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Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca2+ influx in mitosis.

Yu F, Hubrack SZ, Chakraborty S, Sun L, Alcantara-Adap E, Kulkarni R, Billing AM, Graumann J, Taylor CW, Machaca K.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10392-10401. doi: 10.1073/pnas.1821399116. Epub 2019 May 7.


Synthesis of TPEN variants to improve cancer cells selective killing capacity.

Schaefer-Ramadan S, Barlog M, Roach J, Al-Hashimi M, Bazzi HS, Machaca K.

Bioorg Chem. 2019 Jun;87:366-372. doi: 10.1016/j.bioorg.2019.03.045. Epub 2019 Mar 16.


Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity.

Emrich SM, Yoast RE, Xin P, Zhang X, Pathak T, Nwokonko R, Gueguinou MF, Subedi KP, Zhou Y, Ambudkar IS, Hempel N, Machaca K, Gill DL, Trebak M.

J Biol Chem. 2019 Apr 19;294(16):6318-6332. doi: 10.1074/jbc.RA118.006801. Epub 2019 Mar 1.


IP3 receptors and store-operated Ca2+ entry: a license to fill.

Taylor CW, Machaca K.

Curr Opin Cell Biol. 2019 Apr;57:1-7. doi: 10.1016/ Epub 2018 Oct 24. Review.


Regulation and Role of Store-Operated Ca2+ Entry in Cellular Proliferation.

Hodeify R, Yu F, Courjaret R, Nader N, Dib M, Sun L, Adap E, Hubrack S, Machaca K.

In: Kozak JA, Putney JW Jr., editors. Calcium Entry Channels in Non-Excitable Cells. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 12.


The CCT chaperonin is a novel regulator of Ca2+ signaling through modulation of Orai1 trafficking.

Hodeify R, Nandakumar M, Own M, Courjaret RJ, Graumann J, Hubrack SZ, Machaca K.

Sci Adv. 2018 Sep 26;4(9):eaau1935. doi: 10.1126/sciadv.aau1935. eCollection 2018 Sep.


Spatially restricted subcellular Ca2+ signaling downstream of store-operated calcium entry encoded by a cortical tunneling mechanism.

Courjaret R, Dib M, Machaca K.

Sci Rep. 2018 Jul 25;8(1):11214. doi: 10.1038/s41598-018-29562-9.


Ion Channel Function During Oocyte Maturation and Fertilization.

Carvacho I, Piesche M, Maier TJ, Machaca K.

Front Cell Dev Biol. 2018 Jun 26;6:63. doi: 10.3389/fcell.2018.00063. eCollection 2018. Review.


The VLDL receptor regulates membrane progesterone receptor trafficking and non-genomic signaling.

Nader N, Dib M, Courjaret R, Hodeify R, Machaca R, Graumann J, Machaca K.

J Cell Sci. 2018 May 23;131(10). pii: jcs212522. doi: 10.1242/jcs.212522.


Transition metal dependent regulation of the signal transduction cascade driving oocyte meiosis.

Schaefer-Ramadan S, Hubrack S, Machaca K.

J Cell Physiol. 2018 Apr;233(4):3164-3175. doi: 10.1002/jcp.26157. Epub 2017 Oct 5.


Effects of Hyperglycemia on Vascular Smooth Muscle Ca2+ Signaling.

El-Najjar N, Kulkarni RP, Nader N, Hodeify R, Machaca K.

Biomed Res Int. 2017;2017:3691349. doi: 10.1155/2017/3691349. Epub 2017 Jun 21.


Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites.

Petersen OH, Courjaret R, Machaca K.

J Physiol. 2017 May 15;595(10):2999-3014. doi: 10.1113/JP272772. Epub 2017 Mar 16. Review.


Coculturing with endothelial cells promotes in vitro maturation and electrical coupling of human embryonic stem cell-derived cardiomyocytes.

Pasquier J, Gupta R, Rioult D, Hoarau-Véchot J, Courjaret R, Machaca K, Al Suwaidi J, Stanley EG, Rafii S, Elliott DA, Abi Khalil C, Rafii A.

J Heart Lung Transplant. 2017 Jun;36(6):684-693. doi: 10.1016/j.healun.2017.01.001. Epub 2017 Jan 10.


Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells.

Rahal ON, Fatfat M, Hankache C, Osman B, Khalife H, Machaca K, Muhtasib HG.

Cancer Biol Ther. 2016 Nov;17(11):1139-1148. Epub 2016 Oct 3. Erratum in: Cancer Biol Ther. 2017 Jan 2;18(1):77.


Store-Operated Ca2+ Entry in Oocytes Modulate the Dynamics of IP3 -Dependent Ca2+ Release From Oscillatory to Tonic.

Courjaret R, Dib M, Machaca K.

J Cell Physiol. 2017 May;232(5):1095-1103. doi: 10.1002/jcp.25513. Epub 2016 Sep 7.


Xenopus Oocyte As a Model System to Study Store-Operated Ca(2+) Entry (SOCE).

