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Association of APOL1 renal disease risk alleles with Trypanosoma brucei rhodesiense infection outcomes in the northern part of Malawi.

Kamoto K, Noyes H, Nambala P, Senga E, Musaya-Mwalija J, Kumwenda B, Bucheton B, Macleod A, Herz-Fowler C, Matovu E, Chiwaya AM, Chisi JE; TrypanoGEN Research Group as members of The H3Africa Consortium.

PLoS Negl Trop Dis. 2019 Aug 14;13(8):e0007603. doi: 10.1371/journal.pntd.0007603. [Epub ahead of print]


Non-locking screw insertion: No benefit seen if tightness exceeds 80% of the maximum torque.

Fletcher JWA, Ehrhardt B, MacLeod A, Whitehouse MR, Gill H, Preatoni E.

Clin Biomech (Bristol, Avon). 2019 Jul 9;70:40-45. doi: 10.1016/j.clinbiomech.2019.07.009. [Epub ahead of print]


Enabling the medical registrar on take: Royal College of Physicians West Midlands pilot.

Macleod A, Sandhu K, Flood H.

Future Healthc J. 2019 Mar;6(Suppl 1):152-153. doi: 10.7861/futurehosp.6-1-s152. No abstract available.


The contact system proteases play disparate roles in streptococcal sepsis.

Köhler J, Maletzki C, Koczan D, Frank M, Trepesch C, Revenko AS, Crosby JR, MacLeod AR, Mikkat S, Oehmcke-Hecht S.

Haematologica. 2019 Jul 18. pii: haematol.2019.223545. doi: 10.3324/haematol.2019.223545. [Epub ahead of print]


Enhanced Potency of GalNAc-Conjugated Antisense Oligonucleotides in Hepatocellular Cancer Models.

Kim Y, Jo M, Schmidt J, Luo X, Prakash TP, Zhou T, Klein S, Xiao X, Post N, Yin Z, MacLeod AR.

Mol Ther. 2019 Jun 29. pii: S1525-0016(19)30304-1. doi: 10.1016/j.ymthe.2019.06.009. [Epub ahead of print]


A single fast radio burst localized to a massive galaxy at cosmological distance.

Bannister KW, Deller AT, Phillips C, Macquart JP, Prochaska JX, Tejos N, Ryder SD, Sadler EM, Shannon RM, Simha S, Day CK, McQuinn M, North-Hickey FO, Bhandari S, Arcus WR, Bennert VN, Burchett J, Bouwhuis M, Dodson R, Ekers RD, Farah W, Flynn C, James CW, Kerr M, Lenc E, Mahony EK, O'Meara J, Osłowski S, Qiu H, Treu T, U V, Bateman TJ, Bock DC, Bolton RJ, Brown A, Bunton JD, Chippendale AP, Cooray FR, Cornwell T, Gupta N, Hayman DB, Kesteven M, Koribalski BS, MacLeod A, McClure-Griffiths NM, Neuhold S, Norris RP, Pilawa MA, Qiao RY, Reynolds J, Roxby DN, Shimwell TW, Voronkov MA, Wilson CD.

Science. 2019 Aug 9;365(6453):565-570. doi: 10.1126/science.aaw5903. Epub 2019 Jun 27.


Actor-network theory and ethnography: Sociomaterial approaches to researching medical education.

MacLeod A, Cameron P, Ajjawi R, Kits O, Tummons J.

Perspect Med Educ. 2019 Jun;8(3):177-186. doi: 10.1007/s40037-019-0513-6.


Shifting Paradigms in Allergic Contact Dermatitis: The Role of Innate Immunity.

Brys AK, Rodriguez-Homs LG, Suwanpradid J, Atwater AR, MacLeod AS.

J Invest Dermatol. 2019 May 14. pii: S0022-202X(19)31344-2. doi: 10.1016/j.jid.2019.03.1133. [Epub ahead of print] Review.


Cherenkov Radiation from the Quantum Vacuum.

Macleod AJ, Noble A, Jaroszynski DA.

Phys Rev Lett. 2019 Apr 26;122(16):161601. doi: 10.1103/PhysRevLett.122.161601.


Bad "Staph" in the Wound Environment of Diabetic Foot Ulcers.

MacLeod AS.

Cell Host Microbe. 2019 May 8;25(5):638-640. doi: 10.1016/j.chom.2019.04.006.


Evaluating Augmented Depression Therapy (ADepT): study protocol for a pilot randomised controlled trial.

Dunn BD, Widnall E, Reed N, Taylor R, Owens C, Spencer A, Kraag G, Kok G, Geschwind N, Wright K, Moberly NJ, Moulds ML, MacLeod AK, Handley R, Richards D, Campbell J, Kuyken W.

Pilot Feasibility Stud. 2019 Apr 27;5:63. doi: 10.1186/s40814-019-0438-1. eCollection 2019.


