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Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.

Haythorne E, Rohm M, van de Bunt M, Brereton MF, Tarasov AI, Blacker TS, Sachse G, Silva Dos Santos M, Terron Exposito R, Davis S, Baba O, Fischer R, Duchen MR, Rorsman P, MacRae JI, Ashcroft FM.

Nat Commun. 2019 Jun 6;10(1):2474. doi: 10.1038/s41467-019-10189-x.


Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes.

Sellers K, Allen TD, Bousamra M 2nd, Tan J, Méndez-Lucas A, Lin W, Bah N, Chernyavskaya Y, MacRae JI, Higashi RM, Lane AN, Fan TW, Yuneva MO.

Br J Cancer. 2019 May 22. doi: 10.1038/s41416-019-0464-z. [Epub ahead of print]


The role of exercise in improving patient-reported outcomes in individuals on dialysis: A scoping review.

Bohm C, Schick-Makaroff K, MacRae JM, Tan M, Thompson S.

Semin Dial. 2019 Apr 21. doi: 10.1111/sdi.12806. [Epub ahead of print]


Anticoagulation in CKD and ESRD.

Leung KC, MacRae JM.

J Nephrol. 2019 Jan 28. doi: 10.1007/s40620-019-00592-4. [Epub ahead of print] Review.


Buttonhole versus Stepladder Cannulation for Home Hemodialysis: A Multicenter, Randomized, Pilot Trial.

Huang SS, MacRae J, Ross D, Imtiaz R, Hollingsworth B, Nesrallah GE, Copland MA, McFarlane PA, Chan CT, Zimmerman D.

Clin J Am Soc Nephrol. 2019 Mar 7;14(3):403-410. doi: 10.2215/CJN.08310718. Epub 2019 Jan 18.


Characterisation of the Toxoplasma gondii tyrosine transporter and its phosphorylation by the calcium-dependent protein kinase 3.

Wallbank BA, Dominicus CS, Broncel M, Legrave N, Kelly G, MacRae JI, Staines HM, Treeck M.

Mol Microbiol. 2019 May;111(5):1167-1181. doi: 10.1111/mmi.14156. Epub 2018 Nov 25.


Technique Failure in a Multicenter Canadian Home Hemodialysis Cohort.

Pauly RP, Rosychuk RJ, Usman I, Reintjes F, Muneer M, Chan CT, Copland M, Lindsay R, MacRae J, Nesrallah G, Pierratos A, Zimmerman DL, Komenda P.

Am J Kidney Dis. 2019 Feb;73(2):230-239. doi: 10.1053/j.ajkd.2018.08.016. Epub 2018 Nov 2.


Machine Learning for Environmental Toxicology: A Call for Integration and Innovation.

Miller TH, Gallidabino MD, MacRae JI, Hogstrand C, Bury NR, Barron LP, Snape JR, Owen SF.

Environ Sci Technol. 2018 Nov 20;52(22):12953-12955. doi: 10.1021/acs.est.8b05382. Epub 2018 Oct 19. No abstract available.


Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel.

Sampson UKA, McGlynn EA, Perlin JB, Frisse ME, Arnold SB, Benz EJ Jr, Brennan T, Briss P, Beeuwkes Buntin MJ, Khosla S, King RG, Kuntz R, Leider H, Ling SM, Macrae J, Murray R, Thrailkill E, Wager C, Witchey D, Jacobson HR.

Glob Heart. 2018 Dec;13(4):339-345. doi: 10.1016/j.gheart.2018.09.508. Epub 2018 Oct 6. Review.


MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.

Fets L, Driscoll PC, Grimm F, Jain A, Nunes PM, Gounis M, Doglioni G, Papageorgiou G, Ragan TJ, Campos S, Silva Dos Santos M, MacRae JI, O'Reilly N, Wright AJ, Benes CH, Courtney KD, House D, Anastasiou D.

