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Items: 1 to 50 of 132

1.

Low Dose Carbon Monoxide Exposure in Idiopathic Pulmonary Fibrosis Produces a CO Signature Comprised of Oxidative Phosphorylation Genes.

Casanova N, Zhou T, Gonzalez-Garay ML, Rosas IO, Goldberg HJ, Ryter SW, Collard HR, El-Chemaly S, Flaherty KR, Hunninghake GM, Lasky JA, Lederer DJ, Machado RF, Martinez FJ, Noth I, Raghu G, Choi AMK, Garcia JGN.

Sci Rep. 2019 Oct 15;9(1):14802. doi: 10.1038/s41598-019-50585-3.

2.

Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report.

Ruhl AP, Sadreameli SC, Allen JL, Bennett DP, Campbell AD, Coates TD, Diallo DA, Field JJ, Fiorino EK, Gladwin MT, Glassberg JA, Gordeuk VR, Graham LM, Greenough A, Howard J, Kato GJ, Knight-Madden J, Kopp BT, Koumbourlis AC, Lanzkron SM, Liem RI, Machado RF, Mehari A, Morris CR, Ogunlesi FO, Rosen CL, Smith-Whitley K, Tauber D, Terry N, Thein SL, Vichinsky E, Weir NA, Cohen RT, Klings ES.

Ann Am Thorac Soc. 2019 Sep;16(9):e17-e32. doi: 10.1513/AnnalsATS.201906-433ST.

PMID:
31469310
3.

Validation of a composite vascular high-risk profile for adult patients with sickle cell disease.

Nouraie M, Little JA, Hildesheim M, Gibbs JSR, Morris CR, Machado RF, Kato GJ, Gordeuk VR, Gladwin MT.

Am J Hematol. 2019 Aug 23. doi: 10.1002/ajh.25624. [Epub ahead of print] No abstract available.

PMID:
31444803
4.

MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase.

Gao H, Chen J, Chen T, Wang Y, Song Y, Dong Y, Zhao S, Machado RF.

Sci Rep. 2019 Jul 9;9(1):9949. doi: 10.1038/s41598-019-46352-z.

5.

Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension.

Oliveira SDS, Chen J, Castellon M, Mao M, Raj JU, Comhair S, Erzurum S, Silva CLM, Machado RF, Bonini MG, Minshall RD.

Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1191-1202. doi: 10.1161/ATVBAHA.118.312038.

PMID:
30943774
6.

A locus on chromosome 5 shows African ancestry-limited association with alloimmunization in sickle cell disease.

Williams LM, Qi Z, Batai K, Hooker S, Hall NJ, Machado RF, Chen A, Campbell-Lee S, Guan Y, Kittles R, Hanchard NA.

Blood Adv. 2018 Dec 26;2(24):3637-3647. doi: 10.1182/bloodadvances.2018020594.

7.

Integrated analysis of ethionamide resistance loci in Mycobacterium tuberculosis clinical isolates.

da Silva DA, Ferreira NV, Rego AM, Barbosa PCP, Machado RF, Pimentel A, Dos Reis LM, de Pina LC, Redner P, Caldas PCS, Fandinho-Montes FCO, Borga L, Leite SP, da Rocha JL, Bastos LS, Ramos JP, Degrave WM, Antunes LCM, Galvão TC.

Tuberculosis (Edinb). 2018 Dec;113:163-174. doi: 10.1016/j.tube.2018.08.010. Epub 2018 Aug 26.

PMID:
30514498
8.

How I treat hypoxia in adults with hemoglobinopathies and hemolytic disorders.

Machogu EM, Machado RF.

Blood. 2018 Oct 25;132(17):1770-1780. doi: 10.1182/blood-2018-03-818195. Epub 2018 Sep 11. Review.

PMID:
30206115
9.

HMOX1 and acute kidney injury in sickle cell anemia.

Saraf SL, Viner M, Rischall A, Raslan R, Shah BN, Zhang X, Han J, Gowhari M, Jain S, Molokie RE, Machado RF, Lash JP, Gordeuk VR.

Blood. 2018 Oct 11;132(15):1621-1625. doi: 10.1182/blood-2018-05-853929. Epub 2018 Aug 23. No abstract available.

10.

Hemolysis and hemolysis-related complications in females vs. males with sickle cell disease.

Raslan R, Shah BN, Zhang X, Kanias T, Han J, Machado RF, Gladwin MT, Gordeuk VR, Saraf SL.

Am J Hematol. 2018 Nov;93(11):E376-E380. doi: 10.1002/ajh.25258. Epub 2018 Oct 17. No abstract available.

PMID:
30117177
11.

Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure.

