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Items: 1 to 50 of 349

1.

Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease.

Crowe JS, Roberts KJ, Carlton TM, Maggiore L, Cubitt MF, Clare S, Harcourt K, Reckless J, MacDonald TT, Ray KP, Vossenkämper A, West MR.

Sci Rep. 2018 Mar 21;8(1):4941. doi: 10.1038/s41598-018-23277-7.

2.

A functional IL1RL1 variant regulates corticosteroid-induced sST2 expression in ulcerative colitis.

Díaz-Jiménez D, Núñez L, De la Fuente M, Dubois-Camacho K, Sepúlveda H, Montecino M, Torres-Riquelme A, García-González P, Chnaiderman J, Vossenkamper A, MacDonald TT, Simian D, González MJ, Cidlowski JA, Quera R, Hermoso MA.

Sci Rep. 2017 Aug 31;7(1):10180. doi: 10.1038/s41598-017-10465-0.

3.

The Role of Cytokines in the Fibrotic Responses in Crohn's Disease.

Curciarello R, Docena GH, MacDonald TT.

Front Med (Lausanne). 2017 Aug 7;4:126. doi: 10.3389/fmed.2017.00126. eCollection 2017. Review.

4.

Recent advances in gut immunology.

Powell N, MacDonald TT.

Parasite Immunol. 2017 Jun;39(6). doi: 10.1111/pim.12430. Review.

5.

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, King BW, Lehr R, Lan Y, Leister LK, Lich JD, MacDonald TT, Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis RD, Vossenkämper A, Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J.

J Med Chem. 2017 Feb 23;60(4):1247-1261. doi: 10.1021/acs.jmedchem.6b01751. Epub 2017 Feb 10.

PMID:
28151659
6.

Can probiotics modulate human disease by impacting intestinal barrier function?

Bron PA, Kleerebezem M, Brummer RJ, Cani PD, Mercenier A, MacDonald TT, Garcia-Ródenas CL, Wells JM.

Br J Nutr. 2017 Jan;117(1):93-107. doi: 10.1017/S0007114516004037. Review.

7.

Homeostasis of the gut barrier and potential biomarkers.

Wells JM, Brummer RJ, Derrien M, MacDonald TT, Troost F, Cani PD, Theodorou V, Dekker J, Méheust A, de Vos WM, Mercenier A, Nauta A, Garcia-Rodenas CL.

Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G171-G193. doi: 10.1152/ajpgi.00048.2015. Epub 2016 Dec 1. Review.

8.

Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications.

Muthas D, Reznichenko A, Balendran CA, Böttcher G, Clausen IG, Kärrman Mårdh C, Ottosson T, Uddin M, MacDonald TT, Danese S, Berner Hansen M.

Scand J Gastroenterol. 2017 Feb;52(2):125-135. doi: 10.1080/00365521.2016.1235224. Epub 2016 Sep 27. Review.

PMID:
27610713
9.

Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease.

Giles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, MacDonald TT, Lindsay JO, Stagg AJ.

Mucosal Immunol. 2017 Jan;10(1):184-193. doi: 10.1038/mi.2016.44. Epub 2016 May 25.

PMID:
27220814
10.

The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.

Haile PA, Votta BJ, Marquis RW, Bury MJ, Mehlmann JF, Singhaus R Jr, Charnley AK, Lakdawala AS, Convery MA, Lipshutz DB, Desai BM, Swift B, Capriotti CA, Berger SB, Mahajan MK, Reilly MA, Rivera EJ, Sun HH, Nagilla R, Beal AM, Finger JN, Cook MN, King BW, Ouellette MT, Totoritis RD, Pierdomenico M, Negroni A, Stronati L, Cucchiara S, Ziółkowski B, Vossenkämper A, MacDonald TT, Gough PJ, Bertin J, Casillas LN.

J Med Chem. 2016 May 26;59(10):4867-80. doi: 10.1021/acs.jmedchem.6b00211. Epub 2016 May 4.

PMID:
27109867
11.

Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal Proinflammatory Immune Response in Ulcerative Colitis.

Biancheri P, Foster MR, Fyfe MC, MacDonald TT, Sirohi S, Solanke Y, Wood E, Rowley A, Webber S, Walshe CA.

Inflamm Bowel Dis. 2016 Jun;22(6):1306-15. doi: 10.1097/MIB.0000000000000759.

12.

Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease.

Biancheri P, Di Sabatino A, Rescigno M, Giuffrida P, Fornasa G, Tsilingiri K, Pender SL, Papadia C, Wood E, Pasini A, Ubezio C, Vanoli A, Forbes A, MacDonald TT, Corazza GR.

Gut. 2016 Oct;65(10):1670-80. doi: 10.1136/gutjnl-2014-308876. Epub 2015 Sep 4.

