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Severe autoinflammation in 4 patients with C-terminal variants in cell division control protein 42 homolog (CDC42) successfully treated with IL-1β inhibition.

Gernez Y, de Jesus AA, Alsaleem H, Macaubas C, Roy A, Lovell D, Jagadeesh KA, Alehashemi S, Erdman L, Grimley M, Talarico S, Bacchetta R, Lewis DB, Canna SW, Laxer RM, Mellins ED, Goldbach-Mansky R, Weinacht KG.

J Allergy Clin Immunol. 2019 Jul 2. pii: S0091-6749(19)30830-9. doi: 10.1016/j.jaci.2019.06.017. [Epub ahead of print] No abstract available.


Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1.

Yang Z, Yan H, Dai W, Jing J, Yang Y, Mahajan S, Zhou Y, Li W, Macaubas C, Mellins ED, Shih CC, Fitzpatrick JAJ, Faccio R.

J Autoimmun. 2019 Jul;101:94-108. doi: 10.1016/j.jaut.2019.04.015. Epub 2019 Apr 22.


Epithelial MHC Class II Expression and Its Role in Antigen Presentation in the Gastrointestinal and Respiratory Tracts.

Wosen JE, Mukhopadhyay D, Macaubas C, Mellins ED.

Front Immunol. 2018 Sep 25;9:2144. doi: 10.3389/fimmu.2018.02144. eCollection 2018. Review.


Interleukin-1 in monocyte activation phenotypes in systemic juvenile idiopathic arthritis: Observations from a clinical trial of rilonacept, an interleukin-1 inhibitor.

Zhang Y, Gupta S, Ilstad-Minnihan A, Ayyangar S, Hay AD, Pascual V, Ilowite NT, Macaubas C, Mellins ED.

Clin Immunol. 2018 Sep;194:9-18. doi: 10.1016/j.clim.2018.06.005. Epub 2018 Jun 19.


Autoantibody Profiling in Lupus Patients using Synthetic Nucleic Acids.

Klecka M, Thybo C, Macaubas C, Solov'yov I, Simard J, Balboni IM, Fox E, Voss A, Mellins ED, Astakhova K.

Sci Rep. 2018 Apr 3;8(1):5554. doi: 10.1038/s41598-018-23910-5.


The MHC class II antigen presentation pathway in human monocytes differs by subset and is regulated by cytokines.

Lee J, Tam H, Adler L, Ilstad-Minnihan A, Macaubas C, Mellins ED.

PLoS One. 2017 Aug 23;12(8):e0183594. doi: 10.1371/journal.pone.0183594. eCollection 2017.


The Other Function: Class II-Restricted Antigen Presentation by B Cells.

Adler LN, Jiang W, Bhamidipati K, Millican M, Macaubas C, Hung SC, Mellins ED.

Front Immunol. 2017 Mar 23;8:319. doi: 10.3389/fimmu.2017.00319. eCollection 2017. Review.


Novel Phospholipid-Protein Conjugates Allow Improved Detection of Antibodies in Patients with Autoimmune Diseases.

Samuelsen SV, Maity A, Nybo M, Macaubas C, Lønstrup L, Balboni IM, Mellins ED, Astakhova K.

PLoS One. 2016 Jun 3;11(6):e0156125. doi: 10.1371/journal.pone.0156125. eCollection 2016.


Altered signaling in systemic juvenile idiopathic arthritis monocytes.

Macaubas C, Wong E, Zhang Y, Nguyen KD, Lee J, Milojevic D, Shenoi S, Stevens AM, Ilowite N, Saper V, Lee T, Mellins ED.

Clin Immunol. 2016 Feb;163:66-74. doi: 10.1016/j.clim.2015.12.011. Epub 2015 Dec 31.


Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.

Decker CE, Yang Z, Rimer R, Park-Min KH, Macaubas C, Mellins ED, Novack DV, Faccio R.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15654-9. doi: 10.1073/pnas.1511285112. Epub 2015 Dec 7.


