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Prolactin-inducible EDD E3 ubiquitin ligase promotes TORC1 signalling, anti-apoptotic protein expression, and drug resistance in breast cancer cells.

MacDonald TM, Thomas LN, Daze E, Marignani P, Barnes PJ, Too CK.

Am J Cancer Res. 2019 Jul 1;9(7):1484-1503. eCollection 2019.


Reduced sucrose nonfermenting AMPK-related kinase (SNARK) activity aggravates cancer-induced skeletal muscle wasting.

Alves CRR, MacDonald TL, Nigro P, Pathak P, Hirshman MF, Goodyear LJ, Lessard SJ.

Biomed Pharmacother. 2019 Sep;117:109197. doi: 10.1016/j.biopha.2019.109197. Epub 2019 Jul 6.


Blood-based biomarkers in the maternal circulation associated with fetal growth restriction.

Tong S, Joy Kaitu'u-Lino T, Walker SP, MacDonald TM.

Prenat Diagn. 2019 Jul 12. doi: 10.1002/pd.5525. [Epub ahead of print] Review.


Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension.

Gingles CR, Symon R, Gandy SJ, Struthers AD, Houston G, MacDonald TM, Lang CC, Donnan PT, George J.

J Hypertens. 2019 Jul 1. doi: 10.1097/HJH.0000000000002189. [Epub ahead of print]


Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.

Haile PA, Casillas LN, Votta BJ, Wang GZ, Charnley AK, Dong X, Bury MJ, Romano JJ, Mehlmann JF, King BW, Erhard KF, Hanning CR, Lipshutz DB, Desai BM, Capriotti CA, Schaeffer MC, Berger SB, Mahajan MK, Reilly MA, Nagilla R, Rivera EJ, Sun HH, Kenna JK, Beal AM, Ouellette MT, Kelly M, Stemp G, Convery MA, Vossenkämper A, MacDonald TT, Gough PJ, Bertin J, Marquis RW.

J Med Chem. 2019 Jul 25;62(14):6482-6494. doi: 10.1021/acs.jmedchem.9b00575. Epub 2019 Jul 2.


Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism.

Scheiman J, Luber JM, Chavkin TA, MacDonald T, Tung A, Pham LD, Wibowo MC, Wurth RC, Punthambaker S, Tierney BT, Yang Z, Hattab MW, Avila-Pacheco J, Clish CB, Lessard S, Church GM, Kostic AD.

Nat Med. 2019 Jul;25(7):1104-1109. doi: 10.1038/s41591-019-0485-4. Epub 2019 Jun 24.


Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma.

Maximov V, Chen Z, Wei Y, Robinson MH, Herting CJ, Shanmugam NS, Rudneva VA, Goldsmith KC, MacDonald TJ, Northcott PA, Hambardzumyan D, Kenney AM.

Nat Commun. 2019 Jun 3;10(1):2410. doi: 10.1038/s41467-019-10458-9.


Exploring Stereotypes of Athletes With a Disability: A Behaviors From Intergroup Affect and Stereotypes Map Comparison.

Stone RC, Sweet SN, Perrier MJ, MacDonald T, Martin Ginis KA, Latimer-Cheung AE.

Adapt Phys Activ Q. 2019 Jun 27;36(3):339-358. doi: 10.1123/apaq.2018-0066.


Study Design and Cohort Comparability in a Study of Major Cardiovascular Events in New Users of Prucalopride Versus Polyethylene Glycol 3350.

Fortuny J, Gilsenan A, Cainzos-Achirica M, Cantero OF, Flynn RWV, Garcia-Rodriguez L, Kollhorst B, Karlsson P, Linnér L, MacDonald TM, Plana E, Ruigómez A, Schink T, Ziemiecki R, Andrews EB.

Drug Saf. 2019 May 27. doi: 10.1007/s40264-019-00836-z. [Epub ahead of print]


Cardiovascular Safety of Prucalopride in Patients with Chronic Constipation: A Multinational Population-Based Cohort Study.

