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Items: 34


Modulation of megakaryopoiesis and platelet production during inflammation.

Couldwell G, Machlus KR.

Thromb Res. 2019 Jul;179:114-120. doi: 10.1016/j.thromres.2019.05.008. Epub 2019 May 14.


New Insights Into the Differentiation of Megakaryocytes From Hematopoietic Progenitors.

Noetzli LJ, French SL, Machlus KR.

Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1288-1300. doi: 10.1161/ATVBAHA.119.312129. Epub 2019 May 2.


Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets.

Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Wactor A, Nelson-Maney N, Morris A, Guo L, Weyrich A, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA.

Elife. 2019 May 1;8. pii: e44031. doi: 10.7554/eLife.44031.


Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis.

Johnson KE, Ceglowski JR, Roweth HG, Forward JA, Tippy MD, El-Husayni S, Kulenthirarajan R, Malloy MW, Machlus KR, Chen WY, Italiano JE Jr, Battinelli EM.

Blood Adv. 2019 Jan 22;3(2):198-211. doi: 10.1182/bloodadvances.2018026161.


Tyrosyl-tRNA synthetase drives megakaryopoiesis independently of thrombopoietin signaling.

French SL, Machlus KR.

J Thromb Haemost. 2019 Apr;17(4):564-566. doi: 10.1111/jth.14361. Epub 2019 Jan 11. No abstract available.


In vitro culture of murine megakaryocytes from fetal liver-derived hematopoietic stem cells.

Vijey P, Posorske B, Machlus KR.

Platelets. 2018 Sep;29(6):583-588. doi: 10.1080/09537104.2018.1492107. Epub 2018 Jul 26.


Megakaryocyte modification of platelets in thrombocytopenia.

Roweth HG, Parvin S, Machlus KR.

Curr Opin Hematol. 2018 Sep;25(5):410-415. doi: 10.1097/MOH.0000000000000451. Review.


Human platelets express endothelial protein C receptor, which can be utilized to enhance localization of factor VIIa activity.

Fager AM, Machlus KR, Ezban M, Hoffman M.

J Thromb Haemost. 2018 Sep;16(9):1817-1829. doi: 10.1111/jth.14165. Epub 2018 Jun 27.


Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115. Epub 2018 Jan 31.


Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets.

Zufferey A, Speck ER, Machlus KR, Aslam R, Guo L, McVey MJ, Kim M, Kapur R, Boilard E, Italiano JE Jr, Semple JW.

Blood Adv. 2017 Sep 8;1(20):1773-1785. doi: 10.1182/bloodadvances.2017007021. eCollection 2017 Sep 12.


Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice.

Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W.

Blood Adv. 2017 Aug 8;1(18):1398-1408. doi: 10.1182/bloodadvances.2017006973.


Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis.

Machlus KR, Wu SK, Vijey P, Soussou TS, Liu ZJ, Shacham E, Unger TJ, Kashyap T, Klebanov B, Sola-Visner M, Crochiere M, Italiano JE Jr, Landesman Y.

Blood. 2017 Aug 31;130(9):1132-1143. doi: 10.1182/blood-2016-11-752840. Epub 2017 Jun 19.


RBCs pin platelets against the (thrombus) wall.

Machlus KR, Battinelli EM.

Blood. 2017 May 4;129(18):2460-2461. doi: 10.1182/blood-2017-03-772079. No abstract available.


Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis.

Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, Machlus KR, Mayer EL, Italiano JE Jr, Battinelli EM.

Arterioscler Thromb Vasc Biol. 2017 Apr;37(4):664-674. doi: 10.1161/ATVBAHA.116.308791. Epub 2017 Feb 2.


Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation.

Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE Jr.

Blood. 2016 Mar 17;127(11):1468-80. doi: 10.1182/blood-2015-08-663146. Epub 2016 Jan 7.


CCL5 derived from platelets increases megakaryocyte proplatelet formation.

Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE Jr, Battinelli EM.

Blood. 2016 Feb 18;127(7):921-6. doi: 10.1182/blood-2015-05-644583. Epub 2015 Dec 8.


Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice.

Barbieri SS, Petrucci G, Tarantino E, Amadio P, Rocca B, Pesce M, Machlus KR, Ranelletti FO, Gianellini S, Weksler B, Italiano JE Jr, Tremoli E.

Thromb Haemost. 2015 Nov 25;114(6):1218-29. doi: 10.1160/TH14-10-0872. Epub 2015 Aug 13.


Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.

Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE Jr, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, Poncz M, Weiss MJ.

J Clin Invest. 2015 Jun;125(6):2369-74. doi: 10.1172/JCI77670. Epub 2015 May 11.


Platelet bioreactor-on-a-chip.

Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE Jr.

Blood. 2014 Sep 18;124(12):1857-67.


Scalable generation of universal platelets from human induced pluripotent stem cells.

Feng Q, Shabrani N, Thon JN, Huo H, Thiel A, Machlus KR, Kim K, Brooks J, Li F, Luo C, Kimbrel EA, Wang J, Kim KS, Italiano J, Cho J, Lu SJ, Lanza R.

Stem Cell Reports. 2014 Nov 11;3(5):817-31. doi: 10.1016/j.stemcr.2014.09.010. Epub 2014 Oct 16.


Proteasome function is required for platelet production.

Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE Jr, Christensen H, Kahr WH, Li DY, Weyrich AS.

J Clin Invest. 2014 Sep;124(9):3757-66. doi: 10.1172/JCI75247. Epub 2014 Jul 25.


Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation.

Machlus KR, Thon JN, Italiano JE Jr.

Br J Haematol. 2014 Apr;165(2):227-36. doi: 10.1111/bjh.12758. Epub 2014 Feb 6. Review.


Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response.

Battinelli EM, Markens BA, Kulenthirarajan RA, Machlus KR, Flaumenhaft R, Italiano JE Jr.

Blood. 2014 Jan 2;123(1):101-12. doi: 10.1182/blood-2013-02-485011. Epub 2013 Sep 24.


The incredible journey: From megakaryocyte development to platelet formation.

Machlus KR, Italiano JE Jr.

J Cell Biol. 2013 Jun 10;201(6):785-96. doi: 10.1083/jcb.201304054. Review.


Elevated prothrombin promotes venous, but not arterial, thrombosis in mice.

Aleman MM, Walton BL, Byrnes JR, Wang JG, Heisler MJ, Machlus KR, Cooley BC, Wolberg AS.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1829-36. doi: 10.1161/ATVBAHA.113.301607. Epub 2013 May 30.


T granules in human platelets function in TLR9 organization and signaling.

Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE Jr.

J Cell Biol. 2012 Aug 20;198(4):561-74. doi: 10.1083/jcb.201111136.


Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited.

Wolberg AS, Aleman MM, Leiderman K, Machlus KR.

Anesth Analg. 2012 Feb;114(2):275-85. doi: 10.1213/ANE.0b013e31823a088c. Epub 2011 Nov 21. Review.


Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice.

Machlus KR, Lin FC, Wolberg AS.

Blood. 2011 Oct 6;118(14):3960-8. doi: 10.1182/blood-2011-06-362814. Epub 2011 Aug 9.


Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma.

Gray LD, Hussey MA, Larson BM, Machlus KR, Campbell RA, Koch G, Ezban M, Hedner U, Wolberg AS.

Thromb Res. 2011 Dec;128(6):570-6. doi: 10.1016/j.thromres.2011.04.009. Epub 2011 May 10.


Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice.

Machlus KR, Cardenas JC, Church FC, Wolberg AS.

Blood. 2011 May 5;117(18):4953-63. doi: 10.1182/blood-2010-11-316885. Epub 2011 Feb 25.


Update on venous thromboembolism: risk factors, mechanisms, and treatments.

Machlus KR, Aleman MM, Wolberg AS.

Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):476-8. doi: 10.1161/ATVBAHA.111.223008. No abstract available.


Smoking out the cause of thrombosis.

Campbell RA, Machlus KR, Wolberg AS.

Arterioscler Thromb Vasc Biol. 2010 Jan;30(1):7-8. doi: 10.1161/ATVBAHA.109.198051. No abstract available.


Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram.

Machlus KR, Colby EA, Wu JR, Koch GG, Key NS, Wolberg AS.

Thromb Haemost. 2009 Nov;102(5):936-44. doi: 10.1160/TH09-03-0180.


Detection of endogenous tissue factor levels in plasma using the calibrated automated thrombogram assay.

Ollivier V, Wang J, Manly D, Machlus KR, Wolberg AS, Jandrot-Perrus M, Mackman N.

Thromb Res. 2010 Jan;125(1):90-6. doi: 10.1016/j.thromres.2009.03.003. Epub 2009 Apr 5.

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