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No consistent evidence of a disproportionately low resting energy expenditure in long-term successful weight-loss maintainers.

Ostendorf DM, Melanson EL, Caldwell AE, Creasy SA, Pan Z, MacLean PS, Wyatt HR, Hill JO, Catenacci VA.

Am J Clin Nutr. 2018 Oct 1;108(4):658-666. doi: 10.1093/ajcn/nqy179.


Different Risk for Hypertension, Diabetes, Dyslipidemia, and Hyperuricemia According to Level of Body Mass Index in Japanese and American Subjects.

Kuwabara M, Kuwabara R, Niwa K, Hisatome I, Smits G, Roncal-Jimenez CA, MacLean PS, Yracheta JM, Ohno M, Lanaspa MA, Johnson RJ, Jalal DI.

Nutrients. 2018 Aug 3;10(8). pii: E1011. doi: 10.3390/nu10081011.


FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation.

Wellberg EA, Kabos P, Gillen AE, Jacobsen BM, Brechbuhl HM, Johnson SJ, Rudolph MC, Edgerton SM, Thor AD, Anderson SM, Elias A, Zhou XK, Iyengar NM, Morrow M, Falcone DJ, El-Hely O, Dannenberg AJ, Sartorius CA, MacLean PS.

JCI Insight. 2018 Jul 25;3(14). pii: 120594. doi: 10.1172/jci.insight.120594. [Epub ahead of print]


Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer.

Giles ED, Jindal S, Wellberg EA, Schedin T, Anderson SM, Thor AD, Edwards DP, MacLean PS, Schedin P.

Breast Cancer Res. 2018 Jun 14;20(1):50. doi: 10.1186/s13058-018-0974-2.


Maternal obesity during lactation may protect offspring from high fat diet-induced metabolic dysfunction.

Monks J, Orlicky DJ, Stefanski AL, Libby AE, Bales ES, Rudolph MC, Johnson GC, Sherk VD, Jackman MR, Williamson K, Carlson NE, MacLean PS, McManaman JL.

Nutr Diabetes. 2018 Apr 25;8(1):18. doi: 10.1038/s41387-018-0027-z.


Accumulating Data to Optimally Predict Obesity Treatment (ADOPT): Recommendations from the Biological Domain.

Rosenbaum M, Agurs-Collins T, Bray MS, Hall KD, Hopkins M, Laughlin M, MacLean PS, Maruvada P, Savage CR, Small DM, Stoeckel L.

Obesity (Silver Spring). 2018 Apr;26 Suppl 2:S25-S34. doi: 10.1002/oby.22156.


The Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) Core Measures Project: Rationale and Approach.

MacLean PS, Rothman AJ, Nicastro HL, Czajkowski SM, Agurs-Collins T, Rice EL, Courcoulas AP, Ryan DH, Bessesen DH, Loria CM.

Obesity (Silver Spring). 2018 Apr;26 Suppl 2:S6-S15. doi: 10.1002/oby.22154.


High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.

Lanaspa MA, Kuwabara M, Andres-Hernando A, Li N, Cicerchi C, Jensen T, Orlicky DJ, Roncal-Jimenez CA, Ishimoto T, Nakagawa T, Rodriguez-Iturbe B, MacLean PS, Johnson RJ.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3138-3143. doi: 10.1073/pnas.1713837115. Epub 2018 Mar 5. Erratum in: Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9509.


Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle.

Perreault L, Newsom SA, Strauss A, Kerege A, Kahn DE, Harrison KA, Snell-Bergeon JK, Nemkov T, D'Alessandro A, Jackman MR, MacLean PS, Bergman BC.

JCI Insight. 2018 Feb 8;3(3). pii: 96805. doi: 10.1172/jci.insight.96805. [Epub ahead of print]


Is regular exercise an effective strategy for weight loss maintenance?

Foright RM, Presby DM, Sherk VD, Kahn D, Checkley LA, Giles ED, Bergouignan A, Higgins JA, Jackman MR, Hill JO, MacLean PS.

Physiol Behav. 2018 May 1;188:86-93. doi: 10.1016/j.physbeh.2018.01.025. Epub 2018 Jan 31. Review.


Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance.

Rudolph MC, Jackman MR, Presby DM, Houck JA, Webb PG, Johnson GC, Soderborg TK, de la Houssaye BA, Yang IV, Friedman JE, MacLean PS.