Courjaret R, Machaca K.

Front Cell Dev Biol. 2016 Jun 24;4:66. doi: 10.3389/fcell.2016.00066. eCollection 2016.


The Ca2+-activated Cl- channel Ano1 controls microvilli length and membrane surface area in the oocyte.

Courjaret R, Hodeify R, Hubrack S, Ibrahim A, Dib M, Daas S, Machaca K.

J Cell Sci. 2016 Jul 1;129(13):2548-58. doi: 10.1242/jcs.188367. Epub 2016 May 12.


Release from Xenopus oocyte prophase I meiotic arrest is independent of a decrease in cAMP levels or PKA activity.

Nader N, Courjaret R, Dib M, Kulkarni RP, Machaca K.

Development. 2016 Jun 1;143(11):1926-36. doi: 10.1242/dev.136168. Epub 2016 Apr 27.


A novel approach to the expression and purification of recombinant Xenopus Cdc25C.

Schaefer-Ramadan S, Bendriss G, Hubrack S, Al-Abdulmalek A, Machaca K.

Protein Expr Purif. 2016 Apr;120:148-52. doi: 10.1016/j.pep.2015.12.007. Epub 2015 Dec 13.


The Role of Flexible Loops in Folding, Trafficking and Activity of Equilibrative Nucleoside Transporters.

Aseervatham J, Tran L, Machaca K, Boudker O.

PLoS One. 2015 Sep 25;10(9):e0136779. doi: 10.1371/journal.pone.0136779. eCollection 2015.


A STIM1-dependent 'trafficking trap' mechanism regulates Orai1 plasma membrane residence and Ca²⁺ influx levels.

Hodeify R, Selvaraj S, Wen J, Arredouani A, Hubrack S, Dib M, Al-Thani SN, McGraw T, Machaca K.

J Cell Sci. 2015 Aug 15;128(16):3143-54. doi: 10.1242/jcs.172320. Epub 2015 Jun 26.


Role for endocytosis of a constitutively active GPCR (GPR185) in releasing vertebrate oocyte meiotic arrest.

Nader N, Dib M, Daalis A, Kulkarni RP, Machaca K.

Dev Biol. 2014 Nov 15;395(2):355-66. doi: 10.1016/j.ydbio.2014.08.036. Epub 2014 Sep 16.


Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species.

Fatfat M, Merhi RA, Rahal O, Stoyanovsky DA, Zaki A, Haidar H, Kagan VE, Gali-Muhtasib H, Machaca K.

BMC Cancer. 2014 Jul 21;14:527. doi: 10.1186/1471-2407-14-527.


Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ release.

Courjaret R, Machaca K.

Nat Commun. 2014 May 28;5:3916. doi: 10.1038/ncomms4916.


The role of IP3 receptor channel clustering in Ca2+ wave propagation during oocyte maturation.

Ullah A, Jung P, Ullah G, Machaca K.

Prog Mol Biol Transl Sci. 2014;123:83-101. doi: 10.1016/B978-0-12-397897-4.00006-1.


Understanding fertilization through intracytoplasmic sperm injection (ICSI).

Neri QV, Lee B, Rosenwaks Z, Machaca K, Palermo GD.

Cell Calcium. 2014 Jan;55(1):24-37. doi: 10.1016/j.ceca.2013.10.006. Epub 2013 Nov 15. Review.


Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility.

Abou-Saleh H, Pathan AR, Daalis A, Hubrack S, Abou-Jassoum H, Al-Naeimi H, Rusch NJ, Machaca K.

J Biol Chem. 2013 Nov 15;288(46):32941-51. doi: 10.1074/jbc.M113.496802. Epub 2013 Oct 4.


The Xenopus TRPV6 homolog encodes a Mg(2+) -permeant channel that is inhibited by interaction with TRPC1.

Courjaret R, Hubrack S, Daalis A, Dib M, Machaca K.

J Cell Physiol. 2013 Dec;228(12):2386-98. doi: 10.1002/jcp.24411.


Intramolecular shielding maintains the ER Ca²⁺ sensor STIM1 in an inactive conformation.

Yu F, Sun L, Hubrack S, Selvaraj S, Machaca K.

J Cell Sci. 2013 Jun 1;126(Pt 11):2401-10. doi: 10.1242/jcs.117200. Epub 2013 Apr 9.


Polymorphism in endothelial connexin40 enhances sensitivity to intraluminal pressure and increases arterial stiffness.

Chaston DJ, Baillie BK, Grayson TH, Courjaret RJ, Heisler JM, Lau KA, Machaca K, Nicholson BJ, Ashton A, Matthaei KI, Hill CE.

Arterioscler Thromb Vasc Biol. 2013 May;33(5):962-70. doi: 10.1161/ATVBAHA.112.300957. Epub 2013 Mar 7.


Downregulation of store-operated Ca2+ entry during mammalian meiosis is required for the egg-to-embryo transition.

Lee B, Palermo G, Machaca K.

