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Arabidopsis downy mildew effector HaRxL106 suppresses plant immunity by binding to RADICAL-INDUCED CELL DEATH1.

Wirthmueller L, Asai S, Rallapalli G, Sklenar J, Fabro G, Kim DS, Lintermann R, Jaspers P, Wrzaczek M, Kangasjärvi J, MacLean D, Menke FLH, Banfield MJ, Jones JDG.

New Phytol. 2018 Oct;220(1):232-248. doi: 10.1111/nph.15277.


Cross-scale effects of spruce budworm outbreaks on boreal warblers in eastern Canada.

Drever MC, Smith AC, Venier LA, Sleep DJH, MacLean DA.

Ecol Evol. 2018 Jun 27;8(15):7334-7345. doi: 10.1002/ece3.4244. eCollection 2018 Aug.


A workflow for simplified analysis of ATAC-cap-seq data in R.

Shrestha RK, Ding P, Jones JDG, MacLean D.

Gigascience. 2018 Jul 1;7(7). doi: 10.1093/gigascience/giy080.


Too Deep or Not Too Deep?: A Propensity-Matched Comparison of the Analgesic Effects of a Superficial Versus Deep Serratus Fascial Plane Block for Ambulatory Breast Cancer Surgery.

Abdallah FW, Cil T, MacLean D, Madjdpour C, Escallon J, Semple J, Brull R.

Reg Anesth Pain Med. 2018 Jul;43(5):480-487. doi: 10.1097/AAP.0000000000000768.


Using CRISPR/Cas9 genome editing in tomato to create a gibberellin-responsive dominant dwarf DELLA allele.

Tomlinson L, Yang Y, Emenecker R, Smoker M, Taylor J, Perkins S, Smith J, MacLean D, Olszewski NE, Jones JDG.

Plant Biotechnol J. 2018 May 24. doi: 10.1111/pbi.12952. [Epub ahead of print]


The ash dieback invasion of Europe was founded by two genetically divergent individuals.

McMullan M, Rafiqi M, Kaithakottil G, Clavijo BJ, Bilham L, Orton E, Percival-Alwyn L, Ward BJ, Edwards A, Saunders DGO, Garcia Accinelli G, Wright J, Verweij W, Koutsovoulos G, Yoshida K, Hosoya T, Williamson L, Jennings P, Ioos R, Husson C, Hietala AM, Vivian-Smith A, Solheim H, MaClean D, Fosker C, Hall N, Brown JKM, Swarbreck D, Blaxter M, Downie JA, Clark MD.

Nat Ecol Evol. 2018 Jun;2(6):1000-1008. doi: 10.1038/s41559-018-0548-9. Epub 2018 Apr 23.


Prostate artery embolization: a new, minimally invasive treatment for lower urinary tract symptoms secondary to prostate enlargement.

Maclean D, Maher B, Modi S, Harris M, Dyer J, Somani B, Hacking N, Bryant T.

Ther Adv Urol. 2017 Jul 10;9(8):209-216. doi: 10.1177/1756287217717889. eCollection 2017 Aug. Review.


The effects of adenine nucleotide perfusion on interstitial adenosine production in rat skeletal muscle.

Zhao Y, Fabris S, MacLean DA.

Can J Physiol Pharmacol. 2018 Aug;96(8):823-829. doi: 10.1139/cjpp-2017-0347. Epub 2018 Apr 10.


Doxorubicin chemotherapy affects the intracellular and interstitial free amino acid pools in skeletal muscle.

Fabris S, MacLean DA.

PLoS One. 2018 Apr 4;13(4):e0195330. doi: 10.1371/journal.pone.0195330. eCollection 2018.


Use of QSPR Modeling to Characterize In Vitro Binding of Drugs to a Gut-Restricted Polymer.

Brew CT, Blake JF, Mistry A, Liu F, Carreno D, Madsen D, Mu Y, Mayo M, Stahl W, Matthews D, Maclean D, Harrison S.

Pharm Res. 2018 Mar 8;35(4):89. doi: 10.1007/s11095-018-2356-y.


The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.

Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL.

Cell Rep. 2018 Feb 27;22(9):2307-2321. doi: 10.1016/j.celrep.2018.02.021.


Factors Predicting a Good Symptomatic Outcome After Prostate Artery Embolisation (PAE).

Maclean D, Harris M, Drake T, Maher B, Modi S, Dyer J, Somani B, Hacking N, Bryant T.