The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin.

Coates M, Mariottoni P, Corcoran DL, Kirshner HF, Jaleel T, Brown DA, Brooks SR, Murray J, Morasso MI, MacLeod AS.

PLoS One. 2019 May 6;14(5):e0216249. doi: 10.1371/journal.pone.0216249. eCollection 2019.


Autoimmune Theories of Chronic Spontaneous Urticaria.

Bracken SJ, Abraham S, MacLeod AS.

Front Immunol. 2019 Mar 29;10:627. doi: 10.3389/fimmu.2019.00627. eCollection 2019. Review.


Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines.

Linnane E, Davey P, Zhang P, Puri S, Edbrooke M, Chiarparin E, Revenko AS, Macleod AR, Norman JC, Ross SJ.

Nucleic Acids Res. 2019 May 21;47(9):4375-4392. doi: 10.1093/nar/gkz214.


Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population.

Kaboré JW, Camara O, Ilboudo H, Capewell P, Clucas C, Cooper A, Kaboré J, Camara M, Jamonneau V, Hertz-Fowler C, Bélem AMG, Matovu E, Macleod A, Sidibé I, Noyes H, Bucheton B; TrypanoGEN Research Group, as member of the H3Africa Consortium.

Infect Genet Evol. 2019 Jul;71:108-115. doi: 10.1016/j.meegid.2019.03.021. Epub 2019 Mar 23.


An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials.

Henderson CJ, Kapelyukh Y, Scheer N, Rode A, McLaren AW, MacLeod AK, Lin D, Wright J, Stanley LA, Wolf CR.

Drug Metab Dispos. 2019 Jun;47(6):601-615. doi: 10.1124/dmd.119.086397. Epub 2019 Mar 25.


Association between IL1 gene polymorphism and human African trypanosomiasis in populations of sleeping sickness foci of southern Cameroon.

Ofon E, Noyes H, Ebo'o Eyanga V, Njiokou F, Koffi M, Fogue P, Hertz-Fowler C, MacLeod A, Matovu E, Simo G; TrypanoGEN Research Group, as members of The H3Africa Consortium.

PLoS Negl Trop Dis. 2019 Mar 25;13(3):e0007283. doi: 10.1371/journal.pntd.0007283. eCollection 2019 Mar.


An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1-HK2+ Multiple Myeloma.

Xu S, Zhou T, Doh HM, Trinh KR, Catapang A, Lee JT, Braas D, Bayley NA, Yamada RE, Vasuthasawat A, Sasine JP, Timmerman JM, Larson SM, Kim Y, MacLeod AR, Morrison SL, Herschman HR.

Cancer Res. 2019 May 15;79(10):2748-2760. doi: 10.1158/0008-5472.CAN-18-2799. Epub 2019 Mar 18.


IONIS-PKKRx a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production.

Ferrone JD, Bhattacharjee G, Revenko AS, Zanardi TA, Warren MS, Derosier FJ, Viney NJ, Pham NC, Kaeser GE, Baker BF, Schneider E, Hughes SG, Monia BP, MacLeod AR.

Nucleic Acid Ther. 2019 Apr;29(2):82-91. doi: 10.1089/nat.2018.0754. Epub 2019 Feb 28.


Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection.

Chiweshe SM, Steketee PC, Jayaraman S, Paxton E, Neophytou K, Erasmus H, Labuschagne M, Cooper A, MacLeod A, Grey FE, Morrison LJ.

PLoS Negl Trop Dis. 2019 Feb 19;13(2):e0007189. doi: 10.1371/journal.pntd.0007189. eCollection 2019 Feb.


Progressive research collaborations and the limits of soft power.

Kits O, Angus C, MacLeod A, Tummons J.

Perspect Med Educ. 2019 Feb;8(1):28-32. doi: 10.1007/s40037-019-0496-3.


A trichogenic tumor with aggressive features initially diagnosed as basal cell carcinoma.

Kwock JT, Casady M, Handfield C, MacLeod AS, Pavlis MB.

Dermatol Online J. 2018 Sep 15;24(9). pii: 13030/qt1fn5226f.


A public health approach to mobilizing community partners for injury prevention: A scoping review.

Crizzle AM, Dykeman C, Laberge S, MacLeod A, Olsen-Lynch E, Brunet F, Andrews A.

PLoS One. 2019 Jan 22;14(1):e0210734. doi: 10.1371/journal.pone.0210734. eCollection 2019.


The effect of plate design, bridging span, and fracture healing on the performance of high tibial osteotomy plates: An experimental and finite element study.

MacLeod AR, Serrancoli G, Fregly BJ, Toms AD, Gill HS.

Bone Joint Res. 2019 Jan 4;7(12):639-649. doi: 10.1302/2046-3758.712.BJR-2018-0035.R1. eCollection 2018 Dec.


