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Items: 1 to 50 of 79

1.

Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells.

Kalwat MA, Hwang IH, Macho J, Grzemska MG, Yang JZ, McGlynn K, MacMillan JB, Cobb MH.

J Gen Physiol. 2018 Oct 23. pii: jgp.201812177. doi: 10.1085/jgp.201812177. [Epub ahead of print]

PMID:
30352794
2.

HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress.

Nichols BA, Oswald NW, McMillan EA, McGlynn K, Yan J, Kim MS, Saha J, Mallipeddi PL, LaDuke SA, Villalobos PA, Rodriguez-Canales J, Wistuba II, Posner BA, Davis AJ, Minna JD, MacMillan JB, Whitehurst AW.

Cancer Res. 2018 Nov 1;78(21):6196-6208. doi: 10.1158/0008-5472.CAN-18-1377. Epub 2018 Sep 5.

PMID:
30185546
3.

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2018 Jul 13. doi: 10.1039/c7np00064b. [Epub ahead of print] Review.

PMID:
30003207
4.

Author Correction: Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.

Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Oswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA.

Nat Commun. 2018 May 21;9(1):2050. doi: 10.1038/s41467-018-04519-8.

5.

Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer.

McMillan EA, Ryu MJ, Diep CH, Mendiratta S, Clemenceau JR, Vaden RM, Kim JH, Motoyaji T, Covington KR, Peyton M, Huffman K, Wu X, Girard L, Sung Y, Chen PH, Mallipeddi PL, Lee JY, Hanson J, Voruganti S, Yu Y, Park S, Sudderth J, DeSevo C, Muzny DM, Doddapaneni H, Gazdar A, Gibbs RA, Hwang TH, Heymach JV, Wistuba I, Coombes KR, Williams NS, Wheeler DA, MacMillan JB, Deberardinis RJ, Roth MG, Posner BA, Minna JD, Kim HS, White MA.

Cell. 2018 May 3;173(4):864-878.e29. doi: 10.1016/j.cell.2018.03.028. Epub 2018 Apr 19.

PMID:
29681454
6.

A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells.

Das B, Neilsen BK, Fisher KW, Gehring D, Hu Y, Volle DJ, Kim HS, McCall JL, Kelly DL, MacMillan JB, White MA, Lewis RE.

Sci Rep. 2018 Feb 28;8(1):3770. doi: 10.1038/s41598-018-22090-6.

7.

Small-molecule TFEB pathway agonists that ameliorate metabolic syndrome in mice and extend C. elegans lifespan.

Wang C, Niederstrasser H, Douglas PM, Lin R, Jaramillo J, Li Y, Oswald NW, Zhou A, McMillan EA, Mendiratta S, Wang Z, Zhao T, Lin Z, Luo M, Huang G, Brekken RA, Posner BA, MacMillan JB, Gao J, White MA.

Nat Commun. 2017 Dec 22;8(1):2270. doi: 10.1038/s41467-017-02332-3. Erratum in: Nat Commun. 2018 May 21;9(1):2050.

8.

Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways.

Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH.

ACS Sens. 2017 Feb 24;2(2):316. doi: 10.1021/acssensors.7b00012. Epub 2017 Jan 24. No abstract available.

PMID:
28723136
9.

Carpatizine, a novel bridged oxazine derivative generated by non-enzymatic reactions.

Fu P, MacMillan JB.

Org Biomol Chem. 2017 Jun 27;15(25):5275-5278. doi: 10.1039/c7ob01178d.

10.

Robotic-assisted vesicovaginal fistula repair using an extravesical approach without interposition grafting.

Kelly E, Wu MY, MacMillan JB.

J Robot Surg. 2018 Mar;12(1):173-176. doi: 10.1007/s11701-017-0694-0. Epub 2017 Mar 28.

PMID:
28353196
11.

FUSION-Guided Hypothesis Development Leads to the Identification of N⁶,N⁶-Dimethyladenosine, a Marine-Derived AKT Pathway Inhibitor.

Vaden RM, Oswald NW, Potts MB, MacMillan JB, White MA.

