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Items: 25


Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor.

Bashore AC, Liu M, Key CC, Boudyguina E, Wang X, Carroll CM, Sawyer JK, Mullick AE, Lee RG, Macauley SL, Parks JS.

Arterioscler Thromb Vasc Biol. 2019 Jun 6:ATVBAHA119312382. doi: 10.1161/ATVBAHA.119.312382. [Epub ahead of print]


Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome.

Day SM, Yang W, Wang X, Stern JE, Zhou X, Macauley SL, Ma T.

eNeuro. 2019 May 15;6(2). pii: ENEURO.0031-19.2019. doi: 10.1523/ENEURO.0031-19.2019. Print 2019 Mar/Apr.


Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels.

Ju YS, Ooms SJ, Sutphen C, Macauley SL, Zangrilli MA, Jerome G, Fagan AM, Mignot E, Zempel JM, Claassen JAHR, Holtzman DM.

Brain. 2017 Aug 1;140(8):2104-2111. doi: 10.1093/brain/awx148.


Widespread Expression of a Membrane-Tethered Version of the Soluble Lysosomal Enzyme Palmitoyl Protein Thioesterase-1.

Shyng C, Macauley SL, Dearborn JT, Sands MS.

JIMD Rep. 2017;36:85-92. doi: 10.1007/8904_2017_1. Epub 2017 Feb 18.


The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old APP/PS1 Mice.

Stanley M, Macauley SL, Caesar EE, Koscal LJ, Moritz W, Robinson GO, Roh J, Keyser J, Jiang H, Holtzman DM.

J Neurosci. 2016 Nov 16;36(46):11704-11715.


Combination Therapies for Lysosomal Storage Diseases: A Complex Answer to a Simple Problem.

Macauley SL.

Pediatr Endocrinol Rev. 2016 Jun;13 Suppl 1:639-48. Review.


Changes in insulin and insulin signaling in Alzheimer's disease: cause or consequence?

Stanley M, Macauley SL, Holtzman DM.

J Exp Med. 2016 Jul 25;213(8):1375-85. doi: 10.1084/jem.20160493. Epub 2016 Jul 18. Review.


Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis.

Harris RA, Tindale L, Lone A, Singh O, Macauley SL, Stanley M, Holtzman DM, Bartha R, Cumming RC.

J Neurosci. 2016 Feb 10;36(6):1871-8. doi: 10.1523/JNEUROSCI.3131-15.2016.


Recent Advances from the Bench Toward the Bedside in Alzheimer's Disease.

Macauley SL, Holtzman DM.

EBioMedicine. 2015 Jan 9;2(2):94-5. doi: 10.1016/j.ebiom.2015.01.002. eCollection 2015 Feb. No abstract available.


Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo.

Macauley SL, Stanley M, Caesar EE, Yamada SA, Raichle ME, Perez R, Mahan TE, Sutphen CL, Holtzman DM.

J Clin Invest. 2015 Jun;125(6):2463-7. doi: 10.1172/JCI79742. Epub 2015 May 4.


An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis.

Macauley SL, Wong AM, Shyng C, Augner DP, Dearborn JT, Pearse Y, Roberts MS, Fowler SC, Cooper JD, Watterson DM, Sands MS.

J Neurosci. 2014 Sep 24;34(39):13077-82. doi: 10.1523/JNEUROSCI.2518-14.2014.


Synergistic effects of central nervous system-directed gene therapy and bone marrow transplantation in the murine model of infantile neuronal ceroid lipofuscinosis.

Macauley SL, Roberts MS, Wong AM, McSloy F, Reddy AS, Cooper JD, Sands MS.

Ann Neurol. 2012 Jun;71(6):797-804. doi: 10.1002/ana.23545. Epub 2012 Feb 24.


Combination small molecule PPT1 mimetic and CNS-directed gene therapy as a treatment for infantile neuronal ceroid lipofuscinosis.

