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Items: 1 to 50 of 62

1.

Genetic susceptibility to asthma increases the vulnerability to indoor air pollution.

Hüls A, Vanker A, Gray D, Koen N, MacIsaac JL, Lin DTS, Ramadori KE, Sly PD, Stein DJ, Kobor MS, Zar HJ.

Eur Respir J. 2020 Jan 16. pii: 1901831. doi: 10.1183/13993003.01831-2019. [Epub ahead of print]

PMID:
31949118
2.

Epigenetic aging in children from a small-scale farming society in The Congo Basin: Associations with child growth and family conflict.

Gettler LT, Lin DTS, Miegakanda V, Lew-Levy S, Eick GN, Snodgrass JJ, MacIsaac JL, Ramadori KE, Kobor MS, Boyette AH.

Dev Psychobiol. 2019 Nov 13. doi: 10.1002/dev.21935. [Epub ahead of print]

PMID:
31724171
3.

The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.

McEwen LM, O'Donnell KJ, McGill MG, Edgar RD, Jones MJ, MacIsaac JL, Lin DTS, Ramadori K, Morin A, Gladish N, Garg E, Unternaehrer E, Pokhvisneva I, Karnani N, Kee MZL, Klengel T, Adler NE, Barr RG, Letourneau N, Giesbrecht GF, Reynolds JN, Czamara D, Armstrong JM, Essex MJ, de Weerth C, Beijers R, Tollenaar MS, Bradley B, Jovanovic T, Ressler KJ, Steiner M, Entringer S, Wadhwa PD, Buss C, Bush NR, Binder EB, Boyce WT, Meaney MJ, Horvath S, Kobor MS.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201820843. doi: 10.1073/pnas.1820843116. [Epub ahead of print]

PMID:
31611402
4.

Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation.

Clifford RL, Patel J, MacIsaac JL, McEwen LM, Johnson SR, Shaw D, Knox AJ, Hackett TL, Kobor MS.

Sci Rep. 2019 Oct 8;9(1):14409. doi: 10.1038/s41598-019-50873-y.

5.

5-Hydroxymethylcytosine in cord blood and associations of DNA methylation with sex in newborns.

Solomon O, Macisaac JL, Tindula G, Kobor MS, Eskenazi B, Holland N.

Mutagenesis. 2019 Dec 19;34(4):315-322. doi: 10.1093/mutage/gez023.

PMID:
31587037
6.

DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysis.

Humphreys KL, Moore SR, Davis EG, MacIsaac JL, Lin DTS, Kobor MS, Gotlib IH.

Transl Psychiatry. 2019 Oct 3;9(1):245. doi: 10.1038/s41398-019-0582-7.

7.

Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments.

Shen Y, Grisdale CJ, Islam SA, Bose P, Lever J, Zhao EY, Grinshtein N, Ma Y, Mungall AJ, Moore RA, Lun X, Senger DL, Robbins SM, Wang AY, MacIsaac JL, Kobor MS, Luchman HA, Weiss S, Chan JA, Blough MD, Kaplan DR, Cairncross JG, Marra MA, Jones SJM.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19098-19108. doi: 10.1073/pnas.1813495116. Epub 2019 Aug 30.

PMID:
31471491
8.

Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization.

Sbihi H, Jones MJ, MacIsaac JL, Brauer M, Allen RW, Sears MR, Subbarao P, Mandhane PJ, Moraes TJ, Azad MB, Becker AB, Brook JR, Kobor MS, Turvey SE.

J Allergy Clin Immunol. 2019 Dec;144(6):1729-1731.e5. doi: 10.1016/j.jaci.2019.07.047. Epub 2019 Aug 27. No abstract available.

PMID:
31470034
9.

Use of a maltodextrin-based feed with a lysozyme product to alter bacterial in the ileum of market-aged broilers.

Asante R, Rathgeber BM, MacIsaac JL, Anderson DM.

Poult Sci. 2019 Dec 1;98(12):6897-6902. doi: 10.3382/ps/pez426.

