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Items: 49


Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.

Maceyka M, Rohrbach T, Milstien S, Spiegel S.

Handb Exp Pharmacol. 2019 Jul 19. doi: 10.1007/164_2019_217. [Epub ahead of print]


StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis.

Rodriguez-Agudo D, Malacrida L, Kakiyama G, Sparrer T, Fortes C, Maceyka M, Subler MA, Windle JJ, Gratton E, Pandak WM, Gil G.

J Lipid Res. 2019 Jun;60(6):1087-1098. doi: 10.1194/jlr.M091967. Epub 2019 Apr 23.


Mitochondrial Complex I Inhibition by Metformin Limits Reperfusion Injury.

Mohsin AA, Chen Q, Quan N, Rousselle T, Maceyka MW, Samidurai A, Thompson J, Hu Y, Li J, Lesnefsky EJ.

J Pharmacol Exp Ther. 2019 May;369(2):282-290. doi: 10.1124/jpet.118.254300. Epub 2019 Mar 7.


New insights into functions of the sphingosine-1-phosphate transporter SPNS2.

Spiegel S, Maczis MA, Maceyka M, Milstien S.

J Lipid Res. 2019 Mar;60(3):484-489. doi: 10.1194/jlr.S091959. Epub 2019 Jan 17.


Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer.

Maczis MA, Maceyka M, Waters MR, Newton J, Singh M, Rigsby MF, Turner TH, Alzubi MA, Harrell JC, Milstien S, Spiegel S.

J Lipid Res. 2018 Dec;59(12):2297-2307. doi: 10.1194/jlr.M085191. Epub 2018 Oct 12.


Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology.

Rohrbach T, Maceyka M, Spiegel S.

Crit Rev Biochem Mol Biol. 2017 Oct;52(5):543-553. doi: 10.1080/10409238.2017.1337706. Epub 2017 Jun 15. Review.


FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.

Newton J, Hait NC, Maceyka M, Colaco A, Maczis M, Wassif CA, Cougnoux A, Porter FD, Milstien S, Platt N, Platt FM, Spiegel S.

FASEB J. 2017 Apr;31(4):1719-1730. doi: 10.1096/fj.201601041R. Epub 2017 Jan 12.


ORMDL proteins regulate ceramide levels during sterile inflammation.

Cai L, Oyeniran C, Biswas DD, Allegood J, Milstien S, Kordula T, Maceyka M, Spiegel S.

J Lipid Res. 2016 Aug;57(8):1412-22. doi: 10.1194/jlr.M065920. Epub 2016 Jun 16.


Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans.

Huang WC, Liang J, Nagahashi M, Avni D, Yamada A, Maceyka M, Wolen AR, Kordula T, Milstien S, Takabe K, Oravecz T, Spiegel S.

FASEB J. 2016 Aug;30(8):2945-58. doi: 10.1096/fj.201600394R. Epub 2016 Apr 29.


Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling.

Campos LS, Rodriguez YI, Leopoldino AM, Hait NC, Lopez Bergami P, Castro MG, Sanchez ES, Maceyka M, Spiegel S, Alvarez SE.

Mol Cell Biol. 2015 Nov 9;36(2):320-9. doi: 10.1128/MCB.00554-15. Print 2016 Jan 15.


Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases.

Donoviel MS, Hait NC, Ramachandran S, Maceyka M, Takabe K, Milstien S, Oravecz T, Spiegel S.

FASEB J. 2015 Dec;29(12):5018-28. doi: 10.1096/fj.15-274936. Epub 2015 Aug 31.


Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.

Oyeniran C, Sturgill JL, Hait NC, Huang WC, Avni D, Maceyka M, Newton J, Allegood JC, Montpetit A, Conrad DH, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2015 Oct;136(4):1035-46.e6. doi: 10.1016/j.jaci.2015.02.031. Epub 2015 Apr 2.


Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy.

Newton J, Lima S, Maceyka M, Spiegel S.

Exp Cell Res. 2015 May 1;333(2):195-200. doi: 10.1016/j.yexcr.2015.02.025. Epub 2015 Mar 11. Review. No abstract available.


Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.

