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Items: 1 to 50 of 54

1.

Telomerase promotes formation of a telomere protective complex in cancer cells.

Perera ON, Sobinoff AP, Teber ET, Harman A, Maritz MF, Yang SF, Pickett HA, Cesare AJ, Arthur JW, MacKenzie KL, Bryan TM.

Sci Adv. 2019 Oct 2;5(10):eaav4409. doi: 10.1126/sciadv.aav4409. eCollection 2019 Oct.

2.

DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts.

Richards LA, Kumari A, Knezevic K, Thoms JA, von Jonquieres G, Napier CE, Ali Z, O'Brien R, Marks-Bluth J, Maritz MF, Pickett HA, Morris J, Pimanda JE, MacKenzie KL.

Haematologica. 2019 Aug 14. pii: haematol.2018.215699. doi: 10.3324/haematol.2018.215699. [Epub ahead of print]

3.

Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes.

Unnikrishnan A, Papaemmanuil E, Beck D, Deshpande NP, Verma A, Kumari A, Woll PS, Richards LA, Knezevic K, Chandrakanthan V, Thoms JAI, Tursky ML, Huang Y, Ali Z, Olivier J, Galbraith S, Kulasekararaj AG, Tobiasson M, Karimi M, Pellagatti A, Wilson SR, Lindeman R, Young B, Ramakrishna R, Arthur C, Stark R, Crispin P, Curnow J, Warburton P, Roncolato F, Boultwood J, Lynch K, Jacobsen SEW, Mufti GJ, Hellstrom-Lindberg E, Wilkins MR, MacKenzie KL, Wong JWH, Campbell PJ, Pimanda JE.

Cell Rep. 2017 Jul 18;20(3):572-585. doi: 10.1016/j.celrep.2017.06.067.

4.
5.

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network.

Unnikrishnan A, Guan YF, Huang Y, Beck D, Thoms JA, Peirs S, Knezevic K, Ma S, de Walle IV, de Jong I, Ali Z, Zhong L, Raftery MJ, Taghon T, Larsson J, MacKenzie KL, Van Vlierberghe P, Wong JW, Pimanda JE.

Nucleic Acids Res. 2016 Dec 15;44(22):10644-10661. Epub 2016 Sep 6.

6.

A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts.

El-Hoss J, Jing D, Evans K, Toscan C, Xie J, Lee H, Taylor RA, Lawrence MG, Risbridger GP, MacKenzie KL, Sutton R, Lock RB.

Oncotarget. 2016 Sep 13;7(37):60475-60490. doi: 10.18632/oncotarget.11125.

7.

New prospects for targeting telomerase beyond the telomere.

Arndt GM, MacKenzie KL.

Nat Rev Cancer. 2016 Aug;16(8):508-24. doi: 10.1038/nrc.2016.55. Epub 2016 Jun 24. Review.

PMID:
27339602
8.

Effective Management of Advanced Angiosarcoma by the Synergistic Combination of Propranolol and Vinblastine-based Metronomic Chemotherapy: A Bench to Bedside Study.

Pasquier E, André N, Street J, Chougule A, Rekhi B, Ghosh J, Philip DSJ, Meurer M, MacKenzie KL, Kavallaris M, Banavali SD.

EBioMedicine. 2016 Apr;6:87-95. doi: 10.1016/j.ebiom.2016.02.026. Epub 2016 Feb 17.

9.

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin.

O'Brien R, Tran SL, Maritz MF, Liu B, Kong CF, Purgato S, Yang C, Murray J, Russell AJ, Flemming CL, von Jonquieres G, Pickett HA, London WB, Haber M, Gunaratne PH, Norris MD, Perini G, Fletcher JI, MacKenzie KL.

Cancer Res. 2016 Jun 15;76(12):3604-17. doi: 10.1158/0008-5472.CAN-15-0879. Epub 2016 Apr 13.

10.

MAPK/ERK2 phosphorylates ERG at serine 283 in leukemic cells and promotes stem cell signatures and cell proliferation.

Huang Y, Thoms JA, Tursky ML, Knezevic K, Beck D, Chandrakanthan V, Suryani S, Olivier J, Boulton A, Glaros EN, Thomas SR, Lock RB, MacKenzie KL, Bushweller JH, Wong JW, Pimanda JE.

Leukemia. 2016 Jul;30(7):1552-61. doi: 10.1038/leu.2016.55. Epub 2016 Mar 8.

11.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M.