10.

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.

Czamara D, Eraslan G, Page CM, Lahti J, Lahti-Pulkkinen M, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Nystad W, Håberg SE, London SJ, O'Donnell KJ, Garg E, Meaney MJ, Entringer S, Wadhwa PD, Buss C, Jones MJ, Lin DTS, MacIsaac JL, Kobor MS, Koen N, Zar HJ, Koenen KC, Dalvie S, Stein DJ, Kondofersky I, Müller NS, Theis FJ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Räikkönen K, Binder EB.

Nat Commun. 2019 Jun 11;10(1):2548. doi: 10.1038/s41467-019-10461-0.

11.

Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome.

Ong ML, Tuan TA, Poh J, Teh AL, Chen L, Pan H, MacIsaac JL, Kobor MS, Chong YS, Kwek K, Saw SM, Godfrey KM, Gluckman PD, Fortier MV, Karnani N, Meaney MJ, Qiu A, Holbrook JD.

Genes Brain Behav. 2019 Sep;18(7):e12576. doi: 10.1111/gbb.12576. Epub 2019 May 15.

PMID:
31020763
12.

A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions.

Hari Dass SA, McCracken K, Pokhvisneva I, Chen LM, Garg E, Nguyen TTT, Wang Z, Barth B, Yaqubi M, McEwen LM, MacIsaac JL, Diorio J, Kobor MS, O'Donnell KJ, Meaney MJ, Silveira PP.

EBioMedicine. 2019 Apr;42:188-202. doi: 10.1016/j.ebiom.2019.03.051. Epub 2019 Mar 26.

13.

A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment.

Toepfer P, O'Donnell KJ, Entringer S, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C.

J Am Acad Child Adolesc Psychiatry. 2019 Dec;58(12):1207-1216. doi: 10.1016/j.jaac.2019.03.006. Epub 2019 Mar 9.

PMID:
30858011
14.

Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm.

Wu Y, Lin X, Lim IY, Chen L, Teh AL, MacIsaac JL, Tan KH, Kobor MS, Chong YS, Gluckman PD, Karnani N.

Clin Epigenetics. 2019 Feb 11;11(1):26. doi: 10.1186/s13148-018-0599-4.

15.

Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness.

Toepfer P, O'Donnell KJ, Entringer S, Garg E, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C.

Psychoneuroendocrinology. 2019 May;103:156-162. doi: 10.1016/j.psyneuen.2019.01.013. Epub 2019 Jan 14.

16.

Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation.

Islam SA, Goodman SJ, MacIsaac JL, Obradović J, Barr RG, Boyce WT, Kobor MS.

Epigenetics Chromatin. 2019 Jan 2;12(1):1. doi: 10.1186/s13072-018-0245-6.

17.

Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation.

Husquin LT, Rotival M, Fagny M, Quach H, Zidane N, McEwen LM, MacIsaac JL, Kobor MS, Aschard H, Patin E, Quintana-Murci L.

Genome Biol. 2018 Dec 18;19(1):222. doi: 10.1186/s13059-018-1601-3.

18.

The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.

Bush NR, Edgar RD, Park M, MacIsaac JL, McEwen LM, Adler NE, Essex MJ, Kobor MS, Boyce WT.

Epigenomics. 2018 Nov;10(11):1445-1461. doi: 10.2217/epi-2018-0042. Epub 2018 Oct 23.

19.

Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array.

McEwen LM, Jones MJ, Lin DTS, Edgar RD, Husquin LT, MacIsaac JL, Ramadori KE, Morin AM, Rider CF, Carlsten C, Quintana-Murci L, Horvath S, Kobor MS.

Clin Epigenetics. 2018 Oct 16;10(1):123. doi: 10.1186/s13148-018-0556-2.

20.

Exposure to childhood abuse is associated with human sperm DNA methylation.

Roberts AL, Gladish N, Gatev E, Jones MJ, Chen Y, MacIsaac JL, Tworoger SS, Austin SB, Tanrikut C, Chavarro JE, Baccarelli AA, Kobor MS.