13.

The IL-33/ST2 axis: Role in health and disease.

De la Fuente M, MacDonald TT, Hermoso MA.

Cytokine Growth Factor Rev. 2015 Dec;26(6):615-23. doi: 10.1016/j.cytogfr.2015.07.017. Epub 2015 Jul 28. Review.

PMID:
26271893
14.

Proteolytic cleavage and loss of function of biologic agents that neutralize tumor necrosis factor in the mucosa of patients with inflammatory bowel disease.

Biancheri P, Brezski RJ, Di Sabatino A, Greenplate AR, Soring KL, Corazza GR, Kok KB, Rovedatti L, Vossenkämper A, Ahmad N, Snoek SA, Vermeire S, Rutgeerts P, Jordan RE, MacDonald TT.

Gastroenterology. 2015 Nov;149(6):1564-1574.e3. doi: 10.1053/j.gastro.2015.07.002. Epub 2015 Jul 11.

15.

The unusual suspects--innate lymphoid cells as novel therapeutic targets in IBD.

Goldberg R, Prescott N, Lord GM, MacDonald TT, Powell N.

Nat Rev Gastroenterol Hepatol. 2015 May;12(5):271-83. doi: 10.1038/nrgastro.2015.52. Review.

PMID:
25971811
16.

Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation.

Powell N, Lo JW, Biancheri P, Vossenkämper A, Pantazi E, Walker AW, Stolarczyk E, Ammoscato F, Goldberg R, Scott P, Canavan JB, Perucha E, Garrido-Mesa N, Irving PM, Sanderson JD, Hayee B, Howard JK, Parkhill J, MacDonald TT, Lord GM.

Gastroenterology. 2015 Aug;149(2):456-67.e15. doi: 10.1053/j.gastro.2015.04.017. Epub 2015 Apr 25.

17.

Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis.

De Simone V, Ronchetti G, Franzè E, Colantoni A, Ortenzi A, Fantini MC, Rizzo A, Sica GS, Sileri P, Rossi P, MacDonald TT, Pallone F, Monteleone G, Stolfi C.

Oncotarget. 2015 Apr 30;6(12):9908-23.

18.

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease.

Canavan JB, Scottà C, Vossenkämper A, Goldberg R, Elder MJ, Shoval I, Marks E, Stolarczyk E, Lo JW, Powell N, Fazekasova H, Irving PM, Sanderson JD, Howard JK, Yagel S, Afzali B, MacDonald TT, Hernandez-Fuentes MP, Shpigel NY, Lombardi G, Lord GM.

Gut. 2016 Apr;65(4):584-94. doi: 10.1136/gutjnl-2014-306919. Epub 2015 Feb 24.

19.

The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection.

Curciarello R, Steele A, Cooper D, MacDonald TT, Kruidenier L, Kudo T.

PLoS One. 2014 Sep 22;9(9):e107933. doi: 10.1371/journal.pone.0107933. eCollection 2014.

20.

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.

De Simone V, Franzè E, Ronchetti G, Colantoni A, Fantini MC, Di Fusco D, Sica GS, Sileri P, MacDonald TT, Pallone F, Monteleone G, Stolfi C.

Oncogene. 2015 Jul;34(27):3493-503. doi: 10.1038/onc.2014.286. Epub 2014 Sep 1.

21.

Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut.

Caruso R, Marafini I, Franzè E, Stolfi C, Zorzi F, Monteleone I, Caprioli F, Colantoni A, Sarra M, Sedda S, Biancone L, Sileri P, Sica GS, MacDonald TT, Pallone F, Monteleone G.

Mucosal Immunol. 2014 Nov;7(6):1467-79. doi: 10.1038/mi.2014.35. Epub 2014 May 21.

PMID:
24850427
22.

Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities.

Cupi ML, Sarra M, Marafini I, Monteleone I, Franzè E, Ortenzi A, Colantoni A, Sica G, Sileri P, Rosado MM, Carsetti R, MacDonald TT, Pallone F, Monteleone G.

J Immunol. 2014 Jun 15;192(12):6083-91. doi: 10.4049/jimmunol.1302238. Epub 2014 May 16.

23.

A CD3-specific antibody reduces cytokine production and alters phosphoprotein profiles in intestinal tissues from patients with inflammatory bowel disease.

Vossenkämper A, Hundsrucker C, Page K, van Maurik A, Sanders TJ, Stagg AJ, Das L, MacDonald TT.

Gastroenterology. 2014 Jul;147(1):172-83. doi: 10.1053/j.gastro.2014.03.049. Epub 2014 Apr 1.

PMID:
24704524
24.

In Crohn's disease fibrosis-reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts.

Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins R, Poulsom R, Di Sabatino A, Corazza GR, MacDonald TT, Lindsay JO, Silver AR.

