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Items: 10

1.

Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.

Kovarik Z, Maček Hrvat N, Kalisiak J, Katalinić M, Sit RK, Zorbaz T, Radić Z, Fokin VV, Sharpless KB, Taylor P.

Toxicol Appl Pharmacol. 2019 Jun 1;372:40-46. doi: 10.1016/j.taap.2019.04.007. Epub 2019 Apr 9.

PMID:
30978400
2.

Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.

Zorbaz T, Malinak D, Maraković N, Maček Hrvat N, Zandona A, Novotny M, Skarka A, Andrys R, Benkova M, Soukup O, Katalinić M, Kuca K, Kovarik Z, Musilek K.

J Med Chem. 2018 Dec 13;61(23):10753-10766. doi: 10.1021/acs.jmedchem.8b01398. Epub 2018 Nov 20.

PMID:
30383374
3.

Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.

Sit RK, Kovarik Z, Maček Hrvat N, Žunec S, Green C, Fokin VV, Sharpless KB, Radić Z, Taylor P.

J Pharmacol Exp Ther. 2018 Nov;367(2):363-372. doi: 10.1124/jpet.118.249383. Epub 2018 Sep 6.

4.

Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations.

Katalinić M, Šinko G, Maček Hrvat N, Zorbaz T, Bosak A, Kovarik Z.

Toxicology. 2018 Aug 1;406-407:104-113. doi: 10.1016/j.tox.2018.05.008. Epub 2018 May 22.

PMID:
29772260
5.

Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration.

Zorbaz T, Braïki A, Maraković N, Renou J, de la Mora E, Maček Hrvat N, Katalinić M, Silman I, Sussman JL, Mercey G, Gomez C, Mougeot R, Pérez B, Baati R, Nachon F, Weik M, Jean L, Kovarik Z, Renard PY.

Chemistry. 2018 Jul 5;24(38):9675-9691. doi: 10.1002/chem.201801394. Epub 2018 Jun 8.

PMID:
29672968
6.

The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation.

Maček Hrvat N, Zorbaz T, Šinko G, Kovarik Z.

Toxicol Lett. 2018 Sep 1;293:222-228. doi: 10.1016/j.toxlet.2017.11.022. Epub 2017 Nov 24.

PMID:
29180286
7.

A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers.

Katalinić M, Maček Hrvat N, Baumann K, Morasi Piperčić S, Makarić S, Tomić S, Jović O, Hrenar T, Miličević A, Jelić D, Žunec S, Primožič I, Kovarik Z.

Toxicol Appl Pharmacol. 2016 Nov 1;310:195-204. doi: 10.1016/j.taap.2016.09.015. Epub 2016 Sep 18.

PMID:
27654152
8.

HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants.

Maček Hrvat N, Žunec S, Taylor P, Radić Z, Kovarik Z.

Chem Biol Interact. 2016 Nov 25;259(Pt B):148-153. doi: 10.1016/j.cbi.2016.04.023. Epub 2016 Apr 12.

9.

Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning.

Katalinić M, Maček Hrvat N, Žďárová Karasová J, Misik J, Kovarik Z.

Arh Hig Rada Toksikol. 2015 Dec;66(4):291-8. doi: 10.1515/aiht-2015-66-2740.

PMID:
26751861
10.

Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes.

Kovarik Z, Maček Hrvat N, Katalinić M, Sit RK, Paradyse A, Žunec S, Musilek K, Fokin VV, Taylor P, Radić Z.

Chem Res Toxicol. 2015 May 18;28(5):1036-44. doi: 10.1021/acs.chemrestox.5b00060. Epub 2015 Apr 16.

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