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Items: 1 to 50 of 230

1.

Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition.

Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, Liggitt D, Eaton KD, Martins R, Poirier JT, Rudin CM, Milletti F, Cheng WY, Mack F, MacPherson D.

Sci Signal. 2019 Feb 5;12(567). pii: eaau2922. doi: 10.1126/scisignal.aau2922.

PMID:
30723171
2.

Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.

MacPherson DJ, Mills CL, Ondrechen MJ, Hardy JA.

J Biol Chem. 2019 Jan 4;294(1):71-88. doi: 10.1074/jbc.RA118.005914. Epub 2018 Nov 12.

PMID:
30420425
3.

Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition.

Jia D, Augert A, Kim DW, Eastwood E, Wu N, Ibrahim AH, Kim KB, Dunn CT, Pillai SPS, Gazdar AF, Bolouri H, Park KS, MacPherson D.

Cancer Discov. 2018 Nov;8(11):1422-1437. doi: 10.1158/2159-8290.CD-18-0385. Epub 2018 Sep 4.

PMID:
30181244
4.

Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8.

Eron SJ, MacPherson DJ, Dagbay KB, Hardy JA.

ACS Chem Biol. 2018 May 18;13(5):1279-1290. doi: 10.1021/acschembio.8b00064. Epub 2018 Apr 11.

5.

Case Report: Metastatic Infratemporal Soft Tissue Myeloma Presenting as a Numb Lower Lip.

Rice N, Srinivasan B, Macpherson D.

Dent Update. 2017 Jan;44(1):53-4.

PMID:
29172311
6.

Switchable Hydrolase Based on Reversible Formation of Supramolecular Catalytic Site Using a Self-Assembling Peptide.

Zhang C, Shafi R, Lampel A, MacPherson D, Pappas CG, Narang V, Wang T, Maldarelli C, Ulijn RV.

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14511-14515. doi: 10.1002/anie.201708036. Epub 2017 Oct 11.

PMID:
28941038
7.

Effect of footshock stress on place conditioning produced by Δ9-tetrahydrocannabinol and the fatty acid amide hydrolase (FAAH) inhibitor, URB597, in Sprague-Dawley rats.

DeVuono MV, Wills KL, MacPherson DV, Hrelja KM, Parker LA.

Psychopharmacology (Berl). 2017 Nov;234(21):3229-3240. doi: 10.1007/s00213-017-4714-6. Epub 2017 Aug 12.

PMID:
28803323
8.

Erratum to: Telling our stories: heroin-assisted treatment and SNAP activism in the Downtown Eastside of Vancouver.

Boyd S, Murray D; SNAP, MacPherson D.

Harm Reduct J. 2017 Jun 9;14(1):36. doi: 10.1186/s12954-017-0161-2. No abstract available.

9.

Telling our stories: heroin-assisted treatment and SNAP activism in the Downtown Eastside of Vancouver.

Boyd S, Murray D; SNAP, MacPherson D.

Harm Reduct J. 2017 May 18;14(1):27. doi: 10.1186/s12954-017-0152-3. Erratum in: Harm Reduct J. 2017 Jun 9;14 (1):36.

10.

Canadian harm reduction policies: A comparative content analysis of provincial and territorial documents, 2000-2015.

Wild TC, Pauly B, Belle-Isle L, Cavalieri W, Elliott R, Strike C, Tupper K, Hathaway A, Dell C, MacPherson D, Sinclair C, Karekezi K, Tan B, Hyshka E.

Int J Drug Policy. 2017 Jul;45:9-17. doi: 10.1016/j.drugpo.2017.03.014. Epub 2017 Apr 25. Review.

PMID:
28454045
11.

A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence.

Wu N, Jia D, Bates B, Basom R, Eberhart CG, MacPherson D.

J Clin Invest. 2017 Mar 1;127(3):888-898. doi: 10.1172/JCI88508. Epub 2017 Feb 6.

12.

Small Cell Lung Cancer Exhibits Frequent Inactivating Mutations in the Histone Methyltransferase KMT2D/MLL2: CALGB 151111 (Alliance).

Augert A, Zhang Q, Bates B, Cui M, Wang X, Wildey G, Dowlati A, MacPherson D.

J Thorac Oncol. 2017 Apr;12(4):704-713. doi: 10.1016/j.jtho.2016.12.011. Epub 2016 Dec 19.

13.

Lung Cancer Subtypes Generate Unique Immune Responses.

Busch SE, Hanke ML, Kargl J, Metz HE, MacPherson D, Houghton AM.

