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Glucose Control in Adults with Type 1 Diabetes Using a Medtronic Prototype Enhanced-Hybrid Closed-Loop System: A Feasibility Study.

Lee MH, Vogrin S, Paldus B, Jones HM, Obeyesekere V, Sims C, Wyatt SA, Ward GM, McAuley SA, MacIsaac RJ, Krishnamurthy B, Sundararajan V, Jenkins AJ, O'Neal DN.

Diabetes Technol Ther. 2019 Sep;21(9):499-506. doi: 10.1089/dia.2019.0120. Epub 2019 Jul 2.


Sildenafil enhances central hemodynamic responses to exercise, but not V̇o2peak, in people with diabetes mellitus.

Roberts TJ, Burns AT, MacIsaac RJ, MacIsaac AI, Prior DL, La Gerche A.

J Appl Physiol (1985). 2019 Jul 1;127(1):1-10. doi: 10.1152/japplphysiol.00947.2018. Epub 2019 May 2.


Changes in soluble tumor necrosis factor receptor type 1 levels and early renal function decline in patients with diabetes.

MacIsaac RJ, Farag M, Obeyesekere V, Clarke M, Boston R, Ward GM, Jerums G, Ekinci EI.

J Diabetes Investig. 2019 Apr 15. doi: 10.1111/jdi.13061. [Epub ahead of print]


Is hyperfiltration associated with higher urine albumin-to-creatinine ratio at follow up among Indigenous Australians? The eGFR follow-up study.

Ekinci EI, Barr ELM, Barzi F, Hughes JT, Lawton PD, Jones GRD, Hoy W, Cass A, Thomas M, Sinha A, Jerums G, O'Dea K, MacIsaac RJ, Maple-Brown LJ.

J Diabetes Complications. 2019 May;33(5):343-349. doi: 10.1016/j.jdiacomp.2019.02.005. Epub 2019 Feb 21.


SGLT2 Inhibitors Increase the Risk of Diabetic Ketoacidosis Developing in the Community and During Hospital Admission.

Hamblin PS, Wong R, Ekinci EI, Fourlanos S, Shah S, Jones AR, Hare MJL, Calder GL, Epa DS, George EM, Giri R, Kotowicz MA, Kyi M, Lafontaine N, MacIsaac RJ, Nolan BJ, O'Neal DN, Renouf D, Varadarajan S, Wong J, Xu S, Bach LA.

J Clin Endocrinol Metab. 2019 Aug 1;104(8):3077-3087. doi: 10.1210/jc.2019-00139.


Three Dimensional Glomerular Reconstruction: A Novel Approach to Evaluate Renal Microanatomy in Diabetic Kidney Disease.

Torkamani N, Jerums G, Crammer P, Skene A, Power DA, Panagiotopoulos S, Clarke M, MacIsaac RJ, Ekinci EI.

Sci Rep. 2019 Feb 12;9(1):1829. doi: 10.1038/s41598-019-38646-z.


Empagliflozin as an adjunctive therapy for type 1 diabetes.

MacIsaac RJ, Lee MH, McAuley SA, Ward GM, O'Neal DN.

Ann Transl Med. 2018 Dec;6(Suppl 2):S134. doi: 10.21037/atm.2018.12.52. No abstract available.


Glucose Control Using a Standard Versus an Enhanced Hybrid Closed Loop System: A Randomized Crossover Study.

Paldus B, Lee MH, Jones HM, McAuley SA, Horsburgh JC, Roem KL, Ward GM, MacIsaac RJ, Cohen N, Colman PG, Jenkins AJ, O'Neal DN.

Diabetes Technol Ther. 2019 Jan;21(1):56-58. doi: 10.1089/dia.2018.0279.


Mortality in People With Type 1 Diabetes, Severe Hypoglycemia, and Impaired Awareness of Hypoglycemia Referred for Islet Transplantation.

Lee MH, Ward GM, MacIsaac RJ, Howe K, Holmes-Walker DJ, Anderson P, Radford T, Coates PT, Kay TW, O'Connell PJ, Goodman DJ.

Transplant Direct. 2018 Oct 23;4(11):e401. doi: 10.1097/TXD.0000000000000841. eCollection 2018 Nov. No abstract available.