Semin Cancer Biol. 2015 Dec;35 Suppl:S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Review.

12.

p21(WAF1) modulates drug-induced apoptosis and cell cycle arrest in B-cell precursor acute lymphoblastic leukemia.

Davies C, Hogarth LA, Mackenzie KL, Hall AG, Lock RB.

Cell Cycle. 2015;14(22):3602-12. doi: 10.1080/15384101.2015.1100774.

13.

WDR5 Supports an N-Myc Transcriptional Complex That Drives a Protumorigenic Gene Expression Signature in Neuroblastoma.

Sun Y, Bell JL, Carter D, Gherardi S, Poulos RC, Milazzo G, Wong JW, Al-Awar R, Tee AE, Liu PY, Liu B, Atmadibrata B, Wong M, Trahair T, Zhao Q, Shohet JM, Haupt Y, Schulte JH, Brown PJ, Arrowsmith CH, Vedadi M, MacKenzie KL, Hüttelmaier S, Perini G, Marshall GM, Braithwaite A, Liu T.

Cancer Res. 2015 Dec 1;75(23):5143-54. doi: 10.1158/0008-5472.CAN-15-0423. Epub 2015 Oct 15.

14.

Ras Transformation Overrides a Proliferation Defect Induced by Tpm3.1 Knockout.

Coombes JD, Schevzov G, Kan CY, Petti C, Maritz MF, Whittaker S, Mackenzie KL, Gunning PW.

Cell Mol Biol Lett. 2015 Dec;20(4):626-46. doi: 10.1515/cmble-2015-0037.

PMID:
26274783
15.

Therapeutic targeting of replicative immortality.

Yaswen P, MacKenzie KL, Keith WN, Hentosh P, Rodier F, Zhu J, Firestone GL, Matheu A, Carnero A, Bilsland A, Sundin T, Honoki K, Fujii H, Georgakilas AG, Amedei A, Amin A, Helferich B, Boosani CS, Guha G, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Bhakta D, Halicka D, Niccolai E, Aquilano K, Ashraf SS, Nowsheen S, Yang X.

Semin Cancer Biol. 2015 Dec;35 Suppl:S104-S128. doi: 10.1016/j.semcancer.2015.03.007. Epub 2015 Apr 11. Review.

16.

Overexpression of ERG in cord blood progenitors promotes expansion and recapitulates molecular signatures of high ERG leukemias.

Tursky ML, Beck D, Thoms JA, Huang Y, Kumari A, Unnikrishnan A, Knezevic K, Evans K, Richards LA, Lee E, Morris J, Goldberg L, Izraeli S, Wong JW, Olivier J, Lock RB, MacKenzie KL, Pimanda JE.

Leukemia. 2015 Apr;29(4):819-27. doi: 10.1038/leu.2014.299. Epub 2014 Oct 13.

PMID:
25306899
17.

A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells.

Jamieson SM, Gu Y, Manesh DM, El-Hoss J, Jing D, Mackenzie KL, Guise CP, Foehrenbacher A, Pullen SM, Benito J, Smaill JB, Patterson AV, Mulaw MA, Konopleva M, Bohlander SK, Lock RB, Wilson WR.

Biochem Pharmacol. 2014 Mar 1;88(1):36-45. doi: 10.1016/j.bcp.2013.12.019. Epub 2014 Jan 13.

PMID:
24434189
18.

Modeling human endothelial cell transformation in vascular neoplasias.

Wen VW, MacKenzie KL.

Dis Model Mech. 2013 Sep;6(5):1066-79. doi: 10.1242/dmm.012674. Review.

19.

Histone deacetylase 5 blocks neuroblastoma cell differentiation by interacting with N-Myc.

Sun Y, Liu PY, Scarlett CJ, Malyukova A, Liu B, Marshall GM, MacKenzie KL, Biankin AV, Liu T.

Oncogene. 2014 Jun 5;33(23):2987-94. doi: 10.1038/onc.2013.253. Epub 2013 Jul 1.

PMID:
23812427
20.

Up-regulation of survivin during immortalization of human myofibroblasts is linked to repression of tumor suppressor p16(INK4a) protein and confers resistance to oxidative stress.

Kan CY, Petti C, Bracken L, Maritz M, Xu N, O'Brien R, Yang C, Liu T, Yuan J, Lock RB, MacKenzie KL.

J Biol Chem. 2013 Apr 26;288(17):12032-41. doi: 10.1074/jbc.M112.447821. Epub 2013 Feb 28.

