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Erratum: Author Correction: Repression of phagocytosis by human CD33 is not conserved with mouse CD33.

Bhattacherjee A, Rodrigues E, Jung J, Luzentales-Simpson M, Enterina JR, Galleguillos D, St Laurent CD, Nakhaei-Nejad M, Fuchsberger FF, Streith L, Wang Q, Kawasaki N, Duan S, Bains A, Paulson JC, Rademacher C, Giuliani F, Sipione S, Macauley MS.

Commun Biol. 2020 Jan 16;3:36. doi: 10.1038/s42003-020-0769-8. eCollection 2020.


CUPRA-ZYME: An Assay for Measuring Carbohydrate-Active Enzyme Activities, Pathways, and Substrate Specificities.

Li Z, Kitov PI, Kitova EN, Mozenah F, Rodrigues E, Chapla DG, Moremen KW, Macauley MS, Klassen JS.

Anal Chem. 2020 Feb 18;92(4):3228-3236. doi: 10.1021/acs.analchem.9b05007. Epub 2020 Feb 7.


Repression of phagocytosis by human CD33 is not conserved with mouse CD33.

Bhattacherjee A, Rodrigues E, Jung J, Luzentales-Simpson M, Enterina JR, Galleguillos D, St Laurent CD, Nakhaei-Nejad M, Fuchsberger FF, Streith L, Wang Q, Kawasaki N, Duan S, Bains A, Paulson JC, Rademacher C, Giuliani F, Sipione S, Macauley MS.

Commun Biol. 2019 Dec 3;2:450. doi: 10.1038/s42003-019-0698-6. eCollection 2019. Erratum in: Commun Biol. 2020 Jan 16;3:36.


Coordinated roles for glycans in regulating the inhibitory function of CD22 on B cells.

Enterina JR, Jung J, Macauley MS.

Biomed J. 2019 Aug;42(4):218-232. doi: 10.1016/ Epub 2019 Sep 16. Review.


A quantitative, high-throughput method identifies protein-glycan interactions via mass spectrometry.

Kitov PI, Kitova EN, Han L, Li Z, Jung J, Rodrigues E, Hunter CD, Cairo CW, Macauley MS, Klassen JS.

Commun Biol. 2019 Jul 22;2:268. doi: 10.1038/s42003-019-0507-2. eCollection 2019.


Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model.

Natoni A, Farrell ML, Harris S, Falank C, Kirkham-McCarthy L, Macauley MS, Reagan MR, O'Dwyer M.

Haematologica. 2020 Jan 31;105(2):457-467. doi: 10.3324/haematol.2018.212266. Print 2020.


Exploiting CD22 To Selectively Tolerize Autoantibody Producing B-Cells in Rheumatoid Arthritis.

Bednar KJ, Nycholat CM, Rao TS, Paulson JC, Fung-Leung WP, Macauley MS.

ACS Chem Biol. 2019 Apr 19;14(4):644-654. doi: 10.1021/acschembio.8b01018. Epub 2019 Mar 20.


CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen.

Duan S, Koziol-White CJ, Jester WF Jr, Nycholat CM, Macauley MS, Panettieri RA Jr, Paulson JC.

J Clin Invest. 2019 Mar 1;129(3):1387-1401. doi: 10.1172/JCI125456. Epub 2019 Feb 18.


Antigenic Liposomes for Generation of Disease-specific Antibodies.

Bednar KJ, Hardy L, Smeekens J, Raghuwanshi D, Duan S, Kulis MD, Macauley MS.

J Vis Exp. 2018 Oct 25;(140). doi: 10.3791/58285.


Hypersialylation in Cancer: Modulation of Inflammation and Therapeutic Opportunities.

Rodrigues E, Macauley MS.

Cancers (Basel). 2018 Jun 18;10(6). pii: E207. doi: 10.3390/cancers10060207. Review.


Cell-based glycan arrays for probing glycan-glycan binding protein interactions.

Briard JG, Jiang H, Moremen KW, Macauley MS, Wu P.

Nat Commun. 2018 Feb 28;9(1):880. doi: 10.1038/s41467-018-03245-5.


Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid β.

Han KH, Arlian BM, Macauley MS, Paulson JC, Lerner RA.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E372-E381. doi: 10.1073/pnas.1719259115. Epub 2018 Jan 2.


Murine Red Blood Cells Lack Ligands for B Cell Siglecs, Allowing Strong Activation by Erythrocyte Surface Antigens.

Spiller F, Nycholat CM, Kikuchi C, Paulson JC, Macauley MS.

J Immunol. 2018 Feb 1;200(3):949-956. doi: 10.4049/jimmunol.1701257. Epub 2017 Dec 29.


Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model.

Bednar KJ, Shanina E, Ballet R, Connors EP, Duan S, Juan J, Arlian BM, Kulis MD, Butcher EC, Fung-Leung WP, Rao TS, Paulson JC, Macauley MS.

J Immunol. 2017 Nov 1;199(9):3116-3128. doi: 10.4049/jimmunol.1700898. Epub 2017 Sep 29.


Tools for Studying Glycans: Recent Advances in Chemoenzymatic Glycan Labeling.