Mar Drugs. 2017 Mar 15;15(3). pii: E75. doi: 10.3390/md15030075.

12.

Daryamide Analogues from a Marine-Derived Streptomyces species.

Fu P, La S, MacMillan JB.

J Nat Prod. 2017 Apr 28;80(4):1096-1101. doi: 10.1021/acs.jnatprod.7b00011. Epub 2017 Feb 22.

PMID:
28225277
13.

Ammosamides Unveil Novel Biosynthetic Machinery.

Colosimo DA, MacMillan JB.

Cell Chem Biol. 2016 Dec 22;23(12):1444-1446. doi: 10.1016/j.chembiol.2016.12.001.

14.

Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways.

Kalwat MA, Wichaidit C, Nava Garcia AY, McCoy MK, McGlynn K, Hwang IH, MacMillan JB, Posner BA, Cobb MH.

ACS Sens. 2016 Oct 28;1(10):1208-1212. Epub 2016 Oct 12.

15.

Functional Identification of Putrescine C- and N-Hydroxylases.

Li B, Lowe-Power T, Kurihara S, Gonzales S, Naidoo J, MacMillan JB, Allen C, Michael AJ.

ACS Chem Biol. 2016 Oct 21;11(10):2782-2789. Epub 2016 Aug 24.

PMID:
27541336
16.

Ikarugamycin: A Natural Product Inhibitor of Clathrin-Mediated Endocytosis.

Elkin SR, Oswald NW, Reed DK, Mettlen M, MacMillan JB, Schmid SL.

Traffic. 2016 Oct;17(10):1139-49. doi: 10.1111/tra.12425. Epub 2016 Aug 8.

17.

One-Pot Synthesis of 5-Hydroxy-4H-1,3-thiazin-4-ones: Structure Revision, Synthesis, and NMR Shift Dependence of Thiasporine A.

Seitz T, Fu P, Haut FL, Adam L, Habicht M, Lentz D, MacMillan JB, Christmann M.

Org Lett. 2016 Jul 1;18(13):3070-3. doi: 10.1021/acs.orglett.6b01166. Epub 2016 Jun 10.

PMID:
27286418
18.

Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B.

Feng Y, Liu J, Carrasco YP, MacMillan JB, De Brabander JK.

J Am Chem Soc. 2016 Jun 8;138(22):7130-42. doi: 10.1021/jacs.6b03248. Epub 2016 May 27.

PMID:
27232659
19.

Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR.

Sato S, Jung H, Nakagawa T, Pawlosky R, Takeshima T, Lee WR, Sakiyama H, Laxman S, Wynn RM, Tu BP, MacMillan JB, De Brabander JK, Veech RL, Uyeda K.

J Biol Chem. 2016 May 13;291(20):10515-27. doi: 10.1074/jbc.M115.708982. Epub 2016 Mar 16.

20.

Structure Elucidation of Nigricanoside A Through Enantioselective Total Synthesis.

Chen J, Koswatta P, DeBergh JR, Fu P, Pan E, MacMillan JB, Ready JM.

Chem Sci. 2015 May 1;6(5):2932-2937. Epub 2015 Mar 12.

21.

Discovery, Characterization, and Analogue Synthesis of Bohemamine Dimers Generated by Non-enzymatic Biosynthesis.

Fu P, Legako A, La S, MacMillan JB.

Chemistry. 2016 Mar 1;22(10):3491-3495. doi: 10.1002/chem.201600024. Epub 2016 Feb 2.

22.

Detailed Mechanistic Study of the Non-enzymatic Formation of the Discoipyrrole Family of Natural Products.

Colosimo DA, MacMillan JB.

J Am Chem Soc. 2016 Feb 24;138(7):2383-8. doi: 10.1021/jacs.5b13320. Epub 2016 Feb 11.

23.

1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus.

Fu P, La S, MacMillan JB.

J Nat Prod. 2016 Mar 25;79(3):455-62. doi: 10.1021/acs.jnatprod.5b00604. Epub 2015 Oct 21.

24.

Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2.

Scheuermann TH, Stroud D, Sleet CE, Bayeh L, Shokri C, Wang H, Caldwell CG, Longgood J, MacMillan JB, Bruick RK, Gardner KH, Tambar UK.

