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Items: 1 to 50 of 107

1.

Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation.

Melo H, Basso L, Iftinca M, MacNaughton WK, Hollenberg MD, McKay DM, Altier C.

Sci Rep. 2018 Oct 19;8(1):15551. doi: 10.1038/s41598-018-33620-7.

2.

Inhibition of Intestinal Epithelial Wound Healing through Protease-Activated Receptor-2 Activation in Caco2 Cells.

Fernando EH, Gordon MH, Beck PL, MacNaughton WK.

J Pharmacol Exp Ther. 2018 Nov;367(2):382-392. doi: 10.1124/jpet.118.249524. Epub 2018 Sep 6.

PMID:
30190338
3.

Interferon gamma decreases intestinal epithelial aquaporin 3 expression through downregulation of constitutive transcription.

Peplowski MA, Dicay M, Baggio CH, Wysokinski F, Renaux B, Hollenberg MD, Proud D, MacNaughton WK.

J Mol Med (Berl). 2018 Oct;96(10):1081-1093. doi: 10.1007/s00109-018-1681-2. Epub 2018 Aug 8.

PMID:
30090948
4.

ER-stress mobilization of death-associated protein kinase-1-dependent xenophagy counteracts mitochondria stress-induced epithelial barrier dysfunction.

Lopes F, Keita ÅV, Saxena A, Reyes JL, Mancini NL, Al Rajabi A, Wang A, Baggio CH, Dicay M, van Dalen R, Ahn Y, Carneiro MBH, Peters NC, Rho JM, MacNaughton WK, Girardin SE, Jijon H, Philpott DJ, Söderholm JD, McKay DM.

J Biol Chem. 2018 Mar 2;293(9):3073-3087. doi: 10.1074/jbc.RA117.000809. Epub 2018 Jan 9.

PMID:
29317503
5.

Tumor necrosis factor α decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription.

Peplowski MA, Vegso AJ, Iablokov V, Dicay M, Zaheer RS, Renaux B, Proud D, Hollenberg MD, Beck PL, MacNaughton WK.

Physiol Rep. 2017 Oct;5(19). pii: e13451. doi: 10.14814/phy2.13451. Epub 2017 Oct 16.

6.

A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function.

Fernando EH, Dicay M, Stahl M, Gordon MH, Vegso A, Baggio C, Alston L, Lopes F, Baker K, Hirota S, McKay DM, Vallance B, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G467-G475. doi: 10.1152/ajpgi.00152.2017. Epub 2017 Jul 27.

7.

Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function.

Lahey KA, Ronaghan NJ, Shang J, Dion SP, Désilets A, Leduc R, MacNaughton WK.

PLoS One. 2017 Jul 3;12(7):e0180259. doi: 10.1371/journal.pone.0180259. eCollection 2017.

8.

Hydrogen Sulfide-Releasing Therapeutics: Translation to the Clinic.

Wallace JL, Vaughan D, Dicay M, MacNaughton WK, de Nucci G.

Antioxid Redox Signal. 2018 Jun 1;28(16):1533-1540. doi: 10.1089/ars.2017.7068. Epub 2017 May 15.

PMID:
28388861
9.

Constipation-Predominant Irritable Bowel Syndrome Females Have Normal Colonic Barrier and Secretory Function.

Peters SA, Edogawa S, Sundt WJ, Dyer RB, Dalenberg DA, Mazzone A, Singh RJ, Moses N, Smyrk TC, Weber C, Linden DR, MacNaughton WK, Turner JR, Camilleri M, Katzka DA, Farrugia G, Grover M.

Am J Gastroenterol. 2017 Jun;112(6):913-923. doi: 10.1038/ajg.2017.48. Epub 2017 Mar 21.

10.

The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.

Ronaghan NJ, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, Désilets A, Leduc R, Turner JR, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G466-79. doi: 10.1152/ajpgi.00441.2015. Epub 2016 Aug 4.

11.

Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.

Spohn SN, Bianco F, Scott RB, Keenan CM, Linton AA, O'Neill CH, Bonora E, Dicay M, Lavoie B, Wilcox RL, MacNaughton WK, De Giorgio R, Sharkey KA, Mawe GM.

Gastroenterology. 2016 Nov;151(5):933-944.e3. doi: 10.1053/j.gastro.2016.07.032. Epub 2016 Jul 29.