Transl Psychiatry. 2018 Oct 2;8(1):194. doi: 10.1038/s41398-018-0252-1.

21.

Cell type-specific DNA methylation in neonatal cord tissue and cord blood: a 850K-reference panel and comparison of cell types.

Lin X, Tan JYL, Teh AL, Lim IY, Liew SJ, MacIsaac JL, Chong YS, Gluckman PD, Kobor MS, Cheong CY, Karnani N.

Epigenetics. 2018;13(9):941-958. doi: 10.1080/15592294.2018.1522929. Epub 2018 Oct 11.

22.

PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores.

Chen LM, Yao N, Garg E, Zhu Y, Nguyen TTT, Pokhvisneva I, Hari Dass SA, Unternaehrer E, Gaudreau H, Forest M, McEwen LM, MacIsaac JL, Kobor MS, Greenwood CMT, Silveira PP, Meaney MJ, O'Donnell KJ.

BMC Bioinformatics. 2018 Aug 8;19(1):295. doi: 10.1186/s12859-018-2289-9.

23.

The early care environment and DNA methylome variation in childhood.

Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ; Mavan Study Team.

Dev Psychopathol. 2018 Aug;30(3):891-903. doi: 10.1017/S0954579418000627.

PMID:
30068421
24.

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.

Clifford RL, Fishbane N, Patel J, MacIsaac JL, McEwen LM, Fisher AJ, Brandsma CA, Nair P, Kobor MS, Hackett TL, Knox AJ.

Clin Epigenetics. 2018 Mar 5;10:32. doi: 10.1186/s13148-018-0464-5. eCollection 2018.

25.

Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time.

Forest M, O'Donnell KJ, Voisin G, Gaudreau H, MacIsaac JL, McEwen LM, Silveira PP, Steiner M, Kobor MS, Meaney MJ, Greenwood CMT.

Epigenetics. 2018;13(1):19-32. doi: 10.1080/15592294.2017.1411443. Epub 2018 Jan 30.

26.

DNA methylation as a predictor of fetal alcohol spectrum disorder.

Lussier AA, Morin AM, MacIsaac JL, Salmon J, Weinberg J, Reynolds JN, Pavlidis P, Chudley AE, Kobor MS.

Clin Epigenetics. 2018 Jan 12;10:5. doi: 10.1186/s13148-018-0439-6. eCollection 2018.

27.

DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.

O'Donnell KJ, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ.

Transl Psychiatry. 2018 Jan 10;8(1):15. doi: 10.1038/s41398-017-0063-9.

28.

Choice of surrogate tissue influences neonatal EWAS findings.

Lin X, Teh AL, Chen L, Lim IY, Tan PF, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Lee YS, Holbrook JD, Godfrey KM, Meaney MJ, Kobor MS, Chong YS, Gluckman PD, Karnani N.

BMC Med. 2017 Dec 5;15(1):211. doi: 10.1186/s12916-017-0970-x.

29.

Worldwide patterns of human epigenetic variation.

Carja O, MacIsaac JL, Mah SM, Henn BM, Kobor MS, Feldman MW, Fraser HB.

Nat Ecol Evol. 2017 Oct;1(10):1577-1583. doi: 10.1038/s41559-017-0299-z. Epub 2017 Aug 28.

PMID:
29185505
30.

DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: a pilot randomized controlled trial.

McEwen LM, Gatev EG, Jones MJ, MacIsaac JL, McAllister MM, Goulding RE, Madden KM, Dawes MG, Kobor MS, Ashe MC.

Appl Physiol Nutr Metab. 2018 Mar;43(3):233-239. doi: 10.1139/apnm-2017-0436. Epub 2017 Oct 19.

PMID:
29049890
31.

Exploring genetic influences underlying acute aerobic exercise effects on motor learning.

Mang CS, McEwen LM, MacIsaac JL, Snow NJ, Campbell KL, Kobor MS, Ross CJD, Boyd LA.

