Res. 2015 Apr 3;14(4):1920-36. doi: 10.1021/pr5013015. Epub 2015 Mar 18.


Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5.

Lucas M, Gaspar AH, Pallara C, Rojas AL, Fernández-Recio J, Machner MP, Hierro A.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):E3514-23. doi: 10.1073/pnas.1405391111. Epub 2014 Aug 11.


A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi.

Hammond GR, Machner MP, Balla T.

J Cell Biol. 2014 Apr 14;205(1):113-26. doi: 10.1083/jcb.201312072. Epub 2014 Apr 7.


VipD is a Rab5-activated phospholipase A1 that protects Legionella pneumophila from endosomal fusion.

Gaspar AH, Machner MP.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4560-5. doi: 10.1073/pnas.1316376111. Epub 2014 Mar 10.


Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD.

Chen Y, Tascón I, Neunuebel MR, Pallara C, Brady J, Kinch LN, Fernández-Recio J, Rojas AL, Machner MP, Hierro A.

PLoS Pathog. 2013;9(5):e1003382. doi: 10.1371/journal.ppat.1003382. Epub 2013 May 16. Erratum in: PLoS Pathog. 2013;9(7). doi:10.1371/annotation/2b8e6418-2496-4ffb-b230-95d90b748086.


Targeting of the small GTPase Rab6A' by the Legionella pneumophila effector LidA.

Chen Y, Machner MP.

Infect Immun. 2013 Jun;81(6):2226-35. doi: 10.1128/IAI.00157-13. Epub 2013 Apr 8.


The taming of a Rab GTPase by Legionella pneumophila.

Neunuebel MR, Machner MP.

Small GTPases. 2012 Jan-Mar;3(1):28-33. doi: 10.4161/sgtp.18704.


Catch and release: Rab1 exploitation by Legionella pneumophila.

Machner MP, Chen Y.

Cell Logist. 2011 Jul;1(4):133-138. Epub 2011 Jul 1.


Legionella pneumophila LidA affects nucleotide binding and activity of the host GTPase Rab1.

Neunuebel MR, Mohammadi S, Jarnik M, Machner MP.

J Bacteriol. 2012 Mar;194(6):1389-400. doi: 10.1128/JB.06306-11. Epub 2012 Jan 6.


De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila.

Neunuebel MR, Chen Y, Gaspar AH, Backlund PS Jr, Yergey A, Machner MP.

Science. 2011 Jul 22;333(6041):453-6. doi: 10.1126/science.1207193. Epub 2011 Jun 16.


A bifunctional bacterial protein links GDI displacement to Rab1 activation.

Machner MP, Isberg RR.

Science. 2007 Nov 9;318(5852):974-7. Epub 2007 Oct 18.


Folding and stability of the leucine-rich repeat domain of internalin B from Listeri monocytogenes.

Freiberg A, Machner MP, Pfeil W, Schubert WD, Heinz DW, Seckler R.

J Mol Biol. 2004 Mar 19;337(2):453-61.


Aromatic amino acids at the surface of InlB are essential for host cell invasion by Listeria monocytogenes.

Machner MP, Frese S, Schubert WD, Orian-Rousseau V, Gherardi E, Wehland J, Niemann HH, Heinz DW.

Mol Microbiol. 2003 Jun;48(6):1525-36.


Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin.

Schubert WD, Urbanke C, Ziehm T, Beier V, Machner MP, Domann E, Wehland J, Chakraborty T, Heinz DW.

Cell. 2002 Dec 13;111(6):825-36.


ActA from Listeria monocytogenes can interact with up to four Ena/VASP homology 1 domains simultaneously.

Machner MP, Urbanke C, Barzik M, Otten S, Sechi AS, Wehland J, Heinz DW.

J Biol Chem. 2001 Oct 26;276(43):40096-103. Epub 2001 Aug 6.

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