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Osteocalcin Regulates Arterial Calcification via Altered Wnt Signalling and Glucose Metabolism.

Rashdan NA, Sim AM, Cui L, Phadwal K, Roberts FL, Carter R, Ozdemir DD, Hohenstein P, Hung J, Kaczynski J, Newby DE, Baker AH, Karsenty G, Morton NM, MacRae VE.

J Bone Miner Res. 2019 Oct 9. doi: 10.1002/jbmr.3888. [Epub ahead of print]


Inhibition of vascular smooth muscle cell calcification by ATP analogues.

Patel JJ, Bourne LE, Millán JL, Arnett TR, MacRae VE, Wheeler-Jones CPD, Orriss IR.

Purinergic Signal. 2019 Sep;15(3):315-326. doi: 10.1007/s11302-019-09672-3. Epub 2019 Jul 23.


Differing calcification processes in cultured vascular smooth muscle cells and osteoblasts.

Patel JJ, Bourne LE, Davies BK, Arnett TR, MacRae VE, Wheeler-Jones CP, Orriss IR.

Exp Cell Res. 2019 Jul 1;380(1):100-113. doi: 10.1016/j.yexcr.2019.04.020. Epub 2019 Apr 18.


ENPP1 in the Regulation of Mineralization and Beyond.

Roberts F, Zhu D, Farquharson C, Macrae VE.

Trends Biochem Sci. 2019 Jul;44(7):616-628. doi: 10.1016/j.tibs.2019.01.010. Epub 2019 Feb 21. Review.


A novel fluorescein-bisphosphonate based diagnostic tool for the detection of hydroxyapatite in both cell and tissue models.

Sim AM, Rashdan NA, Cui L, Moss AJ, Nudelman F, Dweck MR, MacRae VE, Hulme AN.

Sci Rep. 2018 Nov 26;8(1):17360. doi: 10.1038/s41598-018-35454-9.


Extragonadal Effects of Follicle-Stimulating Hormone on Osteoporosis and Cardiovascular Disease in Women during Menopausal Transition.

Zhu D, Li X, Macrae VE, Simoncini T, Fu X.

Trends Endocrinol Metab. 2018 Aug;29(8):571-580. doi: 10.1016/j.tem.2018.06.001. Epub 2018 Jul 5. Review.


Spermine increases acetylation of tubulins and facilitates autophagic degradation of prion aggregates.

Phadwal K, Kurian D, Salamat MKF, MacRae VE, Diack AB, Manson JC.

Sci Rep. 2018 Jul 3;8(1):10004. doi: 10.1038/s41598-018-28296-y.


Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease.

Dobie R, MacRae VE, Pass C, Milne EM, Ahmed SF, Farquharson C.

Dis Model Mech. 2018 Jan 17;11(1). pii: dmm028456. doi: 10.1242/dmm.028456.


Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification.

Lin C, Zhu D, Markby G, Corcoran BM, Farquharson C, Macrae VE.

J Vis Exp. 2017 Nov 20;(129). doi: 10.3791/56126.


Exploiting novel valve interstitial cell lines to study calcific aortic valve disease.

Tsang HG, Cui L, Farquharson C, Corcoran BM, Summers KM, Macrae VE.

Mol Med Rep. 2018 Feb;17(2):2100-2106. doi: 10.3892/mmr.2017.8163. Epub 2017 Nov 27.


Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human.

Markby GR, Summers KM, MacRae VE, Corcoran BM.

Vet Sci. 2017 Jul 17;4(3). pii: E34. doi: 10.3390/vetsci4030034. Review.


Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms.

Patel JJ, Zhu D, Opdebeeck B, D'Haese P, Millán JL, Bourne LE, Wheeler-Jones CPD, Arnett TR, MacRae VE, Orriss IR.

J Cell Physiol. 2018 Apr;233(4):3230-3243. doi: 10.1002/jcp.26166. Epub 2017 Oct 4.


Skeletal energy homeostasis: a paradigm of endocrine discovery.

