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Regulation of Eag1 gating by its intracellular domains.

Whicher JR, MacKinnon R.

Elife. 2019 Sep 6;8. pii: e49188. doi: 10.7554/eLife.49188.


Force-induced conformational changes in PIEZO1.

Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S.

Nature. 2019 Sep;573(7773):230-234. doi: 10.1038/s41586-019-1499-2. Epub 2019 Aug 21.


Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly.

Ku M, MacKinnon RN, Wall M, Narayan N, Walkley C, Cheng HC, Campbell LJ, Purton LE, Nandurkar H.

Sci Rep. 2019 May 7;9(1):7050. doi: 10.1038/s41598-019-43373-6.


Defining and measuring quality in acute paediatric trauma stabilisation: a phenomenographic study.

MacKinnon RJ, Pukk-Härenstam K, Von Thiele Schwarz U, Kennedy C, Stenfors T.

Adv Simul (Lond). 2019 Apr 11;4:4. doi: 10.1186/s41077-019-0091-z. eCollection 2019.


The effect of an International competitive leaderboard on self-motivated simulation-based CPR practice among healthcare professionals: A randomized control trial.

Chang TP, Raymond T, Dewan M, MacKinnon R, Whitfill T, Harwayne-Gidansky I, Doughty C, Frisell K, Kessler D, Wolfe H, Auerbach M, Rutledge C, Mitchell D, Jani P, Walsh CM; INSPIRE In-Hospital QCPR Leaderboard Investigators.

Resuscitation. 2019 May;138:273-281. doi: 10.1016/j.resuscitation.2019.02.050. Epub 2019 Apr 1.


Objective auditory brainstem response classification using machine learning.

McKearney RM, MacKinnon RC.

Int J Audiol. 2019 Apr;58(4):224-230. doi: 10.1080/14992027.2018.1551633. Epub 2019 Jan 21.


Molecular basis of signaling specificity between GIRK channels and GPCRs.

Touhara KK, MacKinnon R.

Elife. 2018 Dec 10;7. pii: e42908. doi: 10.7554/eLife.42908.


Piezo's membrane footprint and its contribution to mechanosensitivity.

Haselwandter CA, MacKinnon R.

Elife. 2018 Nov 27;7. pii: e41968. doi: 10.7554/eLife.41968.


Tinnitus information online - does it ring true?

McKearney RM, MacKinnon RC, Smith M, Baker R.

J Laryngol Otol. 2018 Nov;132(11):984-989. doi: 10.1017/S0022215118001792. Epub 2018 Oct 24.


Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells.

Del Mármol JI, Touhara KK, Croft G, MacKinnon R.

Elife. 2018 Aug 22;7. pii: e33149. doi: 10.7554/eLife.33149.


An innovative collaborative interdisciplinary approach to new paediatric tracheostomy safety guidelines.

MacKinnon RJ, Volk MS.

Anaesthesia. 2018 Nov;73(11):1309-1312. doi: 10.1111/anae.14378. Epub 2018 Aug 7. No abstract available.


MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.

Sakthianandeswaren A, Parsons MJ, Mouradov D, MacKinnon RN, Catimel B, Liu S, Palmieri M, Love C, Jorissen RN, Li S, Whitehead L, Putoczki TL, Preaudet A, Tsui C, Nowell CJ, Ward RL, Hawkins NJ, Desai J, Gibbs P, Ernst M, Street I, Buchert M, Sieber OM.

Cancer Discov. 2018 Aug;8(8):988-1005. doi: 10.1158/2159-8290.CD-17-0909. Epub 2018 Jun 7.


Structure of the CLC-1 chloride channel from Homo sapiens.

Park E, MacKinnon R.

Elife. 2018 May 29;7. pii: e36629. doi: 10.7554/eLife.36629.


Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures.

Lee CH, MacKinnon R.

Science. 2018 May 4;360(6388):508-513. doi: 10.1126/science.aas9466.


Analysis of Chromothripsis by Combined FISH and Microarray Analysis.

MacKinnon RN.

Methods Mol Biol. 2018;1769:53-77. doi: 10.1007/978-1-4939-7780-2_5.


Conducting multicenter research in healthcare simulation: Lessons learned from the INSPIRE network.

Cheng A, Kessler D, Mackinnon R, Chang TP, Nadkarni VM, Hunt EA, Duval-Arnould J, Lin Y, Pusic M, Auerbach M.

Adv Simul (Lond). 2017 Feb 28;2:6. doi: 10.1186/s41077-017-0039-0. eCollection 2017.


Leveraging Quick Response Code Technology to Facilitate Simulation-Based Leaderboard Competition.