12.

Probiotics Improve Inflammation-Associated Sickness Behavior by Altering Communication between the Peripheral Immune System and the Brain.

D'Mello C, Ronaghan N, Zaheer R, Dicay M, Le T, MacNaughton WK, Surrette MG, Swain MG.

J Neurosci. 2015 Jul 29;35(30):10821-30. doi: 10.1523/JNEUROSCI.0575-15.2015.

13.

Proteases and their receptors as mediators of inflammation-associated colon cancer.

Trusevych EH, MacNaughton WK.

Curr Pharm Des. 2015;21(21):2983-92. Review.

PMID:
26004412
14.

Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis.

MacEachern SJ, Patel BA, Keenan CM, Dicay M, Chapman K, McCafferty DM, Savidge TC, Beck PL, MacNaughton WK, Sharkey KA.

Gastroenterology. 2015 Aug;149(2):445-55.e3. doi: 10.1053/j.gastro.2015.04.007. Epub 2015 Apr 9.

15.

Interferon-γ suppresses intestinal epithelial aquaporin-1 expression via Janus kinase and STAT3 activation.

Dicay MS, Hirota CL, Ronaghan NJ, Peplowski MA, Zaheer RS, Carati CA, MacNaughton WK.

PLoS One. 2015 Mar 20;10(3):e0118713. doi: 10.1371/journal.pone.0118713. eCollection 2015.

16.

Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells.

Iablokov V, Hirota CL, Peplowski MA, Ramachandran R, Mihara K, Hollenberg MD, MacNaughton WK.

J Biol Chem. 2014 Dec 5;289(49):34366-77. doi: 10.1074/jbc.M114.610485. Epub 2014 Oct 20.

17.

Targeting mitochondria-derived reactive oxygen species to reduce epithelial barrier dysfunction and colitis.

Wang A, Keita ÅV, Phan V, McKay CM, Schoultz I, Lee J, Murphy MP, Fernando M, Ronaghan N, Balce D, Yates R, Dicay M, Beck PL, MacNaughton WK, Söderholm JD, McKay DM.

Am J Pathol. 2014 Sep;184(9):2516-27. doi: 10.1016/j.ajpath.2014.05.019. Epub 2014 Jul 14.

18.

MicroRNA-34a mediates the autocrine signaling of PAR2-activating proteinase and its role in colonic cancer cell proliferation.

Ma Y, Bao-Han W, Lv X, Su Y, Zhao X, Yin Y, Zhang X, Zhou Z, MacNaughton WK, Wang H.

PLoS One. 2013 Aug 26;8(8):e72383. doi: 10.1371/journal.pone.0072383. eCollection 2013.

19.

Attenuation of Clostridium difficile toxin-induced damage to epithelial barrier by ecto-5'-nucleotidase (CD73) and adenosine receptor signaling.

Schenck LP, Hirota SA, Hirota CL, Boasquevisque P, Tulk SE, Li Y, Wadhwani A, Doktorchik CT, Macnaughton WK, Beck PL, MacDonald JA.

Neurogastroenterol Motil. 2013 Jun;25(6):e441-53. doi: 10.1111/nmo.12139. Epub 2013 Apr 21. Erratum in: Neurogastroenterol Motil. 2014 Mar;26(3):445. Schenck, L Patrick [corrected to Schenck, L P].

PMID:
23600886
20.

Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure.

Hirota SA, Iablokov V, Tulk SE, Schenck LP, Becker H, Nguyen J, Al Bashir S, Dingle TC, Laing A, Liu J, Li Y, Bolstad J, Mulvey GL, Armstrong GD, MacNaughton WK, Muruve DA, MacDonald JA, Beck PL.

Infect Immun. 2012 Dec;80(12):4474-84. doi: 10.1128/IAI.00933-12. Epub 2012 Oct 8.

21.

Epidermal growth factor receptor transactivation is required for proteinase-activated receptor-2-induced COX-2 expression in intestinal epithelial cells.

Hirota CL, Moreau F, Iablokov V, Dicay M, Renaux B, Hollenberg MD, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2012 Jul;303(1):G111-9. doi: 10.1152/ajpgi.00358.2011. Epub 2012 Apr 19.

