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Spleen tyrosine kinase expression is correlated with human papillomavirus in head and neck cancer.

Black M, Ghasemi F, Sun RX, Stecho W, Datti A, Meens J, Pinto N, Ruicci KM, Khan MI, Han MW, Shaikh M, Yoo J, Fung K, MacNeil D, Palma DA, Winquist E, Howlett CJ, Mymryk JS, Ailles L, Boutros PC, Barrett JW, Nichols AC.

Oral Oncol. 2019 Dec 19;101:104529. doi: 10.1016/j.oraloncology.2019.104529. [Epub ahead of print]


Genomic and human papillomavirus profiling of an oral cancer cohort identifies TP53 as a predictor of overall survival.

Mundi N, Prokopec SD, Ghasemi F, Warner A, Patel K, MacNeil D, Howlett C, Stecho W, Plantinga P, Pinto N, Ruicci KM, Khan MI, Han MW, Yoo J, Fung K, Sahovaler A, Palma DA, Winquist E, Mymryk JS, Barrett JW, Boutros PC, Nichols AC.

Cancers Head Neck. 2019 Dec 5;4:5. doi: 10.1186/s41199-019-0045-0. eCollection 2019.


Erratum to: Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition.

Ruicci KM, Plantinga P, Pinto N, Khan MI, Stecho W, Dhaliwal SS, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Howlett CJ, Nichols AC.

Mol Oncol. 2020 Jan;14(1):230-231. doi: 10.1002/1878-0261.12604. Epub 2019 Dec 5. No abstract available.


Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition.

Ruicci KM, Plantinga P, Pinto N, Khan MI, Stecho W, Dhaliwal SS, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Howlett CJ, Nichols AC.

Mol Oncol. 2019 Oct;13(10):2160-2177. doi: 10.1002/1878-0261.12558. Epub 2019 Aug 28. Erratum in: Mol Oncol. 2020 Jan;14(1):230-231.


N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation.

MacNeil DE, Lambert-Lanteigne P, Autexier C.

Nucleic Acids Res. 2019 Jun 4;47(10):5368-5380. doi: 10.1093/nar/gkz233.


Mutational analysis of head and neck squamous cell carcinoma stratified by smoking status.

Ghasemi F, Prokopec SD, MacNeil D, Mundi N, Gameiro SF, Howlett C, Stecho W, Plantinga P, Pinto N, Ruicci KM, Khan MI, Yoo J, Fung K, Sahovaler A, Palma DA, Winquist E, Mymryk JS, Barrett JW, Boutros PC, Nichols AC.

JCI Insight. 2019 Jan 10;4(1). pii: 123443. doi: 10.1172/jci.insight.123443. [Epub ahead of print]


Shouldering the load of mandible reconstruction: 81 cases of oromandibular reconstruction with the scapular tip free flap.

Yeh DH, Lee DJ, Sahovaler A, Fung K, MacNeil D, Nichols AC, Yoo J.

Head Neck. 2019 Jan;41(1):30-36. doi: 10.1002/hed.25342. Epub 2018 Dec 4.


A controlled trial of HNSCC patient-derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth.

Ruicci KM, Meens J, Sun RX, Rizzo G, Pinto N, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Boutros PC, Ailles L, Nichols AC.

Int J Cancer. 2019 Oct 15;145(8):2100-2106. doi: 10.1002/ijc.32009. Epub 2018 Dec 18. Erratum in: Int J Cancer. 2020 Jan 1;146(1):E23.


Lestaurtinib is a potent inhibitor of anaplastic thyroid cancer cell line models.

Pinto N, Prokopec SD, Vizeacoumar F, Searle K, Lowerison M, Ruicci KM, Yoo J, Fung K, MacNeil D, Lacefield JC, Leong HS, Mymryk JS, Barrett JW, Datti A, Boutros PC, Nichols AC.

PLoS One. 2018 Nov 12;13(11):e0207152. doi: 10.1371/journal.pone.0207152. eCollection 2018.


ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition.

Ruicci KM, Pinto N, Khan MI, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Nichols AC.

Oral Oncol. 2018 Sep;84:95-103. doi: 10.1016/j.oraloncology.2018.07.010. Epub 2018 Jul 27.


High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.