Nat Chem Biol. 2018 Nov;14(11):1032-1042. doi: 10.1038/s41589-018-0136-y. Epub 2018 Oct 8.


CPAP Therapy Delays Cardiovagal Reactivation and Decreases Arterial Renin-Angiotensin System Activity in Humans With Obstructive Sleep Apnea.

Nicholl DDM, Hanly PJ, Zalucky AA, Mann MC, MacRae JM, Poulin MJ, Handley GB, Sola DY, Ahmed SB.

J Clin Sleep Med. 2018 Sep 15;14(9):1509-1520. doi: 10.5664/jcsm.7326.


Outcomes of the First and Second Hemodialysis Fistula: A Cohort Study.

Kamar F, Quinn RR, Oliver MJ, Viecelli AK, Hiremath S, MacRae J, Miller L, Blake P, Moist L, Garg AX, Lam NN, Kabani R, Clarke A, Liu P, Gillespie B, Ravani P.

Am J Kidney Dis. 2019 Jan;73(1):62-71. doi: 10.1053/j.ajkd.2018.06.007. Epub 2018 Aug 16.


Prediction of bioconcentration factors in fish and invertebrates using machine learning.

Miller TH, Gallidabino MD, MacRae JI, Owen SF, Bury NR, Barron LP.

Sci Total Environ. 2019 Jan 15;648:80-89. doi: 10.1016/j.scitotenv.2018.08.122. Epub 2018 Aug 10.


Metabolic oscillations on the circadian time scale in Drosophila cells lacking clock genes.

Rey G, Milev NB, Valekunja UK, Ch R, Ray S, Silva Dos Santos M, Nagy AD, Antrobus R, MacRae JI, Reddy AB.

Mol Syst Biol. 2018 Aug 2;14(8):e8376. doi: 10.15252/msb.20188376.


Can economic incentives increase the use of home dialysis?

Manns B, Agar JWM, Biyani M, Blake PG, Cass A, Culleton B, Kleophas W, Komenda P, Lobbedez T, MacRae J, Marshall MR, Scott-Douglas N, Srivastava V, Magner P.

Nephrol Dial Transplant. 2019 May 1;34(5):731-741. doi: 10.1093/ndt/gfy223.


A comparison of temporal artery thermometers with internal blood monitors to measure body temperature during hemodialysis.

Lunney M, Tonelli B, Lewis R, Wiebe N, Thomas C, MacRae J, Tonelli M.

BMC Nephrol. 2018 Jun 14;19(1):137. doi: 10.1186/s12882-018-0938-x.


Protein Kinase C-β Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis.

Tsui C, Martinez-Martin N, Gaya M, Maldonado P, Llorian M, Legrave NM, Rossi M, MacRae JI, Cameron AJ, Parker PJ, Leitges M, Bruckbauer A, Batista FD.

Immunity. 2018 Jun 19;48(6):1144-1159.e5. doi: 10.1016/j.immuni.2018.04.031. Epub 2018 Jun 5.


Quantifying the incidence and burden of herpes zoster in New Zealand general practice: a retrospective cohort study using a natural language processing software inference algorithm.

Turner NM, MacRae J, Nowlan ML, McBain L, Stubbe MH, Dowell A.

BMJ Open. 2018 May 31;8(5):e021241. doi: 10.1136/bmjopen-2017-021241.


A review of the pharmaceutical exposome in aquatic fauna.

Miller TH, Bury NR, Owen SF, MacRae JI, Barron LP.

Environ Pollut. 2018 Aug;239:129-146. doi: 10.1016/j.envpol.2018.04.012. Epub 2018 Apr 10. Review.


Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.

Rohm M, Savic D, Ball V, Curtis MK, Bonham S, Fischer R, Legrave N, MacRae JI, Tyler DJ, Ashcroft FM.

Diabetes. 2018 Jun;67(6):1057-1067. doi: 10.2337/db17-1195. Epub 2018 Apr 2.


Vascular Access Practice Patterns in Canada: A National Survey.