Suchacki KJ, Roberts F, Lovdel A, Farquharson C, Morton NM, MacRae VE, Cawthorn WP.

J Endocrinol. 2017 Jul;234(1):R67-R79. doi: 10.1530/JOE-17-0147. Epub 2017 Apr 28. Review.


Myxomatous Degeneration of the Canine Mitral Valve: From Gross Changes to Molecular Events.

Markby G, Summers KM, MacRae VE, Del-Pozo J, Corcoran BM.

J Comp Pathol. 2017 May;156(4):371-383. doi: 10.1016/j.jcpa.2017.01.009. Epub 2017 Apr 10. Review.


End stage renal disease-induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived-matrix vesicles.

Cui L, Rashdan NA, Zhu D, Milne EM, Ajuh P, Milne G, Helfrich MH, Lim K, Prasad S, Lerman DA, Vesey AT, Dweck MR, Jenkins WS, Newby DE, Farquharson C, Macrae VE.

J Cell Physiol. 2017 Nov;232(11):2985-2995. doi: 10.1002/jcp.25935. Epub 2017 May 24.


Culture of Murine Embryonic Metatarsals: A Physiological Model of Endochondral Ossification.

Houston DA, Staines KA, MacRae VE, Farquharson C.

J Vis Exp. 2016 Dec 3;(118). doi: 10.3791/54978.


The Expression of PHOSPHO1, nSMase2 and TNAP is Coordinately Regulated by Continuous PTH Exposure in Mineralising Osteoblast Cultures.

Houston DA, Myers K, MacRae VE, Staines KA, Farquharson C.

Calcif Tissue Int. 2016 Nov;99(5):510-524. Epub 2016 Jul 21.


A novel role for the mineralocorticoid receptor in glucocorticoid driven vascular calcification.

Zhu D, Rashdan NA, Chapman KE, Hadoke PW, MacRae VE.

Vascul Pharmacol. 2016 Nov;86:87-93. doi: 10.1016/j.vph.2016.04.005. Epub 2016 May 3.


Ablation of the androgen receptor from vascular smooth muscle cells demonstrates a role for testosterone in vascular calcification.

Zhu D, Hadoke PW, Wu J, Vesey AT, Lerman DA, Dweck MR, Newby DE, Smith LB, MacRae VE.

Sci Rep. 2016 Apr 20;6:24807. doi: 10.1038/srep24807.


Characterisation of matrix vesicles in skeletal and soft tissue mineralisation.

Cui L, Houston DA, Farquharson C, MacRae VE.

Bone. 2016 Jun;87:147-58. doi: 10.1016/j.bone.2016.04.007. Epub 2016 Apr 9. Review.


Editorial overview: Musculoskeletal: Where are we with treating musculoskeletal disorders?

Orriss IR, MacRae VE.

Curr Opin Pharmacol. 2016 Jun;28:iv-vi. doi: 10.1016/j.coph.2016.03.004. Epub 2016 Apr 8. No abstract available.


New perspectives on rare connective tissue calcifying diseases.

Rashdan NA, Rutsch F, Kempf H, Váradi A, Lefthériotis G, MacRae VE.

Curr Opin Pharmacol. 2016 Jun;28:14-23. doi: 10.1016/j.coph.2016.02.002. Epub 2016 Feb 27. Review.


Large animal models of cardiovascular disease.

Tsang HG, Rashdan NA, Whitelaw CB, Corcoran BM, Summers KM, MacRae VE.

Cell Biochem Funct. 2016 Apr;34(3):113-32. doi: 10.1002/cbf.3173. Epub 2016 Feb 24. Review.


Effects of etidronate on the Enpp1⁻/⁻ mouse model of generalized arterial calcification of infancy.

Huesa C, Staines KA, Millán JL, MacRae VE.

Int J Mol Med. 2015 Jul;36(1):159-65. doi: 10.3892/ijmm.2015.2212. Epub 2015 May 15.


Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1.

Dobie R, Ahmed SF, Staines KA, Pass C, Jasim S, MacRae VE, Farquharson C.