Cardiovasc Intervent Radiol. 2018 Aug;41(8):1152-1159. doi: 10.1007/s00270-018-1912-5. Epub 2018 Feb 26.


Planning Prostate Artery Embolisation: Is it Essential to Perform a Pre-procedural CTA?

Maclean D, Maher B, Harris M, Dyer J, Modi S, Hacking N, Bryant T.

Cardiovasc Intervent Radiol. 2018 Apr;41(4):628-632. doi: 10.1007/s00270-017-1842-7. Epub 2017 Nov 22.


The structure-energy landscape of NMDA receptor gating.

Dolino DM, Chatterjee S, MacLean DM, Flatebo C, Bishop LDC, Shaikh SA, Landes CF, Jayaraman V.

Nat Chem Biol. 2017 Dec;13(12):1232-1238. doi: 10.1038/nchembio.2487. Epub 2017 Oct 9.


Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.

Coombs ID, MacLean DM, Jayaraman V, Farrant M, Cull-Candy SG.

Cell Rep. 2017 Aug 1;20(5):1123-1135. doi: 10.1016/j.celrep.2017.07.014.


An automated quantitative image analysis tool for the identification of microtubule patterns in plants.

Faulkner C, Zhou J, Evrard A, Bourdais G, MacLean D, Häweker H, Eckes P, Robatzek S.

Traffic. 2017 Oct;18(10):683-693. doi: 10.1111/tra.12505. Epub 2017 Aug 16.


Pectoralis and Serratus Fascial Plane Blocks Each Provide Early Analgesic Benefits Following Ambulatory Breast Cancer Surgery: A Retrospective Propensity-Matched Cohort Study.

Abdallah FW, MacLean D, Madjdpour C, Cil T, Bhatia A, Brull R.

Anesth Analg. 2017 Jul;125(1):294-302. doi: 10.1213/ANE.0000000000001975.


Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive.

MacLean DM, Jayaraman V.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2504-E2513. doi: 10.1073/pnas.1620508114. Epub 2017 Mar 6.


Plant immune and growth receptors share common signalling components but localise to distinct plasma membrane nanodomains.

Bücherl CA, Jarsch IK, Schudoma C, Segonzac C, Mbengue M, Robatzek S, MacLean D, Ott T, Zipfel C.

Elife. 2017 Mar 6;6. pii: e25114. doi: 10.7554/eLife.25114.


Donald Emslie-Smith.

Maclean D.

BMJ. 2016 Dec 23;355:i6709. doi: 10.1136/bmj.i6709. No abstract available.


Dynamic Lipid-dependent Modulation of Protein Topology by Post-translational Phosphorylation.

Vitrac H, MacLean DM, Karlstaedt A, Taegtmeyer H, Jayaraman V, Bogdanov M, Dowhan W.

J Biol Chem. 2017 Feb 3;292(5):1613-1624. doi: 10.1074/jbc.M116.765719. Epub 2016 Dec 14.


Stargazin Modulation of AMPA Receptors.

Shaikh SA, Dolino DM, Lee G, Chatterjee S, MacLean DM, Flatebo C, Landes CF, Jayaraman V.

Cell Rep. 2016 Oct 4;17(2):328-335. doi: 10.1016/j.celrep.2016.09.014.


The Added Value of Circulating Tumor Cell Enumeration to Standard Markers in Assessing Prognosis in a Metastatic Castration-Resistant Prostate Cancer Population.

Heller G, Fizazi K, McCormack R, Molina A, MacLean D, Webb IJ, Saad F, de Bono JS, Scher HI.

Clin Cancer Res. 2017 Apr 15;23(8):1967-1973. doi: 10.1158/1078-0432.CCR-16-1224. Epub 2016 Sep 27.


Mast cell degranulation and de novo histamine formation contribute to sustained postexercise vasodilation in humans.

Romero SA, McCord JL, Ely MR, Sieck DC, Buck TM, Luttrell MJ, MacLean DA, Halliwill JR.

J Appl Physiol (1985). 2017 Mar 1;122(3):603-610. doi: 10.1152/japplphysiol.00633.2016. Epub 2016 Aug 25.


The Arabidopsis Protein Phosphatase PP2C38 Negatively Regulates the Central Immune Kinase BIK1.

Couto D, Niebergall R, Liang X, Bücherl CA, Sklenar J, Macho AP, Ntoukakis V, Derbyshire P, Altenbach D, Maclean D, Robatzek S, Uhrig J, Menke F, Zhou JM, Zipfel C.

