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Updated nomenclature of delirium and acute encephalopathy: statement of ten Societies.

Slooter AJC, Otte WM, Devlin JW, Arora RC, Bleck TP, Claassen J, Duprey MS, Ely EW, Kaplan PW, Latronico N, Morandi A, Neufeld KJ, Sharshar T, MacLullich AMJ, Stevens RD.

Intensive Care Med. 2020 Feb 13. doi: 10.1007/s00134-019-05907-4. [Epub ahead of print] No abstract available.


The 4AT - an instrument for delirium detection for older patients in the post-anaesthesia care unit.

Saller T, MacLullich AMJ, Perneczky R.

Anaesthesia. 2020 Mar;75(3):410. doi: 10.1111/anae.14937. No abstract available.


A smartphone-based test for the assessment of attention deficits in delirium: A case-control diagnostic test accuracy study in older hospitalised patients.

Tieges Z, Stott DJ, Shaw R, Tang E, Rutter LM, Nouzova E, Duncan N, Clarke C, Weir CJ, Assi V, Ensor H, Barnett JH, Evans J, Green S, Hendry K, Thomson M, McKeever J, Middleton DG, Parks S, Walsh T, Weir AJ, Wilson E, Quasim T, MacLullich AMJ.

PLoS One. 2020 Jan 24;15(1):e0227471. doi: 10.1371/journal.pone.0227471. eCollection 2020.


A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy.

Torvell M, Hampton DW, Connick P, MacLullich AMJ, Cunningham C, Chandran S.

Alzheimers Dement (N Y). 2019 Oct 9;5:579-591. doi: 10.1016/j.trci.2019.09.001. eCollection 2019.


Myocardial injury and anaemia in patients undergoing surgery for fractured neck of femur: An observational study.

Chew E, Ghaffar S, Docherty AB, Lang A, Dawson H, Keerie C, Ray DC, White TO, MacLullich AMJ, Mills NL, Walsh TS, Gillies MA.

Eur J Anaesthesiol. 2019 Nov;36(11):884-886. doi: 10.1097/EJA.0000000000001056. No abstract available.


An interdisciplinary statement of scientific societies for the advancement of delirium care across Europe (EDA, EANS, EUGMS, COTEC, IPTOP/WCPT).

Morandi A, Pozzi C, Milisen K, Hobbelen H, Bottomley JM, Lanzoni A, Tatzer VC, Carpena MG, Cherubini A, Ranhoff A, MacLullich AMJ, Teodorczuk A, Bellelli G.

BMC Geriatr. 2019 Sep 11;19(1):253. doi: 10.1186/s12877-019-1264-2.


Study protocol: ASCRIBED: the impact of Acute SystematiC inflammation upon cerebRospinal fluId and blood BiomarkErs of brain inflammation and injury in dementia: a study in acute hip fracture patients.

Leavey N, Hammond SP, Shepstone L, Cross J, Zetterberg H, Cunningham C, MacLullich A, Leiv Otto Watne, Minihane AM, Ballard C, Knapskog AB, Hall R, Howard G, Hammond M, Fox C.

BMC Neurol. 2019 Sep 7;19(1):223. doi: 10.1186/s12883-019-1447-7.


The 4 'A's test for detecting delirium in acute medical patients: a diagnostic accuracy study.

MacLullich AM, Shenkin SD, Goodacre S, Godfrey M, Hanley J, Stíobhairt A, Lavender E, Boyd J, Stephen J, Weir C, MacRaild A, Steven J, Black P, Diernberger K, Hall P, Tieges Z, Fox C, Anand A, Young J, Siddiqi N, Gray A.

Health Technol Assess. 2019 Aug;23(40):1-194. doi: 10.3310/hta23400.


Delirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method.

Shenkin SD, Fox C, Godfrey M, Siddiqi N, Goodacre S, Young J, Anand A, Gray A, Hanley J, MacRaild A, Steven J, Black PL, Tieges Z, Boyd J, Stephen J, Weir CJ, MacLullich AMJ.

BMC Med. 2019 Jul 24;17(1):138. doi: 10.1186/s12916-019-1367-9.


Delirium research, education and practice.

