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Promising new antifungal treatment targeting chorismate synthase from Paracoccidioides brasiliensis.

Rodrigues-Vendramini FAV, Marschalk C, Toplak M, Macheroux P, Bonfim-Mendonça PS, Svidzinski TIE, Seixas FAV, Kioshima ES.

Antimicrob Agents Chemother. 2018 Oct 22. pii: AAC.01097-18. doi: 10.1128/AAC.01097-18. [Epub ahead of print]


Oxidative stress induced structural changes in the microtubule-associated flavoenzyme Irc15p from Saccharomyces cerevisiae.

Koch K, Strandback E, Jha S, Richter G, Bourgeois B, Madl T, Macheroux P.

Protein Sci. 2018 Sep 29. doi: 10.1002/pro.3517. [Epub ahead of print]


Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family.

Lahham M, Pavkov-Keller T, Fuchs M, Niederhauser J, Chalhoub G, Daniel B, Kroutil W, Gruber K, Macheroux P.

J Biol Chem. 2018 Nov 2;293(44):17021-17032. doi: 10.1074/jbc.RA118.004227. Epub 2018 Sep 7.


In Situ Measurement and Correlation of Cell Density and Light Emission of Bioluminescent Bacteria.

Brodl E, Niederhauser J, Macheroux P.

J Vis Exp. 2018 Jun 28;(136). doi: 10.3791/57881.


Asymmetric Reductive Carbocyclization Using Engineered Ene Reductases.

Heckenbichler K, Schweiger A, Brandner LA, Binter A, Toplak M, Macheroux P, Gruber K, Breinbauer R.

Angew Chem Int Ed Engl. 2018 Jun 11;57(24):7240-7244. doi: 10.1002/anie.201802962. Epub 2018 May 14.


The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase.

Toplak M, Wiedemann G, Ulićević J, Daniel B, Hoernstein SNW, Kothe J, Niederhauser J, Reski R, Winkler A, Macheroux P.

FEBS J. 2018 May;285(10):1923-1943. doi: 10.1111/febs.14458. Epub 2018 Apr 19.


Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein.

Augustin P, Toplak M, Fuchs K, Gerstmann EC, Prassl R, Winkler A, Macheroux P.

J Biol Chem. 2018 Feb 23;293(8):2829-2840. doi: 10.1074/jbc.RA117.000846. Epub 2018 Jan 4.


Crystal structure of dipeptidyl peptidase III from the human gut symbiont Bacteroides thetaiotaomicron.

Sabljić I, Meštrović N, Vukelić B, Macheroux P, Gruber K, Luić M, Abramić M.

PLoS One. 2017 Nov 2;12(11):e0187295. doi: 10.1371/journal.pone.0187295. eCollection 2017.


Regioselective para-Carboxylation of Catechols with a Prenylated Flavin Dependent Decarboxylase.

Payer SE, Marshall SA, Bärland N, Sheng X, Reiter T, Dordic A, Steinkellner G, Wuensch C, Kaltwasser S, Fisher K, Rigby SEJ, Macheroux P, Vonck J, Gruber K, Faber K, Himo F, Leys D, Pavkov-Keller T, Glueck SM.

Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13893-13897. doi: 10.1002/anie.201708091. Epub 2017 Oct 2.


Biosensor for the characterisation of hMAO B inhibitors and the quantification of selegiline.

Aigner M, Preissegger P, Kalcher K, Mehmeti E, Macheroux P, Edmondson D, Ortner A.

Talanta. 2017 Nov 1;174:696-702. doi: 10.1016/j.talanta.2017.06.079. Epub 2017 Jul 4.


The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions.

Daniel B, Konrad B, Toplak M, Lahham M, Messenlehner J, Winkler A, Macheroux P.

Arch Biochem Biophys. 2017 Oct 15;632:88-103. doi: 10.1016/ Epub 2017 Jul 1. Review.


Structure, biochemical and kinetic properties of recombinant Pst2p from Saccharomyces cerevisiae, a FMN-dependent NAD(P)H:quinone oxidoreductase.

Koch K, Hromic A, Sorokina M, Strandback E, Reisinger M, Gruber K, Macheroux P.

Biochim Biophys Acta Proteins Proteom. 2017 Aug;1865(8):1046-1056. doi: 10.1016/j.bbapap.2017.05.005. Epub 2017 May 10.


Evidence for the generation of myristylated FMN by bacterial luciferase.

Tabib CR, Brodl E, Macheroux P.

Mol Microbiol. 2017 Jun;104(6):1027-1036. doi: 10.1111/mmi.13676. Epub 2017 Apr 19.


Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1).

Lienhart WD, Strandback E, Gudipati V, Koch K, Binter A, Uhl MK, Rantasa DM, Bourgeois B, Madl T, Zangger K, Gruber K, Macheroux P.