Bone health in chronic kidney disease-mineral and bone disorder: a clinical case seminar and update.

Aleksova J, Ng KW, Jung C, Zeimer H, Dwyer KM, Milat F, MacIsaac RJ.

Intern Med J. 2018 Dec;48(12):1435-1446. doi: 10.1111/imj.14129. Review.


Use of Readily Accessible Inflammatory Markers to Predict Diabetic Kidney Disease.

Winter L, Wong LA, Jerums G, Seah JM, Clarke M, Tan SM, Coughlan MT, MacIsaac RJ, Ekinci EI.

Front Endocrinol (Lausanne). 2018 May 22;9:225. doi: 10.3389/fendo.2018.00225. eCollection 2018. Review.


Effect of 6 months of hybrid closed-loop insulin delivery in adults with type 1 diabetes: a randomised controlled trial protocol.

McAuley SA, de Bock MI, Sundararajan V, Lee MH, Paldus B, Ambler GR, Bach LA, Burt MG, Cameron FJ, Clarke PM, Cohen ND, Colman PG, Davis EA, Fairchild JM, Hendrieckx C, Holmes-Walker DJ, Horsburgh JC, Jenkins AJ, Kaye J, Keech AC, King BR, Kumareswaran K, MacIsaac RJ, McCallum RW, Nicholas JA, Sims C, Speight J, Stranks SN, Trawley S, Ward GM, Vogrin S, Jones TW, O'Neal DN.

BMJ Open. 2018 Jun 9;8(6):e020274. doi: 10.1136/bmjopen-2017-020274.


Pathophysiological Links Between Diabetes and Blood Pressure.

Libianto R, Batu D, MacIsaac RJ, Cooper ME, Ekinci EI.

Can J Cardiol. 2018 May;34(5):585-594. doi: 10.1016/j.cjca.2018.01.010. Epub 2018 Jan 31. Review.


Experiences of young adults with type 1 diabetes while using alcohol and recreational drugs: An interpretative phenomenological analysis (IPA) of semi-structured interviews.

Pastor A, O'Brien CL, Teng J, Conn J, Loh M, Collins L, MacIsaac RJ, Bonomo Y.

Diabetes Res Clin Pract. 2018 Jul;141:47-55. doi: 10.1016/j.diabres.2018.04.029. Epub 2018 Apr 22.


Diagnostic challenges in a patient with an occult insulinoma:68 Ga-DOTA-exendin-4 PET/CT and 68Ga-DOTATATE PET/CT.

Bongetti E, Lee MH, Pattison DA, Hicks RJ, Norris R, Sachithanandan N, MacIsaac RJ.

Clin Case Rep. 2018 Mar 1;6(4):719-722. doi: 10.1002/ccr3.1448. eCollection 2018 Apr.


Systemic mastocytosis identified in two women developing fragility fractures during lactation.

Zhu JJ, Mahendran D, Lee MH, Seah J, Fourlanos S, Varadarajan S, Ghasem-Zadeh A, MacIsaac RJ, Seeman E.

Osteoporos Int. 2018 Jul;29(7):1671-1674. doi: 10.1007/s00198-018-4498-5. Epub 2018 Apr 4.


Omega-3 polyunsaturated fatty acid supplementation for improving peripheral nerve health: protocol for a systematic review.

Zhang AC, MacIsaac RJ, Roberts L, Kamel J, Craig JP, Busija L, Downie LE.

BMJ Open. 2018 Mar 25;8(3):e020804. doi: 10.1136/bmjopen-2017-020804.


Glycemic Control as Primary Prevention for Diabetic Kidney Disease.

MacIsaac RJ, Jerums G, Ekinci EI.

Adv Chronic Kidney Dis. 2018 Mar;25(2):141-148. doi: 10.1053/j.ackd.2017.11.003. Review.


Suboptimal behaviour and knowledge regarding overnight glycaemia in adults with type 1 diabetes is common.

Larsson CR, Januszewski AS, McGrath RT, Ludvigsson J, Keech AC, MacIsaac RJ, Ward GM, O'Neal DN, Fulcher GR, Jenkins AJ.

Intern Med J. 2018 Sep;48(9):1080-1086. doi: 10.1111/imj.13798.


Exercise capacity in diabetes mellitus is predicted by activity status and cardiac size rather than cardiac function: a case control study.