MacLullich AMJ, Shenkin SD.

Age Ageing. 2019 Sep 1;48(5):619-623. doi: 10.1093/ageing/afz090.


Corrigendum to Correlational structure of 'frontal' tests and intelligence tests indicates two components with asymmetrical neurostructural correlates in old age Intelligence 46 (2014) 94-106.

Cox SR, MacPherson SE, Ferguson KJ, Nissan J, Royle NA, MacLullich AMJ, Wardlaw JM, Deary IJ.

Intelligence. 2018 Nov-Dec;71:97. doi: 10.1016/j.intell.2018.10.001.


Delirium in patients with dementia and in children: Overlap of symptoms profile and possible role for future diagnosis.

Morandi A, Thompson JL, Bellelli G, Lucchi E, Turco R, Gentile S, Trabucchi M, MacLullich A, Meagher D, Ely EW, Pandharipande P, Smith H.

Eur J Intern Med. 2019 Jul;65:44-50. doi: 10.1016/j.ejim.2019.04.023. Epub 2019 May 28.


Screening for delirium after surgery: validation of the 4 A's test (4AT) in the post-anaesthesia care unit.

Saller T, MacLullich AMJ, Schäfer ST, Crispin A, Neitzert R, Schüle C, von Dossow V, Hofmann-Kiefer KF.

Anaesthesia. 2019 Oct;74(10):1260-1266. doi: 10.1111/anae.14682. Epub 2019 Apr 30.


Knowledge, opinions and clinical practice regarding postoperative delirium in older patients: A survey of nurses and anaesthetists.

Igwe EO, Traynor V, Rodgers S, Waite A, MacLullich A, Foo I.

J Clin Anesth. 2019 Nov;57:108-109. doi: 10.1016/j.jclinane.2019.04.004. Epub 2019 Apr 6. No abstract available.


The Oslo Study of Clonidine in Elderly Patients with Delirium; LUCID: a randomised placebo-controlled trial.

Hov KR, Neerland BE, Undseth Ø, Wyller VBB, MacLullich AMJ, Qvigstad E, Skovlund E, Wyller TB.

Int J Geriatr Psychiatry. 2019 Jul;34(7):974-981. doi: 10.1002/gps.5098. Epub 2019 Apr 24.


Delirium Monitoring: Yes or No? That Is The Question.

Marra A, Kotfis K, Hosie A, MacLullich AMJ, Pandharipande PP, Ely EW, Pun BT.

Am J Crit Care. 2019 Mar;28(2):127-135. doi: 10.4037/ajcc2019874. Review.


Investigating speech and language impairments in delirium: A preliminary case-control study.

Green S, Reivonen S, Rutter LM, Nouzova E, Duncan N, Clarke C, MacLullich AMJ, Tieges Z.

PLoS One. 2018 Nov 26;13(11):e0207527. doi: 10.1371/journal.pone.0207527. eCollection 2018.


Impairments in balance and mobility identify delirium in patients with comorbid dementia.

Gual N, Richardson SJ, Davis DHJ, Bellelli G, Hasemann W, Meagher D, Kreisel SH, MacLullich AMJ, Cerejeira J, Inzitari M, Morandi A.

Int Psychogeriatr. 2019 May;31(5):749-753. doi: 10.1017/S1041610218001345. Epub 2018 Oct 15.


Diagnostic test accuracy of a novel smartphone application for the assessment of attention deficits in delirium in older hospitalised patients: a prospective cohort study protocol.

Rutter LM, Nouzova E, Stott DJ, Weir CJ, Assi V, Barnett JH, Clarke C, Duncan N, Evans J, Green S, Hendry K, McGinlay M, McKeever J, Middleton DG, Parks S, Shaw R, Tang E, Walsh T, Weir AJ, Wilson E, Quasim T, MacLullich AMJ, Tieges Z.

BMC Geriatr. 2018 Sep 17;18(1):217. doi: 10.1186/s12877-018-0901-5.


Development and feasibility of a smartphone-based test for the objective detection and monitoring of attention impairments in delirium in the ICU.

Tang E, Laverty M, Weir A, Wilson ES, Walsh TS, Allerhand M, Parks S, MacLullich AMJ, Tieges Z.