J Immunol. 2016 Dec 1;197(11):4493-4503. Epub 2016 Oct 31.

14.

Genomic landscape of retinoblastoma in Rb-/- p130-/- mice resembles human retinoblastoma.

Kooi IE, van Mil SE, MacPherson D, Mol BM, Moll AC, Meijers-Heijboer H, Kaspers GJ, Cloos J, Te Riele H, Dorsman JC.

Genes Chromosomes Cancer. 2017 Mar;56(3):231-242. doi: 10.1002/gcc.22429. Epub 2016 Nov 21.

PMID:
27750399
15.

NFIB overexpression cooperates with Rb/p53 deletion to promote small cell lung cancer.

Wu N, Jia D, Ibrahim AH, Bachurski CJ, Gronostajski RM, MacPherson D.

Oncotarget. 2016 Sep 6;7(36):57514-57524. doi: 10.18632/oncotarget.11583.

16.

Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer.

Kim DW, Wu N, Kim YC, Cheng PF, Basom R, Kim D, Dunn CT, Lee AY, Kim K, Lee CS, Singh A, Gazdar AF, Harris CR, Eisenman RN, Park KS, MacPherson D.

Genes Dev. 2016 Jun 1;30(11):1289-99. doi: 10.1101/gad.279307.116.

17.

Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.

Hill ME, MacPherson DJ, Wu P, Julien O, Wells JA, Hardy JA.

ACS Chem Biol. 2016 Jun 17;11(6):1603-12. doi: 10.1021/acschembio.5b00971. Epub 2016 Mar 31.

18.

Inhibition of renalase expression and signaling has antitumor activity in pancreatic cancer.

Guo X, Hollander L, MacPherson D, Wang L, Velazquez H, Chang J, Safirstein R, Cha C, Gorelick F, Desir GV.

Sci Rep. 2016 Mar 14;6:22996. doi: 10.1038/srep22996.

19.

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR.

J Thorac Oncol. 2016 Apr;11(4):453-74. doi: 10.1016/j.jtho.2016.01.012. Epub 2016 Jan 30. Review. No abstract available.

20.

Apicomplexan Energy Metabolism: Carbon Source Promiscuity and the Quiescence Hyperbole.

Jacot D, Waller RF, Soldati-Favre D, MacPherson DA, MacRae JI.

Trends Parasitol. 2016 Jan;32(1):56-70. doi: 10.1016/j.pt.2015.09.001. Epub 2015 Oct 17. Review.

PMID:
26472327
21.

Illicit drug use and harms, and related interventions and policy in Canada: A narrative review of select key indicators and developments since 2000.

Fischer B, Murphy Y, Rudzinski K, MacPherson D.

Int J Drug Policy. 2016 Jan;27:23-35. doi: 10.1016/j.drugpo.2015.08.007. Epub 2015 Aug 14. Review.

PMID:
26359046
22.

Radiolabeled metabolite and disposition studies in support of safety assessment.

Beattie A, Madden S, Lowrie C, MacPherson D.

Bioanalysis. 2015;7(5):507-11. doi: 10.4155/bio.15.18. No abstract available.

PMID:
25826132
23.

The comparative pathology of genetically engineered mouse models for neuroendocrine carcinomas of the lung.

Gazdar AF, Savage TK, Johnson JE, Berns A, Sage J, Linnoila RI, MacPherson D, McFadden DG, Farago A, Jacks T, Travis WD, Brambilla E.

J Thorac Oncol. 2015 Apr;10(4):553-64. doi: 10.1097/JTO.0000000000000459.

24.

Veteran, primary care provider, and specialist satisfaction with electronic consultation.

Rodriguez KL, Burkitt KH, Bayliss NK, Skoko JE, Switzer GE, Zickmund SL, Fine MJ, Macpherson DS.

JMIR Med Inform. 2015 Jan 14;3(1):e5. doi: 10.2196/medinform.3725.

25.

Treating transcriptional addiction in small cell lung cancer.

Augert A, MacPherson D.

Cancer Cell. 2014 Dec 8;26(6):783-784. doi: 10.1016/j.ccell.2014.11.012.

26.

Management of early stage cutaneous Merkel cell carcinoma of the head and neck.

Blythe JN, Macpherson D, Reuther WJ, Ethunandan M, Ilankovan V, Sharma S, Anand RA, Mellor TK, Kerawala C, Brennan PA.

Br J Oral Maxillofac Surg. 2014 Nov;52(9):806-9. doi: 10.1016/j.bjoms.2014.06.009. Epub 2014 Aug 27.