Sci Rep. 2017 Sep 21;7(1):12123. doi: 10.1038/s41598-017-12422-3.

32.

Accelerated DNA methylation age in adolescent girls: associations with elevated diurnal cortisol and reduced hippocampal volume.

Davis EG, Humphreys KL, McEwen LM, Sacchet MD, Camacho MC, MacIsaac JL, Lin DTS, Kobor MS, Gotlib IH.

Transl Psychiatry. 2017 Aug 29;7(8):e1223. doi: 10.1038/tp.2017.188.

33.

Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs.

Morin AM, Gatev E, McEwen LM, MacIsaac JL, Lin DTS, Koen N, Czamara D, Räikkönen K, Zar HJ, Koenen K, Stein DJ, Kobor MS, Jones MJ.

Clin Epigenetics. 2017 Jul 25;9:75. doi: 10.1186/s13148-017-0370-2. eCollection 2017.

34.

Blood and nasal epigenetics correlate with allergic rhinitis symptom development in the environmental exposure unit.

North ML, Jones MJ, MacIsaac JL, Morin AM, Steacy LM, Gregor A, Kobor MS, Ellis AK.

Allergy. 2018 Jan;73(1):196-205. doi: 10.1111/all.13263. Epub 2017 Sep 22.

PMID:
28755526
35.

DNA methylation signatures of chronic alcohol dependence in purified CD3+ T-cells of patients undergoing alcohol treatment.

Brückmann C, Islam SA, MacIsaac JL, Morin AM, Karle KN, Di Santo A, Wüst R, Lang I, Batra A, Kobor MS, Nieratschker V.

Sci Rep. 2017 Jul 26;7(1):6605. doi: 10.1038/s41598-017-06847-z.

36.

Metastatic Melanoma in Sentinel Node-Negative Patients: The Ottawa Experience.

Ward CE, MacIsaac JL, Heughan CE, Weatherhead L.

J Cutan Med Surg. 2018 Jan/Feb;22(1):14-21. doi: 10.1177/1203475417720201. Epub 2017 Jul 10.

PMID:
28689448
37.

Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood.

McDade TW, Ryan C, Jones MJ, MacIsaac JL, Morin AM, Meyer JM, Borja JB, Miller GE, Kobor MS, Kuzawa CW.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7611-7616. doi: 10.1073/pnas.1620661114. Epub 2017 Jul 3.

38.

Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region.

McEwen LM, Morin AM, Edgar RD, MacIsaac JL, Jones MJ, Dow WH, Rosero-Bixby L, Kobor MS, Rehkopf DH.

Epigenetics Chromatin. 2017 Apr 27;10:21. doi: 10.1186/s13072-017-0128-2. eCollection 2017.

39.

Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome.

Lin X, Lim IY, Wu Y, Teh AL, Chen L, Aris IM, Soh SE, Tint MT, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Holbrook JD, Lee YS, Gluckman PD, Karnani N; GUSTO study group.

BMC Med. 2017 Mar 7;15(1):50. doi: 10.1186/s12916-017-0800-1.

40.

Differential DNA methylation in peripheral blood mononuclear cells in adolescents exposed to significant early but not later childhood adversity.

Esposito EA, Jones MJ, Doom JR, MacIsaac JL, Gunnar MR, Kobor MS.

Dev Psychopathol. 2016 Nov;28(4pt2):1385-1399. Epub 2016 Feb 5.

41.

DNA methylation signature of human fetal alcohol spectrum disorder.

Portales-Casamar E, Lussier AA, Jones MJ, MacIsaac JL, Edgar RD, Mah SM, Barhdadi A, Provost S, Lemieux-Perreault LP, Cynader MS, Chudley AE, Dubé MP, Reynolds JN, Pavlidis P, Kobor MS.

Epigenetics Chromatin. 2016 Jun 29;9:25. doi: 10.1186/s13072-016-0074-4. eCollection 2016.

42.

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation.

