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UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal.

Chagraoui J, Lehnertz B, Girard S, Spinella JF, Fares I, Tomellini E, Mayotte N, Corneau S, MacRae T, Simon L, Sauvageau G.

PLoS One. 2019 Nov 8;14(11):e0224900. doi: 10.1371/journal.pone.0224900. eCollection 2019.


Integrin-α3 Is a Functional Marker of Ex Vivo Expanded Human Long-Term Hematopoietic Stem Cells.

Tomellini E, Fares I, Lehnertz B, Chagraoui J, Mayotte N, MacRae T, Bordeleau MÈ, Corneau S, Bisaillon R, Sauvageau G.

Cell Rep. 2019 Jul 23;28(4):1063-1073.e5. doi: 10.1016/j.celrep.2019.06.084.


Genetic characterization of ABT-199 sensitivity in human AML.

Bisaillon R, Moison C, Thiollier C, Krosl J, Bordeleau ME, Lehnertz B, Lavallée VP, MacRae T, Mayotte N, Labelle C, Boucher G, Spinella JF, Boivin I, D'Angelo G, Lavallée S, Marinier A, Lemieux S, Hébert J, Sauvageau G.

Leukemia. 2019 Jul 12. doi: 10.1038/s41375-019-0485-x. [Epub ahead of print]


Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia.

Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveillé K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallée VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hébert J, Marinier A, Sauvageau G.

Cancer Cell. 2019 Jul 8;36(1):84-99.e8. doi: 10.1016/j.ccell.2019.06.003.


The synthesis of diapause-specific molecular chaperones in embryos of Artemia franciscana is determined by the quantity and location of heat shock factor 1 (Hsf1).

Tan J, MacRae TH.

Cell Stress Chaperones. 2019 Mar;24(2):385-392. doi: 10.1007/s12192-019-00971-7. Epub 2019 Jan 30.


Knockdown of the small heat-shock protein p26 by RNA interference modifies the diapause proteome of Artemia franciscana.

Malitan HS, Cohen AM, MacRae TH.

Biochem Cell Biol. 2019 Aug;97(4):471-479. doi: 10.1139/bcb-2018-0231. Epub 2019 Jan 8.


ArHsp40 and ArHsp40-2 contribute to stress tolerance and longevity in Artemia franciscana, but only ArHsp40 influences diapause entry.

Rowarth NM, MacRae TH.

J Exp Biol. 2018 Oct 19;221(Pt 20). pii: jeb189001. doi: 10.1242/jeb.189001.


Post-diapause synthesis of ArHsp40-2, a type 2 J-domain protein from Artemia franciscana, is developmentally regulated and induced by stress.

Rowarth NM, MacRae TH.

PLoS One. 2018 Jul 26;13(7):e0201477. doi: 10.1371/journal.pone.0201477. eCollection 2018.


Stress tolerance in diapausing embryos of Artemia franciscana is dependent on heat shock factor 1 (Hsf1).

Tan J, MacRae TH.

PLoS One. 2018 Jul 6;13(7):e0200153. doi: 10.1371/journal.pone.0200153. eCollection 2018.


Transcriptomic landscape of acute promyelocytic leukemia reveals aberrant surface expression of the platelet aggregation agonist Podoplanin.

Lavallée VP, Chagraoui J, MacRae T, Marquis M, Bonnefoy A, Krosl J, Lemieux S, Marinier A, Pabst C, Rivard GÉ, Hébert J, Sauvageau G.

Leukemia. 2018 Jun;32(6):1349-1357. doi: 10.1038/s41375-018-0069-1. Epub 2018 Feb 23.


The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output.

Bulut-Karslioglu A, Macrae TA, Oses-Prieto JA, Covarrubias S, Percharde M, Ku G, Diaz A, McManus MT, Burlingame AL, Ramalho-Santos M.

Cell Stem Cell. 2018 Mar 1;22(3):369-383.e8. doi: 10.1016/j.stem.2018.02.004.


Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity.

Simon L, Lavallée VP, Bordeleau ME, Krosl J, Baccelli I, Boucher G, Lehnertz B, Chagraoui J, MacRae T, Ruel R, Chantigny Y, Lemieux S, Marinier A, Hébert J, Sauvageau G.

Clin Cancer Res. 2017 Nov 15;23(22):6969-6981. doi: 10.1158/1078-0432.CCR-17-1259. Epub 2017 Aug 30.


Stimulus Characteristics of Single-Word Tests of Children's Speech Sound Production.

Macrae T.

Lang Speech Hear Serv Sch. 2017 Oct 5;48(4):219-233. doi: 10.1044/2017_LSHSS-16-0050.


EPCR expression marks UM171-expanded CD34+ cord blood stem cells.

Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G.

Blood. 2017 Jun 22;129(25):3344-3351. doi: 10.1182/blood-2016-11-750729. Epub 2017 Apr 13.


Inhibition of mTOR induces a paused pluripotent state.

Bulut-Karslioglu A, Biechele S, Jin H, Macrae TA, Hejna M, Gertsenstein M, Song JS, Ramalho-Santos M.

