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A phase IIb, randomised, double-blind, placebo-controlled, dose-ranging investigation of the safety and efficacy of NTCELL® [immunoprotected (alginate-encapsulated) porcine choroid plexus cells for xenotransplantation] in patients with Parkinson's disease.

Snow B, Mulroy E, Bok A, Simpson M, Smith A, Taylor K, Lockhart M, Lam BJ, Frampton C, Schweder P, Chen B, Finucane G, McMahon A, Macdonald L.

Parkinsonism Relat Disord. 2018 Nov 13. pii: S1353-8020(18)30500-5. doi: 10.1016/j.parkreldis.2018.11.015. [Epub ahead of print]


University physicists and the origins of the National Physical Laboratory, 1830-1900.

Macdonald LT.

Hist Sci. 2018 Nov 26:73275318811445. doi: 10.1177/0073275318811445. [Epub ahead of print]


Evaluation of the capacities of mouse TCR profiling from short read RNA-seq data.

Bai Y, Wang D, Li W, Huang Y, Ye X, Waite J, Barry T, Edelmann KH, Levenkova N, Guo C, Skokos D, Wei Y, Macdonald LE, Fury W.

PLoS One. 2018 Nov 15;13(11):e0207020. doi: 10.1371/journal.pone.0207020. eCollection 2018.


Approaches to variant discovery for conifer transcriptome sequencing.

Telfer E, Graham N, Macdonald L, Sturrock S, Wilcox P, Stanbra L.

PLoS One. 2018 Nov 5;13(11):e0205835. doi: 10.1371/journal.pone.0205835. eCollection 2018.


Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype.

Wang B, Zhang W, Jankovic V, Golubov J, Poon P, Oswald EM, Gurer C, Wei J, Ramos I, Wu Q, Waite J, Ni M, Adler C, Wei Y, Macdonald L, Rowlands T, Brydges S, Siao J, Poueymirou W, MacDonald D, Yancopoulos GD, Sleeman MA, Murphy AJ, Skokos D.

Sci Immunol. 2018 Nov 2;3(29). pii: eaat7061. doi: 10.1126/sciimmunol.aat7061.


Deletion of Adam6 in Mus musculus leads to male subfertility and deficits in sperm ascent into the oviduct.

Voronina VA, Harris FM, Schmahl J, Galligan C, Oristian D, Zamfirova R, Gong G, Bai Y, Fury W, Rajamani S, Walls JR, Poueymirou WT, Esau L, Gale NW, Auerbach W, Murphy AJ, Macdonald LE.

Biol Reprod. 2018 Oct 4. doi: 10.1093/biolre/ioy210. [Epub ahead of print]


Arsenic in groundwater in private wells in rural North Dakota and South Dakota: Water quality assessment for an intervention trial.

Powers M, Yracheta J, Harvey D, O'Leary M, Best LG, Black Bear A, MacDonald L, Susan J, Hasan K, Thomas E, Morgan C, Olmedo P, Chen R, Rule A, Schwab K, Navas-Acien A, George CM.

Environ Res. 2019 Jan;168:41-47. doi: 10.1016/j.envres.2018.09.016. Epub 2018 Sep 15.


Making stars physical: the astronomy of Sir John Herschel.

Macdonald LT.

Ann Sci. 2018 Sep 21:1-4. doi: 10.1080/00033790.2018.1523463. [Epub ahead of print] No abstract available.


A taboo topic? How General Practitioners talk about overweight and obesity in New Zealand.

Gray L, Stubbe M, Macdonald L, Tester R, Hilder J, Dowell AC.

J Prim Health Care. 2018 Jun;10(2):150-158. doi: 10.1071/HC17075.


Classification tree for the prediction of malignant disease and the prediction of non-diagnostic biopsies in patients with small renal masses.

Organ M, Macdonald LP, Jewett MAS, Ajzenberg H, Almatar A, Abdolell M, Acker MR, Rendon R.

Can Urol Assoc J. 2018 Sep 27. doi: 10.5489/cuaj.5196. [Epub ahead of print]


The origins and early years of the Magnetic and Meteorological department at Greenwich Observatory, 1834-1848.

Macdonald LT.

Ann Sci. 2018 Jul;75(3):201-233. doi: 10.1080/00033790.2018.1489979. Epub 2018 Jul 20.


Characterization of Human iPSC-RPE on a Prosthetic Bruch's Membrane Manufactured From Silk Fibroin.

Galloway CA, Dalvi S, Shadforth AMA, Suzuki S, Wilson M, Kuai D, Hashim A, MacDonald LA, Gamm DM, Harkin DG, Singh R.

Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2792-2800. doi: 10.1167/iovs.17-23157.


Versatile catechol dioxygenases in Sphingobium scionense WP01T.

Muthu M, Ophir Y, Macdonald LJ, Vaidya A, Lloyd-Jones G.

Antonie Van Leeuwenhoek. 2018 Dec;111(12):2293-2301. doi: 10.1007/s10482-018-1120-y. Epub 2018 Jun 29.


Urinary cadmium concentration and the risk of ischemic stroke.

Chen C, Xun P, Tsinovoi C, McClure LA, Brockman J, MacDonald L, Cushman M, Cai J, Kamendulis L, Mackey J, He K.

Neurology. 2018 Jul 24;91(4):e382-e391. doi: 10.1212/WNL.0000000000005856. Epub 2018 Jun 22.


A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant.

French SL, Thalmann C, Bray PF, Macdonald LE, Murphy AJ, Sleeman MW, Hamilton JR.

Blood Adv. 2018 Jun 12;2(11):1283-1293. doi: 10.1182/bloodadvances.2017015552.


Public health surveillance for the Toronto 2015 Pan/Parapan American Games.

Chan E, Hohenadel K, Lee B, Helferty M, Harris JR, Macdonald L, Badiani T.

Can Commun Dis Rep. 2017 Jul 6;43(7):156-163. eCollection 2017 Jul 6.


Do 'environmental bads' such as alcohol, fast food, tobacco, and gambling outlets cluster and co-locate in more deprived areas in Glasgow City, Scotland?

Macdonald L, Olsen JR, Shortt NK, Ellaway A.

Health Place. 2018 May;51:224-231. doi: 10.1016/j.healthplace.2018.04.008. Epub 2018 May 7.


Serum mercury concentration and the risk of ischemic stroke: The REasons for Geographic and Racial Differences in Stroke Trace Element Study.

Chen C, Xun P, McClure LA, Brockman J, MacDonald L, Cushman M, Cai J, Kamendulis L, Mackey J, He K.

Environ Int. 2018 Aug;117:125-131. doi: 10.1016/j.envint.2018.05.001. Epub 2018 May 5.


Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis.

Beutier H, Hechler B, Godon O, Wang Y, Gillis CM, de Chaisemartin L, Gouel-Chéron A, Magnenat S, Macdonald LE, Murphy AJ; NASA study group, Chollet-Martin S, Longrois D, Gachet C, Bruhns P, Jönsson F.

Sci Immunol. 2018 Apr 13;3(22). pii: eaan5997. doi: 10.1126/sciimmunol.aan5997.


Results from the third Scottish National Prevalence Survey: is a population health approach now needed to prevent healthcare-associated infections?

Cairns S, Gibbons C, Milne A, King H, Llano M, MacDonald L, Malcolm W, Robertson C, Sneddon J, Weir J, Reilly J.

J Hosp Infect. 2018 Jul;99(3):312-317. doi: 10.1016/j.jhin.2018.03.038. Epub 2018 Apr 2.


A Respiratory Syncytial Virus Vaccine Based on the Small Hydrophobic Protein Ectodomain Presented With a Novel Lipid-Based Formulation Is Highly Immunogenic and Safe in Adults: A First-in-Humans Study.

Langley JM, MacDonald LD, Weir GM, MacKinnon-Cameron D, Ye L, McNeil S, Schepens B, Saelens X, Stanford MM, Halperin SA.

J Infect Dis. 2018 Jul 2;218(3):378-387. doi: 10.1093/infdis/jiy177.


Final-impression techniques and materials for making complete and removable partial dentures.

Jayaraman S, Singh BP, Ramanathan B, Pazhaniappan Pillai M, MacDonald L, Kirubakaran R.

Cochrane Database Syst Rev. 2018 Apr 4;4:CD012256. doi: 10.1002/14651858.CD012256.pub2. Review.


Earthworm-induced shifts in microbial diversity in soils with rare versus established invasive earthworm populations.

de Menezes AB, Prendergast-Miller MT, Macdonald LM, Toscas P, Baker G, Farrell M, Wark T, Richardson AE, Thrall PH.

FEMS Microbiol Ecol. 2018 May 1;94(5). doi: 10.1093/femsec/fiy051.


Cost-effectiveness of percutaneous patent foramen ovale closure as secondary stroke prevention.

Tirschwell DL, Turner M, Thaler D, Choulerton J, Marks D, Carroll J, MacDonald L, Smalling RW, Koullick M, Gu NY, Saver JL.

J Med Econ. 2018 Jul;21(7):656-665. doi: 10.1080/13696998.2018.1456445. Epub 2018 Apr 13.


