Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 382

1.

An Economic Evaluation of Voretigene Neparvovec for the Treatment of Biallelic RPE65-Mediated Inherited Retinal Dystrophies in the UK.

Viriato D, Bennett N, Sidhu R, Hancock E, Lomax H, Trueman D, MacLaren RE.

Adv Ther. 2020 Feb 7. doi: 10.1007/s12325-020-01243-y. [Epub ahead of print]

PMID:
32034665
2.

Repair of Retinal Degeneration following Ex Vivo Minicircle DNA Gene Therapy and Transplantation of Corrected Photoreceptor Progenitors.

Barnea-Cramer AO, Singh M, Fischer D, De Silva S, McClements ME, Barnard AR, MacLaren RE.

Mol Ther. 2020 Jan 29. pii: S1525-0016(20)30055-1. doi: 10.1016/j.ymthe.2020.01.023. [Epub ahead of print]

PMID:
32027843
3.

A Semiautomated, Phenotypic, In Vitro Scratch Assay for Assessing Retinal Pigment Epithelial Cell Wound Healing.

Storm T, Wilson I, Campbell R, Bolinches-Amorós A, Russell AJ, Davies SG, Barnard AR, MacLaren RE.

J Ocul Pharmacol Ther. 2020 Feb 6. doi: 10.1089/jop.2019.0116. [Epub ahead of print]

PMID:
32027217
4.

Reply to: Comment on: PLACE Trial Report No. 3.

van Rijssen TJ, van Dijk EHC, Scholz P, Breukink MB, Blanco-Garavito R, Souied EH, Keunen JEE, MacLaren RE, Querques G, Fauser S, Downes SM, Hoyng CB, Boon CJF.

Am J Ophthalmol. 2020 Jan 29. pii: S0002-9394(19)30579-3. doi: 10.1016/j.ajo.2019.11.022. [Epub ahead of print] No abstract available.

PMID:
32007226
5.

Progress in the development of novel therapies for choroideremia.

Cehajic Kapetanovic J, Patrício MI, MacLaren RE.

Expert Rev Ophthalmol. 2019;14(6):277-285. doi: 10.1080/17469899.2019.1699406. Epub 2019 Dec 26.

6.

RNA editing as a therapeutic approach for retinal gene therapy requiring long coding sequences.

Fry LE, Peddle CF, Barnard AR, McClements ME, MacLaren RE.

Int J Mol Sci. 2020 Jan 25;21(3). pii: E777. doi: 10.3390/ijms21030777. Review.

7.

Establishing the Therapeutic Index of Fluid Resuscitation in the Septic Patient: A Narrative Review and Meta-Analysis.

Reynolds PM, Wells L, MacLaren R, Scoular SK.

Pharmacotherapy. 2020 Jan 22. doi: 10.1002/phar.2371. [Epub ahead of print] Review.

PMID:
31970818
8.

Structural Insights into the Unique Activation Mechanisms of a Non-classical Calpain and Its Disease-Causing Variants.

Velez G, Sun YJ, Khan S, Yang J, Herrmann J, Chemudupati T, MacLaren RE, Gakhar L, Wakatsuki S, Bassuk AG, Mahajan VB.

Cell Rep. 2020 Jan 21;30(3):881-892.e5. doi: 10.1016/j.celrep.2019.12.077.

9.

Inclusion of PF68 Surfactant Improves Stability of rAAV Titer when Passed through a Surgical Device Used in Retinal Gene Therapy.

Patrício MI, Cox CI, Blue C, Barnard AR, Martinez-Fernandez de la Camara C, MacLaren RE.

Mol Ther Methods Clin Dev. 2019 Nov 20;17:99-106. doi: 10.1016/j.omtm.2019.11.005. eCollection 2020 Jun 12.

10.

Coagulation Factor Xa (Recombinant), Inactivated-Zhzo (Andexanet Alfa) Hemostatic Outcomes and Thrombotic Event Incidence at an Academic Medical Center.