J Crit Care. 2018 Dec;48:104-111. doi: 10.1016/j.jcrc.2018.08.019. Epub 2018 Aug 21.


Delirium etiology subtypes and their effect on six-month function and cognition in older emergency department patients.

Cirbus J, MacLullich AMJ, Noel C, Ely EW, Chandrasekhar R, Han JH.

Int Psychogeriatr. 2019 Feb;31(2):267-276. doi: 10.1017/S1041610218000777. Epub 2018 Jul 19.


The use of clonidine in elderly patients with delirium; pharmacokinetics and hemodynamic responses.

Hov KR, Neerland BE, Andersen AM, Undseth Ø, Wyller VB, MacLullich AMJ, Skovlund E, Qvigstad E, Wyller TB.

BMC Pharmacol Toxicol. 2018 Jun 8;19(1):29. doi: 10.1186/s40360-018-0218-1.


Visual Rating Scales of White Matter Hyperintensities and Atrophy: Comparison of Computed Tomography and Magnetic Resonance Imaging.

Ferguson KJ, Cvoro V, MacLullich AMJ, Shenkin SD, Sandercock PAG, Sakka E, Wardlaw JM.

J Stroke Cerebrovasc Dis. 2018 Jul;27(7):1815-1821. doi: 10.1016/j.jstrokecerebrovasdis.2018.02.028. Epub 2018 Mar 23.


Protocol for validation of the 4AT, a rapid screening tool for delirium: a multicentre prospective diagnostic test accuracy study.

Shenkin SD, Fox C, Godfrey M, Siddiqi N, Goodacre S, Young J, Anand A, Gray A, Smith J, Ryan T, Hanley J, MacRaild A, Steven J, Black PL, Boyd J, Weir CJ, MacLullich AM.

BMJ Open. 2018 Feb 10;8(2):e015572. doi: 10.1136/bmjopen-2016-015572.


The delirium and population health informatics cohort study protocol: ascertaining the determinants and outcomes from delirium in a whole population.

Davis D, Richardson S, Hornby J, Bowden H, Hoffmann K, Weston-Clarke M, Green F, Chaturvedi N, Hughes A, Kuh D, Sampson E, Mizoguchi R, Cheah KL, Romain M, Sinha A, Jenkin R, Brayne C, MacLullich A.

BMC Geriatr. 2018 Feb 9;18(1):45. doi: 10.1186/s12877-018-0742-2.


New waves of delirium understanding.

Teodorczuk A, MacLullich A.

Int J Geriatr Psychiatry. 2018 Nov;33(11):1417-1419. doi: 10.1002/gps.4848. Epub 2018 Jan 5. No abstract available.


Reduced level of arousal and increased mortality in adult acute medical admissions: a systematic review and meta-analysis.

Todd A, Blackley S, Burton JK, Stott DJ, Ely EW, Tieges Z, MacLullich AMJ, Shenkin SD.

BMC Geriatr. 2017 Dec 8;17(1):283. doi: 10.1186/s12877-017-0661-7. Review.


PERFECTED enhanced recovery (PERFECT-ER) care versus standard acute care for patients admitted to acute settings with hip fracture identified as experiencing confusion: study protocol for a feasibility cluster randomized controlled trial.

Hammond SP, Cross JL, Shepstone L, Backhouse T, Henderson C, Poland F, Sims E, MacLullich A, Penhale B, Howard R, Lambert N, Varley A, Smith TO, Sahota O, Donell S, Patel M, Ballard C, Young J, Knapp M, Jackson S, Waring J, Leavey N, Howard G, Fox C.

Trials. 2017 Dec 4;18(1):583. doi: 10.1186/s13063-017-2303-y.


Predicting Discharge to Institutional Long-Term Care After Stroke: A Systematic Review and Metaanalysis.

Burton JK, Ferguson EEC, Barugh AJ, Walesby KE, MacLullich AMJ, Shenkin SD, Quinn TJ.

J Am Geriatr Soc. 2018 Jan;66(1):161-169. doi: 10.1111/jgs.15101. Epub 2017 Oct 9.


