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Items: 48


Recombinant dermatan sulfate is a potent activator of heparin cofactor II-dependent inhibition of thrombin.

Tykesson E, Maccarana M, Thorsson H, Liu J, Malmström A, Ellervik U, Westergren-Thorsson G.

Glycobiology. 2019 Jun 1;29(6):446-451. doi: 10.1093/glycob/cwz019.


Dermatan sulfate epimerase 1 and dermatan 4-O-sulfotransferase 1 form complexes that generate long epimerized 4-O-sulfated blocks.

Tykesson E, Hassinen A, Zielinska K, Thelin MA, Frati G, Ellervik U, Westergren-Thorsson G, Malmström A, Kellokumpu S, Maccarana M.

J Biol Chem. 2018 Aug 31;293(35):13725-13735. doi: 10.1074/jbc.RA118.003875. Epub 2018 Jul 5.


Dendritic Cell Migration to Skin-Draining Lymph Nodes Is Controlled by Dermatan Sulfate and Determines Adaptive Immunity Magnitude.

Nadafi R, Koning JJ, Veninga H, Stachtea XN, Konijn T, Zwiers A, Malmström A, den Haan JMM, Mebius RE, Maccarana M, Reijmers RM.

Front Immunol. 2018 Feb 8;9:206. doi: 10.3389/fimmu.2018.00206. eCollection 2018.


Gene expression of the two developmentally regulated dermatan sulfate epimerases in the Xenopus embryo.

Gouignard N, Schön T, Holmgren C, Strate I, Taşöz E, Wetzel F, Maccarana M, Pera EM.

PLoS One. 2018 Jan 25;13(1):e0191751. doi: 10.1371/journal.pone.0191751. eCollection 2018.


Three unreported cases of TMEM199-CDG, a rare genetic liver disease with abnormal glycosylation.

Vajro P, Zielinska K, Ng BG, Maccarana M, Bengtson P, Poeta M, Mandato C, D'Acunto E, Freeze HH, Eklund EA.

Orphanet J Rare Dis. 2018 Jan 10;13(1):4. doi: 10.1186/s13023-017-0757-3.


Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure.

Maccarana M, Svensson RB, Knutsson A, Giannopoulos A, Pelkonen M, Weis M, Eyre D, Warman M, Kalamajski S.

PLoS One. 2017 Aug 31;12(8):e0184028. doi: 10.1371/journal.pone.0184028. eCollection 2017.


Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma.

Olsson PO, Kalamajski S, Maccarana M, Oldberg Å, Rubin K.

PLoS One. 2017 Aug 21;12(8):e0182973. doi: 10.1371/journal.pone.0182973. eCollection 2017.


Increased deposition of glycosaminoglycans and altered structure of heparan sulfate in idiopathic pulmonary fibrosis.

Westergren-Thorsson G, Hedström U, Nybom A, Tykesson E, Åhrman E, Hornfelt M, Maccarana M, van Kuppevelt TH, Dellgren G, Wildt M, Zhou XH, Eriksson L, Bjermer L, Hallgren O.

Int J Biochem Cell Biol. 2017 Feb;83:27-38. doi: 10.1016/j.biocel.2016.12.005. Epub 2016 Dec 11.


The Tyrosine Kinase Inhibitor Imatinib Augments Extracellular Fluid Exchange and Reduces Average Collagen Fibril Diameter in Experimental Carcinoma.

Olsson PO, Gustafsson R, In 't Zandt R, Friman T, Maccarana M, Tykesson E, Oldberg Å, Rubin K, Kalamajski S.

Mol Cancer Ther. 2016 Oct;15(10):2455-2464. Epub 2016 Jul 29.


Drugs affecting glycosaminoglycan metabolism.

Ghiselli G, Maccarana M.

Drug Discov Today. 2016 Jul;21(7):1162-9. doi: 10.1016/j.drudis.2016.05.010. Epub 2016 May 20. Review.


Musculocontractural Ehlers-Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells to migrate and adhere to fibronectin.

Gouignard N, Maccarana M, Strate I, von Stedingk K, Malmström A, Pera EM.

Dis Model Mech. 2016 Jun 1;9(6):607-20. doi: 10.1242/dmm.024661. Epub 2016 Apr 21.


Determination of Autosomal Dominant or Recessive Methionine Adenosyltransferase I/III Deficiencies Based on Clinical and Molecular Studies.

Kim YM, Kim JH, Choi J, Gu-Hwan K, Kim JM, Kang M, Choi IH, Cheon CK, Sohn YB, Maccarana M, Yoo HW, Lee BH.

Mol Med. 2016 Sep;22:147-155. doi: 10.2119/molmed.2015.00254. Epub 2016 Feb 18.


Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry.

Tykesson E, Mao Y, Maccarana M, Pu Y, Gao J, Lin C, Zaia J, Westergren-Thorsson G, Ellervik U, Malmström L, Malmström A.

Chem Sci. 2016 Feb 1;7(2):1447-1456. Epub 2015 Nov 30.


Dermatan Sulfate-Free Mice Display Embryological Defects and Are Neonatal Lethal Despite Normal Lymphoid and Non-Lymphoid Organogenesis.

Stachtea XN, Tykesson E, van Kuppevelt TH, Feinstein R, Malmström A, Reijmers RM, Maccarana M.

PLoS One. 2015 Oct 21;10(10):e0140279. doi: 10.1371/journal.pone.0140279. eCollection 2015.


The serpin PN1 is a feedback regulator of FGF signaling in germ layer and primary axis formation.

Acosta H, Iliev D, Grahn TH, Gouignard N, Maccarana M, Griesbach J, Herzmann S, Sagha M, Climent M, Pera EM.

Development. 2015 Mar 15;142(6):1146-58. doi: 10.1242/dev.113886.


Dermatan sulfate epimerase 1 deficient mice as a model for human abdominal wall defects.

Gustafsson R, Stachtea X, Maccarana M, Grottling E, Eklund E, Malmström A, Oldberg A.

Birth Defects Res A Clin Mol Teratol. 2014 Sep;100(9):712-20. doi: 10.1002/bdra.23300. Epub 2014 Sep 4.


PAPST1 regulates sulfation of heparan sulfate proteoglycans in epithelial MDCK II cells.

Dick G, Akslen-Hoel LK, Grøndahl F, Kjos I, Maccarana M, Prydz K.

Glycobiology. 2015 Jan;25(1):30-41. doi: 10.1093/glycob/cwu084. Epub 2014 Aug 18.


Iduronic acid in chondroitin/dermatan sulfate affects directional migration of aortic smooth muscle cells.

Bartolini B, Thelin MA, Svensson L, Ghiselli G, van Kuppevelt TH, Malmström A, Maccarana M.

PLoS One. 2013 Jul 2;8(7):e66704. doi: 10.1371/journal.pone.0066704. Print 2013.


Biological functions of iduronic acid in chondroitin/dermatan sulfate.

Thelin MA, Bartolini B, Axelsson J, Gustafsson R, Tykesson E, Pera E, Oldberg Å, Maccarana M, Malmstrom A.

FEBS J. 2013 May;280(10):2431-46. doi: 10.1111/febs.12214. Epub 2013 Mar 28. Review.


Iduronic acid in chondroitin/dermatan sulfate: biosynthesis and biological function.

Malmström A, Bartolini B, Thelin MA, Pacheco B, Maccarana M.

J Histochem Cytochem. 2012 Dec;60(12):916-25. doi: 10.1369/0022155412459857. Epub 2012 Aug 16. Review.


Mouse development is not obviously affected by the absence of dermatan sulfate epimerase 2 in spite of a modified brain dermatan sulfate composition.

Bartolini B, Thelin MA, Rauch U, Feinstein R, Oldberg A, Malmström A, Maccarana M.

Glycobiology. 2012 Jul;22(7):1007-16. doi: 10.1093/glycob/cws065. Epub 2012 Apr 10.


Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma.

Thelin MA, Svensson KJ, Shi X, Bagher M, Axelsson J, Isinger-Ekstrand A, van Kuppevelt TH, Johansson J, Nilbert M, Zaia J, Belting M, Maccarana M, Malmström A.

Cancer Res. 2012 Apr 15;72(8):1943-52. doi: 10.1158/0008-5472.CAN-11-1351. Epub 2012 Feb 20.


Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain.

Akatsu C, Mizumoto S, Kaneiwa T, Maccarana M, Malmström A, Yamada S, Sugahara K.

Glycobiology. 2011 May;21(5):565-74. doi: 10.1093/glycob/cwq208. Epub 2010 Dec 21.


Dermatan sulfate epimerase 1-deficient mice have reduced content and changed distribution of iduronic acids in dermatan sulfate and an altered collagen structure in skin.

Maccarana M, Kalamajski S, Kongsgaard M, Magnusson SP, Oldberg A, Malmström A.

Mol Cell Biol. 2009 Oct;29(20):5517-28. doi: 10.1128/MCB.00430-09. Epub 2009 Aug 17.


Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate.

Pacheco B, Maccarana M, Malmström A.

Glycobiology. 2009 Nov;19(11):1197-203. doi: 10.1093/glycob/cwp110. Epub 2009 Aug 6.


Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling.