DeLalio LJ, Keller AS, Chen J, Boyce AKJ, Artamonov MV, Askew-Page HR, Keller TCS 4th, Johnstone SR, Weaver RB, Good ME, Murphy SA, Best AK, Mintz EL, Penuela S, Greenwood IA, Machado RF, Somlyo AV, Swayne LA, Minshall RD, Isakson BE.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2065-2078. doi: 10.1161/ATVBAHA.118.311290.

12.

Risk factors for vitamin D deficiency in sickle cell disease.

Han J, Zhang X, Saraf SL, Gowhari M, Molokie RE, Hassan J, Jain S, Shah BN, Abbasi T, Machado RF, Gordeuk VR.

Br J Haematol. 2018 Jun;181(6):828-835. doi: 10.1111/bjh.15270. Epub 2018 May 16.

13.

A Review of Transcriptome Analysis in Pulmonary Vascular Diseases.

Fraidenburg DR, Machado RF.

Methods Mol Biol. 2018;1783:259-277. doi: 10.1007/978-1-4939-7834-2_13.

14.

Endothelial nitric oxide synthase genotype is associated with pulmonary hypertension severity in left heart failure patients.

Duarte JD, Kansal M, Desai AA, Riden K, Arwood MJ, Yacob AA, Stamos TD, Cavallari LH, Zamanian RT, Shah SJ, Machado RF.

Pulm Circ. 2018 Apr-Jun;8(2):2045894018773049. doi: 10.1177/2045894018773049.

15.

Death of the Endothelium in Sepsis: Understanding the Crime Scene.

Singla S, Machado RF.

Am J Respir Cell Mol Biol. 2018 Jul;59(1):3-4. doi: 10.1165/rcmb.2018-0051ED. No abstract available.

16.

Vascular complications of sickle cell disease.

Usmani A, Machado RF.

Clin Hemorheol Microcirc. 2018;68(2-3):205-221. doi: 10.3233/CH-189008.

PMID:
29614633
17.

Update in Pulmonary Vascular Disease 2016 and 2017.

Brittain EL, Thennapan T, Maron BA, Chan SY, Austin ED, Spiekerkoetter E, Bogaard HJ, Guignabert C, Paulin R, Machado RF, Yu PB.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):13-23. doi: 10.1164/rccm.201801-0062UP. No abstract available.

18.

Progressive glomerular and tubular damage in sickle cell trait and sickle cell anemia mouse models.

Saraf SL, Sysol JR, Susma A, Setty S, Zhang X, Gudehithlu KP, Arruda JAL, Singh AK, Machado RF, Gordeuk VR.

Transl Res. 2018 Jul;197:1-11. doi: 10.1016/j.trsl.2018.01.007. Epub 2018 Feb 2.

19.

Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1.

Sysol JR, Chen J, Singla S, Zhao S, Comhair S, Natarajan V, Machado RF.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L461-L472. doi: 10.1152/ajplung.00057.2017. Epub 2017 Nov 22.

20.

Associations of α-thalassemia and BCL11A with stroke in Nigerian, United States, and United Kingdom sickle cell anemia cohorts.

Saraf SL, Akingbola TS, Shah BN, Ezekekwu CA, Sonubi O, Zhang X, Hsu LL, Gladwin MT, Machado RF, Cooper RS, Gordeuk VR, Tayo BO.

Blood Adv. 2017 Apr 25;1(11):693-698. doi: 10.1182/bloodadvances.2017005231.

21.

Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension.

Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd JE, Austin ED, Machado RF, Minshall RD, Rehman J, Malik AB.

Mol Biol Cell. 2017 May 1;28(9):1177-1185. doi: 10.1091/mbc.E16-11-0790.

22.

Hemin Causes Lung Microvascular Endothelial Barrier Dysfunction by Necroptotic Cell Death.

Singla S, Sysol JR, Dille B, Jones N, Chen J, Machado RF.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):307-314. doi: 10.1165/rcmb.2016-0287OC.

23.

Association of circulating transcriptomic profiles with mortality in sickle cell disease.

Desai AA, Lei Z, Bahroos N, Maienschein-Cline M, Saraf SL, Zhang X, Shah BN, Nouraie SM, Abbasi T, Patel AR, Lang RM, Lussier Y, Garcia JGN, Gordeuk VR, Machado RF.

Blood. 2017 Jun 1;129(22):3009-3016. doi: 10.1182/blood-2016-11-752279. Epub 2017 Apr 3.

24.

Aberrant Caveolin-1-Mediated Smad Signaling and Proliferation Identified by Analysis of Adenine 474 Deletion Mutation (c.474delA) in Patient Fibroblasts: A New Perspective in the Mechanism of Pulmonary Hypertension.

Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd JE, Austin ED, Machado RF, Minshall RD, Rehman J, Malik AB.

Mol Biol Cell. 2017 Mar 15. pii: mbc.E16-06-0380. doi: 10.1091/mbc.E16-06-0380. [Epub ahead of print]

PMID:
28298490
25.

