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Items: 6

1.

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.

Wu Z, Senchuk MM, Dues DJ, Johnson BK, Cooper JF, Lew L, Machiela E, Schaar CE, DeJonge H, Blackwell TK, Van Raamsdonk JM.

BMC Biol. 2018 Dec 18;16(1):147. doi: 10.1186/s12915-018-0615-3.

2.

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models.

Cooper JF, Machiela E, Dues DJ, Spielbauer KK, Senchuk MM, Van Raamsdonk JM.

Sci Rep. 2017 Nov 27;7(1):16441. doi: 10.1038/s41598-017-16637-2.

3.

Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.

Ghosh A, Tyson T, George S, Hildebrandt EN, Steiner JA, Madaj Z, Schulz E, Machiela E, McDonald WG, Escobar Galvis ML, Kordower JH, Van Raamsdonk JM, Colca JR, Brundin P.

Sci Transl Med. 2016 Dec 7;8(368):368ra174.

PMID:
27928028
4.

Oxidative stress is increased in C. elegans models of Huntington's disease but does not contribute to polyglutamine toxicity phenotypes.

Machiela E, Dues DJ, Senchuk MM, Van Raamsdonk JM.

Neurobiol Dis. 2016 Dec;96:1-11. doi: 10.1016/j.nbd.2016.08.008. Epub 2016 Aug 18.

PMID:
27544481
5.

Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models.

Cooper JF, Dues DJ, Spielbauer KK, Machiela E, Senchuk MM, Van Raamsdonk JM.

NPJ Parkinsons Dis. 2015 Nov 19;1:15022. doi: 10.1038/npjparkd.2015.22. eCollection 2015.

6.

Mitochondrial and cytoplasmic ROS have opposing effects on lifespan.

Schaar CE, Dues DJ, Spielbauer KK, Machiela E, Cooper JF, Senchuk M, Hekimi S, Van Raamsdonk JM.

PLoS Genet. 2015 Feb 11;11(2):e1004972. doi: 10.1371/journal.pgen.1004972. eCollection 2015 Feb.

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