Ghasemi F, Black M, Sun RX, Vizeacoumar F, Pinto N, Ruicci KM, Yoo J, Fung K, MacNeil D, Palma DA, Winquist E, Mymryk JS, Ailles LA, Datti A, Barrett JW, Boutros PC, Nichols AC.

Oncotarget. 2018 May 25;9(40):26064-26071. doi: 10.18632/oncotarget.25436. eCollection 2018 May 25.


Troponin T monitoring to detect myocardial injury after noncardiac surgery: a cost-consequence analysis.

Buse GL, Manns B, Lamy A, Guyatt G, Polanczyk CA, Chan MTV, Wang CY, Villar JC, Sigamani A, Sessler DI, Berwanger O, Biccard BM, Pearse R, Urrútia G, Szczeklik W, Garutti I, Srinathan S, Malaga G, Abraham V, Chow CK, Jacka MJ, Tiboni M, Ackland G, Macneil D, Sapsford R, Leuwer M, Le Manach Y, Devereaux PJ.

Can J Surg. 2018 Jun;61(3):185-194.


The impact of seasonal operating room closures on wait times for oral cancer surgery.

Mundi N, Theurer J, Warner A, Yoo J, Fung K, MacNeil D, Dhaliwal S, Winquist E, Palma DA, Nichols AC.

Curr Oncol. 2018 Feb;25(1):67-72. doi: 10.3747/co.25.3726. Epub 2018 Feb 28.


Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer.

Ghasemi F, Black M, Vizeacoumar F, Pinto N, Ruicci KM, Le CCSH, Lowerison MR, Leong HS, Yoo J, Fung K, MacNeil D, Palma DA, Winquist E, Mymryk JS, Boutros PC, Datti A, Barrett JW, Nichols AC.

Oncotarget. 2017 Apr 20;8(42):71512-71519. doi: 10.18632/oncotarget.17292. eCollection 2017 Sep 22.


Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.

Hoyt SB, Taylor J, London C, Ali A, Ujjainwalla F, Tata J, Struthers M, Cully D, Wisniewski T, Ren N, Bopp C, Sok A, Verras A, McMasters D, Chen Q, Tung E, Tang W, Salituro G, Clemas J, Zhou G, MacNeil D, Duffy R, Xiong Y.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2384-2388. doi: 10.1016/j.bmcl.2017.04.021. Epub 2017 Apr 8.


Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension.

Petrilli WL, Hoyt SB, London C, McMasters D, Verras A, Struthers M, Cully D, Wisniewski T, Ren N, Bopp C, Sok A, Chen Q, Li Y, Tung E, Tang W, Salituro G, Knemeyer I, Karanam B, Clemas J, Zhou G, Gibson J, Shipley CA, MacNeil DJ, Duffy R, Tata JR, Ujjainwalla F, Ali A, Xiong Y.

ACS Med Chem Lett. 2016 Nov 22;8(1):128-132. doi: 10.1021/acsmedchemlett.6b00455. eCollection 2017 Jan 12.


Imidazopyridyl compounds as aldosterone synthase inhibitors.

Whitehead BR, Lo MM, Ali A, Park MK, Hoyt SB, Xiong Y, Cai J, Carswell E, Cooke A, MacLean J, Ratcliffe P, Robinson J, Bennett DJ, Clemas JA, Wisniewski T, Struthers M, Cully D, MacNeil DJ.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):143-146. doi: 10.1016/j.bmcl.2016.12.003. Epub 2016 Dec 2.


GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for glioblastoma growth.

Bayin NS, Frenster JD, Kane JR, Rubenstein J, Modrek AS, Baitalmal R, Dolgalev I, Rudzenski K, Scarabottolo L, Crespi D, Redaelli L, Snuderl M, Golfinos JG, Doyle W, Pacione D, Parker EC, Chi AS, Heguy A, MacNeil DJ, Shohdy N, Zagzag D, Placantonakis DG.

Oncogenesis. 2016 Oct 24;5(10):e263. doi: 10.1038/oncsis.2016.63.


Telomerase Regulation from Beginning to the End.

MacNeil DE, Bensoussan HJ, Autexier C.

Genes (Basel). 2016 Sep 14;7(9). pii: E64. doi: 10.3390/genes7090064. Review.


Aqueous-Based Fabrication of Low-VOC Nanostructured Block Copolymer Films as Potential Marine Antifouling Coatings.