J Med Chem. 2015 Aug 13;58(15):5930-41. doi: 10.1021/acs.jmedchem.5b00529. Epub 2015 Jul 30.

PMID:
26226049
25.

Total Syntheses and Biological Evaluation of Both Enantiomers of Several Hydroxylated Dimeric Nuphar Alkaloids.

Korotkov A, Li H, Chapman CW, Xue H, MacMillan JB, Eastman A, Wu J.

Angew Chem Int Ed Engl. 2015 Sep 1;54(36):10604-7. doi: 10.1002/anie.201503934. Epub 2015 Jul 16.

26.

Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus.

Fu P, MacMillan JB.

Org Lett. 2015 Jun 19;17(12):3046-9. doi: 10.1021/acs.orglett.5b01328. Epub 2015 May 29.

27.

Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B.

Potts MB, McMillan EA, Rosales TI, Kim HS, Ou YH, Toombs JE, Brekken RA, Minden MD, MacMillan JB, White MA.

Nat Chem Biol. 2015 Jun;11(6):401-8. doi: 10.1038/nchembio.1797. Epub 2015 Apr 13.

28.

Structural and mechanistic roles of novel chemical ligands on the SdiA quorum-sensing transcription regulator.

Nguyen Y, Nguyen NX, Rogers JL, Liao J, MacMillan JB, Jiang Y, Sperandio V.

MBio. 2015 Mar 31;6(2). pii: e02429-14. doi: 10.1128/mBio.02429-14.

29.

Thiasporines A-C, thiazine and thiazole derivatives from a marine-derived Actinomycetospora chlora.

Fu P, MacMillan JB.

J Nat Prod. 2015 Mar 27;78(3):548-51. doi: 10.1021/np500929z. Epub 2015 Jan 13.

30.

Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.

Fu P, Jamison M, La S, MacMillan JB.

Org Lett. 2014 Nov 7;16(21):5656-9. doi: 10.1021/ol502731p. Epub 2014 Oct 22.

31.

Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.

Derebe MG, Zlatkov CM, Gattu S, Ruhn KA, Vaishnava S, Diehl GE, MacMillan JB, Williams NS, Hooper LV.

Elife. 2014 Jul 29;3:e03206. doi: 10.7554/eLife.03206.

32.

Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived Streptomyces sp.

Fu P, Johnson M, Chen H, Posner BA, MacMillan JB.

J Nat Prod. 2014 May 23;77(5):1245-8. doi: 10.1021/np500207p. Epub 2014 Apr 23.

33.

Using functional signature ontology (FUSION) to identify mechanisms of action for natural products.

Potts MB, Kim HS, Fisher KW, Hu Y, Carrasco YP, Bulut GB, Ou YH, Herrera-Herrera ML, Cubillos F, Mendiratta S, Xiao G, Hofree M, Ideker T, Xie Y, Huang LJ, Lewis RE, MacMillan JB, White MA.

Sci Signal. 2013 Oct 15;6(297):ra90. doi: 10.1126/scisignal.2004657.

34.

Discoipyrroles A-D: isolation, structure determination, and synthesis of potent migration inhibitors from Bacillus hunanensis.

Hu Y, Potts MB, Colosimo D, Herrera-Herrera ML, Legako AG, Yousufuddin M, White MA, MacMillan JB.

J Am Chem Soc. 2013 Sep 11;135(36):13387-92. doi: 10.1021/ja403412y. Epub 2013 Aug 28.

35.

Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor.

Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK.

J Med Chem. 2013 Feb 28;56(4):1739-47. doi: 10.1021/jm301847z. Epub 2013 Feb 18.

36.

Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis.

Hu Y, Wang K, MacMillan JB.

Org Lett. 2013 Jan 18;15(2):390-3. doi: 10.1021/ol303376c. Epub 2013 Jan 10.

PMID:
23305153
37.

Precursor-Directed Generation of Amidine Containing Ammosamide Analogs: Ammosamides E-P.

Pan E, Oswald NW, Legako AG, Life JM, Posner BA, Macmillan JB.