Dumaine C, Kiaii M, Miller L, Moist L, Oliver MJ, Lok CE, Hiremath S, MacRae JM.

Can J Kidney Health Dis. 2018 Feb 28;5:2054358118759675. doi: 10.1177/2054358118759675. eCollection 2018.


As-Needed Vs Immediate Etoposide Chemotherapy in Combination With Antiretroviral Therapy for Mild-to-Moderate AIDS-Associated Kaposi Sarcoma in Resource-Limited Settings: A5264/AMC-067 Randomized Clinical Trial.

Hosseinipour MC, Kang M, Krown SE, Bukuru A, Umbleja T, Martin JN, Orem J, Godfrey C, Hoagland B, Mwelase N, Langat D, Nyirenda M, MacRae J, Borok M, Samaneka W, Moses A, Mngqbisa R, Busakhala N, Martínez-Maza O, Ambinder R, Dittmer DP, Nokta M, Campbell TB; A5264/AMC-067 REACT-KS Team.

Clin Infect Dis. 2018 Jul 2;67(2):251-260. doi: 10.1093/cid/ciy044.


Effectiveness and Cost of Weekly Recombinant Tissue Plasminogen Activator Hemodialysis Catheter Locking Solution.

Hemmelgarn BR, Manns BJ, Soroka SD, Levin A, MacRae J, Tennankore K, Wilson JS, Weaver RG, Ravani P, Quinn RR, Tonelli M, Kiaii M, Mossop P, Scott-Douglas N.

Clin J Am Soc Nephrol. 2018 Mar 7;13(3):429-435. doi: 10.2215/CJN.08510817. Epub 2018 Jan 15.


Developmental diet regulates Drosophila lifespan via lipid autotoxins.

Stefana MI, Driscoll PC, Obata F, Pengelly AR, Newell CL, MacRae JI, Gould AP.

Nat Commun. 2017 Nov 9;8(1):1384. doi: 10.1038/s41467-017-01740-9.


Central venous catheters for chronic hemodialysis: Is "last choice" never the "right choice"?

Dumaine CS, Brown RS, MacRae JM, Oliver MJ, Ravani P, Quinn RR.

Semin Dial. 2018 Jan;31(1):3-10. doi: 10.1111/sdi.12655. Epub 2017 Nov 2. Review.


Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic.

Entwistle LJ, Pelly VS, Coomes SM, Kannan Y, Perez-Lloret J, Czieso S, Silva Dos Santos M, MacRae JI, Collinson L, Sesay A, Nikolov N, Metidji A, Helmby H, Hui DY, Wilson MS.

Cell Host Microbe. 2017 Oct 11;22(4):484-493.e5. doi: 10.1016/j.chom.2017.09.006.


Randomized Crossover Trial of Blood Volume Monitoring-Guided Ultrafiltration Biofeedback to Reduce Intradialytic Hypotensive Episodes with Hemodialysis.

Leung KCW, Quinn RR, Ravani P, Duff H, MacRae JM.

Clin J Am Soc Nephrol. 2017 Nov 7;12(11):1831-1840. doi: 10.2215/CJN.01030117. Epub 2017 Oct 10.


Impact of intradialytic exercise intensity on urea clearance in hemodialysis patients.

Brown PDS, Rowed K, Shearer J, MacRae JM, Parker K.

Appl Physiol Nutr Metab. 2018 Jan;43(1):101-104. doi: 10.1139/apnm-2017-0460. Epub 2017 Sep 29.


Multi-Disciplinary Vascular Access Care and Access Outcomes in People Starting Hemodialysis Therapy.

Gill S, Quinn R, Oliver M, Kamar F, Kabani R, Devoe D, Mysore P, Pannu N, MacRae J, Manns B, Hemmelgarn B, James M, Tonelli M, Lewin A, Liu P, Ravani P.

Clin J Am Soc Nephrol. 2017 Dec 7;12(12):1991-1999. doi: 10.2215/CJN.03430317. Epub 2017 Sep 14.


Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation.

Scheff NN, Ye Y, Bhattacharya A, MacRae J, Hickman DN, Sharma AK, Dolan JC, Schmidt BL.

Pain. 2017 Dec;158(12):2396-2409. doi: 10.1097/j.pain.0000000000001044.


Extensive Metabolic Remodeling Differentiates Non-pathogenic and Pathogenic Growth Forms of the Dimorphic Pathogen Talaromyces marneffei.

Pasricha S, MacRae JI, Chua HH, Chambers J, Boyce KJ, McConville MJ, Andrianopoulos A.

Front Cell Infect Microbiol. 2017 Aug 17;7:368. doi: 10.3389/fcimb.2017.00368. eCollection 2017.


An engineered photoswitchable mammalian pyruvate kinase.

Gehrig S, Macpherson JA, Driscoll PC, Symon A, Martin SR, MacRae JI, Kleinjung J, Fraternali F, Anastasiou D.

FEBS J. 2017 Sep;284(18):2955-2980. doi: 10.1111/febs.14175. Epub 2017 Aug 16.


Examining the Association between Hemodialysis Access Type and Mortality: The Role of Access Complications.

Ravani P, Quinn R, Oliver M, Robinson B, Pisoni R, Pannu N, MacRae J, Manns B, Hemmelgarn B, James M, Tonelli M, Gillespie B.

Clin J Am Soc Nephrol. 2017 Jun 7;12(6):955-964. doi: 10.2215/CJN.12181116. Epub 2017 May 18.


Better, Sooner, More Convenient? The reality of pursuing greater integration between primary and secondary healthcare providers in New Zealand.

Lovelock K, Martin G, Gauld R, MacRae J.

SAGE Open Med. 2017 Apr 11;5:2050312117701052. doi: 10.1177/2050312117701052. eCollection 2017.


Vascular Access Core Curriculum: Introduction.

Miller L, MacRae J.

Can J Kidney Health Dis. 2016 Sep 27;3:2054358116673925. doi: 10.1177/2054358116673925. eCollection 2016. No abstract available.


Hemodialysis Tunneled Catheter Noninfectious Complications.

Miller LM, MacRae JM, Kiaii M, Clark E, Dipchand C, Kappel J, Lok C, Luscombe R, Moist L, Oliver M, Pike P, Hiremath S; Canadian Society of Nephrology Vascular Access Work Group.

Can J Kidney Health Dis. 2016 Sep 27;3:2054358116669130. doi: 10.1177/2054358116669130. eCollection 2016.


Hemodialysis Tunneled Catheter-Related Infections.

Miller LM, Clark E, Dipchand C, Hiremath S, Kappel J, Kiaii M, Lok C, Luscombe R, Moist L, Oliver M, MacRae J; Canadian Society of Nephrology Vascular Access Work Group.

Can J Kidney Health Dis. 2016 Sep 27;3:2054358116669129. doi: 10.1177/2054358116669129. eCollection 2016.


Practical Aspects of Nontunneled and Tunneled Hemodialysis Catheters.

Clark E, Kappel J, MacRae J, Dipchand C, Hiremath S, Kiaii M, Lok C, Moist L, Oliver M, Miller LM; Canadian Society of Nephrology Vascular Access Work Group.

Can J Kidney Health Dis. 2016 Sep 27;3:2054358116669128. doi: 10.1177/2054358116669128. eCollection 2016.


Arteriovenous Access: Infection, Neuropathy, and Other Complications.

MacRae JM, Dipchand C, Oliver M, Moist L, Yilmaz S, Lok C, Leung K, Clark E, Hiremath S, Kappel J, Kiaii M, Luscombe R, Miller LM; Canadian Society of Nephrology Vascular Access Work Group.

Can J Kidney Health Dis. 2016 Sep 27;3:2054358116669127. doi: 10.1177/2054358116669127. eCollection 2016.