Comparison of biomarkers for systemic juvenile idiopathic arthritis.

Shenoi S, Ou JN, Ni C, Macaubas C, Gersuk VH, Wallace CA, Mellins ED, Stevens AM.

Pediatr Res. 2015 Nov;78(5):554-9. doi: 10.1038/pr.2015.144. Epub 2015 Aug 12.


Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies.

Maity A, Macaubas C, Mellins E, Astakhova K.

Molecules. 2015 Jun 3;20(6):10253-63. doi: 10.3390/molecules200610253.


Immunological Basis for Rapid Progression of Diabetes in Older NOD Mouse Recipients Post BM-HSC Transplantation.

Wang N, Rajasekaran N, Hou T, Macaubas C, Mellins ED.

PLoS One. 2015 May 28;10(5):e0128494. doi: 10.1371/journal.pone.0128494. eCollection 2015.


Retraction of the research article: "CD4⁺ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy".

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.

Sci Transl Med. 2014 Jul 30;6(247):247rt1. doi: 10.1126/scitranslmed.3009995. No abstract available.


Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation.

Nguyen KD, Macaubas C, Truong P, Wang N, Hou T, Yoon T, Mellins ED.

Mol Immunol. 2014 Jun;59(2):172-9. doi: 10.1016/j.molimm.2014.02.011. Epub 2014 Mar 13.


CD4+ T cell autoimmunity to hypocretin/orexin and cross-reactivity to a 2009 H1N1 influenza A epitope in narcolepsy.

De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E.

Sci Transl Med. 2013 Dec 18;5(216):216ra176. doi: 10.1126/scitranslmed.3007762. Retraction in: De la Herrán-Arita AK, Kornum BR, Mahlios J, Jiang W, Lin L, Hou T, Macaubas C, Einen M, Plazzi G, Crowe C, Newell EW, Davis MM, Mellins ED, Mignot E. Sci Transl Med. 2014 Jul 30;6(247):247rt1.


B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes.

Rajasekaran N, Wang N, Hang Y, Macaubas C, Rinderknecht C, Beilhack GF, Shizuru JA, Mellins ED.

Clin Exp Immunol. 2013 Oct;174(1):27-37. doi: 10.1111/cei.12163.


Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice.

Rajasekaran N, Wang N, Truong P, Rinderknecht C, Macaubas C, Beilhack GF, Shizuru JA, Mellins ED.

Arthritis Rheum. 2013 Mar;65(3):681-92. doi: 10.1002/art.37800.


Correlation analyses of clinical and molecular findings identify candidate biological pathways in systemic juvenile idiopathic arthritis.

Ling XB, Macaubas C, Alexander HC, Wen Q, Chen E, Peng S, Sun Y, Deshpande C, Pan KH, Lin R, Lih CJ, Chang SY, Lee T, Sandborg C, Begovich AB, Cohen SN, Mellins ED.

BMC Med. 2012 Oct 23;10:125. doi: 10.1186/1741-7015-10-125.


Alternative activation in systemic juvenile idiopathic arthritis monocytes.

Macaubas C, Nguyen KD, Peck A, Buckingham J, Deshpande C, Wong E, Alexander HC, Chang SY, Begovich A, Sun Y, Park JL, Pan KH, Lin R, Lih CJ, Augustine EM, Phillips C, Hadjinicolaou AV, Lee T, Mellins ED.

Clin Immunol. 2012 Mar;142(3):362-72. doi: 10.1016/j.clim.2011.12.008. Epub 2011 Dec 28.


Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions.

Mellins ED, Macaubas C, Grom AA.

Nat Rev Rheumatol. 2011 Jun 7;7(7):416-26. doi: 10.1038/nrrheum.2011.68. Review.


Human cytomegalovirus decreases constitutive transcription of MHC class II genes in mature Langerhans cells by reducing CIITA transcript levels.

Lee AW, Wang N, Hornell TM, Harding JJ, Deshpande C, Hertel L, Lacaille V, Pashine A, Macaubas C, Mocarski ES, Mellins ED.