J Cell Sci. 2013 Apr 1;126(Pt 7):1672-81. doi: 10.1242/jcs.121335. Epub 2013 Feb 19.


Egg activation and the egg-to-embryo transition. Preface.

Muallem S, Machaca K.

Cell Calcium. 2013 Jan;53(1):1. doi: 10.1016/j.ceca.2012.12.002. Epub 2013 Jan 7. No abstract available.


How to make a good egg!: The need for remodeling of oocyte Ca(2+) signaling to mediate the egg-to-embryo transition.

Nader N, Kulkarni RP, Dib M, Machaca K.

Cell Calcium. 2013 Jan;53(1):41-54. doi: 10.1016/j.ceca.2012.11.015. Epub 2012 Dec 23. Review.


Phosphorylation of the rat Ins(1,4,5)P₃ receptor at T930 within the coupling domain decreases its affinity to Ins(1,4,5)P₃.

Haun S, Sun L, Hubrack S, Yule D, Machaca K.

Channels (Austin). 2012 Sep-Oct;6(5):379-84. doi: 10.4161/chan.21170. Epub 2012 Aug 10.


STIM and Orai in cellular proliferation and division.

Courjaret R, Machaca K.

Front Biosci (Elite Ed). 2012 Jan 1;4:331-41. Review.


Endoplasmic reticulum remodeling tunes IP₃-dependent Ca²+ release sensitivity.

Sun L, Yu F, Ullah A, Hubrack S, Daalis A, Jung P, Machaca K.

PLoS One. 2011;6(11):e27928. doi: 10.1371/journal.pone.0027928. Epub 2011 Nov 30.


Ca(2+) signaling, genes and the cell cycle.

Machaca K.

Cell Calcium. 2011 May;49(5):323-30. Review.


Role of the STIM1 C-terminal domain in STIM1 clustering.

Yu F, Sun L, Courjaret R, Machaca K.

J Biol Chem. 2011 Mar 11;286(10):8375-84. doi: 10.1074/jbc.M110.188789. Epub 2011 Jan 10.


Ca(2+) signaling, genes and the cell cycle.

Machaca K.

Cell Calcium. 2010 Nov;48(5):243-50. doi: 10.1016/j.ceca.2010.10.003. Epub 2010 Nov 16. Review.


Constitutive recycling of the store-operated Ca2+ channel Orai1 and its internalization during meiosis.

Yu F, Sun L, Machaca K.

J Cell Biol. 2010 Nov 1;191(3):523-35. doi: 10.1083/jcb.201006022.


Regulation of store-operated Ca2+ entry during the cell cycle.

Arredouani A, Yu F, Sun L, Machaca K.

J Cell Sci. 2010 Jul 1;123(Pt 13):2155-62. doi: 10.1242/jcs.069690.


Orai1 internalization and STIM1 clustering inhibition modulate SOCE inactivation during meiosis.

Yu F, Sun L, Machaca K.

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17401-6. doi: 10.1073/pnas.0904651106. Epub 2009 Sep 30.


Kinase-dependent regulation of inositol 1,4,5-trisphosphate-dependent Ca2+ release during oocyte maturation.

Sun L, Haun S, Jones RC, Edmondson RD, Machaca K.

J Biol Chem. 2009 Jul 24;284(30):20184-96. doi: 10.1074/jbc.M109.004515. Epub 2009 May 27.


Internalization of plasma membrane Ca2+-ATPase during Xenopus oocyte maturation.

El-Jouni W, Haun S, Machaca K.

Dev Biol. 2008 Dec 1;324(1):99-107. doi: 10.1016/j.ydbio.2008.09.007. Epub 2008 Sep 18.


Ca2+ homeostasis regulates Xenopus oocyte maturation.

Sun L, Hodeify R, Haun S, Charlesworth A, MacNicol AM, Ponnappan S, Ponnappan U, Prigent C, Machaca K.

Biol Reprod. 2008 Apr;78(4):726-35. Epub 2007 Dec 19.


Vesicular traffic at the cell membrane regulates oocyte meiotic arrest.

El-Jouni W, Haun S, Hodeify R, Hosein Walker A, Machaca K.

Development. 2007 Sep;134(18):3307-15. Epub 2007 Aug 15.


Ca2+ signaling differentiation during oocyte maturation.

Machaca K.

J Cell Physiol. 2007 Nov;213(2):331-40. Review.


Zinc regulates the ability of Cdc25C to activate MPF/cdk1.

Sun L, Chai Y, Hannigan R, Bhogaraju VK, Machaca K.

J Cell Physiol. 2007 Oct;213(1):98-104.


Modeling Ca2+ signaling differentiation during oocyte maturation.

Ullah G, Jung P, Machaca K.

Cell Calcium. 2007 Dec;42(6):556-64. Epub 2007 Mar 8.


Calcium signaling differentiation during Xenopus oocyte maturation.

El-Jouni W, Jang B, Haun S, Machaca K.

Dev Biol. 2005 Dec 15;288(2):514-25. Epub 2005 Dec 2.

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