FEBS J. 2017 Apr;284(8):1233-1245. doi: 10.1111/febs.14051. Epub 2017 Mar 17.


Synthesis of α,β-unsaturated aldehydes as potential substrates for bacterial luciferases.

Brodl E, Ivkovic J, Tabib CR, Breinbauer R, Macheroux P.

Bioorg Med Chem. 2017 Feb 15;25(4):1487-1495. doi: 10.1016/j.bmc.2017.01.013. Epub 2017 Jan 13.


Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability.

Tongsook C, Niederhauser J, Kronegger E, Straganz G, Macheroux P.

Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):188-199. doi: 10.1016/j.bbadis.2016.10.005. Epub 2016 Oct 18.


Structure and biochemical properties of recombinant human dimethylglycine dehydrogenase and comparison to the disease-related H109R variant.

Augustin P, Hromic A, Pavkov-Keller T, Gruber K, Macheroux P.

FEBS J. 2016 Oct;283(19):3587-3603. doi: 10.1111/febs.13828.


Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae.

Daniel B, Wallner S, Steiner B, Oberdorfer G, Kumar P, van der Graaff E, Roitsch T, Sensen CW, Gruber K, Macheroux P.

PLoS One. 2016 Jun 8;11(6):e0156892. doi: 10.1371/journal.pone.0156892. eCollection 2016.


Substrate complexes of human dipeptidyl peptidase III reveal the mechanism of enzyme inhibition.

Kumar P, Reithofer V, Reisinger M, Wallner S, Pavkov-Keller T, Macheroux P, Gruber K.

Sci Rep. 2016 Mar 30;6:23787. doi: 10.1038/srep23787.


Structural and kinetic studies on RosA, the enzyme catalysing the methylation of 8-demethyl-8-amino-d-riboflavin to the antibiotic roseoflavin.

Tongsook C, Uhl MK, Jankowitsch F, Mack M, Gruber K, Macheroux P.

FEBS J. 2016 Apr;283(8):1531-49. doi: 10.1111/febs.13690. Epub 2016 Mar 17.


Enantioselective Oxidative Aerobic Dealkylation of N-Ethyl Benzylisoquinolines by Employing the Berberine Bridge Enzyme.

Gandomkar S, Fischereder EM, Schrittwieser JH, Wallner S, Habibi Z, Macheroux P, Kroutil W.

Angew Chem Int Ed Engl. 2015 Dec 7;54(50):15051-4. doi: 10.1002/anie.201507970. Epub 2015 Oct 21.


Structural and biochemical properties of LuxF from Photobacterium leiognathi.

Bergner T, Tabib CR, Winkler A, Stipsits S, Kayer H, Lee J, Malthouse JP, Mayhew S, Müller F, Gruber K, Macheroux P.

Biochim Biophys Acta. 2015 Oct;1854(10 Pt A):1466-75. doi: 10.1016/j.bbapap.2015.07.008. Epub 2015 Jul 21.


Mutations in the histamine N-methyltransferase gene, HNMT, are associated with nonsyndromic autosomal recessive intellectual disability.

Heidari A, Tongsook C, Najafipour R, Musante L, Vasli N, Garshasbi M, Hu H, Mittal K, McNaughton AJ, Sritharan K, Hudson M, Stehr H, Talebi S, Moradi M, Darvish H, Arshad Rafiq M, Mozhdehipanah H, Rashidinejad A, Samiei S, Ghadami M, Windpassinger C, Gillessen-Kaesbach G, Tzschach A, Ahmed I, Mikhailov A, Stavropoulos DJ, Carter MT, Keshavarz S, Ayub M, Najmabadi H, Liu X, Ropers HH, Macheroux P, Vincent JB.

Hum Mol Genet. 2015 Oct 15;24(20):5697-710. doi: 10.1093/hmg/ddv286. Epub 2015 Jul 23.


Structure-Based Mechanism of Oleate Hydratase from Elizabethkingia meningoseptica.

Engleder M, Pavkov-Keller T, Emmerstorfer A, Hromic A, Schrempf S, Steinkellner G, Wriessnegger T, Leitner E, Strohmeier GA, Kaluzna I, Mink D, Schürmann M, Wallner S, Macheroux P, Gruber K, Pichler H.

Chembiochem. 2015 Aug 17;16(12):1730-4. doi: 10.1002/cbic.201500269. Epub 2015 Jul 14.


Oxidation of Monolignols by Members of the Berberine Bridge Enzyme Family Suggests a Role in Plant Cell Wall Metabolism.