Stevens VM, Trujillo T, Mueller SW, MacLaren R, Reynolds PM, Kiser TH.

Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619896619. doi: 10.1177/1076029619896619.

PMID:
31876159
11.

Association of Messenger RNA Level With Phenotype in Patients With Choroideremia: Potential Implications for Gene Therapy Dose.

Fry LE, Patrício MI, Williams J, Aylward JW, Hewitt H, Clouston P, Xue K, Barnard AR, MacLaren RE.

JAMA Ophthalmol. 2019 Dec 19. doi: 10.1001/jamaophthalmol.2019.5071. [Epub ahead of print]

PMID:
31855248
12.

Prévention des ulcères: pas de stress!

MacLaren R.

Can J Hosp Pharm. 2019 Nov-Dec;72(6):419-420. Epub 2019 Dec 1. French. No abstract available.

PMID:
31853141
Free PMC Article
13.

Don't Stress about Ulcer Prophylaxis.

MacLaren R.

Can J Hosp Pharm. 2019 Nov-Dec;72(6):417-418. Epub 2019 Dec 1. No abstract available.

14.

Dynamic in vivo quantification of rod photoreceptor degeneration using fluorescent reporter mouse models of retinitis pigmentosa.

Orlans HO, Barnard AR, MacLaren RE.

Exp Eye Res. 2020 Jan;190:107895. doi: 10.1016/j.exer.2019.107895. Epub 2019 Dec 6.

PMID:
31816293
15.

HYPERREFLECTIVE FOCI AS A PATHOGENETIC BIOMARKER IN CHOROIDEREMIA.

Romano F, Arrigo A, MacLaren RE, Charbel Issa P, Birtel J, Bandello F, Battaglia Parodi M.

Retina. 2019 Nov 28. doi: 10.1097/IAE.0000000000002645. [Epub ahead of print]

PMID:
31800458
16.

Transcorneal electrical stimulation for the treatment of retinitis pigmentosa - a multicenter safety study of the OkuStim® System (TESOLA-study).

Jolly JK, Wagner SK, Martus P, MacLaren RE, Wilhelm B, Webster AR, Downes SM, Charbel Issa P, Kellner U, Jägle H, Rüther K, Bertelsen M, Bragadóttir R, Prener Holtan J, van den Born I, Sodi A, Virgili G, Gosheva M, Pach J, Zündorf I, Zrenner E, Gekeler F.

Ophthalmic Res. 2019 Nov 26. doi: 10.1159/000505001. [Epub ahead of print] No abstract available.

PMID:
31775146
17.

A novel splice-site variant in CDH23 in a patient with Usher syndrome type 1.

Menghini M, Cehajic-Kapetanovic J, Yusuf IH, MacLaren RE.

Ophthalmic Genet. 2019 Dec;40(6):545-548. doi: 10.1080/13816810.2019.1692359. Epub 2019 Nov 22.

PMID:
31755791
18.

A distinct retinal pigment epithelial cell autofluorescence pattern in choroideremia predicts early involvement of overlying photoreceptors.

Stevanovic M, Cehajic Kapetanovic J, Jolly JK, MacLaren RE.

Acta Ophthalmol. 2019 Nov 17. doi: 10.1111/aos.14281. [Epub ahead of print]

PMID:
31736270
19.

The Impact of Progressive Visual Field Constriction on Reading Ability in an Inherited Retinal Degeneration.

Jolly JK, Couldridge-Smith CE, Xue K, MacLaren RE.

Ophthalmologica. 2019 Nov 5:1-10. doi: 10.1159/000503294. [Epub ahead of print]

PMID:
31689706
20.

Adverse Hemodynamic Events Associated With Concomitant Dexmedetomidine and Propofol for Sedation in Mechanically Ventilated ICU Patients.

Buckley MS, Agarwal SK, MacLaren R, Kane-Gill SL.

J Intensive Care Med. 2019 Oct 31:885066619884548. doi: 10.1177/0885066619884548. [Epub ahead of print]

PMID:
31672073
21.

