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Items: 1 to 50 of 203

1.

Evolution of academic-industry partnerships in cardiovascular research and development.

MacRae CA.

Nat Rev Cardiol. 2019 Jun 13. doi: 10.1038/s41569-019-0223-0. [Epub ahead of print] No abstract available.

PMID:
31197233
2.

Phenotyping to Facilitate Accrual for a Cardiovascular Intervention.

Wagholikar KB, Fischer CM, Goodson AP, Herrick CD, Maclean TE, Smith KV, Fera L, Gaziano TA, Dunning JR, Bosque-Hamilton J, Matta L, Toscano E, Richter B, Ainsworth L, Oates MF, Aronson S, MacRae CA, Scirica BM, Desai AS, Murphy SN.

J Clin Med Res. 2019 Jun;11(6):458-463. doi: 10.14740/jocmr3830. Epub 2019 May 10.

3.

Phenotypic Characterization of Individuals With Variants in Cardiovascular Genes in the Absence of a Primary Cardiovascular Indication for Testing.

Hylind RJ, Chandler SF, Beausejour Ladouceur V, Roberts AE, Bezzerides V, Christensen KD, Coggins M, Lakdawala NK, MacRae CA, Abrams DJ.

Circ Genom Precis Med. 2019 Mar;12(3):e002463. doi: 10.1161/CIRCGEN.119.002463. No abstract available.

PMID:
30919684
4.

Zebrafish model of amyloid light chain cardiotoxicity: regeneration versus degeneration.

Mishra S, Joshi S, Ward JE, Buys EP, Mishra D, Mishra D, Morgado I, Fisch S, Lavatelli F, Merlini G, Dorbala S, MacRae CA, Liao R.

Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1158-H1166. doi: 10.1152/ajpheart.00788.2018. Epub 2019 Mar 15.

PMID:
30875258
5.

Screening drugs for myocardial disease in vivo with zebrafish: an expert update.

Zhao Y, Zhang K, Sips P, MacRae CA.

Expert Opin Drug Discov. 2019 Apr;14(4):343-353. doi: 10.1080/17460441.2019.1577815. Epub 2019 Mar 6.

PMID:
30836799
6.

Development of an entirely remote, non-physician led hypertension management program.

Fisher NDL, Fera LE, Dunning JR, Desai S, Matta L, Liquori V, Pagliaro J, Pabo E, Merriam M, MacRae CA, Scirica BM.

Clin Cardiol. 2019 Feb;42(2):285-291. doi: 10.1002/clc.23141. Epub 2019 Jan 17.

7.

Zebrafish assay development for cardiovascular disease mechanism and drug discovery.

Kithcart AP, MacRae CA.

Prog Biophys Mol Biol. 2018 Oct;138:126-131. doi: 10.1016/j.pbiomolbio.2018.07.002. Epub 2018 Jul 2. Review. No abstract available.

PMID:
30518489
8.

Trafficking of the human ether-a-go-go-related gene (hERG) potassium channel is regulated by the ubiquitin ligase rififylin (RFFL).

Roder K, Kabakov A, Moshal KS, Murphy KR, Xie A, Dudley S, Turan NN, Lu Y, MacRae CA, Koren G.

J Biol Chem. 2019 Jan 4;294(1):351-360. doi: 10.1074/jbc.RA118.003852. Epub 2018 Nov 6.

PMID:
30401747
9.

Genetics of Atrial Fibrillation.

Feghaly J, Zakka P, London B, MacRae CA, Refaat MM.

J Am Heart Assoc. 2018 Oct 16;7(20):e009884. doi: 10.1161/JAHA.118.009884.

10.

Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk.

Seidelmann SB, Feofanova E, Yu B, Franceschini N, Claggett B, Kuokkanen M, Puolijoki H, Ebeling T, Perola M, Salomaa V, Shah A, Coresh J, Selvin E, MacRae CA, Cheng S, Boerwinkle E, Solomon SD.

