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WASP Restricts Active Rac to Maintain Cells' Front-Rear Polarization.

Amato C, Thomason PA, Davidson AJ, Swaminathan K, Ismail S, Machesky LM, Insall RH.

Curr Biol. 2019 Nov 15. pii: S0960-9822(19)31376-4. doi: 10.1016/j.cub.2019.10.036. [Epub ahead of print]


N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis.

Juin A, Spence HJ, Martin KJ, McGhee E, Neilson M, Cutiongco MFA, Gadegaard N, Mackay G, Fort L, Lilla S, Kalna G, Thomason P, Koh YWH, Norman JC, Insall RH, Machesky LM.

Dev Cell. 2019 Nov 18;51(4):431-445.e7. doi: 10.1016/j.devcel.2019.09.018. Epub 2019 Oct 24.


CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors.

Whitelaw JA, Lilla S, Paul NR, Fort L, Zanivan S, Machesky LM.

Commun Integr Biol. 2019 Jul 23;12(1):112-118. doi: 10.1080/19420889.2019.1643665. eCollection 2019.


Invasion by Force: The C. elegans Anchor Cell Leads the Way.

Nikolaou S, Machesky LM.

Dev Cell. 2019 Feb 11;48(3):287-288. doi: 10.1016/j.devcel.2019.01.024.


Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling.

Kugeratski FG, Atkinson SJ, Neilson LJ, Lilla S, Knight JRP, Serneels J, Juin A, Ismail S, Bryant DM, Markert EK, Machesky LM, Mazzone M, Sansom OJ, Zanivan S.

Sci Signal. 2019 Feb 5;12(567). pii: eaan8247. doi: 10.1126/scisignal.aan8247.


Phenotypic analysis of Myo10 knockout (Myo10tm2/tm2) mice lacking full-length (motorized) but not brain-specific headless myosin X.

Bachg AC, Horsthemke M, Skryabin BV, Klasen T, Nagelmann N, Faber C, Woodham E, Machesky LM, Bachg S, Stange R, Jeong HW, Adams RH, Bähler M, Hanley PJ.

Sci Rep. 2019 Jan 24;9(1):597. doi: 10.1038/s41598-018-37160-y.


Rab11FIP proteins link endocytic recycling vesicles for cytoskeletal transport and tethering.

Machesky LM.

Biosci Rep. 2019 Jan 30;39(1). pii: BSR20182219. doi: 10.1042/BSR20182219. Print 2019 Jan 31.


Tissue engineering the cancer microenvironment-challenges and opportunities.

Papalazarou V, Salmeron-Sanchez M, Machesky LM.

Biophys Rev. 2018 Dec;10(6):1695-1711. doi: 10.1007/s12551-018-0466-8. Epub 2018 Nov 8. Review.


Fam49/CYRI interacts with Rac1 and locally suppresses protrusions.

Fort L, Batista JM, Thomason PA, Spence HJ, Whitelaw JA, Tweedy L, Greaves J, Martin KJ, Anderson KI, Brown P, Lilla S, Neilson MP, Tafelmeyer P, Zanivan S, Ismail S, Bryant DM, Tomkinson NCO, Chamberlain LH, Mastick GS, Insall RH, Machesky LM.

Nat Cell Biol. 2018 Oct;20(10):1159-1171. doi: 10.1038/s41556-018-0198-9. Epub 2018 Sep 24.


Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.

Morris HT, Fort L, Spence HJ, Patel R, Vincent DF, Park JH, Snapper SB, Carey FA, Sansom OJ, Machesky LM.

J Pathol. 2018 Jul;245(3):337-348. doi: 10.1002/path.5086. Epub 2018 May 28.


Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium.

Reid SE, Kay EJ, Neilson LJ, Henze AT, Serneels J, McGhee EJ, Dhayade S, Nixon C, Mackey JB, Santi A, Swaminathan K, Athineos D, Papalazarou V, Patella F, Román-Fernández Á, ElMaghloob Y, Hernandez-Fernaud JR, Adams RH, Ismail S, Bryant DM, Salmeron-Sanchez M, Machesky LM, Carlin LM, Blyth K, Mazzone M, Zanivan S.