Kim KS, Gunari N, MacNeil D, Finlay J, Callow M, Callow J, Walker GC.

ACS Appl Mater Interfaces. 2016 Aug 10;8(31):20342-51. doi: 10.1021/acsami.6b04629. Epub 2016 Jul 27.


The Influence of U.S. Chain Restaurant Food Consumption and Obesity in China and South Korea: An Ecological Perspective of Food Consumption, Self-Efficacy in Weight Management, Willingness to Communicate About Weight/Diet, and Depression.

Wright KB, Mazzone R, Oh H, Du J, Smithson AB, Ryan D, MacNeil D, Tong X, Stiller C.

Health Commun. 2016 Nov;31(11):1356-66. doi: 10.1080/10410236.2015.1072124. Epub 2016 Mar 23.


Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases.

Chu TW, MacNeil DE, Autexier C.

J Biol Chem. 2016 Apr 15;291(16):8374-86. doi: 10.1074/jbc.M116.714782. Epub 2016 Feb 17.


Corrigendum: Comparison of the SIMARD MD to clinical impression in assessing fitness to drive in patients with cognitive impairment.

Wernham M, Jarrett PG, Stewart C, MacDonald E, MacNeil D, Hobbs C.

Can Geriatr J. 2015 Jun 30;18(2):134. doi: 10.5770/cgj.18.200. eCollection 2015 Jun.


The control of anaplastic thyroid carcinoma cell lines by oncolytic poxviruses.

Mundi N, Um S, Yoo J, Rizzo G, Black M, Pinto N, Palma DA, Fung K, MacNeil D, Mymryk JS, Barrett JW, Nichols AC.

Virus Res. 2014 Sep 22;190:53-9. doi: 10.1016/j.virusres.2014.07.009. Epub 2014 Jul 16.


Variable expression of the forgotten oncogene E5 in HPV-positive oropharyngeal cancer.

Um SH, Mundi N, Yoo J, Palma DA, Fung K, MacNeil D, Wehrli B, Mymryk JS, Barrett JW, Nichols AC.

J Clin Virol. 2014 Sep;61(1):94-100. doi: 10.1016/j.jcv.2014.06.019. Epub 2014 Jun 30.


Comparison of the SIMARD MD to Clinical Impression in Assessing Fitness to Drive in Patients with Cognitive Impairment.

Wernham M, Jarrett PG, Stewart C, MacDonald E, MacNeil D, Hobbs C.

Can Geriatr J. 2014 Jun 3;17(2):63-9. doi: 10.5770/cgj.17.100. eCollection 2014 Jun. Erratum in: Can Geriatr J. 2015 Jun;18(2):134.


Myocardial injury after noncardiac surgery: a large, international, prospective cohort study establishing diagnostic criteria, characteristics, predictors, and 30-day outcomes.