Mol Immunol. 2011 May;48(9-10):1160-7. doi: 10.1016/j.molimm.2011.02.010. Epub 2011 Mar 31.


Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways.

Nguyen KD, Macaubas C, Nadeau KC, Truong P, Yoon T, Lee T, Park JL, Mellins ED.

Blood. 2011 Apr 7;117(14):3793-8. doi: 10.1182/blood-2010-11-318832. Epub 2011 Feb 16.


Plasma profiles in active systemic juvenile idiopathic arthritis: Biomarkers and biological implications.

Ling XB, Park JL, Carroll T, Nguyen KD, Lau K, Macaubas C, Chen E, Lee T, Sandborg C, Milojevic D, Kanegaye JT, Gao S, Burns J, Schilling J, Mellins ED.

Proteomics. 2010 Dec;10(24):4415-30. doi: 10.1002/pmic.201000298. Epub 2010 Nov 23.


Urine Peptidomic and Targeted Plasma Protein Analyses in the Diagnosis and Monitoring of Systemic Juvenile Idiopathic Arthritis.

Ling XB, Lau K, Deshpande C, Park JL, Milojevic D, Macaubas C, Xiao C, Lopez-Avila V, Kanegaye J, Burns JC, Cohen H, Schilling J, Mellins ED.

Clin Proteomics. 2010 Dec;6(4):175-193. Epub 2010 Sep 30.


Monocytes are resistant to apoptosis in systemic juvenile idiopathic arthritis.

Srivastava S, Macaubas C, Deshpande C, Alexander HC, Chang SY, Sun Y, Park JL, Lee T, Begovich A, Mellins ED.

Clin Immunol. 2010 Aug;136(2):257-68. doi: 10.1016/j.clim.2010.04.003. Epub 2010 May 11.


DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.

Rinderknecht CH, Roh S, Pashine A, Belmares MP, Patil NS, Lu N, Truong P, Hou T, Macaubas C, Yoon T, Wang N, Busch R, Mellins ED.

Immunology. 2010 Sep;131(1):18-32. doi: 10.1111/j.1365-2567.2010.03282.x. Epub 2010 Apr 12.


Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states.

Macaubas C, Nguyen K, Deshpande C, Phillips C, Peck A, Lee T, Park JL, Sandborg C, Mellins ED.

Clin Immunol. 2010 Feb;134(2):206-16. doi: 10.1016/j.clim.2009.09.010. Epub 2009 Oct 29.


Oligoarticular and polyarticular JIA: epidemiology and pathogenesis.

Macaubas C, Nguyen K, Milojevic D, Park JL, Mellins ED.

Nat Rev Rheumatol. 2009 Nov;5(11):616-26. doi: 10.1038/nrrheum.2009.209. Epub 2009 Oct 6. Review.


Allergen-specific MHC class II tetramer+ cells are detectable in allergic, but not in nonallergic, individuals.

Macaubas C, Wahlstrom J, Galvão da Silva AP, Forsthuber TG, Sønderstrup G, Kwok WW, DeKruyff RH, Umetsu DT.

J Immunol. 2006 Apr 15;176(8):5069-77.


Human dendritic cell expression of HLA-DO is subset specific and regulated by maturation.

Hornell TM, Burster T, Jahnsen FL, Pashine A, Ochoa MT, Harding JJ, Macaubas C, Lee AW, Modlin RL, Mellins ED.

J Immunol. 2006 Mar 15;176(6):3536-47.


Enhancement of vaccine-specific cellular immunity in infants by passively acquired maternal antibody.

Rowe J, Poolman JT, Macaubas C, Sly PD, Loh R, Holt PG.

Vaccine. 2004 Sep 28;22(29-30):3986-92.


Association between antenatal cytokine production and the development of atopy and asthma at age 6 years.

Macaubas C, de Klerk NH, Holt BJ, Wee C, Kendall G, Firth M, Sly PD, Holt PG.