Loss of lung WWOX expression causes neutrophilic inflammation.

Singla S, Chen J, Sethuraman S, Sysol JR, Gampa A, Zhao S, Machado RF.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L903-L911. doi: 10.1152/ajplung.00034.2017. Epub 2017 Mar 10.

26.

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.

Chen J, Sysol JR, Singla S, Zhao S, Yamamura A, Valdez-Jasso D, Abbasi T, Shioura KM, Sahni S, Reddy V, Sridhar A, Gao H, Torres J, Camp SM, Tang H, Ye SQ, Comhair S, Dweik R, Hassoun P, Yuan JX, Garcia JGN, Machado RF.

Circulation. 2017 Apr 18;135(16):1532-1546. doi: 10.1161/CIRCULATIONAHA.116.024557. Epub 2017 Feb 15.

27.

Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling.

Oliveira SDS, Castellon M, Chen J, Bonini MG, Gu X, Elliott MH, Machado RF, Minshall RD.

Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L760-L771. doi: 10.1152/ajplung.00484.2016. Epub 2017 Feb 10.

28.

A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease.

Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, Gordeuk VR.

Hum Mol Genet. 2016 Oct 15;25(20):4601-4609. doi: 10.1093/hmg/ddw299.

29.

Expression profiling elucidates a molecular gene signature for pulmonary hypertension in sarcoidosis.

Singla S, Zhou T, Javaid K, Abbasi T, Casanova N, Zhang W, Ma SF, Wade MS, Noth I, Sweiss NJ, Garcia JG, Machado RF.

Pulm Circ. 2016 Dec;6(4):465-471. doi: 10.1086/688316.

30.

Pulmonary vascular and ventricular dysfunction in the susceptible patient (2015 Grover Conference series).

Maron BA, Machado RF, Shimoda L.

Pulm Circ. 2016 Dec;6(4):426-438. doi: 10.1086/688315. Review. Erratum in: Pulm Circ. 2017 Apr-Jun;7(2):559.

31.

Annexin A11 is associated with pulmonary fibrosis in African American patients with sarcoidosis.

Mirsaeidi M, Vu A, Zhang W, Arbieva Z, Zhang C, Abbasi T, Hakim A, Schraufnagel D, Sweiss N, Baughman R, Garcia JG, Machado RF.

Sarcoidosis Vasc Diffuse Lung Dis. 2016 Dec 23;33(4):418-422.

PMID:
28079857
32.

Reply to Ruan X et al: "A comment on pattern of opioid use in sickle cell disease".

Han J, Saraf SL, Machado RF, Gordeuk VR.

Am J Hematol. 2017 Apr;92(4):E43. doi: 10.1002/ajh.24646. Epub 2017 Feb 7. No abstract available.

33.

Patterns of opioid use in sickle cell disease.

Han J, Saraf SL, Zhang X, Gowhari M, Molokie RE, Hassan J, Alhandalous C, Jain S, Younge J, Abbasi T, Machado RF, Gordeuk VR.

Am J Hematol. 2016 Nov;91(11):1102-1106. doi: 10.1002/ajh.24498. Epub 2016 Aug 8.

34.

Associations of Prolonged QTc in Sickle Cell Disease.

Indik JH, Nair V, Rafikov R, Nyotowidjojo IS, Bisla J, Kansal M, Parikh DS, Robinson M, Desai A, Oberoi M, Gupta A, Abbasi T, Khalpey Z, Patel AR, Lang RM, Dudley SC, Choi BR, Garcia JG, Machado RF, Desai AA.

PLoS One. 2016 Oct 13;11(10):e0164526. doi: 10.1371/journal.pone.0164526. eCollection 2016.

35.

APOL1, α-thalassemia, and BCL11A variants as a genetic risk profile for progression of chronic kidney disease in sickle cell anemia.

Saraf SL, Shah BN, Zhang X, Han J, Tayo BO, Abbasi T, Ostrower A, Guzman E, Molokie RE, Gowhari M, Hassan J, Jain S, Cooper RS, Machado RF, Lash JP, Gordeuk VR.

Haematologica. 2017 Jan;102(1):e1-e6. doi: 10.3324/haematol.2016.154153. Epub 2016 Sep 22. No abstract available.

36.

Genome-Wide Analysis Identifies IL-18 and FUCA2 as Novel Genes Associated with Diastolic Function in African Americans with Sickle Cell Disease.

Duarte JD, Desai AA, Sysol JR, Abbasi T, Patel AR, Lang RM, Gupta A, Garcia JG, Gordeuk VR, Machado RF.

PLoS One. 2016 Sep 16;11(9):e0163013. doi: 10.1371/journal.pone.0163013. eCollection 2016.

37.