The relationship between preoperative frailty and outcomes following transcatheter aortic valve implantation: a systematic review and meta-analysis.

Anand A, Harley C, Visvanathan A, Shah ASV, Cowell J, MacLullich A, Shenkin S, Mills NL.

Eur Heart J Qual Care Clin Outcomes. 2017 Apr 1;3(2):123-132. doi: 10.1093/ehjqcco/qcw030. Review.


Cognitive ability across the life course and cortisol levels in older age.

Harris MA, Cox SR, Brett CE, Deary IJ, MacLullich AMJ.

Neurobiol Aging. 2017 Nov;59:64-71. doi: 10.1016/j.neurobiolaging.2017.07.012. Epub 2017 Aug 8.


Altered cortical brain activity in end stage liver disease assessed by multi-channel near-infrared spectroscopy: Associations with delirium.

Yoshimura A, Goodson C, Johns JT, Towe MM, Irvine ES, Rendradjaja NA, Max LK, LaFlam A, Ledford EC, Probert J, Tieges Z, Edwin DH, MacLullich AMJ, Hogue CW, Lindquist MA, Gurakar A, Neufeld KJ, Kamiya A.

Sci Rep. 2017 Aug 23;7(1):9258. doi: 10.1038/s41598-017-10024-7.


The intensive care delirium research agenda: a multinational, interprofessional perspective.

Pandharipande PP, Ely EW, Arora RC, Balas MC, Boustani MA, La Calle GH, Cunningham C, Devlin JW, Elefante J, Han JH, MacLullich AM, Maldonado JR, Morandi A, Needham DM, Page VJ, Rose L, Salluh JIF, Sharshar T, Shehabi Y, Skrobik Y, Slooter AJC, Smith HAB.

Intensive Care Med. 2017 Sep;43(9):1329-1339. doi: 10.1007/s00134-017-4860-7. Epub 2017 Jun 13. Review.


CSF biomarkers in delirium: a systematic review.

Hall RJ, Watne LO, Cunningham E, Zetterberg H, Shenkin SD, Wyller TB, MacLullich AMJ.

Int J Geriatr Psychiatry. 2018 Nov;33(11):1479-1500. doi: 10.1002/gps.4720. Epub 2017 Jun 6.


Detecting delirium superimposed on dementia: diagnostic accuracy of a simple combined arousal and attention testing procedure.

Richardson SJ, Davis DHJ, Bellelli G, Hasemann W, Meagher D, Kreisel SH, MacLullich AMJ, Cerejeira J, Morandi A.

Int Psychogeriatr. 2017 Oct;29(10):1585-1593. doi: 10.1017/S1041610217000916. Epub 2017 May 31.


A Novel Computerized Test for Detecting and Monitoring Visual Attentional Deficits and Delirium in the ICU.

Green C, Hendry K, Wilson ES, Walsh T, Allerhand M, MacLullich AMJ, Tieges Z.

Crit Care Med. 2017 Jul;45(7):1224-1231. doi: 10.1097/CCM.0000000000002477.


Predicting discharge to institutional long-term care following acute hospitalisation: a systematic review and meta-analysis.

Harrison JK, Walesby KE, Hamilton L, Armstrong C, Starr JM, Reynish EL, MacLullich AMJ, Quinn TJ, Shenkin SD.

Age Ageing. 2017 Jul 1;46(4):547-558. doi: 10.1093/ageing/afx047. Review.


The neuropsychology of delirium: advancing the science of delirium assessment.

Tieges Z, Evans JJ, Neufeld KJ, MacLullich AMJ.

Int J Geriatr Psychiatry. 2018 Nov;33(11):1501-1511. doi: 10.1002/gps.4711. Epub 2017 Apr 9. Review.


Sleep Disruption at Home As an Independent Risk Factor for Postoperative Delirium.

Todd OM, Gelrich L, MacLullich AM, Driessen M, Thomas C, Kreisel SH.

J Am Geriatr Soc. 2017 May;65(5):949-957. doi: 10.1111/jgs.14685. Epub 2017 Mar 17.


Challenges and opportunities in understanding dementia and delirium in the acute hospital.

Jackson TA, Gladman JR, Harwood RH, MacLullich AM, Sampson EL, Sheehan B, Davis DH.