Gilsenan A, Fortuny J, Cainzos-Achirica M, Cantero OF, Flynn RWV, Garcia-Rodriguez L, Harding A, Kollhorst B, Karlsson P, Linnér L, MacDonald TM, Odsbu I, Plana E, Ruigómez A, Schink T, Ziemiecki R, Andrews EB.

Drug Saf. 2019 May 27. doi: 10.1007/s40264-019-00835-0. [Epub ahead of print]


Host Genome Variation is Associated with Neurocognitive Outcome in Survivors of Pediatric Medulloblastoma.

Siegel BI, King TZ, Rupji M, Dwivedi B, Carter AB, Kowalski J, MacDonald TJ.

Transl Oncol. 2019 Jul;12(7):908-916. doi: 10.1016/j.tranon.2019.03.004. Epub 2019 May 9.


Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia.

Whigham CA, MacDonald TM, Walker SP, Pritchard N, Hannan NJ, Hastie R, Alwis N, Cannon P, Nguyen TV, Tong S, Kaitu'u-Lino T.

Pregnancy Hypertens. 2019 Apr;16:16-25. doi: 10.1016/j.preghy.2019.02.003. Epub 2019 Feb 10.


Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation.

Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X, Norris S, Marshall JL, Clear A, Gribben J, MacDonald TT, Buckley CD, Korbonits M, Haworth O.

Cell Rep. 2019 Apr 30;27(5):1461-1471.e4. doi: 10.1016/j.celrep.2019.04.014.


Cucurbituril-mediated quantum dot aggregates formed by aqueous self-assembly for sensing applications.

Peveler WJ, Jia H, Jeen T, Rees K, Macdonald TJ, Xia Z, Chio WK, Moorthy S, Parkin IP, Carmalt CJ, Algar WR, Lee TC.

Chem Commun (Camb). 2019 May 7;55(38):5495-5498. doi: 10.1039/c9cc00410f.


Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease.

Reisdorf WC, Xie Q, Zeng X, Xie W, Rajpal N, Hoang B, Burgert ME, Kumar V, Hurle MR, Rajpal DK, O'Donnell S, MacDonald TT, Vossenkämper A, Wang L, Reilly M, Votta BJ, Sanchez Y, Agarwal P.

PLoS One. 2019 Apr 19;14(4):e0215033. doi: 10.1371/journal.pone.0215033. eCollection 2019.


Surface radio-mineralisation mediates chelate-free radiolabelling of iron oxide nanoparticles.

Patrick PS, Bogart LK, Macdonald TJ, Southern P, Powell MJ, Zaw-Thin M, Voelcker NH, Parkin IP, Pankhurst QA, Lythgoe MF, Kalber TL, Bear JC.

Chem Sci. 2019 Jan 9;10(9):2592-2597. doi: 10.1039/c8sc04895a. eCollection 2019 Mar 7.


Case report: Severe and treatment-resistant spontaneous ejaculation secondary to atomoxetine.

MacDonald T, Wimalaguna PS, Akosile W.

Australas Psychiatry. 2019 Apr;27(2):198-199. doi: 10.1177/1039856218815746. No abstract available.


Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study.

Wei L, Lai EC, Kao-Yang YH, Walker BR, MacDonald TM, Andrew R.

BMJ. 2019 Apr 10;365:l1204. doi: 10.1136/bmj.l1204.


Copper Metallopolymer Catalyst for the Electrocatalytic Hydrogen Evolution Reaction (HER).

Elmas S, Macdonald TJ, Skinner W, Andersson M, Nann T.

Polymers (Basel). 2019 Jan 10;11(1). pii: E110. doi: 10.3390/polym11010110.


Corrigendum: Time-Resolved Diffusion NMR Measurements for Transient Processes.

MacDonald TSC, Price WS, Beves JE.