Kim EY, Sturgill JL, Hait NC, Avni D, Valencia EC, Maceyka M, Lima S, Allegood J, Huang WC, Zhang S, Milstien S, Conrad D, Spiegel S.

FASEB J. 2014 Oct;28(10):4347-58. doi: 10.1096/fj.14-251611. Epub 2014 Jul 1.


Sphingolipid metabolites in inflammatory disease.

Maceyka M, Spiegel S.

Nature. 2014 Jun 5;510(7503):58-67. doi: 10.1038/nature13475. Review.


Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injury.

Xu A, Szczepanek K, Maceyka MW, Ross T, Bowler E, Hu Y, Kenny B, Mehfoud C, Desai PN, Baumgarten CM, Chen Q, Lesnefsky EJ.

Am J Physiol Cell Physiol. 2014 Jun 15;306(12):C1142-53. doi: 10.1152/ajpcell.00241.2013. Epub 2014 Apr 2.


Lysophospholipid receptor nomenclature review: IUPHAR Review 8.

Kihara Y, Maceyka M, Spiegel S, Chun J.

Br J Pharmacol. 2014 Aug;171(15):3575-94. doi: 10.1111/bph.12678. Epub 2014 Jul 12. Review.


Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.

Nagahashi M, Hait NC, Maceyka M, Avni D, Takabe K, Milstien S, Spiegel S.

Adv Biol Regul. 2014 Jan;54:112-20. doi: 10.1016/j.jbior.2013.10.001. Epub 2013 Oct 16. Review.


The potential of histone deacetylase inhibitors in Niemann - Pick type C disease.

Maceyka M, Milstien S, Spiegel S.

FEBS J. 2013 Dec;280(24):6367-72. doi: 10.1111/febs.12505. Epub 2013 Sep 23. Review.


Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.

Kunkel GT, Maceyka M, Milstien S, Spiegel S.

Nat Rev Drug Discov. 2013 Sep;12(9):688-702. doi: 10.1038/nrd4099. Epub 2013 Aug 19. Review.


Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network.

Nagahashi M, Kim EY, Yamada A, Ramachandran S, Allegood JC, Hait NC, Maceyka M, Milstien S, Takabe K, Spiegel S.

FASEB J. 2013 Mar;27(3):1001-11. doi: 10.1096/fj.12-219618. Epub 2012 Nov 24.


Sphingosine-1-phosphate signaling and its role in disease.

Maceyka M, Harikumar KB, Milstien S, Spiegel S.

Trends Cell Biol. 2012 Jan;22(1):50-60. doi: 10.1016/j.tcb.2011.09.003. Epub 2011 Oct 14. Review.


Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.

Strub GM, Paillard M, Liang J, Gomez L, Allegood JC, Hait NC, Maceyka M, Price MM, Chen Q, Simpson DC, Kordula T, Milstien S, Lesnefsky EJ, Spiegel S.

FASEB J. 2011 Feb;25(2):600-12. doi: 10.1096/fj.10-167502. Epub 2010 Oct 19.


Extracellular and intracellular actions of sphingosine-1-phosphate.

Strub GM, Maceyka M, Hait NC, Milstien S, Spiegel S.

Adv Exp Med Biol. 2010;688:141-55. Review.


Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S.

Nature. 2010 Jun 24;465(7301):1084-8. doi: 10.1038/nature09128.


Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S.

Science. 2009 Sep 4;325(5945):1254-7. doi: 10.1126/science.1176709. Erratum in: Science. 2009 Oct 16;326(5951):366.


Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling.

Maceyka M, Milstien S, Spiegel S.

J Lipid Res. 2009 Apr;50 Suppl:S272-6. doi: 10.1194/jlr.R800065-JLR200. Epub 2008 Nov 5. Review.


Filamin A links sphingosine kinase 1 and sphingosine-1-phosphate receptor 1 at lamellipodia to orchestrate cell migration.

Maceyka M, Alvarez SE, Milstien S, Spiegel S.

Mol Cell Biol. 2008 Sep;28(18):5687-97. doi: 10.1128/MCB.00465-08. Epub 2008 Jul 21.


Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo.

Maceyka M, Milstien S, Spiegel S.

