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Items: 35

1.

Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes.

Rey G, Milev NB, Valekunja UK, Ch R, Ray S, Silva Dos Santos M, Nagy AD, Antrobus R, MacRae JI, Reddy AB.

Mol Syst Biol. 2018 Aug 2;14(8):e8376. doi: 10.15252/msb.20188376.

2.

Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis.

Tsui C, Martinez-Martin N, Gaya M, Maldonado P, Llorian M, Legrave NM, Rossi M, MacRae JI, Cameron AJ, Parker PJ, Leitges M, Bruckbauer A, Batista FD.

Immunity. 2018 Jun 19;48(6):1144-1159.e5. doi: 10.1016/j.immuni.2018.04.031. Epub 2018 Jun 5.

3.

A review of the pharmaceutical exposome in aquatic fauna.

Miller TH, Bury NR, Owen SF, MacRae JI, Barron LP.

Environ Pollut. 2018 Aug;239:129-146. doi: 10.1016/j.envpol.2018.04.012. Epub 2018 Apr 10. Review.

4.

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.

Rohm M, Savic D, Ball V, Curtis MK, Bonham S, Fischer R, Legrave N, MacRae JI, Tyler DJ, Ashcroft FM.

Diabetes. 2018 Jun;67(6):1057-1067. doi: 10.2337/db17-1195. Epub 2018 Apr 2.

PMID:
29610263
5.

Developmental diet regulates Drosophila lifespan via lipid autotoxins.

Stefana MI, Driscoll PC, Obata F, Pengelly AR, Newell CL, MacRae JI, Gould AP.

Nat Commun. 2017 Nov 9;8(1):1384. doi: 10.1038/s41467-017-01740-9.

6.

Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic.

Entwistle LJ, Pelly VS, Coomes SM, Kannan Y, Perez-Lloret J, Czieso S, Silva Dos Santos M, MacRae JI, Collinson L, Sesay A, Nikolov N, Metidji A, Helmby H, Hui DY, Wilson MS.

Cell Host Microbe. 2017 Oct 11;22(4):484-493.e5. doi: 10.1016/j.chom.2017.09.006.

7.

Extensive Metabolic Remodeling Differentiates Non-pathogenic and Pathogenic Growth Forms of the Dimorphic Pathogen Talaromyces marneffei.

Pasricha S, MacRae JI, Chua HH, Chambers J, Boyce KJ, McConville MJ, Andrianopoulos A.

Front Cell Infect Microbiol. 2017 Aug 17;7:368. doi: 10.3389/fcimb.2017.00368. eCollection 2017.

8.

An engineered photoswitchable mammalian pyruvate kinase.

Gehrig S, Macpherson JA, Driscoll PC, Symon A, Martin SR, MacRae JI, Kleinjung J, Fraternali F, Anastasiou D.

FEBS J. 2017 Sep;284(18):2955-2980. doi: 10.1111/febs.14175. Epub 2017 Aug 16.

9.

Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments.

Srivastava A, Philip N, Hughes KR, Georgiou K, MacRae JI, Barrett MP, Creek DJ, McConville MJ, Waters AP.

PLoS Pathog. 2016 Dec 27;12(12):e1006094. doi: 10.1371/journal.ppat.1006094. eCollection 2016 Dec.

10.

Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.

Creek DJ, Chua HH, Cobbold SA, Nijagal B, MacRae JI, Dickerman BK, Gilson PR, Ralph SA, McConville MJ.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6650-6663. doi: 10.1128/AAC.01226-16. Print 2016 Nov.

11.

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase.

Amiar S, MacRae JI, Callahan DL, Dubois D, van Dooren GG, Shears MJ, Cesbron-Delauw MF, Maréchal E, McConville MJ, McFadden GI, Yamaryo-Botté Y, Botté CY.

PLoS Pathog. 2016 Aug 4;12(8):e1005765. doi: 10.1371/journal.ppat.1005765. eCollection 2016 Aug.