Chemphyschem. 2019 Apr 2;20(7):991. doi: 10.1002/cphc.201900217. Epub 2019 Mar 26. No abstract available.


IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease.

Belarif L, Danger R, Kermarrec L, Nerrière-Daguin V, Pengam S, Durand T, Mary C, Kerdreux E, Gauttier V, Kucik A, Thepenier V, Martin JC, Chang C, Rahman A, Guen NS, Braudeau C, Abidi A, David G, Malard F, Takoudju C, Martinet B, Gérard N, Neveu I, Neunlist M, Coron E, MacDonald TT, Desreumaux P, Mai HL, Le Bas-Bernardet S, Mosnier JF, Merad M, Josien R, Brouard S, Soulillou JP, Blancho G, Bourreille A, Naveilhan P, Vanhove B, Poirier N.

J Clin Invest. 2019 Apr 2;129(5):1910-1925. doi: 10.1172/JCI121668. eCollection 2019 Apr 2.


Lactation Care for Transgender and Non-Binary Patients: Empowering Clients and Avoiding Aversives.

MacDonald TK.

J Hum Lact. 2019 May;35(2):223-226. doi: 10.1177/0890334419830989. Epub 2019 Mar 28. No abstract available.


Infectious Complications Are Associated With Alterations in the Gut Microbiome in Pediatric Patients With Acute Lymphoblastic Leukemia.

Nearing JT, Connors J, Whitehouse S, Van Limbergen J, Macdonald T, Kulkarni K, Langille MGI.

Front Cell Infect Microbiol. 2019 Feb 19;9:28. doi: 10.3389/fcimb.2019.00028. eCollection 2019.


Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis.

Paine MRL, Liu J, Huang D, Ellis SR, Trede D, Kobarg JH, Heeren RMA, Fernández FM, MacDonald TJ.

Sci Rep. 2019 Feb 18;9(1):2205. doi: 10.1038/s41598-018-38257-0.


Time-Resolved Diffusion NMR Measurements for Transient Processes.

MacDonald TSC, Price WS, Beves JE.

Chemphyschem. 2019 Apr 2;20(7):926-930. doi: 10.1002/cphc.201900150. Epub 2019 Mar 5. Erratum in: Chemphyschem. 2019 Apr 2;20(7):991.


The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress-Driven Mucus Depletion and Exacerbates Intestinal Inflammation.

Laudisi F, Di Fusco D, Dinallo V, Stolfi C, Di Grazia A, Marafini I, Colantoni A, Ortenzi A, Alteri C, Guerrieri F, Mavilio M, Ceccherini-Silberstein F, Federici M, MacDonald TT, Monteleone I, Monteleone G.

Cell Mol Gastroenterol Hepatol. 2019;7(2):457-473. doi: 10.1016/j.jcmgh.2018.09.002. Epub 2018 Sep 11.


The effects of dietary selenomethionine on tissue-specific accumulation and toxicity of dietary arsenite in rainbow trout (Oncorhynchus mykiss) during chronic exposure.

Jamwal A, Saibu Y, MacDonald TC, George GN, Niyogi S.

Metallomics. 2019 Mar 20;11(3):643-655. doi: 10.1039/c8mt00309b.


The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development.

Whigham CA, MacDonald TM, Walker SP, Hannan NJ, Tong S, Kaitu'u-Lino TJ.

Placenta. 2019 Sep 1;84:28-31. doi: 10.1016/j.placenta.2019.02.002. Epub 2019 Feb 4. Review.


Asparaginase activity monitoring experience from the Maritimes, Canada.

Pike M, Kulkarni K, MacDonald T.

Leuk Lymphoma. 2019 Feb 5:1-4. doi: 10.1080/10428194.2019.1571196. [Epub ahead of print] No abstract available.


Does the provision of a DVD-based audio-visual presentation improve recruitment in a clinical trial? A randomised trial of DVD trial invitations.

Rogers A, Flynn RWV, Mackenzie IS, MacDonald TM.