J Cell Physiol. 2015 Nov;230(11):2796-806. doi: 10.1002/jcp.25006.


Endocrine role of bone: recent and emerging perspectives beyond osteocalcin.

Oldknow KJ, MacRae VE, Farquharson C.

J Endocrinol. 2015 Apr;225(1):R1-19. doi: 10.1530/JOE-14-0584. Epub 2015 Feb 5. Review.


Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes.

Huesa C, Zhu D, Glover JD, Ferron M, Karsenty G, Milne EM, Millan JL, Ahmed SF, Farquharson C, Morton NM, MacRae VE.

Dis Model Mech. 2014 Dec;7(12):1341-50. doi: 10.1242/dmm.017905. Epub 2014 Oct 31.


BMP-9 regulates the osteoblastic differentiation and calcification of vascular smooth muscle cells through an ALK1 mediated pathway.

Zhu D, Mackenzie NC, Shanahan CM, Shroff RC, Farquharson C, MacRae VE.

J Cell Mol Med. 2015 Jan;19(1):165-74. doi: 10.1111/jcmm.12373. Epub 2014 Oct 9.


Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1(-/-) mice.

Hajjawi MO, MacRae VE, Huesa C, Boyde A, Millán JL, Arnett TR, Orriss IR.

Bone. 2014 Dec;69:139-47. doi: 10.1016/j.bone.2014.09.016. Epub 2014 Sep 28.


Optimisation of the differing conditions required for bone formation in vitro by primary osteoblasts from mice and rats.

Orriss IR, Hajjawi MO, Huesa C, MacRae VE, Arnett TR.

Int J Mol Med. 2014 Nov;34(5):1201-8. doi: 10.3892/ijmm.2014.1926. Epub 2014 Sep 8.


Direct stimulation of bone mass by increased GH signalling in the osteoblasts of Socs2-/- mice.

Dobie R, MacRae VE, Huesa C, van't Hof R, Ahmed SF, Farquharson C.

J Endocrinol. 2014 Oct;223(1):93-106. doi: 10.1530/JOE-14-0292. Epub 2014 Jul 29.


miRNA-221 and miRNA-222 synergistically function to promote vascular calcification.

Mackenzie NC, Staines KA, Zhu D, Genever P, Macrae VE.

Cell Biochem Funct. 2014 Mar;32(2):209-16. doi: 10.1002/cbf.3005. Epub 2013 Oct 8.


Upregulation of IGF2 expression during vascular calcification.

Zhu D, Mackenzie NC, Millan JL, Farquharson C, Macrae VE.

J Mol Endocrinol. 2014 Jan 30;52(2):77-85. doi: 10.1530/JME-13-0136. Print 2014 Apr.


A new method for the quantification of aortic calcification by three-dimensional micro-computed tomography.

Huesa C, Millán JL, van 't Hof RJ, MacRae VE.

Int J Mol Med. 2013 Nov;32(5):1047-50. doi: 10.3892/ijmm.2013.1490. Epub 2013 Sep 12.


Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling.

Staines KA, Zhu D, Farquharson C, MacRae VE.

J Bone Miner Metab. 2014 May;32(3):240-51. doi: 10.1007/s00774-013-0493-2. Epub 2013 Aug 8.


A protective role for FGF-23 in local defence against disrupted arterial wall integrity?

Zhu D, Mackenzie NC, Millan JL, Farquharson C, MacRae VE.

Mol Cell Endocrinol. 2013 Jun 15;372(1-2):1-11. doi: 10.1016/j.mce.2013.03.008. Epub 2013 Mar 21.


Chondrogenic ATDC5 cells: an optimised model for rapid and physiological matrix mineralisation.

Newton PT, Staines KA, Spevak L, Boskey AL, Teixeira CC, Macrae VE, Canfield AE, Farquharson C.

Int J Mol Med. 2012 Nov;30(5):1187-93. doi: 10.3892/ijmm.2012.1114. Epub 2012 Aug 31.