12.

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.

Shears MJ, MacRae JI, Mollard V, Goodman CD, Sturm A, Orchard LM, Llinás M, McConville MJ, Botté CY, McFadden GI.

Cell Microbiol. 2017 Jan;19(1). doi: 10.1111/cmi.12633. Epub 2016 Aug 1.

13.

Reduced cholesterol levels impair Smoothened activation in Smith-Lemli-Opitz syndrome.

Blassberg R, Macrae JI, Briscoe J, Jacob J.

Hum Mol Genet. 2016 Feb 15;25(4):693-705. doi: 10.1093/hmg/ddv507. Epub 2015 Dec 18.

14.

Apicomplexan Energy Metabolism: Carbon Source Promiscuity and the Quiescence Hyperbole.

Jacot D, Waller RF, Soldati-Favre D, MacPherson DA, MacRae JI.

Trends Parasitol. 2016 Jan;32(1):56-70. doi: 10.1016/j.pt.2015.09.001. Epub 2015 Oct 17. Review.

PMID:
26472327
15.

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila.

Bailey AP, Koster G, Guillermier C, Hirst EM, MacRae JI, Lechene CP, Postle AD, Gould AP.

Cell. 2015 Oct 8;163(2):340-53. doi: 10.1016/j.cell.2015.09.020.

16.

Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target.

Allen SM, Lim EE, Jortzik E, Preuss J, Chua HH, MacRae JI, Rahlfs S, Haeussler K, Downton MT, McConville MJ, Becker K, Ralph SA.

FEBS J. 2015 Oct;282(19):3808-23. doi: 10.1111/febs.13380. Epub 2015 Aug 17.

17.

Endosymbiosis undone by stepwise elimination of the plastid in a parasitic dinoflagellate.

Gornik SG, Febrimarsa, Cassin AM, MacRae JI, Ramaprasad A, Rchiad Z, McConville MJ, Bacic A, McFadden GI, Pain A, Waller RF.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5767-72. doi: 10.1073/pnas.1423400112. Epub 2015 Apr 20.

18.

The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell.

Ramakrishnan S, Docampo MD, MacRae JI, Ralton JE, Rupasinghe T, McConville MJ, Striepen B.

Mol Microbiol. 2015 Jul;97(1):64-76. doi: 10.1111/mmi.13010. Epub 2015 Apr 23.

19.

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei.

Oppenheim RD, Creek DJ, Macrae JI, Modrzynska KK, Pino P, Limenitakis J, Polonais V, Seeber F, Barrett MP, Billker O, McConville MJ, Soldati-Favre D.

PLoS Pathog. 2014 Jul 17;10(7):e1004263. doi: 10.1371/journal.ppat.1004263. eCollection 2014 Jul.

20.

Plasmodium falciparum is dependent on de novo myo-inositol biosynthesis for assembly of GPI glycolipids and infectivity.

Macrae JI, Lopaticki S, Maier AG, Rupasinghe T, Nahid A, Cowman AF, McConville MJ.

Mol Microbiol. 2014 Feb;91(4):762-76. doi: 10.1111/mmi.12496. Epub 2014 Jan 16.

21.

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum.

MacRae JI, Dixon MW, Dearnley MK, Chua HH, Chambers JM, Kenny S, Bottova I, Tilley L, McConville MJ.

BMC Biol. 2013 Jun 13;11:67. doi: 10.1186/1741-7007-11-67.

22.

Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites.

Botté CY, Yamaryo-Botté Y, Rupasinghe TW, Mullin KA, MacRae JI, Spurck TP, Kalanon M, Shears MJ, Coppel RL, Crellin PK, Maréchal E, McConville MJ, McFadden GI.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7506-11. doi: 10.1073/pnas.1301251110. Epub 2013 Apr 15.

23.

Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii.

MacRae JI, Sheiner L, Nahid A, Tonkin C, Striepen B, McConville MJ.