Botto F, Alonso-Coello P, Chan MT, Villar JC, Xavier D, Srinathan S, Guyatt G, Cruz P, Graham M, Wang CY, Berwanger O, Pearse RM, Biccard BM, Abraham V, Malaga G, Hillis GS, Rodseth RN, Cook D, Polanczyk CA, Szczeklik W, Sessler DI, Sheth T, Ackland GL, Leuwer M, Garg AX, Lemanach Y, Pettit S, Heels-Ansdell D, Luratibuse G, Walsh M, Sapsford R, Schünemann HJ, Kurz A, Thomas S, Mrkobrada M, Thabane L, Gerstein H, Paniagua P, Nagele P, Raina P, Yusuf S, Devereaux PJ, Devereaux PJ, Sessler DI, Walsh M, Guyatt G, McQueen MJ, Bhandari M, Cook D, Bosch J, Buckley N, Yusuf S, Chow CK, Hillis GS, Halliwell R, Li S, Lee VW, Mooney J, Polanczyk CA, Furtado MV, Berwanger O, Suzumura E, Santucci E, Leite K, Santo JA, Jardim CA, Cavalcanti AB, Guimaraes HP, Jacka MJ, Graham M, McAlister F, McMurtry S, Townsend D, Pannu N, Bagshaw S, Bessissow A, Bhandari M, Duceppe E, Eikelboom J, Ganame J, Hankinson J, Hill S, Jolly S, Lamy A, Ling E, Magloire P, Pare G, Reddy D, Szalay D, Tittley J, Weitz J, Whitlock R, Darvish-Kazim S, Debeer J, Kavsak P, Kearon C, Mizera R, O'Donnell M, McQueen M, Pinthus J, Ribas S, Simunovic M, Tandon V, Vanhelder T, Winemaker M, Gerstein H, McDonald S, O'Bryne P, Patel A, Paul J, Punthakee Z, Raymer K, Salehian O, Spencer F, Walter S, Worster A, Adili A, Clase C, Cook D, Crowther M, Douketis J, Gangji A, Jackson P, Lim W, Lovrics P, Mazzadi S, Orovan W, Rudkowski J, Soth M, Tiboni M, Acedillo R, Garg A, Hildebrand A, Lam N, Macneil D, Mrkobrada M, Roshanov PS, Srinathan SK, Ramsey C, John PS, Thorlacius L, Siddiqui FS, Grocott HP, McKay A, Lee TW, Amadeo R, Funk D, McDonald H, Zacharias J, Villar JC, Cortés OL, Chaparro MS, Vásquez S, Castañeda A, Ferreira S, Coriat P, Monneret D, Goarin JP, Esteve CI, Royer C, Daas G, Chan MT, Choi GY, Gin T, Lit LC, Xavier D, Sigamani A, Faruqui A, Dhanpal R, Almeida S, Cherian J, Furruqh S, Abraham V, Afzal L, George P, Mala S, Schünemann H, Muti P, Vizza E, Wang CY, Ong GS, Mansor M, Tan AS, Shariffuddin II, Vasanthan V, Hashim NH, Undok AW, Ki U, Lai HY, Ahmad WA, Razack AH, Malaga G, Valderrama-Victoria V, Loza-Herrera JD, De Los Angeles Lazo M, Rotta-Rotta A, Szczeklik W, Sokolowska B, Musial J, Gorka J, Iwaszczuk P, Kozka M, Chwala M, Raczek M, Mrowiecki T, Kaczmarek B, Biccard B, Cassimjee H, Gopalan D, Kisten T, Mugabi A, Naidoo P, Naidoo R, Rodseth R, Skinner D, Torborg A, Paniagua P, Urrutia G, Maestre ML, Santaló M, Gonzalez R, Font A, Martínez C, Pelaez X, De Antonio M, Villamor JM, García JA, Ferré MJ, Popova E, Alonso-Coello P, Garutti I, Cruz P, Fernández C, Palencia M, Díaz S, Del Castillo T, Varela A, de Miguel A, Muñoz M, Piñeiro P, Cusati G, Del Barrio M, Membrillo MJ, Orozco D, Reyes F, Sapsford RJ, Barth J, Scott J, Hall A, Howell S, Lobley M, Woods J, Howard S, Fletcher J, Dewhirst N, Williams C, Rushton A, Welters I, Leuwer M, Pearse R, Ackland G, Khan A, Niebrzegowska E, Benton S, Wragg A, Archbold A, Smith A, McAlees E, Ramballi C, Macdonald N, Januszewska M, Stephens R, Reyes A, Paredes LG, Sultan P, Cain D, Whittle J, Del Arroyo AG, Sessler DI, Kurz A, Sun Z, Finnegan PS, Egan C, Honar H, Shahinyan A, Panjasawatwong K, Fu AY, Wang S, Reineks E, Nagele P, Blood J, Kalin M, Gibson D, Wildes T; Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Writing Group, on behalf of The Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Investigators; Appendix 1. The Vascular events In noncardiac Surgery patIents cOhort evaluatioN (VISION) Study Investigators Writing Group; Appendix 2. The Vascular events In noncardiac Surgery patIents cOhort evaluatioN Operations Committee; Vascular events In noncardiac Surgery patIents cOhort evaluatioN VISION Study Investigators.

Anesthesiology. 2014 Mar;120(3):564-78. doi: 10.1097/ALN.0000000000000113.


The role of melanin-concentrating hormone and its receptors in energy homeostasis.

Macneil DJ.

Front Endocrinol (Lausanne). 2013 Apr 22;4:49. doi: 10.3389/fendo.2013.00049. eCollection 2013.


Electrochemical characterisation of a lithium-ion battery electrolyte based on mixtures of carbonates with a ferrocene-functionalised imidazolium electroactive ionic liquid.

Forgie JC, El Khakani S, MacNeil DD, Rochefort D.

