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Items: 1 to 50 of 92

1.

Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation.

Mackenzie AE, Quon T, Lin LC, Hauser AS, Jenkins L, Inoue A, Tobin AB, Gloriam DE, Hudson BD, Milligan G.

FASEB J. 2019 Apr;33(4):5005-5017. doi: 10.1096/fj.201801956R. Epub 2019 Jan 2.

2.

Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35.

Binti Mohd Amir NAS, Mackenzie AE, Jenkins L, Boustani K, Hillier MC, Tsuchiya T, Milligan G, Pease JE.

J Immunol. 2018 Jul 15;201(2):714-724. doi: 10.4049/jimmunol.1700884. Epub 2018 Jun 6.

3.

G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.

McCallum JE, Mackenzie AE, Divorty N, Clarke C, Delles C, Milligan G, Nicklin SA.

J Vasc Res. 2015;52(6):383-95. doi: 10.1159/000444754. Epub 2016 Apr 12.

4.

Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands.

Sergeev E, Hansen AH, Pandey SK, MacKenzie AE, Hudson BD, Ulven T, Milligan G.

J Biol Chem. 2016 Jan 1;291(1):303-17. doi: 10.1074/jbc.M115.687939. Epub 2015 Oct 29.

5.

The emerging pharmacology and function of GPR35 in the nervous system.

Mackenzie AE, Milligan G.

Neuropharmacology. 2017 Feb;113(Pt B):661-671. doi: 10.1016/j.neuropharm.2015.07.035. Epub 2015 Jul 29. Review.

PMID:
26232640
6.

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease.

Divorty N, Mackenzie AE, Nicklin SA, Milligan G.

Front Pharmacol. 2015 Mar 10;6:41. doi: 10.3389/fphar.2015.00041. eCollection 2015. Review.

7.

The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35.

MacKenzie AE, Caltabiano G, Kent TC, Jenkins L, McCallum JE, Hudson BD, Nicklin SA, Fawcett L, Markwick R, Charlton SJ, Milligan G.

Mol Pharmacol. 2014 Jan;85(1):91-104. doi: 10.1124/mol.113.089482. Epub 2013 Oct 10.

8.

Rare-disease genetics in the era of next-generation sequencing: discovery to translation.

Boycott KM, Vanstone MR, Bulman DE, MacKenzie AE.

Nat Rev Genet. 2013 Oct;14(10):681-91. doi: 10.1038/nrg3555. Epub 2013 Sep 3. Review.

PMID:
23999272
9.

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.

Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G.

Mol Pharmacol. 2013 Nov;84(5):710-25. doi: 10.1124/mol.113.087783. Epub 2013 Aug 26.

10.

Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor.

Hudson BD, Due-Hansen ME, Christiansen E, Hansen AM, Mackenzie AE, Murdoch H, Pandey SK, Ward RJ, Marquez R, Tikhonova IG, Ulven T, Milligan G.

J Biol Chem. 2013 Jun 14;288(24):17296-312. doi: 10.1074/jbc.M113.455337. Epub 2013 Apr 15.

11.

High-throughput identification and characterization of novel, species-selective GPR35 agonists.

Neetoo-Isseljee Z, MacKenzie AE, Southern C, Jerman J, McIver EG, Harries N, Taylor DL, Milligan G.

J Pharmacol Exp Ther. 2013 Mar;344(3):568-78. doi: 10.1124/jpet.112.201798. Epub 2012 Dec 21.

12.

Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.

Jenkins L, Harries N, Lappin JE, MacKenzie AE, Neetoo-Isseljee Z, Southern C, McIver EG, Nicklin SA, Taylor DL, Milligan G.

J Pharmacol Exp Ther. 2012 Dec;343(3):683-95. doi: 10.1124/jpet.112.198945. Epub 2012 Sep 11.

13.

A generalizable pre-clinical research approach for orphan disease therapy.

Beaulieu CL, Samuels ME, Ekins S, McMaster CR, Edwards AM, Krainer AR, Hicks GG, Frey BJ, Boycott KM, Mackenzie AE.

Orphanet J Rare Dis. 2012 Jun 15;7:39. Review.

14.

GPR35 as a Novel Therapeutic Target.

Mackenzie AE, Lappin JE, Taylor DL, Nicklin SA, Milligan G.

Front Endocrinol (Lausanne). 2011 Nov 9;2:68. doi: 10.3389/fendo.2011.00068. eCollection 2011.

15.