PMID:
25174318
27.

RET mutation and expression in small-cell lung cancer.

Dabir S, Babakoohi S, Kluge A, Morrow JJ, Kresak A, Yang M, MacPherson D, Wildey G, Dowlati A.

J Thorac Oncol. 2014 Sep;9(9):1316-23. doi: 10.1097/JTO.0000000000000234.

28.

Primary care staff perspectives on a virtual learning collaborative to support medical home implementation.

Butler A, Canamucio A, Macpherson D, Skoko J, True G.

J Gen Intern Med. 2014 Jul;29 Suppl 2:S579-88. doi: 10.1007/s11606-013-2668-x.

29.

PTEN is a potent suppressor of small cell lung cancer.

Cui M, Augert A, Rongione M, Conkrite K, Parazzoli S, Nikitin AY, Ingolia N, MacPherson D.

Mol Cancer Res. 2014 May;12(5):654-9. doi: 10.1158/1541-7786.MCR-13-0554. Epub 2014 Jan 30.

30.

The Diabetes Telemonitoring Study Extension: an exploratory randomized comparison of alternative interventions to maintain glycemic control after withdrawal of diabetes home telemonitoring.

Stone RA, Sevick MA, Rao RH, Macpherson DS, Cheng C, Kim S, Hough LJ, DeRubertis FR.

J Am Med Inform Assoc. 2012 Nov-Dec;19(6):973-9. doi: 10.1136/amiajnl-2012-000815. Epub 2012 May 19.

31.

Update in general internal medicine: evidence published in 2011.

Brooks RC, Hasley PB, Jasti H, Macpherson D.

Ann Intern Med. 2012 May 1;156(9):649-53. doi: 10.7326/0003-4819-156-9-201205010-00410. Epub 2012 Apr 18. Review. No abstract available.

PMID:
22517813
32.

Cooperation between Rb and Arf in suppressing mouse retinoblastoma.

Conkrite K, Sundby M, Mu D, Mukai S, MacPherson D.

J Clin Invest. 2012 May;122(5):1726-33. doi: 10.1172/JCI61403. Epub 2012 Apr 9.

33.

Small cell lung cancer: new insights into origins.

MacPherson D.

Cell Cycle. 2011 Oct 15;10(20):3432. doi: 10.4161/cc.10.20.17664. Epub 2011 Oct 15. No abstract available.

PMID:
22030465
34.

miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma.

Conkrite K, Sundby M, Mukai S, Thomson JM, Mu D, Hammond SM, MacPherson D.

Genes Dev. 2011 Aug 15;25(16):1734-45. doi: 10.1101/gad.17027411. Epub 2011 Aug 4.

35.

Oral elastofibromatous lesions: a review and case series.

Darling MR, Kutalowski M, MacPherson DG, Jackson-Boeters L, Wysocki GP.

Head Neck Pathol. 2011 Sep;5(3):254-8. doi: 10.1007/s12105-011-0274-y. Epub 2011 Jun 18. Review.

36.

On the utility of S-mesitylsulfinimines for the stereoselective synthesis of chiral amines and aziridines.

Roe C, Moragas Solá T, Sasraku-Neequaye L, Hobbs H, Churcher I, MacPherson D, Stockman RA.

Chem Commun (Camb). 2011 Jul 14;47(26):7491-3. doi: 10.1039/c1cc11870f. Epub 2011 May 31.

PMID:
21629906
37.

Health aspects of the pre-departure phase of migration.

Gushulak BD, MacPherson DW.

PLoS Med. 2011 May;8(5):e1001035. doi: 10.1371/journal.pmed.1001035. Epub 2011 May 24. No abstract available.

38.

Metabolism of [(14)c]chlorantraniliprole in the lactating goat.

Gaddamidi V, Scott MT, Swain RS, Macpherson D, Lowrie C.

J Agric Food Chem. 2011 Feb 23;59(4):1316-23. doi: 10.1021/jf103558n. Epub 2011 Jan 11.

PMID:
21222458
39.

Is a new definition required for travelers who visit friends and relatives?

Matteelli A, Stauffer WM, Barnett ED, MacPherson DW, Loutan L, Hatz C, Behrens RH.

J Travel Med. 2010 Nov-Dec;17(6):430-1; discussion 431. doi: 10.1111/j.1708-8305.2010.00468_1.x. No abstract available.

40.

Head and neck pilomatricoma: an analysis of 201 cases.