Comment on: 'Sector retinitis pigmentosa caused by mutations of the RHO gene'.

Orlans HO, MacLaren RE.

Eye (Lond). 2019 Oct 28. doi: 10.1038/s41433-019-0648-z. [Epub ahead of print] No abstract available.

PMID:
31659286
22.

Presence of corneal crystals confirms an unusual presentation of Bietti's retinal dystrophy.

Song WK, Clouston P, MacLaren RE.

Ophthalmic Genet. 2019 Oct;40(5):461-465. doi: 10.1080/13816810.2019.1678176. Epub 2019 Oct 22.

PMID:
31638456
23.

Outcome Measures Used in Ocular Gene Therapy Trials: A Scoping Review of Current Practice.

Jolly JK, Bridge H, MacLaren RE.

Front Pharmacol. 2019 Sep 18;10:1076. doi: 10.3389/fphar.2019.01076. eCollection 2019. Review.

24.

RPGR gene therapy presents challenges in cloning the coding sequence.

Martinez-Fernandez De La Camara C, Cehajic-Kapetanovic J, MacLaren RE.

Expert Opin Biol Ther. 2020 Jan;20(1):63-71. doi: 10.1080/14712598.2020.1680635. Epub 2019 Oct 20.

PMID:
31612744
25.

Validation of electronic visual acuity (EVA) measurement against standardised ETDRS charts in patients with visual field loss from inherited retinal degenerations.

Jolly JK, Juenemann K, Boagey H, Nadsady M, Bridge H, Maclaren RE.

Br J Ophthalmol. 2019 Oct 4. pii: bjophthalmol-2019-315124. doi: 10.1136/bjophthalmol-2019-315124. [Epub ahead of print]

PMID:
31585961
26.

Molecular Therapies for Choroideremia.

Cehajic Kapetanovic J, Barnard AR, MacLaren RE.

Genes (Basel). 2019 Sep 23;10(10). pii: E738. doi: 10.3390/genes10100738. Review.

27.

Retinal stem cell transplantation: Balancing safety and potential.

Singh MS, Park SS, Albini TA, Canto-Soler MV, Klassen H, MacLaren RE, Takahashi M, Nagiel A, Schwartz SD, Bharti K.

Prog Retin Eye Res. 2019 Sep 5:100779. doi: 10.1016/j.preteyeres.2019.100779. [Epub ahead of print] Review.

28.

Predictors of gastrointestinal bleeding in adult ICU patients: a systematic review and meta-analysis.

Granholm A, Zeng L, Dionne JC, Perner A, Marker S, Krag M, MacLaren R, Ye Z, Møller MH, Alhazzani W; GUIDE Group.

Intensive Care Med. 2019 Oct;45(10):1347-1359. doi: 10.1007/s00134-019-05751-6. Epub 2019 Sep 5. Review.

PMID:
31489445
29.

Molecular Strategies for RPGR Gene Therapy.

Cehajic Kapetanovic J, McClements ME, Martinez-Fernandez de la Camara C, MacLaren RE.

Genes (Basel). 2019 Sep 4;10(9). pii: E674. doi: 10.3390/genes10090674. Review.

30.

Clinical Characterization of Retinitis Pigmentosa Associated With Variants in SNRNP200.

Yusuf IH, Birtel J, Shanks ME, Clouston P, Downes SM, Charbel Issa P, MacLaren RE.

JAMA Ophthalmol. 2019 Sep 5. doi: 10.1001/jamaophthalmol.2019.3298. [Epub ahead of print]

PMID:
31486839
31.

Efficacy and Safety of Retinal Gene Therapy Using Adeno-Associated Virus Vector for Patients With Choroideremia: A Randomized Clinical Trial.

Fischer MD, Ochakovski GA, Beier B, Seitz IP, Vaheb Y, Kortuem C, Reichel FFL, Kuehlewein L, Kahle NA, Peters T, Girach A, Zrenner E, Ueffing M, MacLaren RE, Bartz-Schmidt KU, Wilhelm B.