Lancet. 2003 Oct 11;362(9391):1192-7.


Respiratory tolerance in the protection against asthma.

Macaubas C, DeKruyff RH, Umetsu DT.

Curr Drug Targets Inflamm Allergy. 2003 Jun;2(2):175-86. Review.


Immunology: hepatitis A virus link to atopic disease.

McIntire JJ, Umetsu SE, Macaubas C, Hoyte EG, Cinnioglu C, Cavalli-Sforza LL, Barsh GS, Hallmayer JF, Underhill PA, Risch NJ, Freeman GJ, DeKruyff RH, Umetsu DT.

Nature. 2003 Oct 9;425(6958):576. No abstract available.


Asthma: an epidemic of dysregulated immunity.

Umetsu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff RH.

Nat Immunol. 2002 Aug;3(8):715-20. Review.


Reciprocal patterns of allergen-induced GATA-3 expression in peripheral blood mononuclear cells from atopics vs. non-atopics.

Macaubas C, Lee PT, Smallacombe TB, Holt BJ, Wee C, Sly PD, Holt PG.

Clin Exp Allergy. 2002 Jan;32(1):97-106.


"Bystander" amplification of PBMC cytokine responses to seasonal allergen in polysensitized atopic children.

Rudin A, Macaubas C, Wee C, Holt BJ, Slya PD, Holt PG.

Allergy. 2001 Nov;56(11):1042-8.


Heterogeneity in diphtheria-tetanus-acellular pertussis vaccine-specific cellular immunity during infancy: relationship to variations in the kinetics of postnatal maturation of systemic th1 function.

Rowe J, Macaubas C, Monger T, Holt BJ, Harvey J, Poolman JT, Loh R, Sly PD, Holt PG.

J Infect Dis. 2001 Jul 1;184(1):80-8. Epub 2001 May 29.


Primary sensitization to inhalant allergens.

Macaubas C, Prescott SL, Venaille TJ, Holt BJ, Smallacombe TB, Sly PD, Holt PG.

Pediatr Allergy Immunol. 2000;11 Suppl 13:9-11.


Primary sensitization to inhalant allergens.

Holt PG, Macaubas C, Prescott SL, Sly PD.

Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 2):S91-4. Review. No abstract available.


Antigen-specific responses to diphtheria-tetanus-acellular pertussis vaccine in human infants are initially Th2 polarized.

Rowe J, Macaubas C, Monger TM, Holt BJ, Harvey J, Poolman JT, Sly PD, Holt PG.

Infect Immun. 2000 Jul;68(7):3873-7.


Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children.

Holt PG, Rudin A, Macaubas C, Holt BJ, Rowe J, Loh R, Sly PD.

J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1117-22.


The role of allergy in the development of asthma.

Holt PG, Macaubas C, Stumbles PA, Sly PD.

Nature. 1999 Nov 25;402(6760 Suppl):B12-7. Review.


Allergen-induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses.

Jenmalm MC, Björkstén B, Macaubas C, Holt BJ, Smallacombe TB, Holt PG.

Pediatr Allergy Immunol. 1999 Aug;10(3):168-77.


Regulation of T-helper cell responses to inhalant allergen during early childhood.

Macaubas C, Sly PD, Burton P, Tiller K, Yabuhara A, Holt BJ, Smallacombe TB, Kendall G, Jenmalm MC, Holt PG.

Clin Exp Allergy. 1999 Sep;29(9):1223-31.


Microbial stimulation as an aetiologic factor in atopic disease.

Holt PG, Macaubas C, Prescott SL, Sly PD.

Allergy. 1999;54 Suppl 49:12-6.


Reciprocal age-related patterns of allergen-specific T-cell immunity in normal vs. atopic infants.

Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Loh R, Holt PG.

Clin Exp Allergy. 1998 Nov;28 Suppl 5:39-44; discussion 50-1.


Development of allergen-specific T-cell memory in atopic and normal children.

Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG.

Lancet. 1999 Jan 16;353(9148):196-200.


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