Roberts TJ, Burns AT, MacIsaac RJ, MacIsaac AI, Prior DL, La Gerche A.

Cardiovasc Diabetol. 2018 Mar 23;17(1):44. doi: 10.1186/s12933-018-0688-x.


Feasibility and patient acceptability of a novel artificial intelligence-based screening model for diabetic retinopathy at endocrinology outpatient services: a pilot study.

Keel S, Lee PY, Scheetz J, Li Z, Kotowicz MA, MacIsaac RJ, He M.

Sci Rep. 2018 Mar 12;8(1):4330. doi: 10.1038/s41598-018-22612-2.


Systematic review and meta-analysis of prevalence of sarcopenia in post acute inpatient rehabilitation.

Churilov I, Churilov L, MacIsaac RJ, Ekinci EI.

Osteoporos Int. 2018 Apr;29(4):805-812. doi: 10.1007/s00198-018-4381-4. Epub 2018 Feb 18.


Lipid-lowering therapy use and achievement of cholesterol targets in an Australian diabetes clinic.

Kiburg KV, Ward GM, O'Neal DN, MacIsaac RJ.

Intern Med J. 2018 Feb;48(2):201-204. doi: 10.1111/imj.13691.


High Baseline Levels of Tumor Necrosis Factor Receptor 1 Are Associated With Progression of Kidney Disease in Indigenous Australians With Diabetes: The eGFR Follow-up Study.

Barr ELM, Barzi F, Hughes JT, Jerums G, Hoy WE, O'Dea K, Jones GRD, Lawton PD, Brown ADH, Thomas M, Ekinci EI, Sinha A, Cass A, MacIsaac RJ, Maple-Brown LJ.

Diabetes Care. 2018 Apr;41(4):739-747. doi: 10.2337/dc17-1919. Epub 2018 Jan 24.


Trajectories of eGFR decline over a four year period in an Indigenous Australian population at high risk of CKD-the eGFR follow up study.

Barzi F, Jones GRD, Hughes JT, Lawton PD, Hoy W, O'Dea K, Jerums G, MacIsaac RJ, Cass A, Maple-Brown LJ.

Clin Biochem. 2018 Mar;53:58-64. doi: 10.1016/j.clinbiochem.2018.01.011.


Diagnosis and Significance of Pulmonary Microvascular Disease in Diabetes.

Roberts TJ, Burns AT, MacIsaac RJ, MacIsaac AI, Prior DL, La Gerche A.

Diabetes Care. 2018 Apr;41(4):854-861. doi: 10.2337/dc17-1904. Epub 2018 Jan 19.


Effects of Diabetes Medications Targeting the Incretin System on the Kidney.

MacIsaac RJ, Thomas MC.

Clin J Am Soc Nephrol. 2018 Feb 7;13(2):321-323. doi: 10.2215/CJN.10380917. Epub 2018 Jan 10. No abstract available.


Diabetic ketoacidosis in adult patients: an audit of factors influencing time to normalisation of metabolic parameters.

Lee MH, Calder GL, Santamaria JD, MacIsaac RJ.

Intern Med J. 2018 May;48(5):529-534. doi: 10.1111/imj.13735.


Comparative effectiveness of cardiovascular outcomes in new users of sodium-glucose cotransporter-2 inhibitors: SGLT2 inhibitors in the real world.

MacIsaac RJ, Ekinci EI.

Ann Transl Med. 2017 Dec;5(23):474. doi: 10.21037/atm.2017.10.11. No abstract available.


Cross-sectional associations of albuminuria among Aboriginal and Torres Strait Islander adults: the eGFR Study.

Hughes JT, Maple-Brown LJ, Thomas M, Lawton PD, Sinha A, Cass A, Barzi F, Jones G, Jerums G, MacIsaac RJ, O'Dea K, Hoy WE.

Nephrology (Carlton). 2018 Jan;23(1):37-45. doi: 10.1111/nep.12956.


Long-term intra-individual variability of albuminuria in type 2 diabetes mellitus: implications for categorization of albumin excretion rate.

Leong A, Ekinci EI, Nguyen C, Milne M, Hachem M, Dobson M, MacIsaac RJ, Jerums G.

BMC Nephrol. 2017 Dec 6;18(1):355. doi: 10.1186/s12882-017-0767-3.


