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Items: 1 to 50 of 136

1.

Nebulized hypertonic saline triggers nervous system-mediated active liquid secretion in cystic fibrosis swine trachea.

Luan X, Tam JS, Belev G, Jagadeeshan S, Murray B, Hassan N, Machen TE, Chapman LD, Ianowski JP.

Sci Rep. 2019 Jan 24;9(1):540. doi: 10.1038/s41598-018-36695-4.

2.

Cystic fibrosis swine fail to secrete airway surface liquid in response to inhalation of pathogens.

Luan X, Belev G, Tam JS, Jagadeeshan S, Hassan N, Gioino P, Grishchenko N, Huang Y, Carmalt JL, Duke T, Jones T, Monson B, Burmester M, Simovich T, Yilmaz O, Campanucci VA, Machen TE, Chapman LD, Ianowski JP.

Nat Commun. 2017 Oct 5;8(1):786. doi: 10.1038/s41467-017-00835-7.

3.

N-(3-Oxo-acyl)-homoserine lactone induces apoptosis primarily through a mitochondrial pathway in fibroblasts.

Neely AM, Zhao G, Schwarzer C, Stivers NS, Whitt AG, Meng S, Burlison JA, Machen TE, Li C.

Cell Microbiol. 2018 Jan;20(1). doi: 10.1111/cmi.12787. Epub 2017 Oct 9.

4.

Chemotaxis and Binding of Pseudomonas aeruginosa to Scratch-Wounded Human Cystic Fibrosis Airway Epithelial Cells.

Schwarzer C, Fischer H, Machen TE.

PLoS One. 2016 Mar 31;11(3):e0150109. doi: 10.1371/journal.pone.0150109. eCollection 2016.

5.

Computer modeling of gastric parietal cell: significance of canalicular space, gland lumen, and variable canalicular [K+].

Crothers JM Jr, Forte JG, Machen TE.

Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G671-81. doi: 10.1152/ajpgi.00431.2015. Epub 2016 Feb 4. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2017 May 1;312(5):G535.

6.

N-(3-oxo-acyl) homoserine lactone inhibits tumor growth independent of Bcl-2 proteins.

Zhao G, Neely AM, Schwarzer C, Lu H, Whitt AG, Stivers NS, Burlison JA, White C, Machen TE, Li C.

Oncotarget. 2016 Feb 2;7(5):5924-42. doi: 10.18632/oncotarget.6827.

7.

Paraoxonase 2 serves a proapopotic function in mouse and human cells in response to the Pseudomonas aeruginosa quorum-sensing molecule N-(3-Oxododecanoyl)-homoserine lactone.

Schwarzer C, Fu Z, Morita T, Whitt AG, Neely AM, Li C, Machen TE.

J Biol Chem. 2015 Mar 13;290(11):7247-58. doi: 10.1074/jbc.M114.620039. Epub 2015 Jan 27.

8.

Developmental stage oxidoreductive states of Chlamydia and infected host cells.

Wang X, Schwarzer C, Hybiske K, Machen TE, Stephens RS.

MBio. 2014 Oct 28;5(6):e01924. doi: 10.1128/mBio.01924-14.

9.

Pseudomonas aeruginosa triggers CFTR-mediated airway surface liquid secretion in swine trachea.

Luan X, Campanucci VA, Nair M, Yilmaz O, Belev G, Machen TE, Chapman D, Ianowski JP.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12930-5. doi: 10.1073/pnas.1406414111. Epub 2014 Aug 18.

10.

Pseudomonas aeruginosa quorum-sensing molecule homoserine lactone modulates inflammatory signaling through PERK and eI-F2α.

Grabiner MA, Fu Z, Wu T, Barry KC, Schwarzer C, Machen TE.

J Immunol. 2014 Aug 1;193(3):1459-67. doi: 10.4049/jimmunol.1303437. Epub 2014 Jul 2.

11.

Thapsigargin blocks Pseudomonas aeruginosa homoserine lactone-induced apoptosis in airway epithelia.

Schwarzer C, Ravishankar B, Patanwala M, Shuai S, Fu Z, Illek B, Fischer H, Machen TE.

Am J Physiol Cell Physiol. 2014 May 1;306(9):C844-55. doi: 10.1152/ajpcell.00002.2014. Epub 2014 Mar 5.

12.

Myosin IIB and F-actin control apical vacuolar morphology and histamine-induced trafficking of H-K-ATPase-containing tubulovesicles in gastric parietal cells.

Natarajan P, Crothers JM Jr, Rosen JE, Nakada SL, Rakholia M, Okamoto CT, Forte JG, Machen TE.

Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15;306(8):G699-710. doi: 10.1152/ajpgi.00316.2013. Epub 2014 Feb 27.

13.

Pseudomonas aeruginosa homoserine lactone triggers apoptosis and Bak/Bax-independent release of mitochondrial cytochrome C in fibroblasts.

Schwarzer C, Fu Z, Shuai S, Babbar S, Zhao G, Li C, Machen TE.

Cell Microbiol. 2014 Jul;16(7):1094-104. doi: 10.1111/cmi.12263. Epub 2014 Feb 13.

