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Items: 35


Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits.

Xiang R, Berg IVD, MacLeod IM, Hayes BJ, Prowse-Wilkins CP, Wang M, Bolormaa S, Liu Z, Rochfort SJ, Reich CM, Mason BA, Vander Jagt CJ, Daetwyler HD, Lund MS, Chamberlain AJ, Goddard ME.

Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19398-19408. doi: 10.1073/pnas.1904159116. Epub 2019 Sep 9.


Fine-mapping sequence mutations with a major effect on oligosaccharide content in bovine milk.

Liu Z, Wang T, Pryce JE, MacLeod IM, Hayes BJ, Chamberlain AJ, Jagt CV, Reich CM, Mason BA, Rochfort S, Cocks BG.

Sci Rep. 2019 Feb 14;9(1):2137. doi: 10.1038/s41598-019-38488-9.


Predicting the effect of reference population on the accuracy of within, across, and multibreed genomic prediction.

van den Berg I, Meuwissen THE, MacLeod IM, Goddard ME.

J Dairy Sci. 2019 Apr;102(4):3155-3174. doi: 10.3168/jds.2018-15231. Epub 2019 Feb 7.


Accuracy of imputation to whole-genome sequence in sheep.

Bolormaa S, Chamberlain AJ, Khansefid M, Stothard P, Swan AA, Mason B, Prowse-Wilkins CP, Duijvesteijn N, Moghaddar N, van der Werf JH, Daetwyler HD, MacLeod IM.

Genet Sel Evol. 2019 Jan 17;51(1):1. doi: 10.1186/s12711-018-0443-5.


Genomic Prediction Using Prior Quantitative Trait Loci Information Reveals a Large Reservoir of Underutilised Blackleg Resistance in Diverse Canola (Brassica napus L.) Lines.

Fikere M, Barbulescu DM, Malmberg MM, Shi F, Koh JCO, Slater AT, MacLeod IM, Bowman PJ, Salisbury PA, Spangenberg GC, Cogan NOI, Daetwyler HD.

Plant Genome. 2018 Jul;11(2). doi: 10.3835/plantgenome2017.11.0100.


Genome variants associated with RNA splicing variations in bovine are extensively shared between tissues.

Xiang R, Hayes BJ, Vander Jagt CJ, MacLeod IM, Khansefid M, Bowman PJ, Yuan Z, Prowse-Wilkins CP, Reich CM, Mason BA, Garner JB, Marett LC, Chen Y, Bolormaa S, Daetwyler HD, Chamberlain AJ, Goddard ME.

BMC Genomics. 2018 Jul 4;19(1):521. doi: 10.1186/s12864-018-4902-8.


Multi-breed genomic prediction using Bayes R with sequence data and dropping variants with a small effect.

van den Berg I, Bowman PJ, MacLeod IM, Hayes BJ, Wang T, Bolormaa S, Goddard ME.

Genet Sel Evol. 2017 Sep 21;49(1):70. doi: 10.1186/s12711-017-0347-9.


Genome-wide comparative analyses of correlated and uncorrelated phenotypes identify major pleiotropic variants in dairy cattle.

Xiang R, MacLeod IM, Bolormaa S, Goddard ME.

Sci Rep. 2017 Aug 23;7(1):9248. doi: 10.1038/s41598-017-09788-9.


Application of a Bayesian non-linear model hybrid scheme to sequence data for genomic prediction and QTL mapping.

Wang T, Chen YP, MacLeod IM, Pryce JE, Goddard ME, Hayes BJ.

BMC Genomics. 2017 Aug 15;18(1):618. doi: 10.1186/s12864-017-4030-x.


Putative enhancer sites in the bovine genome are enriched with variants affecting complex traits.

Wang M, Hancock TP, MacLeod IM, Pryce JE, Cocks BG, Hayes BJ.

Genet Sel Evol. 2017 Jul 6;49(1):56. doi: 10.1186/s12711-017-0331-4.


Evaluation of the accuracy of imputed sequence variant genotypes and their utility for causal variant detection in cattle.

Pausch H, MacLeod IM, Fries R, Emmerling R, Bowman PJ, Daetwyler HD, Goddard ME.

Genet Sel Evol. 2017 Feb 21;49(1):24. doi: 10.1186/s12711-017-0301-x.


Genetics of complex traits: prediction of phenotype, identification of causal polymorphisms and genetic architecture.

Goddard ME, Kemper KE, MacLeod IM, Chamberlain AJ, Hayes BJ.

Proc Biol Sci. 2016 Jul 27;283(1835). pii: 20160569. doi: 10.1098/rspb.2016.0569. Review.


Exploiting biological priors and sequence variants enhances QTL discovery and genomic prediction of complex traits.

MacLeod IM, Bowman PJ, Vander Jagt CJ, Haile-Mariam M, Kemper KE, Chamberlain AJ, Schrooten C, Hayes BJ, Goddard ME.

BMC Genomics. 2016 Feb 27;17:144. doi: 10.1186/s12864-016-2443-6.


Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle.