Characterization of highly multiplexed monolithic PET / gamma camera detector modules.

Pierce LA, Pedemonte S, DeWitt D, MacDonald L, Hunter WCJ, Van Leemput K, Miyaoka R.

Phys Med Biol. 2018 Mar 29;63(7):075017. doi: 10.1088/1361-6560/aab380.


Universal videolaryngoscopy: a structured approach to conversion to videolaryngoscopy for all intubations in an anaesthetic and intensive care department.

Cook TM, Boniface NJ, Seller C, Hughes J, Damen C, MacDonald L, Kelly FE.

Br J Anaesth. 2018 Jan;120(1):173-180. doi: 10.1016/j.bja.2017.11.014. Epub 2017 Nov 21.


Community Participatory Interventions to Improve Farmer Knowledge and Practices of Household Biogas Unit Operation in Ha Nam Province, Vietnam.

Luu QT, Nguyen MH, Nguyen-Viet H, Pham G, Dinh-Xuan T, MacDonald LE, Pham-Duc P.

J Public Health Manag Pract. 2018 Mar/Apr;24 Suppl 2 Supplement, Public Health in Vietnam:S28-S35. doi: 10.1097/PHH.0000000000000727.


Daily decision-making about food during pregnancy: a New Zealand study.

Pullon S, Ballantyne A, Macdonald L, Barthow C, Wickens K, Crane J.

Health Promot Int. 2018 Jan 12. doi: 10.1093/heapro/dax098. [Epub ahead of print]


Selective hydrogenation of nitroarenes using an electrogenerated polyoxometalate redox mediator.

MacDonald L, Rausch B, Symes MD, Cronin L.

Chem Commun (Camb). 2018 Jan 25;54(9):1093-1096. doi: 10.1039/c7cc09036f.


Probing the molecular basis of hERG drug block with unnatural amino acids.

Macdonald LC, Kim RY, Kurata HT, Fedida D.

Sci Rep. 2018 Jan 10;8(1):289. doi: 10.1038/s41598-017-18448-x.


A Longitudinal Study of Interactions Between Health Professionals and People With Newly Diagnosed Diabetes.

Dowell A, Stubbe M, Macdonald L, Tester R, Gray L, Vernall S, Kenealy T, Sheridan N, Docherty B, Hall DA, Raphael D, Dew K.

Ann Fam Med. 2018 Jan;16(1):37-44. doi: 10.1370/afm.2144.


Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer.

Tucker DW, Getchell CR, McCarthy ET, Ohman AW, Sasamoto N, Xu S, Ko JY, Gupta M, Shafrir A, Medina JE, Lee JJ, MacDonald LA, Malik A, Hasselblatt KT, Li W, Zhang H, Kaplan SJ, Murphy GF, Hirsch MS, Liu JF, Matulonis UA, Terry KL, Lian CG, Dinulescu DM.

Clin Cancer Res. 2018 Mar 15;24(6):1389-1401. doi: 10.1158/1078-0432.CCR-17-1958. Epub 2017 Dec 20.


Changing Health Professionals' Attitudes and Practice Behaviors Through Interprofessional Continuing Education in Oral-Systemic Health.

Mowat S, Hein C, Walsh T, MacDonald L, Grymonpre R, Sisler J.

J Dent Educ. 2017 Dec;81(12):1421-1429. doi: 10.21815/JDE.017.102.


Turning poop into profit: Cost-effectiveness and soil transmitted helminth infection risk associated with human excreta reuse in Vietnam.

Tran-Thi N, Lowe RJ, Schurer JM, Vu-Van T, MacDonald LE, Pham-Duc P.

PLoS Negl Trop Dis. 2017 Nov 27;11(11):e0006088. doi: 10.1371/journal.pntd.0006088. eCollection 2017 Nov. Review.


Review: In age-related macular degeneration, antioxidant multivitamins and zinc supplements each decrease progression.

Macdonald L.

Ann Intern Med. 2017 Nov 21;167(10):JC57. doi: 10.7326/ACPJC-2017-167-10-057. No abstract available.


Review: Antioxidant vitamin or mineral supplements do not prevent age-related macular degeneration.

Macdonald L.

Ann Intern Med. 2017 Nov 21;167(10):JC56. doi: 10.7326/ACPJC-2017-167-10-056. No abstract available.


Simulation study of quantitative precision of the PET/X dedicated breast PET scanner.

Zeng C, Kinahan PE, Qian H, Harrison RL, Champley KM, MacDonald LR.

J Med Imaging (Bellingham). 2017 Oct;4(4):045502. doi: 10.1117/1.JMI.4.4.045502. Epub 2017 Oct 30.