Hyponatraemia and hypopituitarism: an easily missed entity.

Lee MH, Calder GL, MacIsaac RJ, Sachithanandan N.

Med J Aust. 2017 Sep 2;207(7):282-283. No abstract available.


Relationship between urinary sodium-to-potassium ratio and ambulatory blood pressure in patients with diabetes mellitus.

Libianto R, Moran J, O'Callaghan C, Baqar S, Chen AX, Baker ST, Clarke M, MacIsaac RJ, Jerums G, Ekinci EI.

Clin Exp Pharmacol Physiol. 2018 Jan;45(1):94-97. doi: 10.1111/1440-1681.12852. Epub 2017 Oct 25.


Bilirubin concentration is positively associated with haemoglobin concentration and inversely associated with albumin to creatinine ratio among Indigenous Australians: eGFR Study.

Hughes JT, Barzi F, Hoy WE, Jones GRD, Rathnayake G, Majoni SW, Thomas MAB, Sinha A, Cass A, MacIsaac RJ, O'Dea K, Maple-Brown LJ.

Clin Biochem. 2017 Dec;50(18):1040-1047. doi: 10.1016/j.clinbiochem.2017.08.011. Epub 2017 Aug 20.


Closed-Loop Insulin Delivery for Adults with Type 1 Diabetes Undertaking High-Intensity Interval Exercise Versus Moderate-Intensity Exercise: A Randomized, Crossover Study.

Jayawardene DC, McAuley SA, Horsburgh JC, Gerche A, Jenkins AJ, Ward GM, MacIsaac RJ, Roberts TJ, Grosman B, Kurtz N, Roy A, O'Neal DN.

Diabetes Technol Ther. 2017 Jun;19(6):340-348. doi: 10.1089/dia.2016.0461. Epub 2017 Jun 2.


Effects of glycaemic management on diabetic kidney disease.

MacIsaac RJ, Jerums G, Ekinci EI.

World J Diabetes. 2017 May 15;8(5):172-186. doi: 10.4239/wjd.v8.i5.172. Review.


"It Is Definitely a Game Changer": A Qualitative Study of Experiences with In-home Overnight Closed-Loop Technology Among Adults with Type 1 Diabetes.

Hendrieckx C, Poole LA, Sharifi A, Jayawardene D, Loh MM, Horsburgh JC, Bach LA, Colman PG, Kumareswaran K, Jenkins AJ, MacIsaac RJ, Ward GM, Grosman B, Roy A, O'Neal DN, Speight J.

Diabetes Technol Ther. 2017 Jul;19(7):410-416. doi: 10.1089/dia.2017.0007. Epub 2017 May 24.


Overnight Counter-Regulatory Hormone Levels and Next Day Glycemia in Adults with Type 1 Diabetes During Closed-Loop Insulin Delivery Versus Sensor-Augmented Pump with Low-Glucose Suspend.

Graf A, Ward GM, Vogrin S, Sundararajan V, Sharifi A, De Bock MI, Jayawardene D, Loh MM, Horsburgh JC, Berthold CL, Paramalingam N, Bach LA, Colman PG, Davis EA, Grosman B, Jenkins AJ, Kumareswaran K, Kurtz N, Kyoong A, MacIsaac RJ, Roy A, Jones TW, O'Neal DN.

Diabetes Technol Ther. 2017 Jul;19(7):438-439. doi: 10.1089/dia.2017.0049. Epub 2017 May 24. No abstract available.


Contribution of cardiometabolic risk factors to estimated glomerular filtration rate decline in Indigenous Australians with and without albuminuria - the eGFR Follow-up Study.

Barr EL, Barzi F, Hughes JT, Jerums G, O'Dea K, Brown AD, Ekinci EI, Jones GR, Lawton PD, Sinha A, MacIsaac RJ, Cass A, Maple-Brown LJ.

Nephrology (Carlton). 2018 Jul;23(7):682-689. doi: 10.1111/nep.13073.


Assessing cutaneous microvascular function with iontophoresis: Avoiding non-specific vasodilation.

Loader J, Roustit M, Taylor F, MacIsaac RJ, Stewart S, Lorenzen C, Walther G.