J Am Coll Cardiol. 2018 Oct 9;72(15):1763-1773. doi: 10.1016/j.jacc.2018.07.061.

11.

Extraction of Ejection Fraction from Echocardiography Notes for Constructing a Cohort of Patients having Heart Failure with reduced Ejection Fraction (HFrEF).

Wagholikar KB, Fischer CM, Goodson A, Herrick CD, Rees M, Toscano E, MacRae CA, Scirica BM, Desai AS, Murphy SN.

J Med Syst. 2018 Sep 25;42(11):209. doi: 10.1007/s10916-018-1066-7.

12.

Rare Diseases Inform Myocardial Phenotypes for Precision Medicine.

Macrae CA.

J Card Fail. 2018 Oct;24(10):680-681. doi: 10.1016/j.cardfail.2018.09.005. Epub 2018 Sep 13. No abstract available.

PMID:
30218700
13.

An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.

Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D; Undiagnosed Diseases Network, Brigham and Women’s Hospital FaceBase Project, Brigham Genomic Medicine (BGM).

NPJ Genom Med. 2018 Aug 13;3:21. doi: 10.1038/s41525-018-0060-9. eCollection 2018. Review.

14.

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.

Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA.

PLoS One. 2018 Jun 7;13(6):e0193889. doi: 10.1371/journal.pone.0193889. eCollection 2018.

15.

Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association.

Musunuru K, Arora P, Cooke JP, Ferguson JF, Hershberger RE, Hickey KT, Lee JM, Lima JAC, Loscalzo J, Pereira NL, Russell MW, Shah SH, Sheikh F, Wang TJ, MacRae CA; American Heart Association Council on Genomic and Precision Medicine; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council.

Circ Genom Precis Med. 2018 Jun;11(6):e000046. doi: 10.1161/HCG.0000000000000046. Review.

PMID:
29844141
16.

A New Approach to an Old Problem: One Brave Idea.

Cranley J, MacRae CA.

Circ Res. 2018 Apr 27;122(9):1172-1175. doi: 10.1161/CIRCRESAHA.118.310941. No abstract available.

PMID:
29700065
17.

Network Analysis to Risk Stratify Patients With Exercise Intolerance.

Oldham WM, Oliveira RKF, Wang RS, Opotowsky AR, Rubins DM, Hainer J, Wertheim BM, Alba GA, Choudhary G, Tornyos A, MacRae CA, Loscalzo J, Leopold JA, Waxman AB, Olschewski H, Kovacs G, Systrom DM, Maron BA.

Circ Res. 2018 Mar 16;122(6):864-876. doi: 10.1161/CIRCRESAHA.117.312482. Epub 2018 Feb 5.

18.

Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression.

Colombo S, de Sena-Tomás C, George V, Werdich AA, Kapur S, MacRae CA, Targoff KL.

Development. 2018 Feb 5;145(3). pii: dev161497. doi: 10.1242/dev.161497.

19.

Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration.

Natarajan N, Abbas Y, Bryant DM, Gonzalez-Rosa JM, Sharpe M, Uygur A, Cocco-Delgado LH, Ho NN, Gerard NP, Gerard CJ, MacRae CA, Burns CE, Burns CG, Whited JL, Lee RT.

Circulation. 2018 May 15;137(20):2152-2165. doi: 10.1161/CIRCULATIONAHA.117.030801. Epub 2018 Jan 18.

20.

Closing the Genotype-Phenotype Loop for Precision Medicine.

MacRae CA, Seidman CE.

Circulation. 2017 Oct 17;136(16):1492-1494. doi: 10.1161/CIRCULATIONAHA.117.030831. No abstract available.

21.

A Comparison of Whole Genome Sequencing to Multigene Panel Testing in Hypertrophic Cardiomyopathy Patients.

Cirino AL, Lakdawala NK, McDonough B, Conner L, Adler D, Weinfeld M, O'Gara P, Rehm HL, Machini K, Lebo M, Blout C, Green RC, MacRae CA, Seidman CE, Ho CY; MedSeq Project*.

Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001768. doi: 10.1161/CIRCGENETICS.117.001768.

22.

Discovering New Diseases to Accelerate Precision Medicine.

Macrae CA.

Trans Am Clin Climatol Assoc. 2017;128:83-89.

23.

Genomic Medicine in Cardiovascular Fellowship Training.

Aday AW, MacRae CA.

Circulation. 2017 Jul 25;136(4):345-346. doi: 10.1161/CIRCULATIONAHA.117.027568. Review. No abstract available.

24.

Identification of pathogenic gene mutations in LMNA and MYBPC3 that alter RNA splicing.

Ito K, Patel PN, Gorham JM, McDonough B, DePalma SR, Adler EE, Lam L, MacRae CA, Mohiuddin SM, Fatkin D, Seidman CE, Seidman JG.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7689-7694. doi: 10.1073/pnas.1707741114. Epub 2017 Jul 5.

25.

The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial.

Vassy JL, Christensen KD, Schonman EF, Blout CL, Robinson JO, Krier JB, Diamond PM, Lebo M, Machini K, Azzariti DR, Dukhovny D, Bates DW, MacRae CA, Murray MF, Rehm HL, McGuire AL, Green RC; MedSeq Project.

Ann Intern Med. 2017 Jun 27;167(3):159-169. doi: 10.7326/M17-0188. Print 2017 Aug 1.

26.

Skin and Vascular Disease-Inside-Out/Outside-In.

MacRae CA.

JAMA Cardiol. 2017 Sep 1;2(9):944-945. doi: 10.1001/jamacardio.2017.1420. No abstract available.

PMID:
28564684
27.

Family history of atrial fibrillation as a predictor of atrial substrate and arrhythmia recurrence in patients undergoing atrial fibrillation catheter ablation.

Kapur S, Kumar S, John RM, Stevenson WG, Tedrow UB, Koplan BA, Epstein LM, MacRae CA, Michaud GF.

Europace. 2018 Jun 1;20(6):921-928. doi: 10.1093/europace/eux107.

PMID:
28541417
28.

The Design of the Valsartan for Attenuating Disease Evolution in Early Sarcomeric Hypertrophic Cardiomyopathy (VANISH) Trial.

Ho CY, McMurray JJV, Cirino AL, Colan SD, Day SM, Desai AS, Lipshultz SE, MacRae CA, Shi L, Solomon SD, Orav EJ, Braunwald E; VANISH trial investigators and executive committee.

Am Heart J. 2017 May;187:145-155. doi: 10.1016/j.ahj.2017.02.008. Epub 2017 Feb 16.

29.

Cisplatin Analogs Confer Protection against Cyanide Poisoning.

Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT.

Cell Chem Biol. 2017 May 18;24(5):565-575.e4. doi: 10.1016/j.chembiol.2017.03.013. Epub 2017 Apr 13.

30.

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.

Wild PS, Felix JF, Schillert A, Teumer A, Chen MH, Leening MJG, Völker U, Großmann V, Brody JA, Irvin MR, Shah SJ, Pramana S, Lieb W, Schmidt R, Stanton AV, Malzahn D, Smith AV, Sundström J, Minelli C, Ruggiero D, Lyytikäinen LP, Tiller D, Smith JG, Monnereau C, Di Tullio MR, Musani SK, Morrison AC, Pers TH, Morley M, Kleber ME, Aragam J, Benjamin EJ, Bis JC, Bisping E, Broeckel U, Cheng S, Deckers JW, Del Greco M F, Edelmann F, Fornage M, Franke L, Friedrich N, Harris TB, Hofer E, Hofman A, Huang J, Hughes AD, Kähönen M, Investigators K, Kruppa J, Lackner KJ, Lannfelt L, Laskowski R, Launer LJ, Leosdottir M, Lin H, Lindgren CM, Loley C, MacRae CA, Mascalzoni D, Mayet J, Medenwald D, Morris AP, Müller C, Müller-Nurasyid M, Nappo S, Nilsson PM, Nuding S, Nutile T, Peters A, Pfeufer A, Pietzner D, Pramstaller PP, Raitakari OT, Rice KM, Rivadeneira F, Rotter JI, Ruohonen ST, Sacco RL, Samdarshi TE, Schmidt H, Sharp ASP, Shields DC, Sorice R, Sotoodehnia N, Stricker BH, Surendran P, Thom S, Töglhofer AM, Uitterlinden AG, Wachter R, Völzke H, Ziegler A, Münzel T, März W, Cappola TP, Hirschhorn JN, Mitchell GF, Smith NL, Fox ER, Dueker ND, Jaddoe VWV, Melander O, Russ M, Lehtimäki T, Ciullo M, Hicks AA, Lind L, Gudnason V, Pieske B, Barron AJ, Zweiker R, Schunkert H, Ingelsson E, Liu K, Arnett DK, Psaty BM, Blankenberg S, Larson MG, Felix SB, Franco OH, Zeller T, Vasan RS, Dörr M.