Daniel B, Pavkov-Keller T, Steiner B, Dordic A, Gutmann A, Nidetzky B, Sensen CW, van der Graaff E, Wallner S, Gruber K, Macheroux P.

J Biol Chem. 2015 Jul 24;290(30):18770-81. doi: 10.1074/jbc.M115.659631. Epub 2015 Jun 2.


Anthranoyl-CoA monooxygenase/reductase from Azoarcus evansii possesses both FMN and FAD in two distinct and independent active sites.

Bergner T, Pavkov-Keller T, Kreuzer K, Kowaliuk J, Plank M, Runggatscher K, Turrini NG, Zucol B, Wallner S, Faber K, Gruber K, Macheroux P.

Biochim Biophys Acta. 2015 Aug;1854(8):890-6. doi: 10.1016/j.bbapap.2015.03.011. Epub 2015 Apr 2.


Rationally engineered flavin-dependent oxidase reveals steric control of dioxygen reduction.

Zafred D, Steiner B, Teufelberger AR, Hromic A, Karplus PA, Schofield CJ, Wallner S, Macheroux P.

FEBS J. 2015 Aug;282(16):3060-74. doi: 10.1111/febs.13212. Epub 2015 Feb 24.


Structure and stability of an unusual zinc-binding protein from Bacteroides thetaiotaomicron.

Knaus T, Uhl MK, Monschein S, Moratti S, Gruber K, Macheroux P.

Biochim Biophys Acta. 2014 Dec;1844(12):2298-305. doi: 10.1016/j.bbapap.2014.08.008. Epub 2014 Sep 28.


Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase(1.).

Lienhart WD, Gudipati V, Uhl MK, Binter A, Pulido SA, Saf R, Zangger K, Gruber K, Macheroux P.

FEBS J. 2014 Oct;281(20):4691-4704. doi: 10.1111/febs.12975. Epub 2014 Sep 19.


Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations.

Steinkellner G, Gruber CC, Pavkov-Keller T, Binter A, Steiner K, Winkler C, Lyskowski A, Schwamberger O, Oberer M, Schwab H, Faber K, Macheroux P, Gruber K.

Nat Commun. 2014 Jun 23;5:4150. doi: 10.1038/ncomms5150.


Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability.

Bernkopf M, Webersinke G, Tongsook C, Koyani CN, Rafiq MA, Ayaz M, Müller D, Enzinger C, Aslam M, Naeem F, Schmidt K, Gruber K, Speicher MR, Malle E, Macheroux P, Ayub M, Vincent JB, Windpassinger C, Duba HC.

Hum Mol Genet. 2014 Aug 1;23(15):4015-23. doi: 10.1093/hmg/ddu115. Epub 2014 Mar 13.


Deracemization by simultaneous bio-oxidative kinetic resolution and stereoinversion.

Schrittwieser JH, Groenendaal B, Resch V, Ghislieri D, Wallner S, Fischereder EM, Fuchs E, Grischek B, Sattler JH, Macheroux P, Turner NJ, Kroutil W.

Angew Chem Int Ed Engl. 2014 Apr 1;53(14):3731-4. doi: 10.1002/anie.201400027. Epub 2014 Feb 24.


The flavoproteome of the yeast Saccharomyces cerevisiae.

Gudipati V, Koch K, Lienhart WD, Macheroux P.

Biochim Biophys Acta. 2014 Mar;1844(3):535-44. doi: 10.1016/j.bbapap.2013.12.015. Epub 2013 Dec 27. Review.


Determination of free and bound riboflavin in cow's milk using a novel flavin-binding protein.

Koop J, Monschein S, Pauline Macheroux E, Knaus T, Macheroux P.

Food Chem. 2014 Mar 1;146:94-7. doi: 10.1016/j.foodchem.2013.09.026. Epub 2013 Sep 12.


The shikimate pathway in apicomplexan parasites: implications for drug development.

Derrer B, Macheroux P, Kappes B.

Front Biosci (Landmark Ed). 2013 Jun 1;18:944-69. Review.


The flavoenzyme azobenzene reductase AzoR from Escherichia coli binds roseoflavin mononucleotide (RoFMN) with high affinity and is less active in its RoFMN form.

Langer S, Nakanishi S, Mathes T, Knaus T, Binter A, Macheroux P, Mase T, Miyakawa T, Tanokura M, Mack M.

Biochemistry. 2013 Jun 25;52(25):4288-95. doi: 10.1021/bi400348d. Epub 2013 Jun 10.


The structure of glycerol trinitrate reductase NerA from Agrobacterium radiobacter reveals the molecular reason for nitro- and ene-reductase activity in OYE homologues.

Oberdorfer G, Binter A, Wallner S, Durchschein K, Hall M, Faber K, Macheroux P, Gruber K.