EMBO J. 2017 Aug 15;36(16):2373-2389. doi: 10.15252/embj.201694912. Epub 2017 Jul 10.


Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin.

Woodham EF, Paul NR, Tyrrell B, Spence HJ, Swaminathan K, Scribner MR, Giampazolias E, Hedley A, Clark W, Kage F, Marston DJ, Hahn KM, Tait SW, Larue L, Brakebusch CH, Insall RH, Machesky LM.

Curr Biol. 2017 Mar 6;27(5):624-637. doi: 10.1016/j.cub.2017.01.033. Epub 2017 Feb 23.


The actin binding proteins cortactin and HS1 are dispensable for platelet actin nodule and megakaryocyte podosome formation.

Thomas SG, Poulter NS, Bem D, Finney B, Machesky LM, Watson SP.

Platelets. 2017 Jun;28(4):372-379. doi: 10.1080/09537104.2016.1235688. Epub 2016 Oct 25.


Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.

Tyrrell BJ, Woodham EF, Spence HJ, Strathdee D, Insall RH, Machesky LM.

Pigment Cell Melanoma Res. 2016 Sep;29(5):559-71. doi: 10.1111/pcmr.12506.


WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasion.

García E, Ragazzini C, Yu X, Cuesta-García E, Bernardino de la Serna J, Zech T, Sarrió D, Machesky LM, Antón IM.

Sci Rep. 2016 Mar 24;6:23590. doi: 10.1038/srep23590.


Overflow in science and its implications for trust.

Siebert S, Machesky LM, Insall RH.

Elife. 2015 Sep 14;4. doi: 10.7554/eLife.10825.


Alan Hall 1952-2015.

Giancotti FG, Haynes CM, Machesky LM, Olson MF, Overholtzer M.

Nat Cell Biol. 2015 Jul;17(7):839-40. doi: 10.1038/ncb3190. Epub 2015 May 25. No abstract available.


Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract.

Morris HT, Machesky LM.

Br J Cancer. 2015 Feb 17;112(4):613-20. doi: 10.1038/bjc.2014.658. Epub 2015 Jan 22. Review.


Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma.

Ma Y, Faller WJ, Sansom OJ, Brown ER, Doig TN, Melton DW, Machesky LM.

Melanoma Res. 2015 Apr;25(2):169-72. doi: 10.1097/CMR.0000000000000135.


Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages.

Vijayakumar V, Monypenny J, Chen XJ, Machesky LM, Lilla S, Thrasher AJ, Antón IM, Calle Y, Jones GE.

J Cell Sci. 2015 Jan 15;128(2):251-65. doi: 10.1242/jcs.154880. Epub 2014 Nov 20.


Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.

Muinonen-Martin AJ, Susanto O, Zhang Q, Smethurst E, Faller WJ, Veltman DM, Kalna G, Lindsay C, Bennett DC, Sansom OJ, Herd R, Jones R, Machesky LM, Wakelam MJ, Knecht DA, Insall RH.

PLoS Biol. 2014 Oct 14;12(10):e1001966. doi: 10.1371/journal.pbio.1001966. eCollection 2014 Oct.


Fascin1 in carcinomas: Its regulation and prognostic value.

Ma Y, Machesky LM.

Int J Cancer. 2015 Dec 1;137(11):2534-44. doi: 10.1002/ijc.29260. Epub 2014 Oct 28. Review.


WIP is necessary for matrix invasion by breast cancer cells.

García E, Machesky LM, Jones GE, Antón IM.

Eur J Cell Biol. 2014 Oct;93(10-12):413-23. doi: 10.1016/j.ejcb.2014.07.008. Epub 2014 Aug 7.


A Rac1-independent role for P-Rex1 in melanoblasts.

Lindsay CR, Li A, Faller W, Ozanne B, Welch H, Machesky LM, Sansom OJ.