PLoS Pathog. 2016 Aug 5;12(8):e1005811. doi: 10.1371/journal.ppat.1005811. eCollection 2016 Aug.


A Phase 1, Randomized, Single-Dose Crossover Pharmacokinetic Study to Investigate the Effect of Food Intake on Absorption of Orteronel (TAK-700) in Healthy Male Subjects.

Suri A, Pham T, MacLean DB.

Clin Pharmacol Drug Dev. 2016 May;5(3):188-95. doi: 10.1002/cpdd.233. Epub 2016 Jan 8.


A pigeonpea gene confers resistance to Asian soybean rust in soybean.

Kawashima CG, Guimarães GA, Nogueira SR, MacLean D, Cook DR, Steuernagel B, Baek J, Bouyioukos C, Melo Bdo V, Tristão G, de Oliveira JC, Rauscher G, Mittal S, Panichelli L, Bacot K, Johnson E, Iyer G, Tabor G, Wulff BB, Ward E, Rairdan GJ, Broglie KE, Wu G, van Esse HP, Jones JD, Brommonschenkel SH.

Nat Biotechnol. 2016 Jun;34(6):661-5. doi: 10.1038/nbt.3554. Epub 2016 Apr 25.


Improving trauma imaging in Wales through Kotter's theory of change.

Maclean DF, Vannet N.

Clin Radiol. 2016 May;71(5):427-31. doi: 10.1016/j.crad.2016.02.003. Epub 2016 Mar 11.


Acid-sensing ion channels are tuned to follow high-frequency stimuli.

MacLean DM, Jayaraman V.

J Physiol. 2016 May 15;594(10):2629-45. doi: 10.1113/JP271915. Epub 2016 Apr 10.


blastjs: a BLAST+ wrapper for Node.js.

Page M, MacLean D, Schudoma C.

BMC Res Notes. 2016 Feb 27;9:130. doi: 10.1186/s13104-016-1938-1.


Re: comparison of clinically suspected injuries detected at whole-body CT in suspected multi-trauma victims.

Maclean DF, Sampson M.

Clin Radiol. 2016 Apr;71(4):399. doi: 10.1016/j.crad.2015.11.022. Epub 2016 Jan 12. No abstract available.


Dynamic membrane protein topological switching upon changes in phospholipid environment.

Vitrac H, MacLean DM, Jayaraman V, Bogdanov M, Dowhan W.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13874-9. doi: 10.1073/pnas.1512994112. Epub 2015 Oct 28.


Medical Castration Using the Investigational Oral GnRH Antagonist TAK-385 (Relugolix): Phase 1 Study in Healthy Males.

MacLean DB, Shi H, Faessel HM, Saad F.

J Clin Endocrinol Metab. 2015 Dec;100(12):4579-87. doi: 10.1210/jc.2015-2770. Epub 2015 Oct 26.


Skeletal Muscle an Active Compartment in the Sequestering and Metabolism of Doxorubicin Chemotherapy.

Fabris S, MacLean DA.

PLoS One. 2015 Sep 24;10(9):e0139070. doi: 10.1371/journal.pone.0139070. eCollection 2015.


Critical Cysteine Residues in Both the Calcium-Sensing Receptor and the Allosteric Activator AMG 416 Underlie the Mechanism of Action.

Alexander ST, Hunter T, Walter S, Dong J, Maclean D, Baruch A, Subramanian R, Tomlinson JE.

Mol Pharmacol. 2015 Nov;88(5):853-65. doi: 10.1124/mol.115.098392. Epub 2015 Aug 19.


Lessons from Fraxinus, a crowd-sourced citizen science game in genomics.

Rallapalli G; Fraxinus Players, Saunders DG, Yoshida K, Edwards A, Lugo CA, Collin S, Clavijo B, Corpas M, Swarbreck D, Clark M, Downie JA, Kamoun S; Team Cooper, MacLean D.

Elife. 2015 Jul 29;4:e07460. doi: 10.7554/eLife.07460.


A Novel Modelling Approach for Predicting Forest Growth and Yield under Climate Change.

Ashraf MI, Meng FR, Bourque CP, MacLean DA.

PLoS One. 2015 Jul 14;10(7):e0132066. doi: 10.1371/journal.pone.0132066. eCollection 2015.


A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc.