Methods Enzymol. 2007;434:243-56.


Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2.

Le Stunff H, Giussani P, Maceyka M, Lépine S, Milstien S, Spiegel S.

J Biol Chem. 2007 Nov 23;282(47):34372-80. Epub 2007 Sep 25.


Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis.

Lamour NF, Stahelin RV, Wijesinghe DS, Maceyka M, Wang E, Allegood JC, Merrill AH Jr, Cho W, Chalfant CE.

J Lipid Res. 2007 Jun;48(6):1293-304. Epub 2007 Mar 27.


Ceramide kinase regulates growth and survival of A549 human lung adenocarcinoma cells.

Mitra P, Maceyka M, Payne SG, Lamour N, Milstien S, Chalfant CE, Spiegel S.

FEBS Lett. 2007 Feb 20;581(4):735-40. Epub 2007 Jan 25.


Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate.

Maceyka M, Milstien S, Spiegel S.

Circ Res. 2007 Jan 5;100(1):7-9. Review. No abstract available.


Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.

Giussani P, Maceyka M, Le Stunff H, Mikami A, Lépine S, Wang E, Kelly S, Merrill AH Jr, Milstien S, Spiegel S.

Mol Cell Biol. 2006 Jul;26(13):5055-69.


Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors.

Saini HS, Coelho RP, Goparaju SK, Jolly PS, Maceyka M, Spiegel S, Sato-Bigbee C.

J Neurochem. 2005 Dec;95(5):1298-310.


Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells.

Sarkar S, Maceyka M, Hait NC, Paugh SW, Sankala H, Milstien S, Spiegel S.

FEBS Lett. 2005 Oct 10;579(24):5313-7.


SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism.

Maceyka M, Sankala H, Hait NC, Le Stunff H, Liu H, Toman R, Collier C, Zhang M, Satin LS, Merrill AH Jr, Milstien S, Spiegel S.

J Biol Chem. 2005 Nov 4;280(44):37118-29. Epub 2005 Aug 23.


Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics.

Maceyka M, Milstien S, Spiegel S.

Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):15-22. Review.


Role of sphingosine kinase 2 in cell migration toward epidermal growth factor.

Hait NC, Sarkar S, Le Stunff H, Mikami A, Maceyka M, Milstien S, Spiegel S.

J Biol Chem. 2005 Aug 19;280(33):29462-9. Epub 2005 Jun 10.


Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension.

Toman RE, Payne SG, Watterson KR, Maceyka M, Lee NH, Milstien S, Bigbee JW, Spiegel S.

J Cell Biol. 2004 Aug 2;166(3):381-92.


Aminoacylase 1 is a sphingosine kinase 1-interacting protein.

Maceyka M, Nava VE, Milstien S, Spiegel S.

FEBS Lett. 2004 Jun 18;568(1-3):30-4.


Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2.

Pettus BJ, Bielawska A, Subramanian P, Wijesinghe DS, Maceyka M, Leslie CC, Evans JH, Freiberg J, Roddy P, Hannun YA, Chalfant CE.

J Biol Chem. 2004 Mar 19;279(12):11320-6. Epub 2003 Dec 15.


Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis.

Liu H, Toman RE, Goparaju SK, Maceyka M, Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, Milstien S, Spiegel S.

J Biol Chem. 2003 Oct 10;278(41):40330-6. Epub 2003 Jun 30.


Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.

Maceyka M, Payne SG, Milstien S, Spiegel S.

Biochim Biophys Acta. 2002 Dec 30;1585(2-3):193-201. Review.


Sphingosine kinases: a novel family of lipid kinases.

Liu H, Chakravarty D, Maceyka M, Milstien S, Spiegel S.

Prog Nucleic Acid Res Mol Biol. 2002;71:493-511. Review.


EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration.

Rosenfeldt HM, Hobson JP, Maceyka M, Olivera A, Nava VE, Milstien S, Spiegel S.

FASEB J. 2001 Dec;15(14):2649-59.


Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor.

Kleuser B, Maceyka M, Milstien S, Spiegel S.

FEBS Lett. 2001 Aug 10;503(1):85-90.

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