BMC Med Res Methodol. 2019 Jan 30;19(1):24. doi: 10.1186/s12874-019-0663-6.


Disruption of selenium transport and function is a major contributor to mercury toxicity in zebrafish larvae.

Dolgova NV, Nehzati S, MacDonald TC, Summers KL, Crawford AM, Krone PH, George GN, Pickering IJ.

Metallomics. 2019 Mar 20;11(3):621-631. doi: 10.1039/c8mt00315g.


Transcriptional repressor REST drives lineage stage-specific chromatin compaction at Ptch1 and increases AKT activation in a mouse model of medulloblastoma.

Dobson THW, Tao RH, Swaminathan J, Maegawa S, Shaik S, Bravo-Alegria J, Sharma A, Kennis B, Yang Y, Callegari K, Haltom AR, Taylor P, Kogiso M, Qi L, Khatua S, Goldman S, Lulla RR, Fangusaro J, MacDonald TJ, Li XN, Hawkins C, Rajaram V, Gopalakrishnan V.

Sci Signal. 2019 Jan 22;12(565). pii: eaan8680. doi: 10.1126/scisignal.aan8680.


Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin.

Whigham CA, MacDonald TM, Walker SP, Pritchard N, Hannan NJ, Cannon P, Nguyen TV, Hastie R, Tong S, Kaitu'u-Lino TJ.

Sci Rep. 2019 Jan 18;9(1):235. doi: 10.1038/s41598-018-36645-0.


Application of the Theoretical Domains Framework to identify factors that influence hand hygiene compliance in long-term care.

Smith JD, Corace KM, MacDonald TK, Fabrigar LR, Saedi A, Chaplin A, MacFarlane S, Valickis D, Garber GE.

J Hosp Infect. 2019 Apr;101(4):393-398. doi: 10.1016/j.jhin.2018.12.014. Epub 2018 Dec 28.


Evaluation of pregnancy outcomes in patients with multiple sclerosis after fingolimod exposure.

Geissbühler Y, Vile J, Koren G, Guennec M, Butzkueven H, Tilson H, MacDonald TM, Hellwig K.

Ther Adv Neurol Disord. 2018 Nov 3;11:1756286418804760. doi: 10.1177/1756286418804760. eCollection 2018.


The effect of changes to GOLD severity stage on long term morbidity and mortality in COPD.

Flynn RWV, MacDonald TM, Chalmers JD, Schembri S.

Respir Res. 2018 Dec 12;19(1):249. doi: 10.1186/s12931-018-0960-3.


Identifying poor adherence to antihypertensive medications in patients with resistant hypertension.

Mackenzie IS, MacDonald TM.

Br J Clin Pharmacol. 2019 Jan;85(1):5-7. doi: 10.1111/bcp.13806. Epub 2018 Nov 26. No abstract available.


Reaching an ACCORD on Glycemia and Systolic Blood Pressure Targets in Type 2 Diabetes Mellitus.

MacDonald TM, Mackenzie IS.

J Am Heart Assoc. 2018 Sep 18;7(18):e010508. doi: 10.1161/JAHA.118.010508. No abstract available.


T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function.

Garrido-Mesa N, Schroeder JH, Stolarczyk E, Gallagher AL, Lo JW, Bailey C, Campbell L, Sexl V, MacDonald TT, Howard JK, Grencis RK, Powell N, Lord GM.

Mucosal Immunol. 2019 Jan;12(1):51-63. doi: 10.1038/s41385-018-0092-6. Epub 2018 Oct 24.


A new family of urea-based low molecular-weight organogelators for environmental remediation: the influence of structure.

Peveler WJ, Packman H, Alexander S, Chauhan RR, Hayes LM, Macdonald TJ, Cockcroft JK, Rogers S, Aarts DGAL, Carmalt CJ, Parkin IP, Bear JC.

Soft Matter. 2018 Nov 7;14(43):8821-8827. doi: 10.1039/c8sm01682h.