22.

Escherichia coli-induced epithelial hyporesponsiveness to secretagogues is associated with altered CFTR localization.

Ohland CL, DeVinney R, MacNaughton WK.

Cell Microbiol. 2012 Apr;14(4):447-59. doi: 10.1111/j.1462-5822.2011.01744.x. Epub 2012 Feb 8.

PMID:
22212348
23.

Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors.

Fichna J, Dicay M, Lewellyn K, Janecka A, Zjawiony JK, MacNaughton WK, Storr MA.

Inflamm Bowel Dis. 2012 Jun;18(6):1137-45. doi: 10.1002/ibd.21873. Epub 2011 Sep 26.

PMID:
21953882
24.

Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum.

Fichna J, Dicay M, Hirota SA, Traboulsi D, Macdonald JA, Janecka A, Beck PL, Zjawiony JK, Macnaughton WK, Storr MA.

Neurogastroenterol Motil. 2011 Jun;23(6):583-e212. doi: 10.1111/j.1365-2982.2011.01699.x. Epub 2011 Mar 17.

PMID:
21414104
25.

Adaptation of intestinal secretomotor function and nutrient absorption in response to diet-induced obesity.

Hyland NP, Rybicka JM, Ho W, Pittman QJ, Macnaughton WK, Sharkey KA.

Neurogastroenterol Motil. 2010 Jun;22(6):602-e171. doi: 10.1111/j.1365-2982.2010.01504.x. Epub 2010 Apr 20.

PMID:
20426798
26.

Probiotic bacteria and intestinal epithelial barrier function.

Ohland CL, Macnaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G807-19. doi: 10.1152/ajpgi.00243.2009. Epub 2010 Mar 18. Review.

27.

Differential effects of CB(1) neutral antagonists and inverse agonists on gastrointestinal motility in mice.

Storr MA, Bashashati M, Hirota C, Vemuri VK, Keenan CM, Duncan M, Lutz B, Mackie K, Makriyannis A, Macnaughton WK, Sharkey KA.

Neurogastroenterol Motil. 2010 Jul;22(7):787-96, e223. doi: 10.1111/j.1365-2982.2010.01478.x. Epub 2010 Feb 24.

28.

Proteinase-activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation.

Wang H, Moreau F, Hirota CL, MacNaughton WK.

FASEB J. 2010 Jun;24(6):1971-80. doi: 10.1096/fj.09-137646. Epub 2010 Jan 11.

PMID:
20065107
29.

Serine proteases decrease intestinal epithelial ion permeability by activation of protein kinase Czeta.

Swystun VA, Renaux B, Moreau F, Wen S, Peplowski MA, Hollenberg MD, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G60-70. doi: 10.1152/ajpgi.00096.2009. Epub 2009 May 21.

30.

Protease-activated receptor-2 stimulates intestinal epithelial chloride transport through activation of PLC and selective PKC isoforms.

van der Merwe JQ, Moreau F, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1258-66. doi: 10.1152/ajpgi.90425.2008. Epub 2009 Apr 9.

31.

Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis.

Wang H, Zhang R, Wen S, McCafferty DM, Beck PL, MacNaughton WK.

J Mol Med (Berl). 2009 Apr;87(4):435-45. doi: 10.1007/s00109-009-0445-4. Epub 2009 Feb 24.

PMID:
19238344
32.

Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2.

van der Merwe JQ, Ohland CL, Hirota CL, MacNaughton WK.

J Pharmacol Exp Ther. 2009 May;329(2):747-52. doi: 10.1124/jpet.108.145466. Epub 2009 Feb 3.

33.

EGF receptor transactivation and MAP kinase mediate proteinase-activated receptor-2-induced chloride secretion in intestinal epithelial cells.

van der Merwe JQ, Hollenberg MD, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2008 Feb;294(2):G441-51. Epub 2007 Nov 21.

34.

Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein.

Wang H, Wen S, Bunnett NW, Leduc R, Hollenberg MD, MacNaughton WK.

J Biol Chem. 2008 Jan 11;283(2):809-15. Epub 2007 Oct 25.

35.

Proteinase-activated receptor-2 activating peptides: distinct canine coronary artery receptor systems.