21.

HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses.

Bolden JE, Shi W, Jankowski K, Kan CY, Cluse L, Martin BP, MacKenzie KL, Smyth GK, Johnstone RW.

Cell Death Dis. 2013 Feb 28;4:e519. doi: 10.1038/cddis.2013.9.

22.

Assessment and quantification of telomerase enzyme activity.

Maritz MF, Richards LA, Mackenzie KL.

Methods Mol Biol. 2013;965:215-31. doi: 10.1007/978-1-62703-239-1_14.

PMID:
23296661
23.

Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells.

Pasquier E, Tuset MP, Street J, Sinnappan S, MacKenzie KL, Braguer D, Andre N, Kavallaris M.

Angiogenesis. 2013 Apr;16(2):373-86. doi: 10.1007/s10456-012-9321-x. Epub 2012 Nov 10.

24.

Endothelial cell dysfunction and cytoskeletal changes associated with repression of p16(INK4a) during immortalization.

Kan CY, Wen VW, Pasquier E, Jankowski K, Chang M, Richards LA, Kavallaris M, MacKenzie KL.

Oncogene. 2012 Nov 15;31(46):4815-27. doi: 10.1038/onc.2011.645. Epub 2012 Feb 6.

25.

Induction of vascular endothelial growth factor secretion by childhood acute lymphoblastic leukemia cells via the FLT-3 signaling pathway.

Markovic A, MacKenzie KL, Lock RB.

Mol Cancer Ther. 2012 Jan;11(1):183-93. doi: 10.1158/1535-7163.MCT-11-0503. Epub 2011 Nov 14.

26.

p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia.

Davies C, Hogarth LA, Dietrich PA, Bachmann PS, Mackenzie KL, Hall AG, Lock RB.

J Biol Chem. 2011 Oct 28;286(43):37639-50. doi: 10.1074/jbc.M111.272336. Epub 2011 Sep 7.

27.

SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.

Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, Iraci N, Valli E, Ling D, Thomas W, van Bekkum M, Sekyere E, Jankowski K, Trahair T, Mackenzie KL, Haber M, Norris MD, Biankin AV, Perini G, Liu T.

PLoS Genet. 2011 Jun;7(6):e1002135. doi: 10.1371/journal.pgen.1002135. Epub 2011 Jun 16.

28.

ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer.

Thoms JA, Birger Y, Foster S, Knezevic K, Kirschenbaum Y, Chandrakanthan V, Jonquieres G, Spensberger D, Wong JW, Oram SH, Kinston SJ, Groner Y, Lock R, MacKenzie KL, Göttgens B, Izraeli S, Pimanda JE.

Blood. 2011 Jun 30;117(26):7079-89. doi: 10.1182/blood-2010-12-317990. Epub 2011 May 2.

PMID:
21536859
29.

Mild hyperoxia limits hTR levels, telomerase activity, and telomere length maintenance in hTERT-transduced bone marrow endothelial cells.

Napier CE, Veas LA, Kan CY, Taylor LM, Yuan J, Wen VW, James A, O'Brien TA, Lock RB, MacKenzie KL.

Biochim Biophys Acta. 2010 Oct;1803(10):1142-53. doi: 10.1016/j.bbamcr.2010.06.010. Epub 2010 Jul 7.

30.

Targeting telomerase in hematologic malignancy.

Maritz MF, Napier CE, Wen VW, MacKenzie KL.

Future Oncol. 2010 May;6(5):769-89. doi: 10.2217/fon.10.42. Review.

PMID:
20465390
31.

Upregulation of survivin during immortalization of nontransformed human fibroblasts transduced with telomerase reverse transcriptase.

Yuan J, Yang BM, Zhong ZH, Shats I, Milyavsky M, Rotter V, Lock RB, Reddel RR, MacKenzie KL.

Oncogene. 2009 Jul 23;28(29):2678-89. doi: 10.1038/onc.2009.136. Epub 2009 Jun 1.

PMID:
19483728
32.

A role for altered microtubule polymer levels in vincristine resistance of childhood acute lymphoblastic leukemia xenografts.

Ong V, Liem NL, Schmid MA, Verrills NM, Papa RA, Marshall GM, Mackenzie KL, Kavallaris M, Lock RB.

J Pharmacol Exp Ther. 2008 Feb;324(2):434-42. Epub 2007 Nov 6.

PMID:
17986648
33.

p53 determines multidrug sensitivity of childhood neuroblastoma.

