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Items: 10


Simvastatin Promotes Cardiac Myocyte Relaxation in Association with Phosphorylation of Troponin I.

MacDougall DA, Pugh SD, Bassi HS, Lotteau S, Porter KE, Calaghan S.

Front Pharmacol. 2017 Apr 19;8:203. doi: 10.3389/fphar.2017.00203. eCollection 2017.


The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway.

Yang Z, Kirton HM, MacDougall DA, Boyle JP, Deuchars J, Frater B, Ponnambalam S, Hardy ME, White E, Calaghan SC, Peers C, Steele DS.

Sci Signal. 2015 Oct 13;8(398):ra101. doi: 10.1126/scisignal.aaa7677.


Caveolin contributes to the modulation of basal and β-adrenoceptor stimulated function of the adult rat ventricular myocyte by simvastatin: a novel pleiotropic effect.

Pugh SD, MacDougall DA, Agarwal SR, Harvey RD, Porter KE, Calaghan S.

PLoS One. 2014 Sep 11;9(9):e106905. doi: 10.1371/journal.pone.0106905. eCollection 2014.


A novel approach to the Langendorff technique: preparation of isolated cardiomyocytes and myocardial samples from the same rat heart.

MacDougall DA, Calaghan S.

Exp Physiol. 2013 Aug;98(8):1295-300. doi: 10.1113/expphysiol.2013.072827. Epub 2013 Apr 19.


Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte.

Macdougall DA, Agarwal SR, Stopford EA, Chu H, Collins JA, Longster AL, Colyer J, Harvey RD, Calaghan S.

J Mol Cell Cardiol. 2012 Feb;52(2):388-400. doi: 10.1016/j.yjmcc.2011.06.014. Epub 2011 Jun 26.


Effects of cholesterol depletion on compartmentalized cAMP responses in adult cardiac myocytes.

Agarwal SR, MacDougall DA, Tyser R, Pugh SD, Calaghan SC, Harvey RD.

J Mol Cell Cardiol. 2011 Mar;50(3):500-9. doi: 10.1016/j.yjmcc.2010.11.015. Epub 2010 Nov 27.


Separate elements within a single IQ-like motif in adenylyl cyclase type 8 impart ca2+/calmodulin binding and autoinhibition.

Macdougall DA, Wachten S, Ciruela A, Sinz A, Cooper DM.

J Biol Chem. 2009 Jun 5;284(23):15573-88. doi: 10.1074/jbc.M809585200. Epub 2009 Mar 21.


Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles.

Masada N, Ciruela A, Macdougall DA, Cooper DM.

J Biol Chem. 2009 Feb 13;284(7):4451-63. doi: 10.1074/jbc.M807359200. Epub 2008 Nov 24. Erratum in: J Biol Chem. 2010 Jun 4;285(23):18122.


Economic burden of deep-vein thrombosis, pulmonary embolism, and post-thrombotic syndrome.

MacDougall DA, Feliu AL, Boccuzzi SJ, Lin J.

Am J Health Syst Pharm. 2006 Oct 15;63(20 Suppl 6):S5-15.


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