Resolving the apparent transmission paradox of African sleeping sickness.

Capewell P, Atkins K, Weir W, Jamonneau V, Camara M, Clucas C, Swar NK, Ngoyi DM, Rotureau B, Garside P, Galvani AP, Bucheton B, MacLeod A.

PLoS Biol. 2019 Jan 11;17(1):e3000105. doi: 10.1371/journal.pbio.3000105. eCollection 2019 Jan.


Inverted U-shaped relationship between vitamin D and ever-reported eczema in US adults.

Wei J, Jaleel T, MacLeod AS, Ji JS.

Allergy. 2019 May;74(5):964-975. doi: 10.1111/all.13708. Epub 2019 Jan 15.


Innate antimicrobial immunity in the skin: A protective barrier against bacteria, viruses, and fungi.

Coates M, Blanchard S, MacLeod AS.

PLoS Pathog. 2018 Dec 6;14(12):e1007353. doi: 10.1371/journal.ppat.1007353. eCollection 2018 Dec. Review. No abstract available.


Technologies of Exposure: Videoconferenced Distributed Medical Education as a Sociomaterial Practice.

MacLeod A, Cameron P, Kits O, Tummons J.

Acad Med. 2019 Mar;94(3):412-418. doi: 10.1097/ACM.0000000000002536.


STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial.

Reilley MJ, McCoon P, Cook C, Lyne P, Kurzrock R, Kim Y, Woessner R, Younes A, Nemunaitis J, Fowler N, Curran M, Liu Q, Zhou T, Schmidt J, Jo M, Lee SJ, Yamashita M, Hughes SG, Fayad L, Piha-Paul S, Nadella MVP, Xiao X, Hsu J, Revenko A, Monia BP, MacLeod AR, Hong DS.

J Immunother Cancer. 2018 Nov 16;6(1):119. doi: 10.1186/s40425-018-0436-5.


Is greenery associated with mental health among residents of aged care facilities? A systematic search and narrative review.

Carver A, Lorenzon A, Veitch J, Macleod A, Sugiyama T.

Aging Ment Health. 2018 Nov 15:1-7. doi: 10.1080/13607863.2018.1516193. [Epub ahead of print]


Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.

Choi HW, Suwanpradid J, Kim IH, Staats HF, Haniffa M, MacLeod AS, Abraham SN.

Science. 2018 Nov 9;362(6415). pii: eaao0666. doi: 10.1126/science.aao0666.


Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation.

Smith JS, Nicholson LT, Suwanpradid J, Glenn RA, Knape NM, Alagesan P, Gundry JN, Wehrman TS, Atwater AR, Gunn MD, MacLeod AS, Rajagopal S.

Sci Signal. 2018 Nov 6;11(555). pii: eaaq1075. doi: 10.1126/scisignal.aaq1075.


Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.

Baker SK, Chen ZL, Norris EH, Revenko AS, MacLeod AR, Strickland S.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9687-E9696. doi: 10.1073/pnas.1811172115. Epub 2018 Sep 25.


Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.

Shastri A, Choudhary G, Teixeira M, Gordon-Mitchell S, Ramachandra N, Bernard L, Bhattacharyya S, Lopez R, Pradhan K, Giricz O, Ravipati G, Wong LF, Cole S, Bhagat TD, Feld J, Dhar Y, Bartenstein M, Thiruthuvanathan VJ, Wickrema A, Ye BH, Frank DA, Pellagatti A, Boultwood J, Zhou T, Kim Y, MacLeod AR, Epling-Burnette PK, Ye M, McCoon P, Woessner R, Steidl U, Will B, Verma A.

J Clin Invest. 2018 Dec 3;128(12):5479-5488. doi: 10.1172/JCI120156. Epub 2018 Nov 5.


Working adults' well-being: An online self-help goal-based intervention.

Oliver JJ, MacLeod AK.

J Occup Organ Psychol. 2018 Sep;91(3):665-680. doi: 10.1111/joop.12212. Epub 2018 Mar 23.


Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer.

Xiao L, Tien JC, Vo J, Tan M, Parolia A, Zhang Y, Wang L, Qiao Y, Shukla S, Wang X, Zheng H, Su F, Jing X, Luo E, Delekta A, Juckette KM, Xu A, Cao X, Alva AS, Kim Y, MacLeod AR, Chinnaiyan AM.

Cancer Res. 2018 Oct 15;78(20):5731-5740. doi: 10.1158/0008-5472.CAN-18-0941. Epub 2018 Aug 22.


Author response: Early weight loss in parkinsonism predicts poor outcomes: Evidence from an incident cohort study.

Macleod AD, Myint PK, Counsell CE.

Neurology. 2018 Aug 7;91(6):287. doi: 10.1212/WNL.0000000000005937. No abstract available.