J Clin Invest. 2017 May 1;127(5):1798-1812. doi: 10.1172/JCI84840. Epub 2017 Apr 10.

31.

An NPPB Promoter Polymorphism Associated With Elevated N-Terminal pro-B-Type Natriuretic Peptide and Lower Blood Pressure, Hypertension, and Mortality.

Seidelmann SB, Vardeny O, Claggett B, Yu B, Shah AM, Ballantyne CM, Selvin E, MacRae CA, Boerwinkle E, Solomon SD.

J Am Heart Assoc. 2017 Mar 24;6(4). pii: e005257. doi: 10.1161/JAHA.116.005257.

32.

Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research.

Manolio TA, Fowler DM, Starita LM, Haendel MA, MacArthur DG, Biesecker LG, Worthey E, Chisholm RL, Green ED, Jacob HJ, McLeod HL, Roden D, Rodriguez LL, Williams MS, Cooper GM, Cox NJ, Herman GE, Kingsmore S, Lo C, Lutz C, MacRae CA, Nussbaum RL, Ordovas JM, Ramos EM, Robinson PN, Rubinstein WS, Seidman C, Stranger BE, Wang H, Westerfield M, Bult C.

Cell. 2017 Mar 23;169(1):6-12. doi: 10.1016/j.cell.2017.03.005.

33.

Elucidation of MRAS-mediated Noonan syndrome with cardiac hypertrophy.

Higgins EM, Bos JM, Mason-Suares H, Tester DJ, Ackerman JP, MacRae CA, Sol-Church K, Gripp KW, Urrutia R, Ackerman MJ.

JCI Insight. 2017 Mar 9;2(5):e91225. doi: 10.1172/jci.insight.91225.

34.

Using Zebrafish for High-Throughput Screening of Novel Cardiovascular Drugs.

Kithcart A, MacRae CA.

JACC Basic Transl Sci. 2017 Feb 27;2(1):1-12. doi: 10.1016/j.jacbts.2017.01.004. eCollection 2017 Feb. Review.

35.

Zebrafish mesonephric renin cells are functionally conserved and comprise two distinct morphological populations.

Rider SA, Christian HC, Mullins LJ, Howarth AR, MacRae CA, Mullins JJ.

Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F778-F790. doi: 10.1152/ajprenal.00608.2016. Epub 2017 Feb 8.

36.

THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage.

Santiago-Sim T, Fang X, Hennessy ML, Nalbach SV, DePalma SR, Lee MS, Greenway SC, McDonough B, Hergenroeder GW, Patek KJ, Colosimo SM, Qualmann KJ, Hagan JP, Milewicz DM, MacRae CA, Dymecki SM, Seidman CE, Seidman JG, Kim DH.

Stroke. 2016 Dec;47(12):3005-3013. Epub 2016 Nov 15. Erratum in: Stroke. 2017 Aug;48(8):e240.

37.

A countermeasure development pipeline.

MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT.