Diabetes. 2018 Apr;67(4):651-661. doi: 10.2337/db17-0890. Epub 2017 Nov 14.


The Androgen Receptor Supports Tumor Progression After the Loss of Ovarian Function in a Preclinical Model of Obesity and Breast Cancer.

Wellberg EA, Checkley LA, Giles ED, Johnson SJ, Oljira R, Wahdan-Alaswad R, Foright RM, Dooley G, Edgerton SM, Jindal S, Johnson GC, Richer JK, Kabos P, Thor AD, Schedin P, MacLean PS, Anderson SM.

Horm Cancer. 2017 Dec;8(5-6):269-285. doi: 10.1007/s12672-017-0302-9. Epub 2017 Jul 24.


Prior weight loss exacerbates the biological drive to gain weight after the loss of ovarian function.

Sherk VD, Jackman MR, Giles ED, Higgins JA, Foright RM, Presby DM, Johnson GC, Houck JA, Houser JL, Oljira R, MacLean PS.

Physiol Rep. 2017 May;5(10). pii: e13272. doi: 10.14814/phy2.13272.


Biological control of appetite: A daunting complexity.

MacLean PS, Blundell JE, Mennella JA, Batterham RL.

Obesity (Silver Spring). 2017 Mar;25 Suppl 1:S8-S16. doi: 10.1002/oby.21771. Review.


Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo.

Checkley LA, Rudolph MC, Wellberg EA, Giles ED, Wahdan-Alaswad RS, Houck JA, Edgerton SM, Thor AD, Schedin P, Anderson SM, MacLean PS.

Cancer Prev Res (Phila). 2017 Mar;10(3):198-207. doi: 10.1158/1940-6207.CAPR-16-0211-T. Epub 2017 Feb 2.


Ibuprofen before Exercise Does Not Prevent Cortical Bone Adaptations to Training.

Sherk VD, Carpenter RD, Giles ED, Higgins JA, Oljira RM, Johnson GC, Mills S, Maclean PS.

Med Sci Sports Exerc. 2017 May;49(5):888-895. doi: 10.1249/MSS.0000000000001194.


Modeling Diet-Induced Obesity with Obesity-Prone Rats: Implications for Studies in Females.

Giles ED, Jackman MR, MacLean PS.

Front Nutr. 2016 Nov 24;3:50. eCollection 2016. Review.


Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI.

Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS.

Int J Obes (Lond). 2017 Apr;41(4):510-517. doi: 10.1038/ijo.2016.211. Epub 2016 Nov 23.


Role of fructose and fructokinase in acute dehydration-induced vasopressin gene expression and secretion in mice.

Song 宋志林 Z, Roncal-Jimenez CA, Lanaspa-Garcia MA, Oppelt SA, Kuwabara M, Jensen T, Milagres T, Andres-Hernando A, Ishimoto T, Garcia GE, Johnson G, MacLean PS, Sanchez-Lozada LG, Tolan DR, Johnson RJ.

J Neurophysiol. 2017 Feb 1;117(2):646-654. doi: 10.1152/jn.00781.2016. Epub 2016 Nov 16.


Human Milk Fatty Acid Composition: Comparison of Novel Dried Milk Spot Versus Standard Liquid Extraction Methods.

Rudolph MC, Young BE, Jackson KH, Krebs NF, Harris WS, MacLean PS.

J Mammary Gland Biol Neoplasia. 2016 Dec;21(3-4):131-138. Epub 2016 Oct 28.


A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity.

Catenacci VA, Pan Z, Ostendorf D, Brannon S, Gozansky WS, Mattson MP, Martin B, MacLean PS, Melanson EL, Troy Donahoo W.

Obesity (Silver Spring). 2016 Sep;24(9):1874-83. doi: 10.1002/oby.21581.


Increased aerobic capacity reduces susceptibility to acute high-fat diet-induced weight gain.

Matthew Morris E, Meers GM, Koch LG, Britton SL, MacLean PS, Thyfault JP.

Obesity (Silver Spring). 2016 Sep;24(9):1929-37. doi: 10.1002/oby.21564. Epub 2016 Jul 28.


Weight restoration on a high carbohydrate refeeding diet promotes rapid weight regain and hepatic lipid accumulation in female anorexic rats.

Giles ED, Hagman J, Pan Z, MacLean PS, Higgins JA.

Nutr Metab (Lond). 2016 Mar 1;13:18. doi: 10.1186/s12986-016-0077-y. eCollection 2016.