The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues.

Dou Y, Macdonald LC, Wu Y, Fedida D.

Biophys J. 2017 Nov 7;113(9):1979-1991. doi: 10.1016/j.bpj.2017.09.004.


Exploring interprofessional, interagency multimorbidity care: case study based observational research.

McKinlay EM, Morgan SJ, Gray BV, Macdonald LM, Pullon SRH.

J Comorb. 2017 Jun 12;7(1):64-78. doi: 10.15256/joc.2017.7.103. eCollection 2017.


Humanized mouse model supports development, function, and tissue residency of human natural killer cells.

Herndler-Brandstetter D, Shan L, Yao Y, Stecher C, Plajer V, Lietzenmayer M, Strowig T, de Zoete MR, Palm NW, Chen J, Blish CA, Frleta D, Gurer C, Macdonald LE, Murphy AJ, Yancopoulos GD, Montgomery RR, Flavell RA.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9626-E9634. doi: 10.1073/pnas.1705301114. Epub 2017 Oct 25.


"I can't bend it and it hurts like mad": direct observation of gout consultations in routine primary health care.

Dowell A, Morris C, Macdonald L, Stubbe M.

BMC Fam Pract. 2017 Oct 18;18(1):91. doi: 10.1186/s12875-017-0662-9.


Changes over time in population level transport satisfaction and mode of travel: A 13 year repeat cross-sectional study, UK.

Olsen JR, Macdonald L, Ellaway A.

J Transp Health. 2017 Sep;6:366-378. doi: 10.1016/j.jth.2017.03.012.


The Role of Occupation in Explaining Cognitive Functioning in Later Life: Education and Occupational Complexity in a U.S. National Sample of Black and White Men and Women.

Fujishiro K, MacDonald LA, Crowe M, McClure LA, Howard VJ, Wadley VG.

J Gerontol B Psychol Sci Soc Sci. 2017 Aug 21. doi: 10.1093/geronb/gbx112. [Epub ahead of print]


Type III hypersensitivity reactions to a B cell epitope antigen are abrogated using a depot forming vaccine platform.

MacDonald LD, MacKay A, Kaliaperumal V, Weir G, Penwell A, Rajagopalan R, Langley JM, Halperin S, Mansour M, Stanford MM.

Hum Vaccin Immunother. 2018 Jan 2;14(1):59-66. doi: 10.1080/21645515.2017.1375637. Epub 2017 Oct 30.


Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke.

Saver JL, Carroll JD, Thaler DE, Smalling RW, MacDonald LA, Marks DS, Tirschwell DL; RESPECT Investigators.

N Engl J Med. 2017 Sep 14;377(11):1022-1032. doi: 10.1056/NEJMoa1610057.


Participation in a US community-based cardiovascular health study: investigating nonrandom selection effects related to employment, perceived stress, work-related stress, and family caregiving.

MacDonald LA, Fujishiro K, Howard VJ, Landsbergis P, Hein MJ.

Ann Epidemiol. 2017 Sep;27(9):545-552.e2. doi: 10.1016/j.annepidem.2017.08.008. Epub 2017 Aug 15.


Drusen in patient-derived hiPSC-RPE models of macular dystrophies.

Galloway CA, Dalvi S, Hung SSC, MacDonald LA, Latchney LR, Wong RCB, Guymer RH, Mackey DA, Williams DS, Chung MM, Gamm DM, Pébay A, Hewitt AW, Singh R.

Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8214-E8223. doi: 10.1073/pnas.1710430114. Epub 2017 Sep 6.


Household Exposure to Livestock and Health in the CHILILAB HDSS Cohort, Vietnam.

Dang-Xuan S, MacDonald LE, Schurer JM, Nguyen-Viet H, Pham-Duc P.

Asia Pac J Public Health. 2017 Jul;29(5_suppl):72S-83S. doi: 10.1177/1010539517712758.


The Effect of Changes in Cervical Cancer Screening Guidelines on Chlamydia Testing.

Naimer MS, Kwong JC, Bhatia D, Moineddin R, Whelan M, Campitelli MA, Macdonald L, Lofters A, Tuite A, Bogler T, Permaul JA, McIsaac WJ.

Ann Fam Med. 2017 Jul;15(4):329-334. doi: 10.1370/afm.2097.


Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo.

Weir GM, Karkada M, Hoskin D, Stanford MM, MacDonald L, Mansour M, Liwski RS.

PLoS One. 2017 Jun 29;12(6):e0180073. doi: 10.1371/journal.pone.0180073. eCollection 2017.

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