Arteriovenous Access Failure, Stenosis, and Thrombosis.

MacRae JM, Dipchand C, Oliver M, Moist L, Lok C, Clark E, Hiremath S, Kappel J, Kiaii M, Luscombe R, Miller LM; Canadian Society of Nephrology Vascular Access Work Group.

Can J Kidney Health Dis. 2016 Sep 27;3:2054358116669126. doi: 10.1177/2054358116669126. eCollection 2016.


Arteriovenous Vascular Access Selection and Evaluation.

MacRae JM, Oliver M, Clark E, Dipchand C, Hiremath S, Kappel J, Kiaii M, Lok C, Luscombe R, Miller LM, Moist L; Canadian Society of Nephrology Vascular Access Work Group.

Can J Kidney Health Dis. 2016 Sep 27;3:2054358116669125. doi: 10.1177/2054358116669125. eCollection 2016.


The Effect of Predialysis Fistula Attempt on Risk of All-Cause and Access-Related Death.

Quinn RR, Oliver MJ, Devoe D, Poinen K, Kabani R, Kamar F, Mysore P, Lewin AM, Hiremath S, MacRae J, James MT, Miller L, Hemmelgarn BR, Moist LM, Garg AX, Chowdhury TT, Ravani P.

J Am Soc Nephrol. 2017 Feb;28(2):613-620. doi: 10.1681/ASN.2016020151. Epub 2016 Oct 6.


Emergency Department Use among Patients with CKD: A Population-Based Analysis.

Ronksley PE, Tonelli M, Manns BJ, Weaver RG, Thomas CM, MacRae JM, Ravani P, Quinn RR, James MT, Lewanczuk R, Hemmelgarn BR.

Clin J Am Soc Nephrol. 2017 Feb 7;12(2):304-314. doi: 10.2215/CJN.06280616. Epub 2017 Jan 24.


Sex differences in associations between insulin resistance, heart rate variability, and arterial stiffness in healthy women and men: a physiology study.

Rannelli LA, MacRae JM, Mann MC, Ramesh S, Hemmelgarn BR, Rabi D, Sola DY, Ahmed SB.

Can J Physiol Pharmacol. 2017 Apr;95(4):349-355. doi: 10.1139/cjpp-2016-0122. Epub 2016 Nov 2.


Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments.

Srivastava A, Philip N, Hughes KR, Georgiou K, MacRae JI, Barrett MP, Creek DJ, McConville MJ, Waters AP.

PLoS Pathog. 2016 Dec 27;12(12):e1006094. doi: 10.1371/journal.ppat.1006094. eCollection 2016 Dec.


A Clinical Risk Prediction Tool for 6-Month Mortality After Dialysis Initiation Among Older Adults.

Wick JP, Turin TC, Faris PD, MacRae JM, Weaver RG, Tonelli M, Manns BJ, Hemmelgarn BR.

Am J Kidney Dis. 2017 May;69(5):568-575. doi: 10.1053/j.ajkd.2016.08.035. Epub 2016 Nov 14.


The VITAH Trial-Vitamin D Supplementation and Cardiac Autonomic Tone in Patients with End-Stage Kidney Disease on Hemodialysis: A Blinded, Randomized Controlled Trial.

Mann MC, Exner DV, Hemmelgarn BR, Hanley DA, Turin TC, MacRae JM, Wheeler DC, Sola DY, Ramesh S, Ahmed SB.

Nutrients. 2016 Sep 28;8(10). pii: E608.


Microbial metabolisms in a 2.5-km-deep ecosystem created by hydraulic fracturing in shales.

Daly RA, Borton MA, Wilkins MJ, Hoyt DW, Kountz DJ, Wolfe RA, Welch SA, Marcus DN, Trexler RV, MacRae JD, Krzycki JA, Cole DR, Mouser PJ, Wrighton KC.

Nat Microbiol. 2016 Sep 5;1:16146. doi: 10.1038/nmicrobiol.2016.146.


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