PLoS Med. 2017 Mar 14;14(3):e1002247. doi: 10.1371/journal.pmed.1002247. eCollection 2017 Mar.


Associations between hippocampal morphology, diffusion characteristics, and salivary cortisol in older men.

Cox SR, Valdés Hernández MDC, Kim J, Royle NA, MacPherson SE, Ferguson KJ, Muñoz Maniega S, Anblagan D, Aribisala BS, Bastin ME, Park J, Starr JM, Deary IJ, MacLullich AMJ, Wardlaw JM.

Psychoneuroendocrinology. 2017 Apr;78:151-158. doi: 10.1016/j.psyneuen.2017.01.027. Epub 2017 Jan 27.


European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium.

Aldecoa C, Bettelli G, Bilotta F, Sanders RD, Audisio R, Borozdina A, Cherubini A, Jones C, Kehlet H, MacLullich A, Radtke F, Riese F, Slooter AJ, Veyckemans F, Kramer S, Neuner B, Weiss B, Spies CD.

Eur J Anaesthesiol. 2017 Apr;34(4):192-214. doi: 10.1097/EJA.0000000000000594. Review. Erratum in: Eur J Anaesthesiol. 2018 Sep;35(9):718-719.


Stress in childhood, adolescence and early adulthood, and cortisol levels in older age.

Harris MA, Cox SR, Brett CE, Deary IJ, MacLullich AM.

Stress. 2017 Mar;20(2):140-148. doi: 10.1080/10253890.2017.1289168. Epub 2017 Feb 21.


Psychiatric symptomatology after delirium: a systematic review.

Langan C, Sarode DP, Russ TC, Shenkin SD, Carson A, Maclullich AMJ.

Psychogeriatrics. 2017 Sep;17(5):327-335. doi: 10.1111/psyg.12240. Epub 2017 Jan 27. Review.


Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies.

Davis DH, Muniz-Terrera G, Keage HA, Stephan BC, Fleming J, Ince PG, Matthews FE, Cunningham C, Ely EW, MacLullich AM, Brayne C; Epidemiological Clinicopathological Studies in Europe (EClipSE) Collaborative Members.

JAMA Psychiatry. 2017 Mar 1;74(3):244-251. doi: 10.1001/jamapsychiatry.2016.3423.


Acetylcholinesterase Activity Measurement and Clinical Features of Delirium.

Jackson TA, Moorey HC, Sheehan B, Maclullich AM, Gladman JR, Lord JM.

Dement Geriatr Cogn Disord. 2017;43(1-2):29-37. doi: 10.1159/000452832. Epub 2016 Dec 15.


The Diagnosis of Delirium Superimposed on Dementia: An Emerging Challenge.

Morandi A, Davis D, Bellelli G, Arora RC, Caplan GA, Kamholz B, Kolanowski A, Fick DM, Kreisel S, MacLullich A, Meagher D, Neufeld K, Pandharipande PP, Richardson S, Slooter AJ, Taylor JP, Thomas C, Tieges Z, Teodorczuk A, Voyer P, Rudolph JL.

J Am Med Dir Assoc. 2017 Jan;18(1):12-18. doi: 10.1016/j.jamda.2016.07.014. Epub 2016 Sep 16. Review.


Erratum to: Haloperidol Use Among Elderly Patients Undergoing Surgery: A Retrospective 1-Year Study in a Hospital Population.

Nijboer H, Lefeber G, MacLullich A, van Munster B.

Drugs Real World Outcomes. 2016 Jun;3(2):239. No abstract available.


New institutionalisation following acute hospital admission: a retrospective cohort study.

Harrison JK, Garrido AG, Rhynas SJ, Logan G, MacLullich AM, MacArthur J, Shenkin S.

Age Ageing. 2017 Mar 1;46(2):238-244. doi: 10.1093/ageing/afw188.


Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture.

Hall RJ, Watne LO, Idland AV, Raeder J, Frihagen F, MacLullich AM, Staff AC, Wyller TB, Fekkes D.

J Neuroinflammation. 2016 Jun 29;13(1):170. doi: 10.1186/s12974-016-0636-1.

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