J Invest Dermatol. 2015 Jan;135(1):314-318. doi: 10.1038/jid.2014.323. Epub 2014 Jul 30. No abstract available.


Polarised cell migration: intrinsic and extrinsic drivers.

Woodham EF, Machesky LM.

Curr Opin Cell Biol. 2014 Oct;30:25-32. doi: 10.1016/ Epub 2014 Jun 20. Review.


Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes.

Li A, Morton JP, Ma Y, Karim SA, Zhou Y, Faller WJ, Woodham EF, Morris HT, Stevenson RP, Juin A, Jamieson NB, MacKay CJ, Carter CR, Leung HY, Yamashiro S, Blyth K, Sansom OJ, Machesky LM.

Gastroenterology. 2014 May;146(5):1386-96.e1-17. doi: 10.1053/j.gastro.2014.01.046. Epub 2014 Jan 23.


Fascin 1 is dispensable for developmental and tumour angiogenesis.

Ma Y, Reynolds LE, Li A, Stevenson RP, Hodivala-Dilke KM, Yamashiro S, Machesky LM.

Biol Open. 2013 Sep 19;2(11):1187-91. doi: 10.1242/bio.20136031. eCollection 2013.


Biophysical approaches for investigation of the cytoskeleton. A special issue stemming from research presented at the 2012 ECF meeting: a FEBS/EMBO workshop lecture course in Pécs, Hungary.

Ampe C, Machesky LM, Nyitrai M.

Cytoskeleton (Hoboken). 2013 Oct;70(10):539. doi: 10.1002/cm.21145. No abstract available.


Predicting cell shapes in melanomas.

Tyrrell BJ, Neilson M, Insall RH, Machesky LM.

Pigment Cell Melanoma Res. 2014 Jan;27(1):5-6. doi: 10.1111/pcmr.12176. Epub 2013 Oct 23. No abstract available.


Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain.

Sonego M, Gajendra S, Parsons M, Ma Y, Hobbs C, Zentar MP, Williams G, Machesky LM, Doherty P, Lalli G.

J Neurosci. 2013 Jul 24;33(30):12171-85. doi: 10.1523/JNEUROSCI.0653-13.2013.


Membrane binding properties of IRSp53-missing in metastasis domain (IMD) protein.

Futó K, Bódis E, Machesky LM, Nyitrai M, Visegrády B.

Biochim Biophys Acta. 2013 Nov;1831(11):1651-5. doi: 10.1016/j.bbalip.2013.07.006. Epub 2013 Jul 17.


Podosomes in adhesion, migration, mechanosensing and matrix remodeling.

Schachtner H, Calaminus SD, Thomas SG, Machesky LM.

Cytoskeleton (Hoboken). 2013 Oct;70(10):572-89. doi: 10.1002/cm.21119. Epub 2013 Jul 19. Review.


Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation.

Ma Y, Li A, Faller WJ, Libertini S, Fiorito F, Gillespie DA, Sansom OJ, Yamashiro S, Machesky LM.

Development. 2013 May;140(10):2203-11. doi: 10.1242/dev.089789.


Rac1 cycling fast in melanoma with P29S.

Li A, Machesky LM.

Pigment Cell Melanoma Res. 2013 Feb 8. doi: 10.1111/pcmr.12074. [Epub ahead of print] No abstract available.


In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis.

Zanivan S, Meves A, Behrendt K, Schoof EM, Neilson LJ, Cox J, Tang HR, Kalna G, van Ree JH, van Deursen JM, Trempus CS, Machesky LM, Linding R, Wickström SA, Fässler R, Mann M.

Cell Rep. 2013 Feb 21;3(2):552-66. doi: 10.1016/j.celrep.2013.01.003. Epub 2013 Jan 31.


Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment.

Park L, Thomason PA, Zech T, King JS, Veltman DM, Carnell M, Ura S, Machesky LM, Insall RH.

Dev Cell. 2013 Jan 28;24(2):169-81. doi: 10.1016/j.devcel.2012.12.014.


Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane.