Clin Sci (Lond). 2014 Sep;127(5):341-50. doi: 10.1042/CS20140048.

PMID:
24641356
25.

A functional role for Smad7 in sustaining colon cancer cell growth and survival.

Stolfi C, De Simone V, Colantoni A, Franzè E, Ribichini E, Fantini MC, Caruso R, Monteleone I, Sica GS, Sileri P, MacDonald TT, Pallone F, Monteleone G.

Cell Death Dis. 2014 Feb 20;5:e1073. doi: 10.1038/cddis.2014.49.

26.

Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells.

Rizzo A, De Mare V, Rocchi C, Stolfi C, Colantoni A, Neurath MF, Macdonald TT, Pallone F, Monteleone G, Fantini MC.

Carcinogenesis. 2014 Jul;35(7):1536-46. doi: 10.1093/carcin/bgu027. Epub 2014 Jan 30.

PMID:
24480808
27.

Proteases and small intestinal barrier function in health and disease.

Giuffrida P, Biancheri P, MacDonald TT.

Curr Opin Gastroenterol. 2014 Mar;30(2):147-53. doi: 10.1097/MOG.0000000000000042. Review.

PMID:
24445329
28.

Absence of a role for interleukin-13 in inflammatory bowel disease.

Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque SS, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza GR, MacDonald TT.

Eur J Immunol. 2014 Feb;44(2):370-85. doi: 10.1002/eji.201343524.

29.

The role of transforming growth factor (TGF)-β in modulating the immune response and fibrogenesis in the gut.

Biancheri P, Giuffrida P, Docena GH, MacDonald TT, Corazza GR, Di Sabatino A.

Cytokine Growth Factor Rev. 2014 Feb;25(1):45-55. doi: 10.1016/j.cytogfr.2013.11.001. Epub 2013 Nov 28. Review.

PMID:
24332927
30.

Analysis of the cytokine profile in the duodenal mucosa of refractory coeliac disease patients.

Caruso R, Marafini I, Sedda S, Del Vecchio Blanco G, Giuffrida P, MacDonald TT, Corazza GR, Pallone F, Di Sabatino A, Monteleone G.

Clin Sci (Lond). 2014 Mar;126(6):451-8. doi: 10.1042/CS20130478.

PMID:
24125165
31.

The challenges of stratifying patients for trials in inflammatory bowel disease.

Biancheri P, Powell N, Monteleone G, Lord G, MacDonald TT.

Trends Immunol. 2013 Nov;34(11):564-71. doi: 10.1016/j.it.2013.08.002. Epub 2013 Sep 10. Review.

PMID:
24035478
32.

A role for gut-associated lymphoid tissue in shaping the human B cell repertoire.

Vossenkämper A, Blair PA, Safinia N, Fraser LD, Das L, Sanders TJ, Stagg AJ, Sanderson JD, Taylor K, Chang F, Choong LM, D'Cruz DP, Macdonald TT, Lombardi G, Spencer J.

J Exp Med. 2013 Aug 26;210(9):1665-74. doi: 10.1084/jem.20122465. Epub 2013 Aug 12.

33.

Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells.

McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ, Whelan K, MacDonald TT, Lindsay JO, Stagg AJ.

J Immunol. 2013 Sep 1;191(5):2752-63. doi: 10.4049/jimmunol.1202959. Epub 2013 Jul 31.

34.

The role of interleukin 17 in Crohn's disease-associated intestinal fibrosis.

Biancheri P, Pender SL, Ammoscato F, Giuffrida P, Sampietro G, Ardizzone S, Ghanbari A, Curciarello R, Pasini A, Monteleone G, Corazza GR, Macdonald TT, Di Sabatino A.

Fibrogenesis Tissue Repair. 2013 Jul 8;6(1):13. doi: 10.1186/1755-1536-6-13.

35.

IL-25 prevents and cures fulminant hepatitis in mice through a myeloid-derived suppressor cell-dependent mechanism.

Sarra M, Cupi ML, Bernardini R, Ronchetti G, Monteleone I, Ranalli M, Franzè E, Rizzo A, Colantoni A, Caprioli F, Maggioni M, Gambacurta A, Mattei M, Macdonald TT, Pallone F, Monteleone G.

Hepatology. 2013 Oct;58(4):1436-50. doi: 10.1002/hep.26446. Epub 2013 Aug 26.

PMID:
23564603
36.

High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases.

Franzè E, Caruso R, Stolfi C, Sarra M, Cupi ML, Ascolani M, Sedda S, Antenucci C, Ruffa A, Caprioli F, MacDonald TT, Pallone F, Monteleone G.

Inflamm Bowel Dis. 2013 Mar;19(3):501-11. doi: 10.1097/MIB.0b013e31828028e8.