Sirrieh RE, MacLean DM, Jayaraman V.

J Gen Physiol. 2015 Aug;146(2):173-81. doi: 10.1085/jgp.201511422. Epub 2015 Jul 13.


Oxandrolone Augmentation of Resistance Training in Older Women: A Randomized Trial.

Mavros Y, O'Neill E, Connerty M, Bean JF, Broe K, Kiel DP, Maclean D, Taylor A, Fielding RA, Singh MA.

Med Sci Sports Exerc. 2015 Nov;47(11):2257-67. doi: 10.1249/MSS.0000000000000690.


Subtype-dependent N-methyl-D-aspartate receptor amino-terminal domain conformations and modulation by spermine.

Sirrieh RE, MacLean DM, Jayaraman V.

J Biol Chem. 2015 May 15;290(20):12812-20. doi: 10.1074/jbc.M115.649723. Epub 2015 Mar 31.


bio-samtools 2: a package for analysis and visualization of sequence and alignment data with SAMtools in Ruby.

Etherington GJ, Ramirez-Gonzalez RH, MacLean D.

Bioinformatics. 2015 Aug 1;31(15):2565-7. doi: 10.1093/bioinformatics/btv178. Epub 2015 Mar 29.


Orteronel plus prednisone in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (ELM-PC 4): a double-blind, multicentre, phase 3, randomised, placebo-controlled trial.

Saad F, Fizazi K, Jinga V, Efstathiou E, Fong PC, Hart LL, Jones R, McDermott R, Wirth M, Suzuki K, MacLean DB, Wang L, Akaza H, Nelson J, Scher HI, Dreicer R, Webb IJ, de Wit R; ELM-PC 4 investigators.

Lancet Oncol. 2015 Mar;16(3):338-48. doi: 10.1016/S1470-2045(15)70027-6. Epub 2015 Feb 18.


Physical and chemical properties of pomegranate fruit accessions from Croatia.

Radunić M, Jukić Špika M, Goreta Ban S, Gadže J, Díaz-Pérez JC, MacLean D.

Food Chem. 2015 Jun 15;177:53-60. doi: 10.1016/j.foodchem.2014.12.102. Epub 2015 Jan 5.


An open science peer review oath.

Aleksic J, Alexa A, Attwood TK, Chue Hong N, Dahlö M, Davey R, Dinkel H, Förstner KU, Grigorov I, Hériché JK, Lahti L, MacLean D, Markie ML, Molloy J, Schneider MV, Scott C, Smith-Unna R, Vieira BM; as part of the AllBio: Open Science & Reproducibility Best Practice Workshop.

Version 2. F1000Res. 2014 Nov 12 [revised 2015 Jan 1];3:271. doi: 10.12688/f1000research.5686.2. eCollection 2014.


Mapping mutations in plant genomes with the user-friendly web application CandiSNP.

Etherington GJ, Monaghan J, Zipfel C, MacLean D.

Plant Methods. 2014 Dec 30;10(1):41. doi: 10.1186/s13007-014-0041-7. eCollection 2014.


The calcium-dependent protein kinase CPK28 buffers plant immunity and regulates BIK1 turnover.

Monaghan J, Matschi S, Shorinola O, Rovenich H, Matei A, Segonzac C, Malinovsky FG, Rathjen JP, MacLean D, Romeis T, Zipfel C.

Cell Host Microbe. 2014 Nov 12;16(5):605-15. doi: 10.1016/j.chom.2014.10.007. Epub 2014 Nov 12.


Stargazin promotes closure of the AMPA receptor ligand-binding domain.

MacLean DM, Ramaswamy SS, Du M, Howe JR, Jayaraman V.

J Gen Physiol. 2014 Dec;144(6):503-12. doi: 10.1085/jgp.201411287.


Using 2k + 2 bubble searches to find single nucleotide polymorphisms in k-mer graphs.

Younsi R, MacLean D.

Bioinformatics. 2015 Mar 1;31(5):642-6. doi: 10.1093/bioinformatics/btu706. Epub 2014 Oct 24.


Health-related quality of life in advanced prostate cancer and its treatments: biochemical failure and metastatic disease populations.

Sartor O, Flood E, Beusterien K, Park J, Webb I, MacLean D, Wong BJ, Mark Lin H.

Clin Genitourin Cancer. 2015 Apr;13(2):101-12. doi: 10.1016/j.clgc.2014.08.001. Epub 2014 Aug 19.


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