An engineered zinc finger protein reveals a role for the insulin VNTR in the regulation of the insulin and adjacent IGF2 genes.

Ferguson LA, Docherty HM, MacKenzie AE, Docherty K.

FEBS Lett. 2009 Oct 6;583(19):3181-6. doi: 10.1016/j.febslet.2009.08.041. Epub 2009 Sep 5.

16.

A two-site ELISA can quantify upregulation of SMN protein by drugs for spinal muscular atrophy.

Nguyen thi Man, Humphrey E, Lam LT, Fuller HR, Lynch TA, Sewry CA, Goodwin PR, Mackenzie AE, Morris GE.

Neurology. 2008 Nov 25;71(22):1757-63. doi: 10.1212/01.wnl.0000313038.34337.b1. Epub 2008 Jul 16.

PMID:
18633133
17.

Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.

Arbour N, Vanderluit JL, Le Grand JN, Jahani-Asl A, Ruzhynsky VA, Cheung EC, Kelly MA, MacKenzie AE, Park DS, Opferman JT, Slack RS.

J Neurosci. 2008 Jun 11;28(24):6068-78. doi: 10.1523/JNEUROSCI.4940-07.2008.

18.

Neurodevelopmental abnormalities in neurosphere-derived neural stem cells from SMN-depleted mice.

Shafey D, MacKenzie AE, Kothary R.

J Neurosci Res. 2008 Oct;86(13):2839-47. doi: 10.1002/jnr.21743.

PMID:
18521935
19.

The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26.

Davoodi J, Kelly J, Gendron NH, MacKenzie AE.

Proteomics. 2007 Jun;7(13):2300-10.

PMID:
17549790
20.

Histologic and transcriptional assessment of a mild SMA model.

Balabanian S, Gendron NH, MacKenzie AE.

Neurol Res. 2007 Jul;29(5):413-24.

PMID:
17535551
21.

Distribution of neuronal apoptosis inhibitory protein in human tissues.

Maier JK, Balabanian S, Coffill CR, Stewart A, Pelletier L, Franks DJ, Gendron NH, MacKenzie AE.

J Histochem Cytochem. 2007 Sep;55(9):911-23. Epub 2007 May 17.

PMID:
17510375
22.

Hypoxia alters the expression of inhibitor of apoptosis proteins after brain trauma in the mouse.

Mikrogianakis A, Shaye RE, Griffin P, Kawesa S, Lockwood J, Gendron NH, Gaboury I, Merali Z, Mackenzie AE, Hutchison JS.

J Neurotrauma. 2007 Feb;24(2):338-53.

PMID:
17375998
23.
24.

The impact of a multidisciplinary stroke education programme on Chinese family carers.

Lee S, Lui MH, MacKenzie AE.

J Interprof Care. 2005 Aug;19(4):406-7. No abstract available.

PMID:
16076601
25.

Neuronal apoptosis-inhibitory protein does not interact with Smac and requires ATP to bind caspase-9.

Davoodi J, Lin L, Kelly J, Liston P, MacKenzie AE.

J Biol Chem. 2004 Sep 24;279(39):40622-8. Epub 2004 Jul 26.

26.

The context, measures and outcomes of psychosocial care interventions in long-term health care for older people.

Mackenzie AE, Lee DT, Ross FM.

Int J Nurs Pract. 2004 Feb;10(1):39-44. Review.

PMID:
14764021
27.

Rapid detection of single nucleotide polymorphisms associated with spinal muscular atrophy by use of a reusable fibre-optic biosensor.

Watterson JH, Raha S, Kotoris CC, Wust CC, Gharabaghi F, Jantzi SC, Haynes NK, Gendron NH, Krull UJ, Mackenzie AE, Piunno PA.

Nucleic Acids Res. 2004 Jan 23;32(2):e18.

28.
29.

The cultural context of adjusting to nursing home life: Chinese elders' perspectives.

Lee DT, Woo J, Mackenzie AE.

Gerontologist. 2002 Oct;42(5):667-75.

PMID:
12351802
30.

Effects of a care protocol on care outcomes in older nursing home patients with chronic obstructive pulmonary disease.

Lee DT, Lee IF, Mackenzie AE, Ho RN.

J Am Geriatr Soc. 2002 May;50(5):870-6.

PMID:
12028174
31.

Predictors of quality of life following stroke.

Mackenzie AE, Chang AM.

Disabil Rehabil. 2002 Mar 20;24(5):259-65.

PMID:
12004971
32.

Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes.