Chang TP, Doughty CB, Mitchell D, Rutledge C, Auerbach MA, Frisell K, Jani P, Kessler DO, Wolfe H, MacKinnon RJ, Dewan M, Pirie J, Lemke D, Khattab M, Tofil N, Nagamuthu C, Walsh CM; INSPIRE In-Hospital QCPR Leaderboard Investigators.

Simul Healthc. 2018 Feb;13(1):64-71. doi: 10.1097/SIH.0000000000000281.


Molecular structure of human KATP in complex with ATP and ADP.

Lee KPK, Chen J, MacKinnon R.

Elife. 2017 Dec 29;6. pii: e32481. doi: 10.7554/eLife.32481.


Structure-based membrane dome mechanism for Piezo mechanosensitivity.

Guo YR, MacKinnon R.

Elife. 2017 Dec 12;6. pii: e33660. doi: 10.7554/eLife.33660.


Building a Community of Practice for Researchers: The International Network for Simulation-Based Pediatric Innovation, Research and Education.

Cheng A, Auerbach M, Calhoun A, Mackinnon R, Chang TP, Nadkarni V, Hunt EA, Duval-Arnould J, Peiris N, Kessler D; INSPIRE Investigators*.

Simul Healthc. 2018 Jun;13(3S Suppl 1):S28-S34. doi: 10.1097/SIH.0000000000000269.


Ten years of simulation-based training in pediatric anesthesia: The inception, evolution, and dissemination of the Managing Emergencies in Pediatric Anesthesia (MEPA) course.

Everett TC, MacKinnon R, de Beer D, Taylor M, Bould MD.

Paediatr Anaesth. 2017 Oct;27(10):984-990. doi: 10.1111/pan.13224. Epub 2017 Aug 17. Review.


Mortality and morbidity in oesophageal atresia.

Peters RT, Ragab H, Columb MO, Bruce J, MacKinnon RJ, Craigie RJ.

Pediatr Surg Int. 2017 Sep;33(9):989-994. doi: 10.1007/s00383-017-4124-1. Epub 2017 Jul 12.


Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.

Sun J, MacKinnon R.

Cell. 2017 Jun 1;169(6):1042-1050.e9. doi: 10.1016/j.cell.2017.05.019.


Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG.

Wang W, MacKinnon R.

Cell. 2017 Apr 20;169(3):422-430.e10. doi: 10.1016/j.cell.2017.03.048.


The Dicentric Chromosome dic(20;22) Is a Recurrent Abnormality in Myelodysplastic Syndromes and Is a Product of Telomere Fusion.

MacKinnon RN, Duivenvoorden HM, Campbell LJ, Wall M.

Cytogenet Genome Res. 2016;150(3-4):262-272. doi: 10.1159/000456677. Epub 2017 Mar 4.


Structural Titration of Slo2.2, a Na+-Dependent K+ Channel.

Hite RK, MacKinnon R.

Cell. 2017 Jan 26;168(3):390-399.e11. doi: 10.1016/j.cell.2016.12.030. Epub 2017 Jan 19.


Structures of the Human HCN1 Hyperpolarization-Activated Channel.

Lee CH, MacKinnon R.

Cell. 2017 Jan 12;168(1-2):111-120.e11. doi: 10.1016/j.cell.2016.12.023. Epub 2017 Jan 12.


Structure of a CLC chloride ion channel by cryo-electron microscopy.

Park E, Campbell EB, MacKinnon R.

Nature. 2017 Jan 26;541(7638):500-505. doi: 10.1038/nature20812. Epub 2016 Dec 21.


Structural basis for gating the high-conductance Ca2+-activated K+ channel.

Hite RK, Tao X, MacKinnon R.

Nature. 2017 Jan 5;541(7635):52-57. doi: 10.1038/nature20775. Epub 2016 Dec 14.


Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel.

Tao X, Hite RK, MacKinnon R.

Nature. 2017 Jan 5;541(7635):46-51. doi: 10.1038/nature20608. Epub 2016 Dec 14.


Lifetime leisure music exposure associated with increased frequency of tinnitus.

Moore DR, Zobay O, Mackinnon RC, Whitmer WM, Akeroyd MA.

Hear Res. 2017 Apr;347:18-27. doi: 10.1016/j.heares.2016.10.030. Epub 2016 Nov 5.


An International Interprofessional Study of Mental Models and Factors Delaying Neuroimaging of Critically Head-Injured Children Presenting to Emergency Departments.

Auerbach M, Cole J, Violano P, Roney L, Doherty C, Shepherd M, MacKinnon R.

Pediatr Emerg Care. 2018 Nov;34(11):797-801. doi: 10.1097/PEC.0000000000000915.


Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism.

Whicher JR, MacKinnon R.

Science. 2016 Aug 12;353(6300):664-9. doi: 10.1126/science.aaf8070.


Reporting Guidelines for Health Care Simulation Research: Extensions to the CONSORT and STROBE Statements.

Cheng A, Kessler D, Mackinnon R, Chang TP, Nadkarni VM, Hunt EA, Duval-Arnould J, Lin Y, Cook DA, Pusic M, Hui J, Moher D, Egger M, Auerbach M; International Network for Simulation-based Pediatric Innovation, Research, and Education (INSPIRE) Reporting Guidelines Investigators.

Simul Healthc. 2016 Aug;11(4):238-48. doi: 10.1097/SIH.0000000000000150.


Reporting guidelines for health care simulation research: extensions to the CONSORT and STROBE statements.

Cheng A, Kessler D, Mackinnon R, Chang TP, Nadkarni VM, Hunt EA, Duval-Arnould J, Lin Y, Cook DA, Pusic M, Hui J, Moher D, Egger M, Auerbach M; International Network for Simulation-based Pediatric Innovation, Research, and Education (INSPIRE) Reporting Guidelines Investigators.

Adv Simul (Lond). 2016 Jul 25;1:25. doi: 10.1186/s41077-016-0025-y. eCollection 2016.


Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels.

Su Z, Brown EC, Wang W, MacKinnon R.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5748-53. doi: 10.1073/pnas.1602815113. Epub 2016 Apr 18.


The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers.

Touhara KK, Wang W, MacKinnon R.

Elife. 2016 Apr 13;5. pii: e15750. doi: 10.7554/eLife.15750.


Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels.

Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R.

Elife. 2016 Apr 13;5. pii: e15751. doi: 10.7554/eLife.15751.


Active centromere and chromosome identification in fixed cell lines.

Beh TT, MacKinnon RN, Kalitsis P.

Mol Cytogenet. 2016 Mar 22;9:28. doi: 10.1186/s13039-016-0236-x. eCollection 2016.


Exploring Mechanisms for Effective Technology-Enhanced Simulation-based Education in Wilderness Medicine: A Systematic Review.

MacKinnon R, Aitken D, Humphries C.

Cureus. 2015 Dec 17;7(12):e412. doi: 10.7759/cureus.412.


Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel.

Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R.

Nature. 2015 Nov 12;527(7577):198-203. doi: 10.1038/nature14958. Epub 2015 Oct 5.


Fitness for purpose study of the Field Assessment Conditioning Tool (FACT): a research protocol.

MacKinnon RJ, Kennedy C, Doherty C, Shepherd M, Cole J, Stenfors-Hayes T; INSPIRE Trauma Outreach Research Group (

BMJ Open. 2015 Apr 13;5(4):e006386. doi: 10.1136/bmjopen-2014-006386.


Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel.

Brohawn SG, Campbell EB, MacKinnon R.

Nature. 2014 Dec 4;516(7529):126-30. doi: 10.1038/nature14013.


Phosphatidic acid modulation of Kv channel voltage sensor function.

Hite RK, Butterwick JA, MacKinnon R.

Elife. 2014 Oct 6;3. doi: 10.7554/eLife.04366.


Automated screening for high-frequency hearing loss.

Vlaming MS, MacKinnon RC, Jansen M, Moore DR.

Ear Hear. 2014 Nov-Dec;35(6):667-79. doi: 10.1097/AUD.0000000000000073.


Src family kinases and their role in hematological malignancies.

Ku M, Wall M, MacKinnon RN, Walkley CR, Purton LE, Tam C, Izon D, Campbell L, Cheng HC, Nandurkar H.

Leuk Lymphoma. 2015 Mar;56(3):577-86. doi: 10.3109/10428194.2014.907897. Epub 2015 Jan 21. Review.


Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels.

Brohawn SG, Su Z, MacKinnon R.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3614-9. doi: 10.1073/pnas.1320768111. Epub 2014 Feb 18.


Genome organization and the role of centromeres in evolution of the erythroleukaemia cell line HEL.

Mackinnon RN, Wall M, Zordan A, Nutalapati S, Mercer B, Peverall J, Campbell LJ.

Evol Med Public Health. 2013 Jan;2013(1):225-40. doi: 10.1093/emph/eot020. Epub 2013 Oct 1.


Chromothripsis under the microscope: a cytogenetic perspective of two cases of AML with catastrophic chromosome rearrangement.

Mackinnon RN, Campbell LJ.

Cancer Genet. 2013 Jun;206(6):238-51. doi: 10.1016/j.cancergen.2013.05.021. Epub 2013 Aug 2.


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