14.

Reaction of proton pump inhibitors with model peptides results in novel products.

Watson C, Zhu L, Guan S, Machen TE, Forte JG.

J Pharmacol Sci. 2013;122(3):213-22.

15.

Apical vacuole formation by gastric parietal cells in primary culture: effect of low extracellular Ca2+.

Nakada SL, Crothers JM Jr, Machen TE, Forte JG.

Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1301-11. doi: 10.1152/ajpcell.00244.2012. Epub 2012 Oct 24.

16.

The cytokines interleukin-1β and tumor necrosis factor-α stimulate CFTR-mediated fluid secretion by swine airway submucosal glands.

Baniak N, Luan X, Grunow A, Machen TE, Ianowski JP.

Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L327-33. doi: 10.1152/ajplung.00058.2012. Epub 2012 Jun 8.

17.

Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia.

Schwarzer C, Fu Z, Patanwala M, Hum L, Lopez-Guzman M, Illek B, Kong W, Lynch SV, Machen TE.

Cell Microbiol. 2012 May;14(5):698-709. doi: 10.1111/j.1462-5822.2012.01753.x. Epub 2012 Feb 9.

18.

Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia.

Schwarzer C, Wong S, Shi J, Matthes E, Illek B, Ianowski JP, Arant RJ, Isacoff E, Vais H, Foskett JK, Maiellaro I, Hofer AM, Machen TE.

J Biol Chem. 2010 Nov 5;285(45):34850-63. doi: 10.1074/jbc.M110.167668. Epub 2010 Aug 25.

19.

Pseudomonas aeruginosa Inhibition of Flagellin-activated NF-kappaB and interleukin-8 by human airway epithelial cells.

Pena J, Fu Z, Schwarzer C, Machen TE.

Infect Immun. 2009 Jul;77(7):2857-65. doi: 10.1128/IAI.01355-08. Epub 2009 May 18.

20.

Oxidative stress caused by pyocyanin impairs CFTR Cl(-) transport in human bronchial epithelial cells.

Schwarzer C, Fischer H, Kim EJ, Barber KJ, Mills AD, Kurth MJ, Gruenert DC, Suh JH, Machen TE, Illek B.

Free Radic Biol Med. 2008 Dec 15;45(12):1653-62. doi: 10.1016/j.freeradbiomed.2008.09.011. Epub 2008 Sep 23.

21.

Redox-independent activation of NF-kappaB by Pseudomonas aeruginosa pyocyanin in a cystic fibrosis airway epithelial cell line.

Schwarzer C, Fu Z, Fischer H, Machen TE.

J Biol Chem. 2008 Oct 3;283(40):27144-53. doi: 10.1074/jbc.M709693200. Epub 2008 Aug 5.

22.

Flagellin-stimulated Cl- secretion and innate immune responses in airway epithelia: role for p38.

Illek B, Fu Z, Schwarzer C, Banzon T, Jalickee S, Miller SS, Machen TE.

Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L531-42. doi: 10.1152/ajplung.90292.2008. Epub 2008 Jul 25.

23.

Effects of cystic fibrosis transmembrane conductance regulator and DeltaF508CFTR on inflammatory response, ER stress, and Ca2+ of airway epithelia.

Hybiske K, Fu Z, Schwarzer C, Tseng J, Do J, Huang N, Machen TE.

Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1250-60. Epub 2007 Sep 7.

24.

Organelle redox of CF and CFTR-corrected airway epithelia.

Schwarzer C, Illek B, Suh JH, Remington SJ, Fischer H, Machen TE.

Free Radic Biol Med. 2007 Jul 15;43(2):300-16. Epub 2007 Apr 29.

25.

Role of Ca2+ in responses of airway epithelia to Pseudomonas aeruginosa, flagellin, ATP, and thapsigargin.

Fu Z, Bettega K, Carroll S, Buchholz KR, Machen TE.

Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L353-64. Epub 2006 Sep 8.

26.

Innate immune response in CF airway epithelia: hyperinflammatory?

Machen TE.

Am J Physiol Cell Physiol. 2006 Aug;291(2):C218-30. Review.

27.

Innate immune responses of human tracheal epithelium to Pseudomonas aeruginosa flagellin, TNF-alpha, and IL-1beta.

Tseng J, Do J, Widdicombe JH, Machen TE.

Am J Physiol Cell Physiol. 2006 Mar;290(3):C678-90. Epub 2005 Oct 26.

28.

A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells.

Fischer H, Machen TE, Widdicombe JH, Carlson TJ, King SR, Chow JW, Illek B.

J Ethnopharmacol. 2004 Aug;93(2-3):351-7.

PMID:
15234776
29.

NADPH oxidase-dependent acid production in airway epithelial cells.

Schwarzer C, Machen TE, Illek B, Fischer H.

J Biol Chem. 2004 Aug 27;279(35):36454-61. Epub 2004 Jun 21.

30.

Cystic fibrosis airway epithelial cell polarity and bacterial flagellin determine host response to Pseudomonas aeruginosa.

Hybiske K, Ichikawa JK, Huang V, Lory SJ, Machen TE.