Chem Sci. 2013 Jan;4(1):482-488.

38.

Anthraquinones from a marine-derived Streptomyces spinoverrucosus.

Hu Y, Martinez ED, MacMillan JB.

J Nat Prod. 2012 Oct 26;75(10):1759-64. doi: 10.1021/np3004326. Epub 2012 Oct 11.

39.

A labeled substrate approach to discovery of biocatalytic reactions: a proof of concept transformation with N-methylindole.

Rogers JL, MacMillan JB.

J Am Chem Soc. 2012 Aug 1;134(30):12378-81. doi: 10.1021/ja304767m. Epub 2012 Jul 18.

PMID:
22809085
40.

Ammosamide D, an oxidatively ring opened ammosamide analog from a marine-derived Streptomyces variabilis.

Pan E, Jamison M, Yousufuddin M, MacMillan JB.

Org Lett. 2012 May 4;14(9):2390-3. doi: 10.1021/ol300806e. Epub 2012 Apr 20.

41.

A new peptide isolated from a marine derived Streptomyces bacillaris.

Hu Y, MacMillan JB.

Nat Prod Commun. 2012 Feb;7(2):211-4.

42.

Erythrolic acids A-E, meroterpenoids from a marine-derived Erythrobacter sp.

Hu Y, Legako AG, Espindola AP, MacMillan JB.

J Org Chem. 2012 Apr 6;77(7):3401-7. doi: 10.1021/jo300197z. Epub 2012 Mar 12.

43.

Erythrazoles A-B, cytotoxic benzothiazoles from a marine-derived Erythrobacter sp.

Hu Y, MacMillan JB.

Org Lett. 2011 Dec 16;13(24):6580-3. doi: 10.1021/ol202944g. Epub 2011 Nov 22.

44.

Chromomycin SA analogs from a marine-derived Streptomyces sp.

Hu Y, Espindola AP, Stewart NA, Wei S, Posner BA, MacMillan JB.

Bioorg Med Chem. 2011 Sep 1;19(17):5183-9. doi: 10.1016/j.bmc.2011.07.013. Epub 2011 Jul 20.

45.

Towards patient-based cancer therapeutics.

Cancer Target Discovery and Development Network, Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, Sordella R, Stein L, Trotman LC, Califano A, Dalla-Favera R, Ferrando A, Iavarone A, Pasqualucci L, Silva J, Stockwell BR, Hahn WC, Chin L, DePinho RA, Boehm JS, Gopal S, Huang A, Root DE, Weir BA, Gerhard DS, Zenklusen JC, Roth MG, White MA, Minna JD, MacMillan JB, Posner BA.

Nat Biotechnol. 2010 Sep;28(9):904-6. doi: 10.1038/nbt0910-904. No abstract available.

46.

Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.

Maloney KN, Macmillan JB, Kauffman CA, Jensen PR, Dipasquale AG, Rheingold AL, Fenical W.

Org Lett. 2009 Dec 3;11(23):5422-4. doi: 10.1021/ol901997k.

47.

Deconvolution of complex NMR spectra in small molecules by multi frequency homonuclear decoupling (MDEC).

Espindola AP, Crouch R, DeBergh JR, Ready JM, MacMillan JB.

J Am Chem Soc. 2009 Nov 11;131(44):15994-5. doi: 10.1021/ja907110e.

PMID:
19845379
48.

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

Chiu YH, Macmillan JB, Chen ZJ.

Cell. 2009 Aug 7;138(3):576-91. doi: 10.1016/j.cell.2009.06.015. Epub 2009 Jul 23.

49.

Ammosamides A and B target myosin.

Hughes CC, MacMillan JB, Gaudêncio SP, Fenical W, La Clair JJ.

Angew Chem Int Ed Engl. 2009;48(4):728-32. doi: 10.1002/anie.200804107. No abstract available.

50.

The ammosamides: structures of cell cycle modulators from a marine-derived Streptomyces species.

Hughes CC, MacMillan JB, Gaudêncio SP, Jensen PR, Fenical W.

Angew Chem Int Ed Engl. 2009;48(4):725-7. doi: 10.1002/anie.200804890. No abstract available.

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