Phys Chem Chem Phys. 2013 May 28;15(20):7713-21. doi: 10.1039/c3cp50560j. Epub 2013 Apr 17.


Fine-tuning and the stability of recurrent neural networks.

MacNeil D, Eliasmith C.

PLoS One. 2011;6(9):e22885. doi: 10.1371/journal.pone.0022885. Epub 2011 Sep 27.


Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.

Wang L, Hubert JA, Lee SJ, Pan J, Qian S, Reitman ML, Strack AM, Weingarth DT, MacNeil DJ, Weber AE, Edmondson SD.

Bioorg Med Chem Lett. 2011 May 15;21(10):2911-5. doi: 10.1016/j.bmcl.2011.03.069. Epub 2011 Mar 31.


A miniaturized homogenous assay of mitochondrial membrane potential.

Vongs A, Solly KJ, Kiss L, Macneil DJ, Rosenblum CI.

Assay Drug Dev Technol. 2011 Aug;9(4):373-81. doi: 10.1089/adt.2010.0301. Epub 2011 Feb 6.


Identification of genes and networks driving cardiovascular and metabolic phenotypes in a mouse F2 intercross.

Derry JM, Zhong H, Molony C, MacNeil D, Guhathakurta D, Zhang B, Mudgett J, Small K, El Fertak L, Guimond A, Selloum M, Zhao W, Champy MF, Monassier L, Vogt T, Cully D, Kasarskis A, Schadt EE.

PLoS One. 2010 Dec 14;5(12):e14319. doi: 10.1371/journal.pone.0014319.


Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes.

Zhong H, Beaulaurier J, Lum PY, Molony C, Yang X, Macneil DJ, Weingarth DT, Zhang B, Greenawalt D, Dobrin R, Hao K, Woo S, Fabre-Suver C, Qian S, Tota MR, Keller MP, Kendziorski CM, Yandell BS, Castro V, Attie AD, Kaplan LM, Schadt EE.

PLoS Genet. 2010 May 6;6(5):e1000932. doi: 10.1371/journal.pgen.1000932.


Mechanism of the anti-obesity effects induced by a novel melanin-concentrating hormone 1-receptor antagonist in mice.

Ito M, Ishihara A, Gomori A, Matsushita H, Ito M, Metzger JM, Marsh DJ, Haga Y, Iwaasa H, Tokita S, Takenaga N, Sato N, MacNeil DJ, Moriya M, Kanatani A.

Br J Pharmacol. 2010 Jan 1;159(2):374-83. doi: 10.1111/j.1476-5381.2009.00536.x. Epub 2009 Dec 10.


Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.

Ito M, Ishihara A, Gomori A, Egashira S, Matsushita H, Mashiko S, Ito J, Ito M, Nakase K, Haga Y, Iwaasa H, Suzuki T, Ohtake N, Moriya M, Sato N, MacNeil DJ, Takenaga N, Tokita S, Kanatani A.

Eur J Pharmacol. 2009 Dec 10;624(1-3):77-83. doi: 10.1016/j.ejphar.2009.10.004. Epub 2009 Oct 18.


Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice.

Moriya R, Fujikawa T, Ito J, Shirakura T, Hirose H, Suzuki J, Fukuroda T, Macneil DJ, Kanatani A.

Eur J Pharmacol. 2010 Feb 10;627(1-3):258-64. doi: 10.1016/j.ejphar.2009.09.057. Epub 2009 Oct 8.


In vivo optical imaging of LacZ expression using lacZ transgenic mice.

Zhang GJ, Chen TB, Connolly B, Lin SA, Hargreaves R, Vanko A, Bednar B, Macneil DJ, Sur C, Williams DL.

Assay Drug Dev Technol. 2009 Aug;7(4):391-9. doi: 10.1089/adt.2009.0195.


MCH receptor peptide agonists and antagonists.

MacNeil DJ, Bednarek MA.

Peptides. 2009 Nov;30(11):2008-13. doi: 10.1016/j.peptides.2009.04.009. Epub 2009 May 4.


Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.

Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, Coon M, Zhang C, Estrada-Smith D, Farber CR, Wang SS, van Nas A, Ghazalpour A, Zhang B, Macneil DJ, Lamb JR, Dipple KM, Reitman ML, Mehrabian M, Lum PY, Schadt EE, Lusis AJ, Drake TA.