Ann N Y Acad Sci. 2016 Aug;1378(1):58-67. doi: 10.1111/nyas.13224. Review.

38.

Animal-based studies will be essential for precision medicine.

Lloyd KC, Robinson PN, MacRae CA.

Sci Transl Med. 2016 Aug 17;8(352):352ed12. doi: 10.1126/scitranslmed.aaf5474. No abstract available.

PMID:
27535618
39.

The Future of Cardiovascular Education and Training.

Brown DW, MacRae CA, Gardner TJ.

Circulation. 2016 Jun 21;133(25):2734-42. doi: 10.1161/CIRCULATIONAHA.116.023554. Review. No abstract available.

PMID:
27324367
40.

The Future of Genetics and Genomics: Closing the Phenotype Gap in Precision Medicine.

MacRae CA, Vasan RS.

Circulation. 2016 Jun 21;133(25):2634-9. doi: 10.1161/CIRCULATIONAHA.116.022547. Review. No abstract available.

41.

The Future of Cardiovascular Therapeutics.

MacRae CA, Roden DM, Loscalzo J.

Circulation. 2016 Jun 21;133(25):2610-7. doi: 10.1161/CIRCULATIONAHA.116.023555. Review. No abstract available.

PMID:
27324356
42.

The Future of Cardiovascular Biomedicine.

MacRae CA, Loscalzo J.

Circulation. 2016 Jun 21;133(25):2601-2. doi: 10.1161/CIRCULATIONAHA.115.020553. No abstract available.

PMID:
27324354
43.

Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy.

Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R, MacRae CA, Leber R, Kleber AG, Saffitz JE, Judge DP.

JCI Insight. 2016 Apr 21;1(5). pii: 85923. doi: 10.1172/jci.insight.85923.

44.

Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators.

Musso G, Mosimann C, Panáková D, Burger A, Zhou Y, Zon LI, MacRae CA.

Genom Data. 2015 Sep 16;6:199-201. doi: 10.1016/j.gdata.2015.09.015. eCollection 2015 Dec.

45.

In vitro and in vivo reprogramming for the conduction system.

MacRae CA.

Trends Cardiovasc Med. 2016 Jan;26(1):21-2. doi: 10.1016/j.tcm.2015.08.005. Epub 2015 Aug 28. No abstract available.

PMID:
26632016
46.

Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.

Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):E6780-9. doi: 10.1073/pnas.1512968112. Epub 2015 Nov 23.

47.

Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015.

Antman EM, Benjamin EJ, Harrington RA, Houser SR, Peterson ED, Bauman MA, Brown N, Bufalino V, Califf RM, Creager MA, Daugherty A, Demets DL, Dennis BP, Ebadollahi S, Jessup M, Lauer MS, Lo B, MacRae CA, McConnell MV, McCray AT, Mello MM, Mueller E, Newburger JW, Okun S, Packer M, Philippakis A, Ping P, Prasoon P, Roger VL, Singer S, Temple R, Turner MB, Vigilante K, Warner J, Wayte P; American Heart Association Data Sharing Summit Attendees.

J Am Heart Assoc. 2015 Nov 5;4(11). pii: e002810. doi: 10.1161/JAHA.115.002810.

48.

The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3.

Cullere X, Plovie E, Bennett PM, MacRae CA, Mayadas TN.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14284-9. doi: 10.1073/pnas.1510495112. Epub 2015 Nov 4.

49.

Effect Size Does Matter: The Long Road to Mechanistic Insight From Genome-Wide Association.

MacRae CA, Pollak MR.

Circulation. 2015 Nov 24;132(21):1943-5. doi: 10.1161/CIRCULATIONAHA.115.019306. Epub 2015 Oct 20. No abstract available.

PMID:
26487758
50.

Zebrafish as tools for drug discovery.

MacRae CA, Peterson RT.

Nat Rev Drug Discov. 2015 Oct;14(10):721-31. doi: 10.1038/nrd4627. Epub 2015 Sep 11. Review.

PMID:
26361349

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