Ten tips for managing critically ill patients with sickle cell disease.

Mekontso Dessap A, Fartoukh M, Machado RF.

Intensive Care Med. 2017 Jan;43(1):80-82. doi: 10.1007/s00134-016-4472-7. Epub 2016 Aug 4. No abstract available.

PMID:
27492270
38.

PDGF induces SphK1 expression via Egr-1 to promote pulmonary artery smooth muscle cell proliferation.

Sysol JR, Natarajan V, Machado RF.

Am J Physiol Cell Physiol. 2016 Jun 1;310(11):C983-92. doi: 10.1152/ajpcell.00059.2016. Epub 2016 Apr 20.

39.

Pulmonary hypertension associated with thalassemia syndromes.

Fraidenburg DR, Machado RF.

Ann N Y Acad Sci. 2016 Mar;1368(1):127-39. doi: 10.1111/nyas.13037. Epub 2016 Mar 23. Review.

40.

Pathophysiology and treatment of pulmonary hypertension in sickle cell disease.

Gordeuk VR, Castro OL, Machado RF.

Blood. 2016 Feb 18;127(7):820-8. doi: 10.1182/blood-2015-08-618561. Epub 2016 Jan 12. Review.

41.

Conjunctival and pulmonary hemodynamic properties in sickle cell disease subjects with and without pulmonary hypertension.

Kord Valeshabad A, Wanek J, Molokie RE, Machado RF, Gordeuk VR, Shahidi M.

Clin Case Rep. 2015 Nov 6;3(12):1038-41. doi: 10.1002/ccr3.439. eCollection 2015 Dec.

42.

Increased consumption and vasodilatory effect of nitrite during exercise.

Hon YY, Lin EE, Tian X, Yang Y, Sun H, Swenson ER, Taveira-Dasilva AM, Gladwin MT, Machado RF.

Am J Physiol Lung Cell Mol Physiol. 2016 Feb 15;310(4):L354-64. doi: 10.1152/ajplung.00081.2015. Epub 2015 Dec 18.

43.

Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood-Brain Barrier Integrity and Central Nervous System Homeostasis.

Tran KA, Zhang X, Predescu D, Huang X, Machado RF, Göthert JR, Malik AB, Valyi-Nagy T, Zhao YY.

Circulation. 2016 Jan 12;133(2):177-86. doi: 10.1161/CIRCULATIONAHA.115.015982. Epub 2015 Nov 4.

44.

Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy.

Saraf SL, Zhang X, Shah B, Kanias T, Gudehithlu KP, Kittles R, Machado RF, Arruda JA, Gladwin MT, Singh AK, Gordeuk VR.

Haematologica. 2015 Oct;100(10):1275-84. doi: 10.3324/haematol.2015.124875. Epub 2015 Jul 23.

45.

Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease.

Zhang X, Zhang W, Saraf SL, Nouraie M, Han J, Gowhari M, Hassan J, Miasnikova G, Sergueeva A, Nekhai S, Kittles R, Machado RF, Garcia JG, Gladwin MT, Steinberg MH, Sebastiani P, McClain DA, Gordeuk VR.

Hum Genet. 2015 Aug;134(8):895-904. doi: 10.1007/s00439-015-1572-3. Epub 2015 May 30.

46.

The imitation game in pulmonary arterial hypertension. Sex, bone morphogenetic protein receptor, and the estrogen paradox.

Singla S, Machado RF.

Am J Respir Crit Care Med. 2015 Mar 15;191(6):612-3. doi: 10.1164/rccm.201501-0204ED. No abstract available.

47.

[Updated clinical classification of pulmonary hypertension].

Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, Gomez Sanchez MA, Kumar RK, Landzberg M, Machado RF, Olschewski H, Robbins IM, Souza R.

Turk Kardiyol Dern Ars. 2014 Oct;42 Suppl 1:45-54. Turkish.

48.

Response.

Mirsaeidi M, Machado RF, Schraufnagel D, Sweiss NJ, Baughman RP.

Chest. 2015 Feb;147(2):e65-e66. doi: 10.1378/chest.14-2603. No abstract available.

49.

High sodium causes hypertension: evidence from clinical trials and animal experiments.

Reddy V, Sridhar A, Machado RF, Chen J.

J Integr Med. 2015 Jan;13(1):1-8. doi: 10.1016/S2095-4964(15)60155-8. Review.

PMID:
25609366
50.

Pulmonary hypertension in sickle cell disease.

Hayes MM, Vedamurthy A, George G, Dweik R, Klings ES, Machado RF, Gladwin MT, Wilson KC, Thomson CC; American Thoracic Society Implementation Task Force.

Ann Am Thorac Soc. 2014 Nov;11(9):1488-9. doi: 10.1513/AnnalsATS.201408-405CME. No abstract available.

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