Jia J, Maccarana M, Zhang X, Bespalov M, Lindahl U, Li JP.

J Biol Chem. 2009 Jun 5;284(23):15942-50. doi: 10.1074/jbc.M809577200. Epub 2009 Mar 31.


Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate.

Pacheco B, Malmström A, Maccarana M.

J Biol Chem. 2009 Apr 10;284(15):9788-95. doi: 10.1074/jbc.M809339200. Epub 2009 Feb 2.


Identification of the active site of DS-epimerase 1 and requirement of N-glycosylation for enzyme function.

Pacheco B, Maccarana M, Goodlett DR, Malmström A, Malmström L.

J Biol Chem. 2009 Jan 16;284(3):1741-7. doi: 10.1074/jbc.M805479200. Epub 2008 Nov 11.


The secreted serine protease xHtrA1 stimulates long-range FGF signaling in the early Xenopus embryo.

Hou S, Maccarana M, Min TH, Strate I, Pera EM.

Dev Cell. 2007 Aug;13(2):226-41.


Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2.

Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A.

J Biol Chem. 2006 Apr 28;281(17):11560-8. Epub 2006 Feb 27.


Regulation of the chondroitin/dermatan fine structure by transforming growth factor-beta1 through effects on polymer-modifying enzymes.

Tiedemann K, Olander B, Eklund E, Todorova L, Bengtsson M, Maccarana M, Westergren-Thorsson G, Malmström A.

Glycobiology. 2005 Dec;15(12):1277-85. Epub 2005 Aug 23.


A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria.

Ventura A, Maccarana M, Raker VA, Pelicci PG.

J Biol Chem. 2004 Jan 16;279(3):2299-306. Epub 2003 Oct 22.


A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

Trinei M, Giorgio M, Cicalese A, Barozzi S, Ventura A, Migliaccio E, Milia E, Padura IM, Raker VA, Maccarana M, Petronilli V, Minucci S, Bernardi P, Lanfrancone L, Pelicci PG.

Oncogene. 2002 May 30;21(24):3872-8.


Oligomerization of ETO is obligatory for corepressor interaction.

Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA.

Mol Cell Biol. 2001 Jan;21(1):156-63.


The APL-associated fusion proteins.

Minucci S, Cioce M, Maccarana M, Pelicci PG.

Haematologica. 1999 Jun;84 Suppl EHA-4:70-1. Review. No abstract available.


Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

Minucci S, Maccarana M, Cioce M, De Luca P, Gelmetti V, Segalla S, Di Croce L, Giavara S, Matteucci C, Gobbi A, Bianchini A, Colombo E, Schiavoni I, Badaracco G, Hu X, Lazar MA, Landsberger N, Nervi C, Pelicci PG.

Mol Cell. 2000 May;5(5):811-20.


Domain structure of heparan sulfates from bovine organs.

Maccarana M, Sakura Y, Tawada A, Yoshida K, Lindahl U.

J Biol Chem. 1996 Jul 26;271(30):17804-10.


Presence of N-unsubstituted glucosamine units in native heparan sulfate revealed by a monoclonal antibody.

van den Born J, Gunnarsson K, Bakker MA, Kjellén L, Kusche-Gullberg M, Maccarana M, Berden JH, Lindahl U.

J Biol Chem. 1995 Dec 29;270(52):31303-9.


Biosynthesis of heparin. Different molecular forms of O-sulfotransferases.

Wlad H, Maccarana M, Eriksson I, Kjellén L, Lindahl U.

J Biol Chem. 1994 Oct 7;269(40):24538-41.


Interaction of heparin with rat mast cell protease 1.

Pejler G, Maccarana M.

J Biol Chem. 1994 May 20;269(20):14451-6.


Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.

Maccarana M, Casu B, Lindahl U.

J Biol Chem. 1994 Feb 4;269(5):3903. No abstract available.


Multiple interactions between human vitronectin and Staphylococcus aureus.

Liang OD, Maccarana M, Flock JI, Paulsson M, Preissner KT, Wadström T.

Biochim Biophys Acta. 1993 Nov 25;1225(1):57-63.


Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

Guimond S, Maccarana M, Olwin BB, Lindahl U, Rapraeger AC.

J Biol Chem. 1993 Nov 15;268(32):23906-14.


FABMS/derivatisation strategies for the analysis of heparin-derived oligosaccharides.

Khoo KH, Morris HR, McDowell RA, Dell A, Maccarana M, Lindahl U.

Carbohydr Res. 1993 Jun 21;244(2):205-23.


Mode of interaction between platelet factor 4 and heparin.

Maccarana M, Lindahl U.

Glycobiology. 1993 Jun;3(3):271-7.


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