Cell Microbiol. 2004 Jan;6(1):49-63.

PMID:
14678330
31.

pH of TGN and recycling endosomes of H+/K+-ATPase-transfected HEK-293 cells: implications for pH regulation in the secretory pathway.

Machen TE, Leigh MJ, Taylor C, Kimura T, Asano S, Moore HP.

Am J Physiol Cell Physiol. 2003 Jul;285(1):C205-14. Epub 2003 Mar 26.

32.

Modulation of cytosolic Ca(2+) concentration in airway epithelial cells by Pseudomonas aeruginosa.

Jacob T, Lee RJ, Engel JN, Machen TE.

Infect Immun. 2002 Nov;70(11):6399-408.

33.

Biosynthesis and secretion of pituitary hormones: dynamics and regulation.

Moore HP, Andresen JM, Eaton BA, Grabe M, Haugwitz M, Wu MM, Machen TE.

Arch Physiol Biochem. 2002 Apr;110(1-2):16-25. Review.

PMID:
11935396
34.

Ca(2+) and Mg(2+)/ATP independently trigger homotypic membrane fusion in gastric secretory membranes.

Duman JG, Singh G, Lee GY, Machen TE, Forte JG.

Traffic. 2002 Mar;3(3):203-17.

35.

Cystic fibrosis transmembrane conductance regulator and H+ permeability in regulation of Golgi pH.

Machen TE, Chandy G, Wu M, Grabe M, Moore HP.

JOP. 2001 Jul;2(4 Suppl):229-36. Review.

36.

Proton leak and CFTR in regulation of Golgi pH in respiratory epithelial cells.

Chandy G, Grabe M, Moore HP, Machen TE.

Am J Physiol Cell Physiol. 2001 Sep;281(3):C908-21.

37.

ENaC- and CFTR-dependent ion and fluid transport in mammary epithelia.

Blaug S, Hybiske K, Cohn J, Firestone GL, Machen TE, Miller SS.

Am J Physiol Cell Physiol. 2001 Aug;281(2):C633-48.

38.

Mechanisms of pH regulation in the regulated secretory pathway.

Wu MM, Grabe M, Adams S, Tsien RY, Moore HP, Machen TE.

J Biol Chem. 2001 Aug 31;276(35):33027-35. Epub 2001 Jun 11.

39.

Studying organelle physiology with fusion protein-targeted avidin and fluorescent biotin conjugates.

Wu MM, Llopis J, Adams SR, McCaffery JM, Teter K, Kulomaa MS, Machen TE, Moore HP, Tsien RY.

Methods Enzymol. 2000;327:546-64. No abstract available.

PMID:
11045008
40.

Organelle pH studies using targeted avidin and fluorescein-biotin.

Wu MM, Llopis J, Adams S, McCaffery JM, Kulomaa MS, Machen TE, Moore HP, Tsien RY.

Chem Biol. 2000 Mar;7(3):197-209.

41.

Anion selectivity of apical membrane conductance of Calu 3 human airway epithelium.

Illek B, Tam AW, Fischer H, Machen TE.

Pflugers Arch. 1999 May;437(6):812-22.

PMID:
10370058
42.

Genetic disorders of membrane transport. II. Regulation of CFTR by small molecules including HCO3-.

Illek B, Fischer H, Machen TE.

Am J Physiol. 1998 Dec;275(6):G1221-6. doi: 10.1152/ajpgi.1998.275.6.G1221. Review.

PMID:
9843756
43.

Regulation of CFTR by protein phosphatase 2B and protein kinase C.

Fischer H, Illek B, Machen TE.

Pflugers Arch. 1998 Jul;436(2):175-81.

PMID:
9594016
44.

cAMP and genistein stimulate HCO3- conductance through CFTR in human airway epithelia.

Illek B, Yankaskas JR, Machen TE.

Am J Physiol. 1997 Apr;272(4 Pt 1):L752-61.

PMID:
9142951
45.

Does nitric oxide regulate capacitative Ca influx in HEK 293 cells?

Bischof G, Serwold TF, Machen TE.

Cell Calcium. 1997 Feb;21(2):135-42.

PMID:
9132296
46.

How do injured cells communicate with the surviving cell monolayer?

Sammak PJ, Hinman LE, Tran PO, Sjaastad MD, Machen TE.

J Cell Sci. 1997 Feb;110 ( Pt 4):465-75.

48.

HCO3-dependent pHi regulation in tracheal epithelial cells.

Poulsen JH, Machen TE.

Pflugers Arch. 1996 Jul;432(3):546-54.

PMID:
8766016
49.

Effects of extracellular pH on intracellular pH-regulation and growth in a human colon carcinoma cell-line.

Bischof G, Cosentini E, Hamilton G, Riegler M, Zacherl J, Teleky B, Feil W, Schiessel R, Machen TE, Wenzl E.

Biochim Biophys Acta. 1996 Jun 13;1282(1):131-9.

50.

ATP regulates calcium leak from agonist-sensitive internal calcium stores.

Hofer AM, Curci S, Machen TE, Schulz I.

FASEB J. 1996 Feb;10(2):302-8.

PMID:
8641563

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