JAMA Ophthalmol. 2019 Aug 29. doi: 10.1001/jamaophthalmol.2019.3278. [Epub ahead of print]

PMID:
31465092
32.

The Bedside Critical Care Pharmacist: A Mandatory ICU Team Member Essential for Patient Care.

MacLaren R, Devlin JW.

Crit Care Med. 2019 Sep;47(9):1276-1278. doi: 10.1097/CCM.0000000000003888. No abstract available.

PMID:
31415315
33.

A Specific Macula-Predominant Retinal Phenotype Is Associated With the CDHR1 Variant c.783G>A, a Silent Mutation Leading to In-Frame Exon Skipping.

Charbel Issa P, Gliem M, Yusuf IH, Birtel J, Müller PL, Mangold E, Downes SM, MacLaren RE, Betz C, Bolz HJ.

Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3388-3397. doi: 10.1167/iovs.18-26415.

PMID:
31387115
34.

Surgical Technique for Subretinal Gene Therapy in Humans with Inherited Retinal Degeneration.

Davis JL, Gregori NZ, MacLaren RE, Lam BL.

Retina. 2019 Oct;39 Suppl 1:S2-S8. doi: 10.1097/IAE.0000000000002609. No abstract available.

PMID:
31335483
35.

Potential lifetime quality of life benefits of choroideremia gene therapy: projections from a clinically informed decision model.

Halioua-Haubold CL, Jolly JK, Smith JA, Pinedo-Villanueva R, Brindley DA, MacLaren RE.

Eye (Lond). 2019 Aug;33(8):1215-1223. doi: 10.1038/s41433-019-0492-1. Epub 2019 Jul 17.

PMID:
31312000
36.

Enhancement of Adeno-Associated Virus-Mediated Gene Therapy Using Hydroxychloroquine in Murine and Human Tissues.

Chandler LC, Barnard AR, Caddy SL, Patrício MI, McClements ME, Fu H, Rada C, MacLaren RE, Xue K.

Mol Ther Methods Clin Dev. 2019 Jun 4;14:77-89. doi: 10.1016/j.omtm.2019.05.012. eCollection 2019 Sep 13.

37.

Filtration of Short-Wavelength Light Provides Therapeutic Benefit in Retinitis Pigmentosa Caused by a Common Rhodopsin Mutation.

Orlans HO, Merrill J, Barnard AR, Charbel Issa P, Peirson SN, MacLaren RE.

Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2733-2742. doi: 10.1167/iovs.19-26964.

PMID:
31247114
38.

Clinical and Molecular Characterization of PROM1-Related Retinal Degeneration.

Cehajic-Kapetanovic J, Birtel J, McClements ME, Shanks ME, Clouston P, Downes SM, Charbel Issa P, MacLaren RE.

JAMA Netw Open. 2019 Jun 5;2(6):e195752. doi: 10.1001/jamanetworkopen.2019.5752.

39.

Patient characteristics of untreated chronic central serous chorioretinopathy patients with focal versus diffuse leakage.

van Rijssen TJ, van Dijk EHC, Scholz P, Breukink MB, Blanco-Garavito R, Souied EH, MacLaren RE, Querques G, Fauser S, Hoyng CB, Downes SM, Boon CJF.

Graefes Arch Clin Exp Ophthalmol. 2019 Jul;257(7):1419-1425. doi: 10.1007/s00417-019-04333-y. Epub 2019 May 23.

PMID:
31123815
40.
41.

A Randomized Crossover Study to Assess the Usability of Two New Vision Tests in Patients with Low Vision.

Jolly JK, Gray JM, Salvetti AP, Han RC, MacLaren RE.

Optom Vis Sci. 2019 Jun;96(6):443-452. doi: 10.1097/OPX.0000000000001380.

PMID:
31058709
42.

A Quantitative Chloride Channel Conductance Assay for Efficacy Testing of AAV.BEST1.