Exercise Decreases Lipogenic Gene Expression in Adipose Tissue and Alters Adipocyte Cellularity during Weight Regain After Weight Loss.

Giles ED, Steig AJ, Jackman MR, Higgins JA, Johnson GC, Lindstrom RC, MacLean PS.

Front Physiol. 2016 Feb 10;7:32. doi: 10.3389/fphys.2016.00032. eCollection 2016.


The "metabolic sensor" function of rat supraoptic oxytocin and vasopressin neurons is attenuated during lactation but not in diet-induced obesity.

Sladek CD, Stevens W, Song Z, Johnson GC, MacLean PS.

Am J Physiol Regul Integr Comp Physiol. 2016 Feb 15;310(4):R337-45. doi: 10.1152/ajpregu.00422.2015. Epub 2015 Dec 9.


Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine.

Frank DN, Bales ES, Monks J, Jackman MJ, MacLean PS, Ir D, Robertson CE, Orlicky DJ, McManaman JL.

PLoS One. 2015 Jul 6;10(7):e0131944. doi: 10.1371/journal.pone.0131944. eCollection 2015.


The role for adipose tissue in weight regain after weight loss.

MacLean PS, Higgins JA, Giles ED, Sherk VD, Jackman MR.

Obes Rev. 2015 Feb;16 Suppl 1:45-54. doi: 10.1111/obr.12255. Review.


Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia.

Irwin DC, Garat CV, Crossno JT Jr, MacLean PS, Sullivan TM, Erickson PF, Jackman MR, Harral JW, Reusch JE, Klemm DJ.

Pulm Circ. 2014 Dec;4(4):638-53. doi: 10.1086/678510.


NIH working group report: Innovative research to improve maintenance of weight loss.

MacLean PS, Wing RR, Davidson T, Epstein L, Goodpaster B, Hall KD, Levin BE, Perri MG, Rolls BJ, Rosenbaum M, Rothman AJ, Ryan D.

Obesity (Silver Spring). 2015 Jan;23(1):7-15. doi: 10.1002/oby.20967. Epub 2014 Dec 2. Review.


Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis.

Morris EM, Jackman MR, Johnson GC, Liu TW, Lopez JL, Kearney ML, Fletcher JA, Meers GM, Koch LG, Britton SL, Rector RS, Ibdah JA, MacLean PS, Thyfault JP.

Am J Physiol Endocrinol Metab. 2014 Aug 15;307(4):E355-64. doi: 10.1152/ajpendo.00093.2014. Epub 2014 Jun 24.


Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis.

Saben JL, Bales ES, Jackman MR, Orlicky D, MacLean PS, McManaman JL.

PLoS One. 2014 May 21;9(5):e98066. doi: 10.1371/journal.pone.0098066. eCollection 2014.


Reduced hepatic mitochondrial respiration following acute high-fat diet is prevented by PGC-1α overexpression.

Morris EM, Jackman MR, Meers GM, Johnson GC, Lopez JL, MacLean PS, Thyfault JP.

Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(11):G868-80. doi: 10.1152/ajpgi.00179.2013. Epub 2013 Oct 3.


Dynamic regulation of hepatic lipid droplet properties by diet.

Crunk AE, Monks J, Murakami A, Jackman M, Maclean PS, Ladinsky M, Bales ES, Cain S, Orlicky DJ, McManaman JL.

PLoS One. 2013 Jul 11;8(7):e67631. doi: 10.1371/journal.pone.0067631. Print 2013.


High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.

Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ.

Hepatology. 2013 Nov;58(5):1632-43. doi: 10.1002/hep.26594. Epub 2013 Oct 8.


Adaptations of leptin, ghrelin or insulin during weight loss as predictors of weight regain: a review of current literature.

Strohacker K, McCaffery JM, MacLean PS, Wing RR.

Int J Obes (Lond). 2014 Mar;38(3):388-96. doi: 10.1038/ijo.2013.118. Epub 2013 Jun 26. Review.


Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease.

McManaman JL, Bales ES, Orlicky DJ, Jackman M, MacLean PS, Cain S, Crunk AE, Mansur A, Graham CE, Bowman TA, Greenberg AS.

J Lipid Res. 2013 May;54(5):1346-59. doi: 10.1194/jlr.M035063. Epub 2013 Feb 12.


Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer.

Giles ED, Wellberg EA, Astling DP, Anderson SM, Thor AD, Jindal S, Tan AC, Schedin PS, Maclean PS.