Mechanisms and clinical consequences of vascular calcification.

Zhu D, Mackenzie NC, Farquharson C, Macrae VE.

Front Endocrinol (Lausanne). 2012 Aug 6;3:95. doi: 10.3389/fendo.2012.00095. eCollection 2012.


Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification.

Kiffer-Moreira T, Yadav MC, Zhu D, Narisawa S, Sheen C, Stec B, Cosford ND, Dahl R, Farquharson C, Hoylaerts MF, Macrae VE, Millán JL.

J Bone Miner Res. 2013 Jan;28(1):81-91. doi: 10.1002/jbmr.1733.


New insights into NPP1 function: lessons from clinical and animal studies.

Mackenzie NC, Huesa C, Rutsch F, MacRae VE.

Bone. 2012 Nov;51(5):961-8. doi: 10.1016/j.bone.2012.07.014. Epub 2012 Jul 26. Review.


MEPE is a novel regulator of growth plate cartilage mineralization.

Staines KA, Mackenzie NC, Clarkin CE, Zelenchuk L, Rowe PS, MacRae VE, Farquharson C.

Bone. 2012 Sep;51(3):418-30. doi: 10.1016/j.bone.2012.06.022. Epub 2012 Jul 7.


Cartilage development and degeneration: a Wnt Wnt situation.

Staines KA, Macrae VE, Farquharson C.

Cell Biochem Funct. 2012 Dec;30(8):633-42. doi: 10.1002/cbf.2852. Epub 2012 Jun 19. Review.


The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling.

Staines KA, MacRae VE, Farquharson C.

J Endocrinol. 2012 Sep;214(3):241-55. doi: 10.1530/JOE-12-0143. Epub 2012 Jun 13. Review. Erratum in: J Endocrinol. 2013 Nov;219(2):X1.


Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice.

Mackenzie NC, Zhu D, Milne EM, van 't Hof R, Martin A, Darryl Quarles L, Millán JL, Farquharson C, MacRae VE.

PLoS One. 2012;7(2):e32177. doi: 10.1371/journal.pone.0032177. Epub 2012 Feb 16. Erratum in: PLoS One. 2012;7(6). doi:10.1371/annotation/8f71d7e8-d81d-4878-bf14-79a313a7810b. Quarles, Darryl Leigh [corrected to Darryl Quarles, Leigh].


SOCS2 is the critical regulator of GH action in murine growth plate chondrogenesis.

Pass C, MacRae VE, Huesa C, Faisal Ahmed S, Farquharson C.

J Bone Miner Res. 2012 May;27(5):1055-66. doi: 10.1002/jbmr.1544.


The appearance and modulation of osteocyte marker expression during calcification of vascular smooth muscle cells.

Zhu D, Mackenzie NC, Millán JL, Farquharson C, MacRae VE.

PLoS One. 2011;6(5):e19595. doi: 10.1371/journal.pone.0019595. Epub 2011 May 17.


MOVAS-1 cell line: a new in vitro model of vascular calcification.

Mackenzie NC, Zhu D, Longley L, Patterson CS, Kommareddy S, MacRae VE.

Int J Mol Med. 2011 May;27(5):663-8. doi: 10.3892/ijmm.2011.631. Epub 2011 Mar 1.


The role of cellular senescence during vascular calcification: a key paradigm in aging research.

Mackenzie NC, MacRae VE.

Curr Aging Sci. 2011 Jul;4(2):128-36. Review.


Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick.

Macrae VE, Davey MG, McTeir L, Narisawa S, Yadav MC, Millan JL, Farquharson C.

Bone. 2010 Apr;46(4):1146-55. doi: 10.1016/j.bone.2009.12.018. Epub 2010 Jan 4.


Inflammatory cytokines and the GH/IGF-I axis: novel actions on bone growth.

Pass C, MacRae VE, Ahmed SF, Farquharson C.

Cell Biochem Funct. 2009 Apr;27(3):119-27. doi: 10.1002/cbf.1551. Review.


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