Gonzalez-Recio O, Daetwyler HD, MacLeod IM, Pryce JE, Bowman PJ, Hayes BJ, Goddard ME.

PLoS One. 2015 Dec 7;10(12):e0143945. doi: 10.1371/journal.pone.0143945. eCollection 2015.


Two-Variance-Component Model Improves Genetic Prediction in Family Datasets.

Tucker G, Loh PR, MacLeod IM, Hayes BJ, Goddard ME, Berger B, Price AL.

Am J Hum Genet. 2015 Nov 5;97(5):677-90. doi: 10.1016/j.ajhg.2015.10.002.


Population structure and history of the Welsh sheep breeds determined by whole genome genotyping.

Beynon SE, Slavov GT, Farré M, Sunduimijid B, Waddams K, Davies B, Haresign W, Kijas J, MacLeod IM, Newbold CJ, Davies L, Larkin DM.

BMC Genet. 2015 Jun 20;16:65. doi: 10.1186/s12863-015-0216-x.


The effects of demography and long-term selection on the accuracy of genomic prediction with sequence data.

MacLeod IM, Hayes BJ, Goddard ME.

Genetics. 2014 Dec;198(4):1671-84. doi: 10.1534/genetics.114.168344. Epub 2014 Sep 18.


Inferring demography from runs of homozygosity in whole-genome sequence, with correction for sequence errors.

MacLeod IM, Larkin DM, Lewin HA, Hayes BJ, Goddard ME.

Mol Biol Evol. 2013 Sep;30(9):2209-23. doi: 10.1093/molbev/mst125. Epub 2013 Jul 10.


Toward genomic prediction from whole-genome sequence data: impact of sequencing design on genotype imputation and accuracy of predictions.

Druet T, Macleod IM, Hayes BJ.

Heredity (Edinb). 2014 Jan;112(1):39-47. doi: 10.1038/hdy.2013.13. Epub 2013 Apr 3.


Whole-genome resequencing of two elite sires for the detection of haplotypes under selection in dairy cattle.

Larkin DM, Daetwyler HD, Hernandez AG, Wright CL, Hetrick LA, Boucek L, Bachman SL, Band MR, Akraiko TV, Cohen-Zinder M, Thimmapuram J, Macleod IM, Harkins TT, McCague JE, Goddard ME, Hayes BJ, Lewin HA.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7693-8. doi: 10.1073/pnas.1114546109. Epub 2012 Apr 23.


Power of a genome scan to detect and locate quantitative trait loci in cattle using dense single nucleotide polymorphisms.

MacLeod IM, Hayes BJ, Savin KW, Chamberlain AJ, McPartlan HC, Goddard ME.

J Anim Breed Genet. 2010 Apr;127(2):133-42. doi: 10.1111/j.1439-0388.2009.00831.x.


A novel predictor of multilocus haplotype homozygosity: comparison with existing predictors.

MacLeod IM, Meuwissen TH, Hayes BJ, Goddard ME.

Genet Res (Camb). 2009 Dec;91(6):413-26. doi: 10.1017/S0016672309990358.


Sampling strategies for whole genome association studies in aquaculture and outcrossing plant species.

Hayes BJ, MacLeod IM, Baranski M.

Genet Res (Camb). 2009 Dec;91(6):367-71. doi: 10.1017/S0016672309990310. Epub 2009 Dec 8.


Distributed intelligent control system for a continuous-state plant.

Stothert A, Macleod IM.

IEEE Trans Syst Man Cybern B Cybern. 1997;27(3):395-401.


Bandwidths of respiratory gas flow and pressure waveforms in mechanically ventilated infants.

Turner MJ, Davies VA, De Ravel TJ, Rothberg AD, MacLeod IM.

Physiol Meas. 1993 Nov;14(4):419-31.


Calibration of Fleisch and screen pneumotachographs for use with various oxygen concentrations.

Turner MJ, MacLeod IM, Rothberg AD.

Med Biol Eng Comput. 1990 Mar;28(2):200-4. No abstract available.


Effects of temperature and composition on the viscosity of respiratory gases.

Turner MJ, MacLeod IM, Rothberg AD.

J Appl Physiol (1985). 1989 Jul;67(1):472-7.


Lumped parameter approximation for the prediction of the dynamic response of the Fleisch pneumotachograph.

Turner MJ, MacLeod IM, Rothberg AD.

Med Biol Eng Comput. 1988 Jul;26(4):443-8. No abstract available.


Farmer's lung in an iron foundry.

MacLeod IM, Brown WR.

Scott Med J. 1982 Apr;27(2):154-7.


Fatal disseminated BCG infection in an 18-year-old boy.

Mackay A, Macleod T, Alcorn MJ, Laidlaw M, Macleod IM, Millar JS, Stack BH, White RG.

Lancet. 1980 Dec 20-27;2(8208-8209):1332-4.


A case of non-pulmonary tuberculosis due to Mycobacterium africanum.

MacLeod IM.

Tubercle. 1977 Mar;58(1):39-42.


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