Nature. 2016 Dec 1;540(7631):119-123. doi: 10.1038/nature20578. Epub 2016 Nov 23.


ArHsp40, a type 1 J-domain protein, is developmentally regulated and stress inducible in post-diapause Artemia franciscana.

Jiang G, Rowarth NM, Panchakshari S, MacRae TH.

Cell Stress Chaperones. 2016 Nov;21(6):1077-1088. Epub 2016 Aug 31.


Stress tolerance during diapause and quiescence of the brine shrimp, Artemia.

MacRae TH.

Cell Stress Chaperones. 2016 Jan;21(1):9-18. doi: 10.1007/s12192-015-0635-7. Epub 2015 Sep 3. Review.


Predictors of token-to-token inconsistency in preschool children with typical speech-language development.

Macrae T, Sosa AV.

Clin Linguist Phon. 2015;29(12):922-37. doi: 10.3109/02699206.2015.1063085. Epub 2015 Aug 26.


Non-Lethal Heat Shock of the Asian Green Mussel, Perna viridis, Promotes Hsp70 Synthesis, Induces Thermotolerance and Protects Against Vibrio Infection.

Aleng NA, Sung YY, MacRae TH, Abd Wahid ME.

PLoS One. 2015 Aug 19;10(8):e0135603. doi: 10.1371/journal.pone.0135603. eCollection 2015.


A case description of speech disturbance and treatment following corrective surgery for stress velopharyngeal incompetence.

Macrae T, Stierwalt JA, Behel KA.

Clin Linguist Phon. 2015;29(11):826-39. Epub 2015 Aug 3.


Ingestion of food pellets containing Escherichia coli overexpressing the heat-shock protein DnaK protects Penaeus vannamei (Boone) against Vibrio harveyi (Baumann) infection.

Sinnasamy S, Noordin NM, MacRae TH, Bin Abdullah MI, Bossier P, Wahid ME, Noriaki A, Sung YY.

J Fish Dis. 2016 May;39(5):577-84. doi: 10.1111/jfd.12390. Epub 2015 Jun 30.


TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.

Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, He R, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Kantarjian HM, Liang S, Estecio MR, Godley LA, Issa JP.

Cancer Res. 2015 Jul 15;75(14):2833-43. doi: 10.1158/0008-5472.CAN-14-0739. Epub 2015 May 13.


Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate.

Fortier S, MacRae T, Bilodeau M, Sargeant T, Sauvageau G.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2127-32. doi: 10.1073/pnas.1418845112. Epub 2015 Feb 2.


Insect heat shock proteins during stress and diapause.

King AM, MacRae TH.

Annu Rev Entomol. 2015 Jan 7;60:59-75. doi: 10.1146/annurev-ento-011613-162107. Epub 2014 Oct 8. Review.


Speech abilities in preschool children with speech sound disorder with and without co-occurring language impairment.

Macrae T, Tyler AA.

Lang Speech Hear Serv Sch. 2014 Oct;45(4):302-13. doi: 10.1044/2014_LSHSS-13-0081.


Group 1 LEA proteins contribute to the desiccation and freeze tolerance of Artemia franciscana embryos during diapause.

Toxopeus J, Warner AH, MacRae TH.

Cell Stress Chaperones. 2014 Nov;19(6):939-48. doi: 10.1007/s12192-014-0518-3. Epub 2014 May 21.


Artemin, a diapause-specific chaperone, contributes to the stress tolerance of Artemia franciscana cysts and influences their release from females.

King AM, Toxopeus J, MacRae TH.

J Exp Biol. 2014 May 15;217(Pt 10):1719-24. doi: 10.1242/jeb.100081. Epub 2014 Feb 13.


Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.

Madzo J, Liu H, Rodriguez A, Vasanthakumar A, Sundaravel S, Caces DBD, Looney TJ, Zhang L, Lepore JB, Macrae T, Duszynski R, Shih AH, Song CX, Yu M, Yu Y, Grossman R, Raumann B, Verma A, He C, Levine RL, Lavelle D, Lahn BT, Wickrema A, Godley LA.

Cell Rep. 2014 Jan 16;6(1):231-244. doi: 10.1016/j.celrep.2013.11.044. Epub 2013 Dec 27.


RNA-Seq reveals spliceosome and proteasome genes as most consistent transcripts in human cancer cells.

Macrae T, Sargeant T, Lemieux S, Hébert J, Deneault E, Sauvageau G.

PLoS One. 2013 Sep 17;8(9):e72884. doi: 10.1371/journal.pone.0072884. eCollection 2013.


Non-lethal heat shock increased Hsp70 and immune protein transcripts but not Vibrio tolerance in the white-leg shrimp.

Loc NH, Macrae TH, Musa N, Bin Abdullah MD, Abdul Wahid ME, Sung YY.

PLoS One. 2013 Sep 9;8(9):e73199. doi: 10.1371/journal.pone.0073199. eCollection 2013.


Functional differentiation of small heat shock proteins in diapause-destined Artemia embryos.

King AM, Toxopeus J, MacRae TH.