Nat Genet. 2009 Apr;41(4):415-23. doi: 10.1038/ng.325. Epub 2009 Mar 8.


Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.

Sakamoto T, Moriya M, Haga Y, Takahashi T, Shibata T, Okamoto O, Nonoshita K, Kitazawa H, Hidaka M, Gomori A, Iwaasa H, Ishihara A, Kanatani A, Fukami T, Gao YD, Macneil DJ, Yang L.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1564-8. doi: 10.1016/j.bmcl.2009.02.035. Epub 2009 Feb 12.


Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets.

Ronnebaum SM, Jensen MV, Hohmeier HE, Burgess SC, Zhou YP, Qian S, MacNeil D, Howard A, Thornberry N, Ilkayeva O, Lu D, Sherry AD, Newgard CB.

J Biol Chem. 2008 Oct 24;283(43):28909-17. doi: 10.1074/jbc.M804665200. Epub 2008 Aug 28.


2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

Berger R, Zhu C, Hansen AR, Harper B, Chen Z, Holt TG, Hubert J, Lee SJ, Pan J, Qian S, Reitman ML, Strack AM, Weingarth DT, Wolff M, Macneil DJ, Weber AE, Edmondson SD.

Bioorg Med Chem Lett. 2008 Sep 1;18(17):4833-7. doi: 10.1016/j.bmcl.2008.07.083. Epub 2008 Jul 24.


Discovery of imidazole carboxamides as potent and selective CCK1R agonists.

Zhu C, Hansen AR, Bateman T, Chen Z, Holt TG, Hubert JA, Karanam BV, Lee SJ, Pan J, Qian S, Reddy VB, Reitman ML, Strack AM, Tong V, Weingarth DT, Wolff MS, MacNeil DJ, Weber AE, Duffy JL, Edmondson SD.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4393-6. doi: 10.1016/j.bmcl.2008.06.057. Epub 2008 Jun 20.


Antagonism of central melanin-concentrating hormone 1 receptor alleviates steatohepatitis in mice.

Ito M, Gomori A, Suzuki J, Tsujioka S, Sasaki M, Matsuda M, Bednarek MA, Ito M, Ishihara A, Iwaasa H, Macneil DJ, Kanatani A.

J Endocrinol. 2008 Aug;198(2):309-15. doi: 10.1677/JOE-08-0087. Epub 2008 Jun 3.


Effects of a novel Y5 antagonist in obese mice: combination with food restriction or sibutramine.

Mashiko S, Ishihara A, Iwaasa H, Moriya R, Kitazawa H, Mitobe Y, Ito J, Gomori A, Matsushita H, Takahashi T, MacNeil DJ, Van der Ploeg LH, Fukami T, Kanatani A.

Obesity (Silver Spring). 2008 Jul;16(7):1510-5. doi: 10.1038/oby.2008.223. Epub 2008 Apr 10.


Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.

Qian S, Mumick S, Nizner P, Tota MR, Menetski J, Reitman ML, Macneil DJ.

Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):36-42. doi: 10.1111/j.1742-7843.2008.00228.x. Epub 2008 Jul 1.


Variations in DNA elucidate molecular networks that cause disease.

Chen Y, Zhu J, Lum PY, Yang X, Pinto S, MacNeil DJ, Zhang C, Lamb J, Edwards S, Sieberts SK, Leonardson A, Castellini LW, Wang S, Champy MF, Zhang B, Emilsson V, Doss S, Ghazalpour A, Horvath S, Drake TA, Lusis AJ, Schadt EE.

Nature. 2008 Mar 27;452(7186):429-35. doi: 10.1038/nature06757. Epub 2008 Mar 16.


Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents.

Shearman LP, Stribling DS, Camacho RE, Rosko KM, Wang J, Tong S, Feng Y, Marsh DJ, Yu H, Guan X, Spann SK, Macneil DJ, Fong TM, Metzger JM, Goulet MT, Hagmann WK, Plummer CW, Finke PE, Mills SG, Shah SK, Truong Q, Van der Ploeg LH, Macintyre DE, Strack AM.

Eur J Pharmacol. 2008 Jan 28;579(1-3):215-24. Epub 2007 Oct 25.


NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs.

MacNeil DJ.

Curr Top Med Chem. 2007;7(17):1721-33. Review.


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