Lopez Aguilar A, Briard JG, Yang L, Ovryn B, Macauley MS, Wu P.

ACS Chem Biol. 2017 Mar 17;12(3):611-621. doi: 10.1021/acschembio.6b01089. Epub 2017 Feb 13. Review.


Encapsulating an Immunosuppressant Enhances Tolerance Induction by Siglec-Engaging Tolerogenic Liposomes.

Pang L, Macauley MS, Arlian BM, Nycholat CM, Paulson JC.

Chembiochem. 2017 Jul 4;18(13):1226-1233. doi: 10.1002/cbic.201600702. Epub 2017 Apr 4.


Assessing Retinal Microglial Phagocytic Function In Vivo Using a Flow Cytometry-based Assay.

Murinello S, Moreno SK, Macauley MS, Sakimoto S, Westenskow PD, Friedlander M.

J Vis Exp. 2016 Oct 18;(116). doi: 10.3791/54677.


Reproducing SIVΔnef vaccine correlates of protection: trimeric gp41 antibody concentrated at mucosal front lines.

Voss JE, Macauley MS, Rogers KA, Villinger F, Duan L, Shang L, Fink EA, Andrabi R, Colantonio AD, Robinson JE, Johnson RP, Burton DR, Haase AT.

AIDS. 2016 Oct 23;30(16):2427-2438.


Exploiting CD22 on antigen-specific B cells to prevent allergy to the major peanut allergen Ara h 2.

Orgel KA, Duan S, Wright BL, Maleki SJ, Wolf JC, Vickery BP, Burks AW, Paulson JC, Kulis MD, Macauley MS.

J Allergy Clin Immunol. 2017 Jan;139(1):366-369.e2. doi: 10.1016/j.jaci.2016.06.053. Epub 2016 Aug 20. No abstract available.


Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies.

McCoy LE, van Gils MJ, Ozorowski G, Messmer T, Briney B, Voss JE, Kulp DW, Macauley MS, Sok D, Pauthner M, Menis S, Cottrell CA, Torres JL, Hsueh J, Schief WR, Wilson IA, Ward AB, Sanders RW, Burton DR.

Cell Rep. 2016 Aug 30;16(9):2327-38. doi: 10.1016/j.celrep.2016.07.074. Epub 2016 Aug 18.


Siglec-F is a novel intestinal M cell marker.

Gicheva N, Macauley MS, Arlian BM, Paulson JC, Kawasaki N.

Biochem Biophys Res Commun. 2016 Oct 7;479(1):1-4. doi: 10.1016/j.bbrc.2016.08.055. Epub 2016 Aug 11.


Targeting Selectins and Their Ligands in Cancer.

Natoni A, Macauley MS, O'Dwyer ME.

Front Oncol. 2016 Apr 18;6:93. doi: 10.3389/fonc.2016.00093. eCollection 2016. Review.


Transfection of microRNA Mimics Should Be Used with Caution.

Jin HY, Gonzalez-Martin A, Miletic AV, Lai M, Knight S, Sabouri-Ghomi M, Head SR, Macauley MS, Rickert RC, Xiao C.

Front Genet. 2015 Dec 2;6:340. doi: 10.3389/fgene.2015.00340. eCollection 2015.


Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man.

Macauley MS, Kawasaki N, Peng W, Wang SH, He Y, Arlian BM, McBride R, Kannagi R, Khoo KH, Paulson JC.

J Biol Chem. 2015 Dec 11;290(50):30066-77. doi: 10.1074/jbc.M115.691337. Epub 2015 Oct 27.


Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches.

Angata T, Nycholat CM, Macauley MS.

Trends Pharmacol Sci. 2015 Oct;36(10):645-660. doi: 10.1016/ Review.


Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases.

Macauley MS, Arlian BM, Rillahan CD, Pang PC, Bortell N, Marcondes MC, Haslam SM, Dell A, Paulson JC.

J Biol Chem. 2014 Dec 19;289(51):35149-58. doi: 10.1074/jbc.M114.606517. Epub 2014 Nov 3.


Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells.

Macauley MS, Paulson JC.

J Immunol. 2014 Nov 1;193(9):4312-21. doi: 10.4049/jimmunol.1401723. Epub 2014 Sep 24.


Siglec-mediated regulation of immune cell function in disease.

Macauley MS, Crocker PR, Paulson JC.

Nat Rev Immunol. 2014 Oct;14(10):653-66. doi: 10.1038/nri3737. Epub 2014 Sep 19. Review.


Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing.

Lee M, Kiefel H, LaJevic MD, Macauley MS, Kawashima H, O'Hara E, Pan J, Paulson JC, Butcher EC.

Nat Immunol. 2014 Oct;15(10):982-95. doi: 10.1038/ni.2983. Epub 2014 Aug 31. Erratum in: Nat Immunol. 2015 Feb;16(2):214. Kawashima, Hiroto [added].


Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.

Kawasaki N, Rillahan CD, Cheng TY, Van Rhijn I, Macauley MS, Moody DB, Paulson JC.