FEBS J. 2013 Oct;280(19):4761-72. doi: 10.1111/febs.12442. Epub 2013 Aug 19.


Lexical and phonological variability in preschool children with speech sound disorder.

Macrae T, Tyler AA, Lewis KE.

Am J Speech Lang Pathol. 2014 Feb;23(1):27-35.


RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity.

Cellot S, Hope KJ, Chagraoui J, Sauvageau M, Deneault É, MacRae T, Mayotte N, Wilhelm BT, Landry JR, Ting SB, Krosl J, Humphries K, Thompson A, Sauvageau G.

Blood. 2013 Aug 29;122(9):1545-55. doi: 10.1182/blood-2013-04-496281. Epub 2013 Jun 18.


Lexical and child-related factors in word variability and accuracy in infants.

Macrae T.

Clin Linguist Phon. 2013 Jul;27(6-7):497-507. doi: 10.3109/02699206.2012.752867. Epub 2013 Jan 22. Erratum in: Clin Linguist Phon. 2017;31(3):250.


Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.

Yamazaki J, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Shen L, Kantarjian HM, Estecio MR, Jelinek J, Godley LA, Issa JP.

Epigenetics. 2012 Feb;7(2):201-7. doi: 10.4161/epi.7.2.19015.


Priming the prophenoloxidase system of Artemia franciscana by heat shock proteins protects against Vibrio campbellii challenge.

Baruah K, Ranjan J, Sorgeloos P, Macrae TH, Bossier P.

Fish Shellfish Immunol. 2011 Jul;31(1):134-41. doi: 10.1016/j.fsi.2011.04.008. Epub 2011 May 1.


Genome-wide interrogation of Mammalian stem cell fate determinants by nested chromosome deletions.

Fortier S, Bilodeau M, Macrae T, Laverdure JP, Azcoitia V, Girard S, Chagraoui J, Ringuette N, Hébert J, Krosl J, Mayotte N, Sauvageau G.

PLoS Genet. 2010 Dec 9;6(12):e1001241. doi: 10.1371/journal.pgen.1001241.


The structural stability and chaperone activity of artemin, a ferritin homologue from diapause-destined Artemia embryos, depend on different cysteine residues.

Hu Y, Bojikova-Fournier S, King AM, MacRae TH.

Cell Stress Chaperones. 2011 Mar;16(2):133-41. doi: 10.1007/s12192-010-0225-7. Epub 2010 Sep 28.


Evidence for multiple group 1 late embryogenesis abundant proteins in encysted embryos of Artemia and their organelles.

Warner AH, Miroshnychenko O, Kozarova A, Vacratsis PO, MacRae TH, Kim J, Clegg JS.

J Biochem. 2010 Nov;148(5):581-92. doi: 10.1093/jb/mvq091. Epub 2010 Aug 17.


An RNAi screen identifies Msi2 and Prox1 as having opposite roles in the regulation of hematopoietic stem cell activity.

Hope KJ, Cellot S, Ting SB, MacRae T, Mayotte N, Iscove NN, Sauvageau G.

Cell Stem Cell. 2010 Jul 2;7(1):101-13. doi: 10.1016/j.stem.2010.06.007.


Urinary monocyte chemotactic protein 1: marker of renal function decline in diabetic and nondiabetic proteinuric renal disease.

Camilla R, Brachemi S, Pichette V, Cartier P, Laforest-Renald A, MacRae T, Madore F, Troyanov S.

J Nephrol. 2011 Jan-Feb;24(1):60-7.


Diapause termination and development of encysted Artemia embryos: roles for nitric oxide and hydrogen peroxide.

Robbins HM, Van Stappen G, Sorgeloos P, Sung YY, MacRae TH, Bossier P.

J Exp Biol. 2010 May;213(Pt 9):1464-70. doi: 10.1242/jeb.041772.


Stimulability: relationships to other characteristics of children's phonological systems.

Tyler AA, Macrae T.

Clin Linguist Phon. 2010 Jan;24(4-5):300-10. doi: 10.3109/02699200903532516.


Gene expression, metabolic regulation and stress tolerance during diapause.

MacRae TH.

Cell Mol Life Sci. 2010 Jul;67(14):2405-24. doi: 10.1007/s00018-010-0311-0. Epub 2010 Mar 7. Review.


Improving the long-term storage of a mammalian biosensor cell line via genetic engineering.

Petrovick MS, Nargi FE, Towle T, Hogan K, Bohane M, Wright DJ, MacRae TH, Potts M, Helm RF.

Biotechnol Bioeng. 2010 Jun 15;106(3):474-81. doi: 10.1002/bit.22700.


Analysis of blood stem cell activity and cystatin gene expression in a mouse model presenting a chromosomal deletion encompassing Csta and Stfa2l1.

Bilodeau M, MacRae T, Gaboury L, Laverdure JP, Hardy MP, Mayotte N, Paradis V, Harton S, Perreault C, Sauvageau G.

PLoS One. 2009 Oct 19;4(10):e7500. doi: 10.1371/journal.pone.0007500.

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