Xu M, Okada T, Sakai H, Miyamoto N, Yanagisawa Y, MacKenzie AE, Hadano S, Ikeda JE.

Biochim Biophys Acta. 2002 Feb 20;1574(1):35-50.

PMID:
11955612
33.

Distinct expression of neuronal apoptosis inhibitory protein (NAIP) during murine development.

Ingram-Crooks J, Holcik M, Drmanic S, MacKenzie AE.

Neuroreport. 2002 Mar 25;13(4):397-402.

PMID:
11930148
34.

The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7.

Maier JK, Lahoua Z, Gendron NH, Fetni R, Johnston A, Davoodi J, Rasper D, Roy S, Slack RS, Nicholson DW, MacKenzie AE.

J Neurosci. 2002 Mar 15;22(6):2035-43.

35.

Psychosocial consequences of falling: the perspective of older Hong Kong Chinese who had experienced recent falls.

Kong KS, Lee Fk FK, Mackenzie AE, Lee DT.

J Adv Nurs. 2002 Feb;37(3):234-42.

PMID:
11851793
36.

Coping with a child with Down syndrome: the experiences of mothers in Hong Kong.

Lam LW, Mackenzie AE.

Qual Health Res. 2002 Feb;12(2):223-37.

PMID:
11837372
37.

A pilot project to evaluate implementation of clinical guidelines.

Lee FK, Chang AM, Mackenzie AE.

J Nurs Care Qual. 2002 Jan;16(2):50-9.

PMID:
11797478
38.

A review of older people's experiences with residential care placement.

Lee DT, Woo J, Mackenzie AE.

J Adv Nurs. 2002 Jan;37(1):19-27. Review.

PMID:
11784394
39.

Neuronal apoptosis inhibitory protein expression after traumatic brain injury in the mouse.

Hutchison JS, Derrane RE, Johnston DL, Gendron N, Barnes D, Fliss H, King WJ, Rasquinha I, MacManus J, Robertson GS, MacKenzie AE.

J Neurotrauma. 2001 Dec;18(12):1333-47.

PMID:
11780864
40.

Tudor reign.

MacKenzie AE, Gendron NH.

Nat Struct Biol. 2001 Jan;8(1):13-5. No abstract available.

PMID:
11135659
41.

Needs of Chinese families of critically ill patients.

Leung KK, Chien WT, Mackenzie AE.

West J Nurs Res. 2000 Nov;22(7):826-40.

PMID:
11077550
42.

Needs of families with a relative in a critical care unit in Hong Kong.

Lee IY, Chien WT, MacKenzie AE.

J Clin Nurs. 2000 Jan;9(1):46-54.

PMID:
11022492
43.

IAP family proteins delay motoneuron cell death in vivo.

Perrelet D, Ferri A, MacKenzie AE, Smith GM, Korneluk RG, Liston P, Sagot Y, Terrado J, Monnier D, Kato AC.

Eur J Neurosci. 2000 Jun;12(6):2059-67.

PMID:
10886345
44.

Needs of Chinese families with a relative in a critical care unit.

Lee IY, Mackenzie AE, Chien WT.

J Clin Nurs. 1999 Nov;8(6):762-3. No abstract available.

PMID:
10827623
45.

The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury.

Holcik M, Thompson CS, Yaraghi Z, Lefebvre CA, MacKenzie AE, Korneluk RG.

Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2286-90.

46.

Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down syndrome.

Seidl R, Bajo M, Böhm K, LaCasse EC, MacKenzie AE, Cairns N, Lubec G.

J Neural Transm Suppl. 1999;57:283-91.

PMID:
10666683
47.

Hospital readmissions among elderly patients in Hong Kong: a preliminary study.

Lee DT, Mackenzie AE, Lee IF, Chan CW.

J Clin Nurs. 1999 Jul;8(4):478-9. No abstract available.

PMID:
10624266
48.

The psychosocial impact of stroke.

Chang AM, Mackenzie AE, Yip MP, Dhillon R.

J Clin Nurs. 1999 Jul;8(4):477-8. No abstract available.

PMID:
10624265
49.

Chinese elderly patients' perceptions of their rehabilitation needs following a stroke.

Lui MH, MacKenzie AE.

J Adv Nurs. 1999 Aug;30(2):391-400.

PMID:
10457241
50.

Spinal muscular atrophy: molecular pathophysiology.

Gendron NH, MacKenzie AE.

Curr Opin Neurol. 1999 Apr;12(2):137-42. Review.

PMID:
10226744

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