Clifford RL, Jones MJ, MacIsaac JL, McEwen LM, Goodman SJ, Mostafavi S, Kobor MS, Carlsten C.

J Allergy Clin Immunol. 2017 Jan;139(1):112-121. doi: 10.1016/j.jaci.2016.03.046. Epub 2016 May 10.

PMID:
27321436
43.

Low birth weight associates with hippocampal gene expression.

Buschdorf JP, Ong ML, Ong SX, MacIsaac JL, Chng K, Kobor MS, Meaney MJ, Holbrook JD.

Neuroscience. 2016 Mar 24;318:190-205. doi: 10.1016/j.neuroscience.2016.01.013. Epub 2016 Jan 12.

PMID:
26791528
44.

Comparison of Methyl-capture Sequencing vs. Infinium 450K methylation array for methylome analysis in clinical samples.

Teh AL, Pan H, Lin X, Lim YI, Patro CP, Cheong CY, Gong M, MacIsaac JL, Kwoh CK, Meaney MJ, Kobor MS, Chong YS, Gluckman PD, Holbrook JD, Karnani N.

Epigenetics. 2016;11(1):36-48. doi: 10.1080/15592294.2015.1132136. Epub 2016 Jan 19.

45.

The epigenomic landscape of African rainforest hunter-gatherers and farmers.

Fagny M, Patin E, MacIsaac JL, Rotival M, Flutre T, Jones MJ, Siddle KJ, Quach H, Harmant C, McEwen LM, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Perry GH, Barreiro LB, Kobor MS, Quintana-Murci L.

Nat Commun. 2015 Nov 30;6:10047. doi: 10.1038/ncomms10047.

46.

funtooNorm: an R package for normalization of DNA methylation data when there are multiple cell or tissue types.

Oros Klein K, Grinek S, Bernatsky S, Bouchard L, Ciampi A, Colmegna I, Fortin JP, Gao L, Hivert MF, Hudson M, Kobor MS, Labbe A, MacIsaac JL, Meaney MJ, Morin AM, O'Donnell KJ, Pastinen T, Van Ijzendoorn MH, Voisin G, Greenwood CM.

Bioinformatics. 2016 Feb 15;32(4):593-5. doi: 10.1093/bioinformatics/btv615. Epub 2015 Oct 24.

47.

Bacterial infection remodels the DNA methylation landscape of human dendritic cells.

Pacis A, Tailleux L, Morin AM, Lambourne J, MacIsaac JL, Yotova V, Dumaine A, Danckaert A, Luca F, Grenier JC, Hansen KD, Gicquel B, Yu M, Pai A, He C, Tung J, Pastinen T, Kobor MS, Pique-Regi R, Gilad Y, Barreiro LB.

Genome Res. 2015 Dec;25(12):1801-11. doi: 10.1101/gr.192005.115. Epub 2015 Sep 21.

48.

Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats.

Beery AK, McEwen LM, MacIsaac JL, Francis DD, Kobor MS.

Horm Behav. 2016 Jan;77:42-52. doi: 10.1016/j.yhbeh.2015.05.022. Epub 2015 Jun 27.

49.

HIF3A association with adiposity: the story begins before birth.

Pan H, Lin X, Wu Y, Chen L, Teh AL, Soh SE, Lee YS, Tint MT, MacIsaac JL, Morin AM, Tan KH, Yap F, Saw SM, Kobor MS, Meaney MJ, Godfrey KM, Chong YS, Gluckman PD, Karnani N, Holbrook JD; GUSTO Study Group.

Epigenomics. 2015;7(6):937-50. doi: 10.2217/epi.15.45. Epub 2015 May 26.

50.

A pooling-based approach to mapping genetic variants associated with DNA methylation.

Kaplow IM, MacIsaac JL, Mah SM, McEwen LM, Kobor MS, Fraser HB.

Genome Res. 2015 Jun;25(6):907-17. doi: 10.1101/gr.183749.114. Epub 2015 Apr 24.

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