The cerebral-placental-uterine ratio as a novel predictor of late fetal growth restriction: a prospective cohort study.

MacDonald TM, Hui L, Robinson AJ, Dane KM, Middleton AL, Tong S, Walker SP.

Ultrasound Obstet Gynecol. 2018 Oct 18. doi: 10.1002/uog.20150. [Epub ahead of print]


The effect of indapamide vs. bendroflumethiazide for primary hypertension: a systematic review.

Macfarlane TV, Pigazzani F, Flynn RWV, MacDonald TM.

Br J Clin Pharmacol. 2019 Feb;85(2):285-303. doi: 10.1111/bcp.13787. Epub 2018 Nov 28. Review.


Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks' gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study.

MacDonald TM, Tran C, Kaitu'u-Lino TJ, Brennecke SP, Hiscock RJ, Hui L, Dane KM, Middleton AL, Cannon P, Walker SP, Tong S.

BMC Pregnancy Childbirth. 2018 Aug 31;18(1):354. doi: 10.1186/s12884-018-1992-x.


White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors.

Na S, Li L, Crosson B, Dotson V, MacDonald TJ, Mao H, King TZ.

Neuroimage Clin. 2018 Aug 10;20:485-497. doi: 10.1016/j.nicl.2018.08.015. eCollection 2018.


Ibuprofen and Paracetamol: Acceptably Safe for All?

Pigazzani F, Mackenzie I, MacDonald TM.

Drug Saf. 2018 Nov;41(11):999-1001. doi: 10.1007/s40264-018-0717-4. No abstract available.


Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.

Clark AR, Calligaris D, Regan MS, Pomeranz Krummel D, Agar JN, Kallay L, MacDonald T, Schniederjan M, Santagata S, Pomeroy SL, Agar NYR, Sengupta S.

J Neurooncol. 2018 Nov;140(2):269-279. doi: 10.1007/s11060-018-2978-2. Epub 2018 Aug 20.


JNK regulates muscle remodeling via myostatin/SMAD inhibition.

Lessard SJ, MacDonald TL, Pathak P, Han MS, Coffey VG, Edge J, Rivas DA, Hirshman MF, Davis RJ, Goodyear LJ.

Nat Commun. 2018 Aug 2;9(1):3030. doi: 10.1038/s41467-018-05439-3.


SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone Sensitivity.

Boysen G, Rodrigues DN, Rescigno P, Seed G, Dolling D, Riisnaes R, Crespo M, Zafeiriou Z, Sumanasuriya S, Bianchini D, Hunt J, Moloney D, Perez-Lopez R, Tunariu N, Miranda S, Figueiredo I, Ferreira A, Christova R, Gil V, Aziz S, Bertan C, de Oliveira FM, Atkin M, Clarke M, Goodall J, Sharp A, MacDonald T, Rubin MA, Yuan W, Barbieri CE, Carreira S, Mateo J, de Bono JS.

Clin Cancer Res. 2018 Nov 15;24(22):5585-5593. doi: 10.1158/1078-0432.CCR-18-0937. Epub 2018 Aug 1.


Safety and efficacy of nabilone for acute chemotherapy-induced vomiting prophylaxis in pediatric patients: A multicenter, retrospective review.

Polito S, MacDonald T, Romanick M, Jupp J, Wiernikowski J, Vennettilli A, Khanna M, Patel P, Ning W, Sung L, Dupuis LL.

Pediatr Blood Cancer. 2018 Dec;65(12):e27374. doi: 10.1002/pbc.27374. Epub 2018 Jul 26.


The fourth delay and community-driven solutions to reduce maternal mortality in rural Haiti: a community-based action research study.

MacDonald T, Jackson S, Charles MC, Periel M, Jean-Baptiste MV, Salomon A, Premilus É.

BMC Pregnancy Childbirth. 2018 Jun 20;18(1):254. doi: 10.1186/s12884-018-1881-3.

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