Cancer Res. 2012 Dec 15;72(24):6490-501. doi: 10.1158/0008-5472.CAN-12-1653. Epub 2012 Dec 7.


N-acetyl-4-aminophenol and musculoskeletal adaptations to resistance exercise training.

Jankowski CM, Gozansky WS, MacLean PS, Shulman B, Wolfe P, Schwartz RS, Kohrt WM.

Eur J Appl Physiol. 2013 May;113(5):1127-36. doi: 10.1007/s00421-012-2529-z. Epub 2012 Oct 30.


Lactation and neonatal nutrition: defining and refining the critical questions.

Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P.

J Mammary Gland Biol Neoplasia. 2012 Jun;17(2):167-88. doi: 10.1007/s10911-012-9261-5. Epub 2012 Jul 1.


Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice.

McCurdy CE, Schenk S, Holliday MJ, Philp A, Houck JA, Patsouris D, MacLean PS, Majka SM, Klemm DJ, Friedman JE.

Diabetes. 2012 Oct;61(10):2495-505. Epub 2012 Jun 14.


Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice.

Ishimoto T, Lanaspa MA, Le MT, Garcia GE, Diggle CP, Maclean PS, Jackman MR, Asipu A, Roncal-Jimenez CA, Kosugi T, Rivard CJ, Maruyama S, Rodriguez-Iturbe B, Sánchez-Lozada LG, Bonthron DT, Sautin YY, Johnson RJ.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4320-5. doi: 10.1073/pnas.1119908109. Epub 2012 Feb 27.


Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans.

Bergouignan A, Gozansky WS, Barry DW, Leitner W, MacLean PS, Hill JO, Draznin B, Melanson EL.

PLoS One. 2012;7(1):e30164. doi: 10.1371/journal.pone.0030164. Epub 2012 Jan 12.


Resistant starch and exercise independently attenuate weight regain on a high fat diet in a rat model of obesity.

Higgins JA, Jackman MR, Brown IL, Johnson GC, Steig A, Wyatt HR, Hill JO, Maclean PS.

Nutr Metab (Lond). 2011 Jul 7;8:49. doi: 10.1186/1743-7075-8-49.


Impact of high-fat diet and obesity on energy balance and fuel utilization during the metabolic challenge of lactation.

Wahlig JL, Bales ES, Jackman MR, Johnson GC, McManaman JL, Maclean PS.

Obesity (Silver Spring). 2012 Jan;20(1):65-75. doi: 10.1038/oby.2011.196. Epub 2011 Jun 30.


Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain.

Steig AJ, Jackman MR, Giles ED, Higgins JA, Johnson GC, Mahan C, Melanson EL, Wyatt HR, Eckel RH, Hill JO, MacLean PS.

Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R656-67. doi: 10.1152/ajpregu.00212.2011. Epub 2011 Jun 29.


Biology's response to dieting: the impetus for weight regain.

Maclean PS, Bergouignan A, Cornier MA, Jackman MR.

Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R581-600. doi: 10.1152/ajpregu.00755.2010. Epub 2011 Jun 15. Review.


Comment on: Kaiyala et al. (2010) Identification of body fat mass as a major determinant of metabolic rate in mice. Diabetes;59:1657-1666.

MacLean PS.

Diabetes. 2011 Jan;60(1):e3; author reply e4. doi: 10.2337/db10-1343. No abstract available.


Treatment related factors and inhibitor development in children with severe haemophilia A.

Maclean PS, Richards M, Williams M, Collins P, Liesner R, Keeling DM, Yee T, Will AM, Young D, Chalmers EA; Paediatric Working Party of UKHCDO.

Haemophilia. 2011 Mar;17(2):282-7. doi: 10.1111/j.1365-2516.2010.02422.x. Epub 2010 Nov 11.


Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats.

Giles ED, Jackman MR, Johnson GC, Schedin PJ, Houser JL, MacLean PS.

Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1634-42. doi: 10.1152/ajpregu.00219.2010. Epub 2010 Oct 6.


Energy expenditure in obesity-prone and obesity-resistant rats before and after the introduction of a high-fat diet.

Jackman MR, MacLean PS, Bessesen DH.

Am J Physiol Regul Integr Comp Physiol. 2010 Oct;299(4):R1097-105. doi: 10.1152/ajpregu.00549.2009. Epub 2010 Aug 4.

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