Chembiochem. 2013 May 10;14(7):836-45. doi: 10.1002/cbic.201300136. Epub 2013 Apr 18.


The human flavoproteome.

Lienhart WD, Gudipati V, Macheroux P.

Arch Biochem Biophys. 2013 Jul 15;535(2):150-62. doi: 10.1016/ Epub 2013 Mar 15. Review.


One-Pot Deracemization of sec-Alcohols: Enantioconvergent Enzymatic Hydrolysis of Alkyl Sulfates Using Stereocomplementary Sulfatases.

Schober M, Toesch M, Knaus T, Strohmeier GA, van Loo B, Fuchs M, Hollfelder F, Macheroux P, Faber K.

Angew Chem Weinheim Bergstr Ger. 2013 Mar 11;125(11):3359-3361. Epub 2013 Feb 10. No abstract available.


One-pot deracemization of sec-alcohols: enantioconvergent enzymatic hydrolysis of alkyl sulfates using stereocomplementary sulfatases.

Schober M, Toesch M, Knaus T, Strohmeier GA, van Loo B, Fuchs M, Hollfelder F, Macheroux P, Faber K.

Angew Chem Int Ed Engl. 2013 Mar 11;52(11):3277-9. doi: 10.1002/anie.201209946. Epub 2013 Feb 10. No abstract available.


Structure and mechanism of an inverting alkylsulfatase from Pseudomonas sp. DSM6611 specific for secondary alkyl sulfates.

Knaus T, Schober M, Kepplinger B, Faccinelli M, Pitzer J, Faber K, Macheroux P, Wagner U.

FEBS J. 2012 Dec;279(23):4374-84. doi: 10.1111/febs.12027. Epub 2012 Nov 7.


Unusual C=C bond isomerization of an α,β-unsaturated γ-butyrolactone catalysed by flavoproteins from the old yellow enzyme family.

Durchschein K, Wallner S, Macheroux P, Zangger K, Fabian WM, Faber K.

Chembiochem. 2012 Nov 5;13(16):2346-51. doi: 10.1002/cbic.201200475. Epub 2012 Sep 28.


Inverting the regioselectivity of the berberine bridge enzyme by employing customized fluorine-containing substrates.

Resch V, Lechner H, Schrittwieser JH, Wallner S, Gruber K, Macheroux P, Kroutil W.

Chemistry. 2012 Oct 8;18(41):13173-9. doi: 10.1002/chem.201201895. Epub 2012 Sep 7.


Structural and functional characterization of NikO, an enolpyruvyl transferase essential in nikkomycin biosynthesis.

Oberdorfer G, Binter A, Ginj C, Macheroux P, Gruber K.

J Biol Chem. 2012 Sep 7;287(37):31427-36. doi: 10.1074/jbc.M112.352096. Epub 2012 Jul 18.


Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme.

Wallner S, Winkler A, Riedl S, Dully C, Horvath S, Gruber K, Macheroux P.

Biochemistry. 2012 Aug 7;51(31):6139-47. Epub 2012 Jul 25.


Reverse structural genomics: an unusual flavin-binding site in a putative protease from Bacteroides thetaiotaomicron.

Knaus T, Eger E, Koop J, Stipsits S, Kinsland CL, Ealick SE, Macheroux P.

J Biol Chem. 2012 Aug 10;287(33):27490-8. doi: 10.1074/jbc.M112.355388. Epub 2012 Jun 20.


Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors.

Krysiak JM, Kreuzer J, Macheroux P, Hermetter A, Sieber SA, Breinbauer R.

Angew Chem Int Ed Engl. 2012 Jul 9;51(28):7035-40. doi: 10.1002/anie.201201955. Epub 2012 Jun 11.


Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III.

Bezerra GA, Dobrovetsky E, Viertlmayr R, Dong A, Binter A, Abramic M, Macheroux P, Dhe-Paganon S, Gruber K.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6525-30. doi: 10.1073/pnas.1118005109. Epub 2012 Apr 9.


A novel N,N-8-amino-8-demethyl-D-riboflavin Dimethyltransferase (RosA) catalyzing the two terminal steps of roseoflavin biosynthesis in Streptomyces davawensis.

Jankowitsch F, Kühm C, Kellner R, Kalinowski J, Pelzer S, Macheroux P, Mack M.

J Biol Chem. 2011 Nov 4;286(44):38275-85. doi: 10.1074/jbc.M111.292300. Epub 2011 Sep 12.


PLP-dependent enzymes as potential drug targets for protozoan diseases.

Kappes B, Tews I, Binter A, Macheroux P.

Biochim Biophys Acta. 2011 Nov;1814(11):1567-76. doi: 10.1016/j.bbapap.2011.07.018. Epub 2011 Jul 24. Review.


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