J Immunol. 2014 Aug 15;193(4):1560-6. doi: 10.4049/jimmunol.1303278. Epub 2014 Jul 7.


Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas.

Rillahan CD, Macauley MS, Schwartz E, He Y, McBride R, Arlian BM, Rangarajan J, Fokin VV, Paulson JC.

Chem Sci. 2014 Jun 1;5(6):2398-2406.


Immunology: glyco-engineering 'super-self'.

Macauley MS, Paulson JC.

Nat Chem Biol. 2014 Jan;10(1):7-8. doi: 10.1038/nchembio.1415. No abstract available.


Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22.

Pfrengle F, Macauley MS, Kawasaki N, Paulson JC.

J Immunol. 2013 Aug 15;191(4):1724-31. doi: 10.4049/jimmunol.1300921. Epub 2013 Jul 8.


Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis.

Macauley MS, Pfrengle F, Rademacher C, Nycholat CM, Gale AJ, von Drygalski A, Paulson JC.

J Clin Invest. 2013 Jul;123(7):3074-83. doi: 10.1172/JCI69187. Epub 2013 Jun 3.


Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the substrate tolerance of β-O-linked β-N-acetylglucosaminidase.

Macauley MS, Chan J, Zandberg WF, He Y, Whitworth GE, Stubbs KA, Yuzwa SA, Bennet AJ, Varki A, Davies GJ, Vocadlo DJ.

J Biol Chem. 2012 Aug 17;287(34):28882-97. doi: 10.1074/jbc.M112.363721. Epub 2012 Jun 12.


Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

Yuzwa SA, Shan X, Macauley MS, Clark T, Skorobogatko Y, Vosseller K, Vocadlo DJ.

Nat Chem Biol. 2012 Feb 26;8(4):393-9. doi: 10.1038/nchembio.797.


Siglecs as sensors of self in innate and adaptive immune responses.

Paulson JC, Macauley MS, Kawasaki N.

Ann N Y Acad Sci. 2012 Apr;1253:37-48. doi: 10.1111/j.1749-6632.2011.06362.x. Epub 2012 Jan 30. Review.


Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis.

Macauley MS, Shan X, Yuzwa SA, Gloster TM, Vocadlo DJ.

Chem Biol. 2010 Sep 24;17(9):949-58. doi: 10.1016/j.chembiol.2010.07.005. Erratum in: Chem Biol. 2010 Oct 29;17(10):1161.


Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes.

Macauley MS, He Y, Gloster TM, Stubbs KA, Davies GJ, Vocadlo DJ.

Chem Biol. 2010 Sep 24;17(9):937-48. doi: 10.1016/j.chembiol.2010.07.006. Erratum in: Chem Biol. 2010 Oct 29;17(10):1161.


Visualizing the reaction coordinate of an O-GlcNAc hydrolase.

He Y, Macauley MS, Stubbs KA, Vocadlo DJ, Davies GJ.

J Am Chem Soc. 2010 Feb 17;132(6):1807-9. doi: 10.1021/ja9086769.


Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships.

Greig IR, Macauley MS, Williams IH, Vocadlo DJ.

J Am Chem Soc. 2009 Sep 23;131(37):13415-22. doi: 10.1021/ja904506u.


Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).

Sinclair DA, Syrzycka M, Macauley MS, Rastgardani T, Komljenovic I, Vocadlo DJ, Brock HW, Honda BM.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13427-32. doi: 10.1073/pnas.0904638106. Epub 2009 Jul 28.


Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase.

Macauley MS, Vocadlo DJ.

Biochim Biophys Acta. 2010 Feb;1800(2):107-21. doi: 10.1016/j.bbagen.2009.07.028. Epub 2009 Aug 4. Review.


Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase.

Macauley MS, Vocadlo DJ.

Carbohydr Res. 2009 Jun 12;344(9):1079-84. doi: 10.1016/j.carres.2009.04.017. Epub 2009 Apr 20.


Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases.

Abbott DW, Macauley MS, Vocadlo DJ, Boraston AB.

J Biol Chem. 2009 Apr 24;284(17):11676-89. doi: 10.1074/jbc.M809663200. Epub 2009 Jan 30.


A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells.

Stubbs KA, Macauley MS, Vocadlo DJ.

Angew Chem Int Ed Engl. 2009;48(7):1300-3. doi: 10.1002/anie.200804583.


Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance.

Macauley MS, Bubb AK, Martinez-Fleites C, Davies GJ, Vocadlo DJ.

J Biol Chem. 2008 Dec 12;283(50):34687-95. doi: 10.1074/jbc.M804525200. Epub 2008 Oct 8.


A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.

Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ.

Nat Chem Biol. 2008 Aug;4(8):483-90. doi: 10.1038/nchembio.96. Epub 2008 Jun 29.


Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation.

Martinez-Fleites C, Macauley MS, He Y, Shen DL, Vocadlo DJ, Davies GJ.

Nat Struct Mol Biol. 2008 Jul;15(7):764-5. doi: 10.1038/nsmb.1443. Epub 2008 Jun 8.


Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise.

Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ.

J Am Chem Soc. 2007 Jan 24;129(3):635-44.


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