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Items: 8

1.

Calpain 9 as a therapeutic target in TGFβ-induced mesenchymal transition and fibrosis.

Kim DH, Beckett JD, Nagpal V, Seman-Senderos MA, Gould RA, Creamer TJ, MacFarlane EG, Chen Y, Bedja D, Butcher JT, Mitzner W, Rouf R, Hata S, Warren DS, Dietz HC.

Sci Transl Med. 2019 Jul 17;11(501). pii: eaau2814. doi: 10.1126/scitranslmed.aau2814.

PMID:
31316008
2.

Epigenetic activation and memory at a TGFB2 enhancer in systemic sclerosis.

Shin JY, Beckett JD, Bagirzadeh R, Creamer TJ, Shah AA, McMahan Z, Paik JJ, Sampedro MM, MacFarlane EG, Beer MA, Warren D, Wigley FM, Dietz HC.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaaw0790. doi: 10.1126/scitranslmed.aaw0790.

PMID:
31217334
3.

Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome.

Habashi JP, MacFarlane EG, Bagirzadeh R, Bowen C, Huso N, Chen Y, Bedja D, Creamer TJ, Rykiel G, Manning M, Huso D, Dietz HC.

Sci Transl Med. 2019 May 1;11(490). pii: eaat4822. doi: 10.1126/scitranslmed.aat4822.

PMID:
31043570
4.

Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome.

MacFarlane EG, Parker SJ, Shin JY, Kang BE, Ziegler SG, Creamer TJ, Bagirzadeh R, Bedja D, Chen Y, Calderon JF, Weissler K, Frischmeyer-Guerrerio PA, Lindsay ME, Habashi JP, Dietz HC.

J Clin Invest. 2019 Feb 1;129(2):659-675. doi: 10.1172/JCI123547. Epub 2019 Jan 7.

5.

Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.

van der Pluijm I, Burger J, van Heijningen PM, IJpma A, van Vliet N, Milanese C, Schoonderwoerd K, Sluiter W, Ringuette LJ, Dekkers DHW, Que I, Kaijzel EL, Te Riet L, MacFarlane EG, Das D, van der Linden R, Vermeij M, Demmers JA, Mastroberardino PG, Davis EC, Yanagisawa H, Dietz HC, Kanaar R, Essers J.

Cardiovasc Res. 2018 Nov 1;114(13):1776-1793. doi: 10.1093/cvr/cvy150.

6.

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice.

Rouf R, MacFarlane EG, Takimoto E, Chaudhary R, Nagpal V, Rainer PP, Bindman JG, Gerber EE, Bedja D, Schiefer C, Miller KL, Zhu G, Myers L, Amat-Alarcon N, Lee DI, Koitabashi N, Judge DP, Kass DA, Dietz HC.

JCI Insight. 2017 Aug 3;2(15). pii: 91588. doi: 10.1172/jci.insight.91588. eCollection 2017 Aug 3.

7.

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase.

Ziegler SG, Ferreira CR, MacFarlane EG, Riddle RC, Tomlinson RE, Chew EY, Martin L, Ma CT, Sergienko E, Pinkerton AB, Millán JL, Gahl WA, Dietz HC.

Sci Transl Med. 2017 Jun 7;9(393). pii: eaal1669. doi: 10.1126/scitranslmed.aal1669.

8.

TGF-β Family Signaling in Connective Tissue and Skeletal Diseases.

MacFarlane EG, Haupt J, Dietz HC, Shore EM.

Cold Spring Harb Perspect Biol. 2017 Nov 1;9(11). pii: a022269. doi: 10.1101/cshperspect.a022269. Review.

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