PMID:
23429442
37.

Effect of tumor necrosis factor-α blockade on mucosal addressin cell-adhesion molecule-1 in Crohn's disease.

Biancheri P, Di Sabatino A, Rovedatti L, Giuffrida P, Calarota SA, Vetrano S, Vidali F, Pasini A, Danese S, Corazza GR, MacDonald TT.

Inflamm Bowel Dis. 2013 Feb;19(2):259-64. doi: 10.1097/MIB.0b013e31828100a4.

PMID:
23328772
38.

Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α.

Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP, MacDonald TT.

Gut. 2014 Jan;63(1):96-104. doi: 10.1136/gutjnl-2012-303581. Epub 2012 Dec 25.

PMID:
23268370
39.

The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.

Powell N, Walker AW, Stolarczyk E, Canavan JB, Gökmen MR, Marks E, Jackson I, Hashim A, Curtis MA, Jenner RG, Howard JK, Parkhill J, MacDonald TT, Lord GM.

Immunity. 2012 Oct 19;37(4):674-84. doi: 10.1016/j.immuni.2012.09.008. Epub 2012 Oct 11.

40.

Tissue inhibitor of metalloproteinase-3 regulates inflammation in human and mouse intestine.

Monteleone I, Federici M, Sarra M, Franzè E, Casagrande V, Zorzi F, Cavalera M, Rizzo A, Lauro R, Pallone F, MacDonald TT, Monteleone G.

Gastroenterology. 2012 Nov;143(5):1277-1287.e4. doi: 10.1053/j.gastro.2012.07.016. Epub 2012 Jul 20.

PMID:
22819866
41.

Reprogramming the immune system in IBD.

MacDonald TT, Vossenkaemper A, Fantini M, Monteleone G.

Dig Dis. 2012;30(4):392-5. doi: 10.1159/000338136. Epub 2012 Jul 12. Review.

PMID:
22796803
42.

Interleukin-21 in cancer immunotherapy: Friend or foe?

Stolfi C, Pallone F, Macdonald TT, Monteleone G.

Oncoimmunology. 2012 May 1;1(3):351-354.

43.

What's the next best cytokine target in IBD?

MacDonald TT, Biancheri P, Sarra M, Monteleone G.

Inflamm Bowel Dis. 2012 Nov;18(11):2180-9. doi: 10.1002/ibd.22967. Epub 2012 Apr 16. Review.

PMID:
22508526
44.

The aryl hydrocarbon receptor in inflammatory bowel disease: linking the environment to disease pathogenesis.

Monteleone I, MacDonald TT, Pallone F, Monteleone G.

Curr Opin Gastroenterol. 2012 Jul;28(4):310-3. doi: 10.1097/MOG.0b013e328352ad69. Review.

PMID:
22450895
45.

Proteases and the gut barrier.

Biancheri P, Di Sabatino A, Corazza GR, MacDonald TT.

Cell Tissue Res. 2013 Feb;351(2):269-80. doi: 10.1007/s00441-012-1390-z. Epub 2012 Mar 20. Review.

PMID:
22427120
46.

New cytokine targets in inflammatory bowel disease.

Macdonald TT.

Gastroenterol Hepatol (N Y). 2011 Jul;7(7):474-6. No abstract available.

47.

A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.

Canavan JB, Afzali B, Scottà C, Fazekasova H, Edozie FC, Macdonald TT, Hernandez-Fuentes MP, Lombardi G, Lord GM.

Blood. 2012 Feb 23;119(8):e57-66. doi: 10.1182/blood-2011-09-380048. Epub 2012 Jan 4.

48.

Colonic lymphoid nodular hyperplasia in an adolescent.

Vossenkämper A, Fikree A, Fairclough PD, Aziz Q, MacDonald TT.

J Pediatr Gastroenterol Nutr. 2011 Dec;53(6):684-6. doi: 10.1097/MPG.0b013e318223650a. No abstract available.

PMID:
22134496
49.

Recent advances in understanding ulcerative colitis.

Di Sabatino A, Biancheri P, Rovedatti L, Macdonald TT, Corazza GR.

Intern Emerg Med. 2012 Apr;7(2):103-11. doi: 10.1007/s11739-011-0719-z. Epub 2011 Nov 9. Review.

PMID:
22068230
50.

Smad7 expression in T cells prevents colitis-associated cancer.

Rizzo A, Waldner MJ, Stolfi C, Sarra M, Fina D, Becker C, Neurath MF, Macdonald TT, Pallone F, Monteleone G, Fantini MC.

Cancer Res. 2011 Dec 15;71(24):7423-32. doi: 10.1158/0008-5472.CAN-11-1895. Epub 2011 Oct 25.

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