How Well Do Measurement Scales Reflect the Actual Experience of Sexuality in Mid-Life and Beyond?

Macleod A, McCabe MP.

Sex Med Rev. 2019 Jan;7(1):29-45. doi: 10.1016/j.sxmr.2018.04.004. Epub 2018 Jul 26.


Neutrophils cause obstruction of eyelid sebaceous glands in inflammatory eye disease in mice.

Reyes NJ, Yu C, Mathew R, Kunnen CM, Kalnitsky J, Redfern RL, Leonardi A, Perez VL, MacLeod AS, Gupta PK, Saban DR.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaas9164. doi: 10.1126/scitranslmed.aas9164.


Pre-operative planning for fracture fixation using locking plates: device configuration and other considerations.

MacLeod AR, Pankaj P.

Injury. 2018 Jun;49 Suppl 1:S12-S18. doi: 10.1016/S0020-1383(18)30296-1. Review.


Age-related selection bias in Parkinson's disease research: are we recruiting the right participants?

Macleod AD, Henery R, Nwajiugo PC, Scott NW, Caslake R, Counsell CE.

Parkinsonism Relat Disord. 2018 Oct;55:128-133. doi: 10.1016/j.parkreldis.2018.05.027. Epub 2018 May 31.


Differences in pathogenicity and virulence of Trypanosoma brucei gambiense field isolates in experimentally infected Balb/C mice.

Kaboré J, Camara O, Koffi M, Sanou D, Ilboudo H, Sakandé H, Camara M, De Meeûs T, Ravel S, Belem AMG, MacLeod A, Bucheton B, Jamonneau V, Thévenon S.

Infect Genet Evol. 2018 Sep;63:269-276. doi: 10.1016/j.meegid.2018.05.018. Epub 2018 May 25.


Association of glucocerebrosidase polymorphisms and mutations with dementia in incident Parkinson's disease.

Lunde KA, Chung J, Dalen I, Pedersen KF, Linder J, Domellöf ME, Elgh E, Macleod AD, Tzoulis C, Larsen JP, Tysnes OB, Forsgren L, Counsell CE, Alves G, Maple-Grødem J.

Alzheimers Dement. 2018 Oct;14(10):1293-1301. doi: 10.1016/j.jalz.2018.04.006. Epub 2018 May 21.


Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes.

Hedges L, Brown S, MacLeod AK, Vardy A, Doyle E, Song G, Moreau M, Yoon M, Osimitz TG, Lake BG.

Xenobiotica. 2019 May;49(5):521-527. doi: 10.1080/00498254.2018.1474283. Epub 2018 Jun 4.


Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

Steketee PC, Vincent IM, Achcar F, Giordani F, Kim DH, Creek DJ, Freund Y, Jacobs R, Rattigan K, Horn D, Field MC, MacLeod A, Barrett MP.

PLoS Negl Trop Dis. 2018 May 14;12(5):e0006450. doi: 10.1371/journal.pntd.0006450. eCollection 2018 May.


T Cells Expressing the Chemokine Receptor CXCR3 Localize to Positive Patch Test Reaction Sites.

Smith JS, Suwanpradid J, MacLeod AS, Atwater AR.

Dermatitis. 2018 Jul/Aug;29(4):228-229. doi: 10.1097/DER.0000000000000367. No abstract available.


A Jacksonian approach to BPSD.

Macleod ADS.

Int J Geriatr Psychiatry. 2018 May;33(5):797-798. doi: 10.1002/gps.4825. No abstract available.


The resilience of postglacial hunter-gatherers to abrupt climate change.

Blockley S, Candy I, Matthews I, Langdon P, Langdon C, Palmer A, Lincoln P, Abrook A, Taylor B, Conneller C, Bayliss A, MacLeod A, Deeprose L, Darvill C, Kearney R, Beavan N, Staff R, Bamforth M, Taylor M, Milner N.

Nat Ecol Evol. 2018 May;2(5):810-818. doi: 10.1038/s41559-018-0508-4. Epub 2018 Mar 26.


Trabeculectomy training in England: are we safe at training? Two year surgical outcomes.

Walkden A, Huxtable J, Senior M, Lee H, Naylor S, Turner S, Ivanova K, Koppens J, Todd B, Macleod A, Sii F, Anand N, Shah P, King A, Broadway DC, Kirwan JF, McNaught A, Bhan-Bhargava A.

Eye (Lond). 2018 Jul;32(7):1253-1258. doi: 10.1038/s41433-018-0059-6. Epub 2018 Mar 12.


Innate Antiviral Immunity in the Skin.

Handfield C, Kwock J, MacLeod AS.

Trends Immunol. 2018 Apr;39(4):328-340. doi: 10.1016/ Epub 2018 Mar 8. Review.

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