Cell Host Microbe. 2012 Nov 15;12(5):682-92. doi: 10.1016/j.chom.2012.09.013.

24.

Alveolate mitochondrial metabolic evolution: dinoflagellates force reassessment of the role of parasitism as a driver of change in apicomplexans.

Danne JC, Gornik SG, Macrae JI, McConville MJ, Waller RF.

Mol Biol Evol. 2013 Jan;30(1):123-39. doi: 10.1093/molbev/mss205. Epub 2012 Aug 25.

PMID:
22923466
25.

LeishCyc: a guide to building a metabolic pathway database and visualization of metabolomic data.

Saunders EC, MacRae JI, Naderer T, Ng M, McConville MJ, Likić VA.

Methods Mol Biol. 2012;881:505-29. doi: 10.1007/978-1-61779-827-6_17.

PMID:
22639224
26.

The apicoplast: a key target to cure malaria.

MacRae JI, Maréchal E, Biot C, Botté CY.

Curr Pharm Des. 2012;18(24):3490-504. Review.

PMID:
22607142
27.

Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii.

Ramakrishnan S, Docampo MD, Macrae JI, Pujol FM, Brooks CF, van Dooren GG, Hiltunen JK, Kastaniotis AJ, McConville MJ, Striepen B.

J Biol Chem. 2012 Feb 10;287(7):4957-71. doi: 10.1074/jbc.M111.310144. Epub 2011 Dec 16.

28.

Central carbon metabolism of Leishmania parasites.

Saunders EC, DE Souza DP, Naderer T, Sernee MF, Ralton JE, Doyle MA, Macrae JI, Chambers JL, Heng J, Nahid A, Likic VA, McConville MJ.

Parasitology. 2010 Aug;137(9):1303-13. doi: 10.1017/S0031182010000077. Epub 2010 Feb 17. Review.

PMID:
20158936
29.

LeishCyc: a biochemical pathways database for Leishmania major.

Doyle MA, MacRae JI, De Souza DP, Saunders EC, McConville MJ, Likić VA.

BMC Syst Biol. 2009 Jun 5;3:57. doi: 10.1186/1752-0509-3-57.

30.

Surface plasmon resonance imaging for real-time, label-free analysis of protein interactions with carbohydrate microarrays.

Karamanska R, Clarke J, Blixt O, Macrae JI, Zhang JQ, Crocker PR, Laurent N, Wright A, Flitsch SL, Russell DA, Field RA.

Glycoconj J. 2008 Jan;25(1):69-74. Epub 2007 Jun 16.

PMID:
17574526
31.

The suppression of galactose metabolism in Trypanosoma cruzi epimastigotes causes changes in cell surface molecular architecture and cell morphology.

MacRae JI, Obado SO, Turnock DC, Roper JR, Kierans M, Kelly JM, Ferguson MA.

Mol Biochem Parasitol. 2006 May;147(1):126-36. Epub 2006 Mar 9.

PMID:
16569451
32.

Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor.

Blair DE, Schüttelkopf AW, MacRae JI, van Aalten DM.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15429-34. Epub 2005 Oct 12.

33.

The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number.

Roper JR, Güther ML, Macrae JI, Prescott AR, Hallyburton I, Acosta-Serrano A, Ferguson MA.

J Biol Chem. 2005 May 20;280(20):19728-36. Epub 2005 Mar 14.

34.

Structural characterization of NETNES, a novel glycoconjugate in Trypanosoma cruzi epimastigotes.

Macrae JI, Acosta-Serrano A, Morrice NA, Mehlert A, Ferguson MA.

J Biol Chem. 2005 Apr 1;280(13):12201-11. Epub 2005 Jan 13.

35.

A robust and selective method for the quantification of glycosylphosphatidylinositols in biological samples.

Macrae JI, Ferguson MA.

Glycobiology. 2005 Feb;15(2):131-8. Epub 2004 Sep 15.

PMID:
15371345

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