Schachtner H, Calaminus SD, Sinclair A, Monypenny J, Blundell MP, Leon C, Holyoake TL, Thrasher AJ, Michie AM, Vukovic M, Gachet C, Jones GE, Thomas SG, Watson SP, Machesky LM.

Blood. 2013 Mar 28;121(13):2542-52. doi: 10.1182/blood-2012-07-443457. Epub 2013 Jan 10.


Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny.

Calaminus SD, Guitart AV, Sinclair A, Schachtner H, Watson SP, Holyoake TL, Kranc KR, Machesky LM.

PLoS One. 2012;7(12):e51361. doi: 10.1371/journal.pone.0051361. Epub 2012 Dec 27. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/4c610387-c7f0-4330-b772-30ed52a07547. Guitart, Amelie [corrected to Guitart, Amelie V].


Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

Tang H, Li A, Bi J, Veltman DM, Zech T, Spence HJ, Yu X, Timpson P, Insall RH, Frame MC, Machesky LM.

Curr Biol. 2013 Jan 21;23(2):107-17. doi: 10.1016/j.cub.2012.11.059. Epub 2012 Dec 27.


N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods.

Yu X, Zech T, McDonald L, Gonzalez EG, Li A, Macpherson I, Schwarz JP, Spence H, Futó K, Timpson P, Nixon C, Ma Y, Anton IM, Visegrády B, Insall RH, Oien K, Blyth K, Norman JC, Machesky LM.

J Cell Biol. 2012 Oct 29;199(3):527-44. doi: 10.1083/jcb.201203025. Epub 2012 Oct 22.


Actin on trafficking: could actin guide directed receptor transport?

Zech T, Calaminus SD, Machesky LM.

Cell Adh Migr. 2012 Nov-Dec;6(6):476-81. doi: 10.4161/cam.21373. Epub 2012 Oct 17.


Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions.

Spence HJ, Timpson P, Tang HR, Insall RH, Machesky LM.

Biochem J. 2012 Nov 15;448(1):35-42. doi: 10.1042/BJ20112206.


SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods.

Veltman DM, King JS, Machesky LM, Insall RH.

J Cell Biol. 2012 Aug 20;198(4):501-8. doi: 10.1083/jcb.201205058. Epub 2012 Aug 13.


Rac1 in the driver's seat for melanoma.

Machesky LM, Sansom OJ.

Pigment Cell Melanoma Res. 2012 Nov;25(6):762-4. doi: 10.1111/pcmr.12004. No abstract available.


WIP: WASP-interacting proteins at invadopodia and podosomes.

García E, Jones GE, Machesky LM, Antón IM.

Eur J Cell Biol. 2012 Nov-Dec;91(11-12):869-77. doi: 10.1016/j.ejcb.2012.06.002. Epub 2012 Jul 21. Review.


Melanoblasts on the move: Rac1 sets the pace.

Li A, Machesky LM.

Small GTPases. 2012 Apr-Jun;3(2):115-9. doi: 10.4161/sgtp.19494.


Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism.

Li A, Ma Y, Jin M, Mason S, Mort RL, Blyth K, Larue L, Sansom OJ, Machesky LM.

J Invest Dermatol. 2012 Nov;132(11):2610-21. doi: 10.1038/jid.2012.186. Epub 2012 Jun 21.


Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex.

Maritzen T, Zech T, Schmidt MR, Krause E, Machesky LM, Haucke V.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10382-7. doi: 10.1073/pnas.1206468109. Epub 2012 Jun 11.


Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo.

Schachtner H, Li A, Stevenson D, Calaminus SDJ, Thomas S, Watson SP, Sixt M, Wedlich-Soldner R, Strathdee D, Machesky LM.

Eur J Cell Biol. 2012 Nov-Dec;91(11-12):923-929. doi: 10.1016/j.ejcb.2012.04.002. Epub 2012 May 31.


Actin-bundling proteins in cancer progression at a glance.

Stevenson RP, Veltman D, Machesky LM.

J Cell Sci. 2012 Mar 1;125(Pt 5):1073-9. doi: 10.1242/jcs.093799. Review. No abstract available.

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