Wood SR, McClements ME, Martinez-Fernandez de la Camara C, Patrício MI, Uggenti C, Sekaran S, Barnard AR, Manson FD, MacLaren RE.

Hum Gene Ther Methods. 2019 Apr;30(2):44-52. doi: 10.1089/hgtb.2018.267.

PMID:
30963787
43.

Focal and Diffuse Chronic Central Serous Chorioretinopathy Treated With Half-Dose Photodynamic Therapy or Subthreshold Micropulse Laser: PLACE Trial Report No. 3.

van Rijssen TJ, van Dijk EHC, Scholz P, Breukink MB, Blanco-Garavito R, Souied EH, Keunen JEE, MacLaren RE, Querques G, Fauser S, Downes SM, Hoyng CB, Boon CJF.

Am J Ophthalmol. 2019 Sep;205:1-10. doi: 10.1016/j.ajo.2019.03.025. Epub 2019 Apr 3.

PMID:
30951686
44.

Reply.

van Dijk EHC, Fauser S, Breukink MB, Blanco-Garavito R, Groenewoud JMM, Keunen JEE, Peters PJH, Dijkman G, Souied EH, MacLaren RE, Querques G, Downes SM, Hoyng CB, Boon CJF.

Ophthalmology. 2019 Apr;126(4):e30-e31. doi: 10.1016/j.ophtha.2018.11.005. No abstract available.

PMID:
30910048
45.

Comparative evaluation of isavuconazonium sulfate, voriconazole, and posaconazole for the management of invasive fungal infections in an academic medical center.

Van Matre ET, Evans SL, Mueller SW, MacLaren R, Fish DN, Kiser TH.

Ann Clin Microbiol Antimicrob. 2019 Mar 20;18(1):13. doi: 10.1186/s12941-019-0311-3.

46.

Re: Song et al., Toxicology and Pharmacology of an AAV Vector Expressing Codon-Optimized RPGR in RPGR-Deficient Rd9 Mice. Hum Gene Ther Clin Dev 2018; 29(4):188-197.

MacLaren RE, Fischer MD, De La Camara CM.

Hum Gene Ther Clin Dev. 2019 Mar;30(1):40. doi: 10.1089/humc.2019.29041.rem. No abstract available.

PMID:
30888916
47.

Prevention Strategies to Improve Outcomes in Critically Ill Adults.

MacLaren R, Brophy GM.

Pharmacotherapy. 2019 Mar;39(3):212-214. doi: 10.1002/phar.2232. Epub 2019 Mar 15. No abstract available.

PMID:
30873663
48.

Changes in microchip position after implantation of a subretinal vision prosthesis in humans.

Kuehlewein L, Troelenberg N, Stingl K, Schleehauf S, Kusnyerik A, Jackson TL, MacLaren RE, Chee C, Roider J, Wilhelm B, Gekeler F, Bartz-Schmidt KU, Zrenner E, Stingl K.

Acta Ophthalmol. 2019 Sep;97(6):e871-e876. doi: 10.1111/aos.14077. Epub 2019 Feb 28.

PMID:
30816625
49.

The Location of Exon 4 Mutations in RP1 Raises Challenges for Genetic Counseling and Gene Therapy.

Nanda A, McClements ME, Clouston P, Shanks ME, MacLaren RE.

Am J Ophthalmol. 2019 Jun;202:23-29. doi: 10.1016/j.ajo.2019.01.027. Epub 2019 Feb 4.

PMID:
30731082
50.

Digital Technology in Somatic and Gene Therapy Trials of Pediatric Patients With Ocular Diseases: Protocol for a Scoping Review.

Meinert E, Alturkistani A, Osama T, Halioua-Haubold CL, Car J, Majeed A, Wells G, MacLaren RE, Brindley D.

JMIR Res Protoc. 2019 Feb 7;8(2):e10705. doi: 10.2196/10705.

Supplemental Content

Loading ...
Support Center