Xue C, Haber M, Flemming C, Marshall GM, Lock RB, MacKenzie KL, Gurova KV, Norris MD, Gudkov AV.

Cancer Res. 2007 Nov 1;67(21):10351-60.

34.

Telomere length of cord blood-derived CD34(+) progenitors predicts erythroid proliferative potential.

Schuller CE, Jankowski K, Mackenzie KL.

Leukemia. 2007 May;21(5):983-91. Epub 2007 Mar 8.

PMID:
17344914
35.

Telomere-driven karyotypic complexity concurs with p16INK4a inactivation in TP53-competent immortal endothelial cells.

Wen VW, Wu K, Baksh S, Hinshelwood RA, Lock RB, Clark SJ, Moore MA, Mackenzie KL.

Cancer Res. 2006 Nov 15;66(22):10691-700.

36.

Over-expression of p53 mutants in LNCaP cells alters tumor growth and angiogenesis in vivo.

Perryman LA, Blair JM, Kingsley EA, Szymanska B, Ow KT, Wen VW, MacKenzie KL, Vermeulen PB, Jackson P, Russell PJ.

Biochem Biophys Res Commun. 2006 Jul 7;345(3):1207-14. Epub 2006 May 11.

PMID:
16723121
37.

Osteopetrotic mouse stroma with thrombopoietin, c-kit ligand, and flk-2 ligand supports long-term mobilized CD34+ hematopoiesis in vitro.

Feugier P, Li N, Jo DY, Shieh JH, MacKenzie KL, Lesesve JF, Latger-Cannard V, Bensoussan D, Crystal RG, Rafii S, Stoltz JF, Moore MA.

Stem Cells Dev. 2005 Oct;14(5):505-16.

PMID:
16305336
38.

FLT-3: a new focus in the understanding of acute leukemia.

Markovic A, MacKenzie KL, Lock RB.

Int J Biochem Cell Biol. 2005 Jun;37(6):1168-72. Epub 2005 Jan 26. Review.

PMID:
15778081
39.

Dexamethasone resistance in B-cell precursor childhood acute lymphoblastic leukemia occurs downstream of ligand-induced nuclear translocation of the glucocorticoid receptor.

Bachmann PS, Gorman R, Mackenzie KL, Lutze-Mann L, Lock RB.

Blood. 2005 Mar 15;105(6):2519-26. Epub 2004 Nov 30.

PMID:
15572593
40.

Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse.

Shen SW, Dolnikov A, Passioura T, Millington M, Wotherspoon S, Rice A, MacKenzie KL, Symonds G.

Exp Hematol. 2004 Sep;32(9):852-60.

PMID:
15345287
41.

Inactivation of p16INK4a, with retention of pRB and p53/p21cip1 function, in human MRC5 fibroblasts that overcome a telomere-independent crisis during immortalization.

Taylor LM, James A, Schuller CE, Brce J, Lock RB, Mackenzie KL.

J Biol Chem. 2004 Oct 15;279(42):43634-45. Epub 2004 Aug 10.

42.

Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies.

Liem NL, Papa RA, Milross CG, Schmid MA, Tajbakhsh M, Choi S, Ramirez CD, Rice AM, Haber M, Norris MD, MacKenzie KL, Lock RB.

Blood. 2004 May 15;103(10):3905-14. Epub 2004 Feb 5.

PMID:
14764536
43.
44.

Limited proliferation and telomere dysfunction following telomerase inhibition in immortal murine fibroblasts.

Boklan J, Nanjangud G, MacKenzie KL, May C, Sadelain M, Moore MA.

Cancer Res. 2002 Apr 1;62(7):2104-14.

46.
47.

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells.

Mulloy JC, Cammenga J, MacKenzie KL, Berguido FJ, Moore MA, Nimer SD.

Blood. 2002 Jan 1;99(1):15-23.

PMID:
11756147
48.

Clonal variation in phenotype and life span of human embryonic fibroblasts (MRC-5) transduced with the catalytic component of telomerase (hTERT).

Franco S, MacKenzie KL, Dias S, Alvarez S, Rafii S, Moore MA.

Exp Cell Res. 2001 Aug 1;268(1):14-25.

PMID:
11461114
49.

Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation.

MacKenzie KL, Franco S, May C, Sadelain M, Moore MA.

Exp Cell Res. 2000 Sep 15;259(2):336-50.

PMID:
10964501
50.

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