Roberts MS, Macauley SL, Wong AM, Yilmas D, Hohm S, Cooper JD, Sands MS.

J Inherit Metab Dis. 2012 Sep;35(5):847-57. doi: 10.1007/s10545-011-9446-x. Epub 2012 Feb 7.


The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis.

Macauley SL, Pekny M, Sands MS.

J Neurosci. 2011 Oct 26;31(43):15575-85. doi: 10.1523/JNEUROSCI.3579-11.2011.


Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophy.

Reddy AS, Kim JH, Hawkins-Salsbury JA, Macauley SL, Tracy ET, Vogler CA, Han X, Song SK, Wozniak DF, Fowler SC, Klein RS, Sands MS.

J Neurosci. 2011 Jul 6;31(27):9945-57. doi: 10.1523/JNEUROSCI.1802-11.2011.


Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease.

Kielar C, Wishart TM, Palmer A, Dihanich S, Wong AM, Macauley SL, Chan CH, Sands MS, Pearce DA, Cooper JD, Gillingwater TH.

Hum Mol Genet. 2009 Nov 1;18(21):4066-80. doi: 10.1093/hmg/ddp355. Epub 2009 Jul 29.


Cerebellar pathology and motor deficits in the palmitoyl protein thioesterase 1-deficient mouse.

Macauley SL, Wozniak DF, Kielar C, Tan Y, Cooper JD, Sands MS.

Exp Neurol. 2009 May;217(1):124-35. doi: 10.1016/j.expneurol.2009.01.022. Epub 2009 Feb 10.


Promising CNS-directed enzyme replacement therapy for lysosomal storage diseases.

Macauley SL, Sands MS.

Exp Neurol. 2009 Jul;218(1):5-8. doi: 10.1016/j.expneurol.2009.03.040. Epub 2009 Apr 8. No abstract available.


Neuropathology of the acid sphingomyelinase knockout mouse model of Niemann-Pick A disease including structure-function studies associated with cerebellar Purkinje cell degeneration.

Macauley SL, Sidman RL, Schuchman EH, Taksir T, Stewart GR.

Exp Neurol. 2008 Dec;214(2):181-92. doi: 10.1016/j.expneurol.2008.07.026. Epub 2008 Aug 16.


Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis.

Kielar C, Maddox L, Bible E, Pontikis CC, Macauley SL, Griffey MA, Wong M, Sands MS, Cooper JD.

Neurobiol Dis. 2007 Jan;25(1):150-62. Epub 2006 Oct 12.


AAV2-mediated ocular gene therapy for infantile neuronal ceroid lipofuscinosis.

Griffey M, Macauley SL, Ogilvie JM, Sands MS.

Mol Ther. 2005 Sep;12(3):413-21.


AAV vector-mediated correction of brain pathology in a mouse model of Niemann-Pick A disease.

Passini MA, Macauley SL, Huff MR, Taksir TV, Bu J, Wu IH, Piepenhagen PA, Dodge JC, Shihabuddin LS, O'Riordan CR, Schuchman EH, Stewart GR.

Mol Ther. 2005 May;11(5):754-62.


Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to a marked decrease in lysosomal storage pathology.

Shihabuddin LS, Numan S, Huff MR, Dodge JC, Clarke J, Macauley SL, Yang W, Taksir TV, Parsons G, Passini MA, Gage FH, Stewart GR.

J Neurosci. 2004 Nov 24;24(47):10642-51.


A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration.

Sleat DE, Wiseman JA, El-Banna M, Kim KH, Mao Q, Price S, Macauley SL, Sidman RL, Shen MM, Zhao Q, Passini MA, Davidson BL, Stewart GR, Lobel P.

J Neurosci. 2004 Oct 13;24(41):9117-26.


The effects of transforming growth factor-beta2 on dopaminergic graft survival.

Macauley SL, Horsch AD, Oterdoom M, Zheng MH, Stewart GR.

Cell Transplant. 2004;13(3):245-52.


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