O'Connor N, Patel M, Umar T, Macpherson DW, Ethunandan M.

Br J Oral Maxillofac Surg. 2011 Jul;49(5):354-8. doi: 10.1016/j.bjoms.2010.06.002. Epub 2010 Jul 1.

PMID:
20594627
41.

The visiting friends or relatives traveler in the 21st century: time for a new definition.

Barnett ED, MacPherson DW, Stauffer WM, Loutan L, Hatz CF, Matteelli A, Behrens RH.

J Travel Med. 2010 May-Jun;17(3):163-70. doi: 10.1111/j.1708-8305.2010.00411.x. Review.

42.

Travel case scenarios as a demonstration of risk assessment of VFR travelers: introduction to criteria and evidence-based definition and framework.

Behrens RH, Stauffer WM, Barnett ED, Loutan L, Hatz CF, Matteelli A, Macpherson DW.

J Travel Med. 2010 May-Jun;17(3):153-62. doi: 10.1111/j.1708-8305.2010.00398.x.

43.

Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine.

Nichols PL, Brand J, Briggs M, D'Angeli M, Farge J, Garland SL, Goldsmith P, Hutchings R, Kilford I, Li HY, MacPherson D, Nimmo F, Sanderson FD, Sehmi S, Shuker N, Skidmore J, Stott M, Sweeting J, Tajuddin H, Takle AK, Trani G, Wall ID, Ward R, Wilson DM, Witty D.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1368-72. doi: 10.1016/j.bmcl.2010.01.012. Epub 2010 Jan 11.

PMID:
20097071
44.

Active care management supported by home telemonitoring in veterans with type 2 diabetes: the DiaTel randomized controlled trial.

Stone RA, Rao RH, Sevick MA, Cheng C, Hough LJ, Macpherson DS, Franko CM, Anglin RA, Obrosky DS, Derubertis FR.

Diabetes Care. 2010 Mar;33(3):478-84. doi: 10.2337/dc09-1012. Epub 2009 Dec 15.

45.

Population mobility, globalization, and antimicrobial drug resistance.

MacPherson DW, Gushulak BD, Baine WB, Bala S, Gubbins PO, Holtom P, Segarra-Newnham M.

Emerg Infect Dis. 2009 Nov;15(11):1727-32. Review.

46.

GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility.

Sanger GJ, Westaway SM, Barnes AA, Macpherson DT, Muir AI, Jarvie EM, Bolton VN, Cellek S, Näslund E, Hellström PM, Borman RA, Unsworth WP, Matthews KL, Lee K.

Neurogastroenterol Motil. 2009 Jun;21(6):657-64, e30-1. doi: 10.1111/j.1365-2982.2008.01270.x.

PMID:
19374732
47.

Online communication as a potential travel medicine research tool: analysis of messages posted on the TravelMed listserv.

Macdonald L, MacPherson DW, Gushulak BD.

J Travel Med. 2009 Jan-Feb;16(1):7-12. doi: 10.1111/j.1708-8305.2008.00255.x.

48.

Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.

Westaway SM, Brown SL, Fell SC, Johnson CN, MacPherson DT, Mitchell DJ, Myatt JW, Stanway SJ, Seal JT, Stemp G, Thompson M, Lawless K, McKay F, Muir AI, Barford JM, Cluff C, Mahmood SR, Matthews KL, Mohamed S, Smith B, Stevens AJ, Bolton VJ, Jarvie EM, Sanger GJ.

J Med Chem. 2009 Feb 26;52(4):1180-9. doi: 10.1021/jm801332q.

PMID:
19191554
49.

Migrants and emerging public health issues in a globalized world: threats, risks and challenges, an evidence-based framework.

Gushulak B, Weekers J, Macpherson D.

Emerg Health Threats J. 2009;2:e10. doi: 10.3134/ehtj.09.010. Epub 2010 Mar 31.

50.

The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor.

Westaway SM, Brown SL, Conway E, Heightman TD, Johnson CN, Lapsley K, Macdonald GJ, MacPherson DT, Mitchell DJ, Myatt JW, Seal JT, Stanway SJ, Stemp G, Thompson M, Celestini P, Colombo A, Consonni A, Gagliardi S, Riccaboni M, Ronzoni S, Briggs MA, Matthews KL, Stevens AJ, Bolton VJ, Boyfield I, Jarvie EM, Stratton SC, Sanger GJ.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6429-36. doi: 10.1016/j.bmcl.2008.10.072. Epub 2008 Oct 19.

PMID:
19006669

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