Saifeddine M, Seymour ML, Xiao YP, Compton SJ, Houle S, Ramachandran R, MacNaughton WK, Simonet S, Vayssettes-Courchay C, Verbeuren TJ, Hollenberg MD.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3279-89. Epub 2007 Aug 31.

36.

The risk of gastrointestinal malignancies in cystic fibrosis: case report of a patient with a near obstructing villous adenoma found on colon cancer screening and Barrett's esophagus.

Alexander CL, Urbanski SJ, Hilsden R, Rabin H, MacNaughton WK, Beck PL.

J Cyst Fibros. 2008 Jan;7(1):1-6. Epub 2007 Sep 4. Review.

37.

Combined challenge of mice with Citrobacter rodentium and ionizing radiation promotes bacterial translocation.

Skinn AC, Vergnolle N, Cellars L, Sherman PM, MacNaughton WK.

Int J Radiat Biol. 2007 Jun;83(6):375-82.

PMID:
17487677
38.

Citrobacter rodentium infection causes iNOS-independent intestinal epithelial dysfunction in mice.

Skinn AC, Vergnolle N, Zamuner SR, Wallace JL, Cellars L, MacNaughton WK, Sherman PM.

Can J Physiol Pharmacol. 2006 Dec;84(12):1301-12.

PMID:
17487239
39.

Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function.

Nasser Y, Fernandez E, Keenan CM, Ho W, Oland LD, Tibbles LA, Schemann M, MacNaughton WK, Rühl A, Sharkey KA.

Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G912-27. Epub 2006 Jun 22.

40.

Contractile activity of lymphatic vessels is altered in the TNBS model of guinea pig ileitis.

Wu TF, Carati CJ, Macnaughton WK, von der Weid PY.

Am J Physiol Gastrointest Liver Physiol. 2006 Oct;291(4):G566-74. Epub 2006 May 4.

41.

Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon.

O'Hara JR, Skinn AC, MacNaughton WK, Sherman PM, Sharkey KA.

Cell Microbiol. 2006 Apr;8(4):646-60.

PMID:
16548890
42.
43.

Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells.

Kawao N, Nagataki M, Nagasawa K, Kubo S, Cushing K, Wada T, Sekiguchi F, Ichida S, Hollenberg MD, MacNaughton WK, Nishikawa H, Kawabata A.

J Pharmacol Exp Ther. 2005 Nov;315(2):576-89. Epub 2005 Aug 24.

44.

Expression of proteinase-activated receptor 2 on human primary gastrointestinal myofibroblasts and stimulation of prostaglandin synthesis.

Seymour ML, Binion DG, Compton SJ, Hollenberg MD, MacNaughton WK.

Can J Physiol Pharmacol. 2005 Jul;83(7):605-16.

PMID:
16091786
45.

Nitric oxide inhibits cAMP-dependent CFTR trafficking in intestinal epithelial cells.

Skinn AC, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G739-44. Epub 2005 Jun 30.

46.

Epithelial effects of proteinase-activated receptors in the gastrointestinal tract.

MacNaughton WK.

Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:211-5. Epub 2005 Jun 14. Review.

47.

Lymphatic vessel contractile activity and intestinal inflammation.

Wu TF, MacNaughton WK, von der Weid PY.

Mem Inst Oswaldo Cruz. 2005 Mar;100 Suppl 1:107-10. Epub 2005 Jun 14.

48.

Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro.

Buresi MC, Vergnolle N, Sharkey KA, Keenan CM, Andrade-Gordon P, Cirino G, Cirillo D, Hollenberg MD, MacNaughton WK.

Am J Physiol Gastrointest Liver Physiol. 2005 Feb;288(2):G337-45. Epub 2004 Sep 2.

49.

Aquaporin expression is downregulated in a murine model of colitis and in patients with ulcerative colitis, Crohn's disease and infectious colitis.

Hardin JA, Wallace LE, Wong JF, O'Loughlin EV, Urbanski SJ, Gall DG, MacNaughton WK, Beck PL.

Cell Tissue Res. 2004 Nov;318(2):313-23. Epub 2004 Aug 27.

PMID:
15338270
50.

Submucosal secretomotor and vasodilator reflexes.

Vanner S, Macnaughton WK.

Neurogastroenterol Motil. 2004 Apr;16 Suppl 1:39-43. Review.

PMID:
15066003

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