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Items: 16


Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.

Cardaci S, Zheng L, MacKay G, van den Broek NJ, MacKenzie ED, Nixon C, Stevenson D, Tumanov S, Bulusu V, Kamphorst JJ, Vazquez A, Fleming S, Schiavi F, Kalna G, Blyth K, Strathdee D, Gottlieb E.

Nat Cell Biol. 2015 Oct;17(10):1317-26. doi: 10.1038/ncb3233. Epub 2015 Aug 24.


Fumarate induces redox-dependent senescence by modifying glutathione metabolism.

Zheng L, Cardaci S, Jerby L, MacKenzie ED, Sciacovelli M, Johnson TI, Gaude E, King A, Leach JD, Edrada-Ebel R, Hedley A, Morrice NA, Kalna G, Blyth K, Ruppin E, Frezza C, Gottlieb E.

Nat Commun. 2015 Jan 23;6:6001. doi: 10.1038/ncomms7001.


Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells.

Zheng L, MacKenzie ED, Karim SA, Hedley A, Blyth K, Kalna G, Watson DG, Szlosarek P, Frezza C, Gottlieb E.

Cancer Metab. 2013 Mar 21;1(1):12. doi: 10.1186/2049-3002-1-12.


HIF-independent role of prolyl hydroxylases in the cellular response to amino acids.

DurĂ¡n RV, MacKenzie ED, Boulahbel H, Frezza C, Heiserich L, Tardito S, Bussolati O, Rocha S, Hall MN, Gottlieb E.

Oncogene. 2013 Sep 19;32(38):4549-56. doi: 10.1038/onc.2012.465. Epub 2012 Oct 22.


Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.

Frezza C, Zheng L, Folger O, Rajagopalan KN, MacKenzie ED, Jerby L, Micaroni M, Chaneton B, Adam J, Hedley A, Kalna G, Tomlinson IP, Pollard PJ, Watson DG, Deberardinis RJ, Shlomi T, Ruppin E, Gottlieb E.

Nature. 2011 Aug 17;477(7363):225-8. doi: 10.1038/nature10363.


Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death.

Tennant DA, Frezza C, MacKenzie ED, Nguyen QD, Zheng L, Selak MA, Roberts DL, Dive C, Watson DG, Aboagye EO, Gottlieb E.

Oncogene. 2009 Nov 12;28(45):4009-21. doi: 10.1038/onc.2009.250. Epub 2009 Aug 31.


Cardiolipin provides an essential activating platform for caspase-8 on mitochondria.

Gonzalvez F, Schug ZT, Houtkooper RH, MacKenzie ED, Brooks DG, Wanders RJ, Petit PX, Vaz FM, Gottlieb E.

J Cell Biol. 2008 Nov 17;183(4):681-96. doi: 10.1083/jcb.200803129. Epub 2008 Nov 10.


Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells.

MacKenzie ED, Selak MA, Tennant DA, Payne LJ, Crosby S, Frederiksen CM, Watson DG, Gottlieb E.

Mol Cell Biol. 2007 May;27(9):3282-9. Epub 2007 Feb 26.


Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.

Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Pan Y, Simon MC, Thompson CB, Gottlieb E.

Cancer Cell. 2005 Jan;7(1):77-85.


AP-1-mediated invasion requires increased expression of the hyaluronan receptor CD44.

Lamb RF, Hennigan RF, Turnbull K, Katsanakis KD, MacKenzie ED, Birnie GD, Ozanne BW.

Mol Cell Biol. 1997 Feb;17(2):963-76.


Fine needle aspiration cytology in maxillofacial surgery--experience in a district general hospital.

Barnard NA, Paterson AW, Irvine GH, Mackenzie ED, White H.

Br J Oral Maxillofac Surg. 1993 Aug;31(4):223-6.


Sequestration of Philadelphia chromosome-positive cells in the bone marrow of a chronic myeloid leukemia patient in very prolonged remission.

Birnie GD, MacKenzie ED, Goyns MH, Pollock A.

Leukemia. 1990 Jun;4(6):452-4. No abstract available.


Further evidence that the site of the breakpoint in the major breakpoint cluster region (M-bcr) may be a prognostic indicator.

Mills KI, Hynds SA, Burnett AK, MacKenzie ED, Birnie GD.

Leukemia. 1989 Dec;3(12):837-40.


Differentiation stage-specific expression of a gene during granulopoiesis.

Wiedemann LM, Francis GE, Lamb RF, Burns JH, Winnie JN, MacKenzie ED, Birnie GD.

Leukemia. 1989 Mar;3(3):227-34.


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