Microvasc Res. 2017 Sep;113:29-39. doi: 10.1016/j.mvr.2017.04.006. Epub 2017 Apr 28.


Asymmetric changes in circulating insulin levels after an increase compared with a reduction in insulin pump basal rate in people with Type 1 diabetes.

McAuley SA, Ward GM, Horsburgh JC, Gooley JL, Jenkins AJ, MacIsaac RJ, O'Neal DN.

Diabet Med. 2017 Aug;34(8):1158-1164. doi: 10.1111/dme.13371. Epub 2017 May 23.


Effectiveness of the cardiac-diabetes transcare program: protocol for a randomised controlled trial.

Wu CJ, Atherton JJ, MacIsaac RJ, Courtney M, Chang AM, Thompson DR, Kostner K, MacIsaac AI, d'Emden M, Graves N, McPhail SM.

BMC Health Serv Res. 2017 Feb 2;17(1):109. doi: 10.1186/s12913-017-2043-4.


Aceruloplasminaemia: a disorder of diabetes and neurodegeneration.

Calder GL, Lee MH, Sachithanandan N, Bell S, Zeimer H, MacIsaac RJ.

Intern Med J. 2017 Jan;47(1):115-118. doi: 10.1111/imj.13309.


Comparison of creatinine and cystatin C based eGFR in the estimation of glomerular filtration rate in Indigenous Australians: The eGFR Study.

Barr EL, Maple-Brown LJ, Barzi F, Hughes JT, Jerums G, Ekinci EI, Ellis AG, Jones GR, Lawton PD, Sajiv C, Majoni SW, Brown AD, Hoy WE, O'Dea K, Cass A, MacIsaac RJ.

Clin Biochem. 2017 Apr;50(6):301-308. doi: 10.1016/j.clinbiochem.2016.11.024. Epub 2016 Nov 25.


Cardio-renal protection with empagliflozin.

MacIsaac RJ, Jerums G, Ekinci EI.

Ann Transl Med. 2016 Oct;4(20):409.


Glycemia, Treatment Satisfaction, Cognition, and Sleep Quality in Adults and Adolescents with Type 1 Diabetes When Using a Closed-Loop System Overnight Versus Sensor-Augmented Pump with Low-Glucose Suspend Function: A Randomized Crossover Study.

Sharifi A, De Bock MI, Jayawardene D, Loh MM, Horsburgh JC, Berthold CL, Paramalingam N, Bach LA, Colman PG, Davis EA, Grosman B, Hendrieckx C, Jenkins AJ, Kumareswaran K, Kurtz N, Kyoong A, MacIsaac RJ, Speight J, Trawley S, Ward GM, Roy A, Jones TW, O'Neal DN.

Diabetes Technol Ther. 2016 Dec;18(12):772-783. Epub 2016 Nov 11.


A Prospective Study of Renal Transplant Recipients: A Fall in Insulin Secretion Underpins Dysglycemia After Renal Transplantation.

Langsford D, Obeyesekere V, Vogrin S, Teng J, MacIsaac RJ, Ward G, Alford F, Dwyer KM.

Transplant Direct. 2016 Oct 7;2(11):e107. eCollection 2016 Nov.


The Mental Health in Diabetes Service (MINDS) to enhance psychosocial health: study protocol for a randomized controlled trial.

O'Brien CL, Ski CF, Thompson DR, Moore G, Mancuso S, Jenkins A, Ward G, MacIsaac RJ, Loh M, Knowles SR, Rossell SL, Castle DJ.

Trials. 2016 Sep 9;17(1):444. doi: 10.1186/s13063-016-1561-4.


Clinical predictive factors in diabetic kidney disease progression.

Radcliffe NJ, Seah JM, Clarke M, MacIsaac RJ, Jerums G, Ekinci EI.

J Diabetes Investig. 2017 Jan;8(1):6-18. doi: 10.1111/jdi.12533. Epub 2016 Jun 8. Review.


Insulin pump basal adjustment for exercise in type 1 diabetes: a randomised crossover study.

McAuley SA, Horsburgh JC, Ward GM, La Gerche A, Gooley JL, Jenkins AJ, MacIsaac RJ, O'Neal DN.

Diabetologia. 2016 Aug;59(8):1636-44. doi: 10.1007/s00125-016-3981-9. Epub 2016 May 11.


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