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Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation-Based Mechanism.

Krah NM, Narayanan SM, Yugawa DE, Straley JA, Wright CVE, MacDonald RJ, Murtaugh LC.

Dev Cell. 2019 Aug 13. pii: S1534-5807(19)30584-2. doi: 10.1016/j.devcel.2019.07.012. [Epub ahead of print]


Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML.

Bunaciu RP, MacDonald RJ, Jensen HA, Gao F, Wang X, Johnson L, Varner JD, Yen A.

Leuk Lymphoma. 2019 Jul;60(7):1697-1708. doi: 10.1080/10428194.2018.1543880. Epub 2018 Dec 20.


CXCR5 overexpression in HL-60 cells enhances chemotaxis toward CXCL13 without anticipated interaction partners or enhanced MAPK signaling.

MacDonald RJ, Yen A.

In Vitro Cell Dev Biol Anim. 2018 Dec;54(10):725-735. doi: 10.1007/s11626-018-0293-z. Epub 2018 Oct 1.


The role of osteopathy in the Swiss primary health care system: a practice review.

Vaucher P, Macdonald RJD, Carnes D.

BMJ Open. 2018 Sep 1;8(8):e023770. doi: 10.1136/bmjopen-2018-023770.


Src family kinase inhibitor bosutinib enhances retinoic acid-induced differentiation of HL-60 leukemia cells.

MacDonald RJ, Bunaciu RP, Ip V, Dai D, Tran D, Varner JD, Yen A.

Leuk Lymphoma. 2018 Dec;59(12):2941-2951. doi: 10.1080/10428194.2018.1452213. Epub 2018 Mar 23.


An inflammatory transcriptional switch.

Murtaugh LC, MacDonald RJ.

Nature. 2018 Feb 22;554(7693):470-472. doi: 10.1038/d41586-018-01262-4. No abstract available.


Potential for subsets of wt-NPM1 primary AML blasts to respond to retinoic acid treatment.

Bunaciu RP, MacDonald RJ, Gao F, Johnson LM, Varner JD, Wang X, Nataraj S, Guzman ML, Yen A.

Oncotarget. 2017 Dec 23;9(3):4134-4149. doi: 10.18632/oncotarget.23642. eCollection 2018 Jan 9.


Probing the requirement for CD38 in retinoic acid-induced HL-60 cell differentiation with a small molecule dimerizer and genetic knockout.

MacDonald RJ, Shrimp JH, Jiang H, Zhang L, Lin H, Yen A.

Sci Rep. 2017 Dec 12;7(1):17406. doi: 10.1038/s41598-017-17720-4.


Detection of titanium oxide in the atmosphere of a hot Jupiter.

Sedaghati E, Boffin HMJ, MacDonald RJ, Gandhi S, Madhusudhan N, Gibson NP, Oshagh M, Claret A, Rauer H.

Nature. 2017 Sep 13;549(7671):238-241. doi: 10.1038/nature23651.


Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.

Hoang CQ, Hale MA, Azevedo-Pouly AC, Elsässer HP, Deering TG, Willet SG, Pan FC, Magnuson MA, Wright CV, Swift GH, MacDonald RJ.

Mol Cell Biol. 2016 Nov 28;36(24):3033-3047. Print 2016 Dec 15.


MIST1 and PTF1 Collaborate in Feed-Forward Regulatory Loops That Maintain the Pancreatic Acinar Phenotype in Adult Mice.

Jiang M, Azevedo-Pouly AC, Deering TG, Hoang CQ, DiRenzo D, Hess DA, Konieczny SF, Swift GH, MacDonald RJ.

Mol Cell Biol. 2016 Nov 14;36(23):2945-2955. doi: 10.1128/MCB.00370-16. Print 2016 Dec 1.


MIST1 Links Secretion and Stress as both Target and Regulator of the Unfolded Protein Response.

Hess DA, Strelau KM, Karki A, Jiang M, Azevedo-Pouly AC, Lee AH, Deering TG, Hoang CQ, MacDonald RJ, Konieczny SF.

Mol Cell Biol. 2016 Nov 14;36(23):2931-2944. doi: 10.1128/MCB.00366-16. Print 2016 Dec 1.


Isolated Pancreatic Aplasia Due to a Hypomorphic PTF1A Mutation.

Houghton JA, Swift GH, Shaw-Smith C, Flanagan SE, de Franco E, Caswell R, Hussain K, Mohamed S, Abdulrasoul M, Hattersley AT, MacDonald RJ, Ellard S.

Diabetes. 2016 Sep;65(9):2810-5. doi: 10.2337/db15-1666. Epub 2016 Jun 9.


6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells.

Bunaciu RP, Jensen HA, MacDonald RJ, LaTocha DH, Varner JD, Yen A.

PLoS One. 2015 Aug 19;10(8):e0135668. doi: 10.1371/journal.pone.0135668. eCollection 2015.


The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma.

Krah NM, De La O JP, Swift GH, Hoang CQ, Willet SG, Chen Pan F, Cash GM, Bronner MP, Wright CV, MacDonald RJ, Murtaugh LC.

Elife. 2015 Jul 7;4. doi: 10.7554/eLife.07125.


Dominant and context-specific control of endodermal organ allocation by Ptf1a.

Willet SG, Hale MA, Grapin-Botton A, Magnuson MA, MacDonald RJ, Wright CV.

Development. 2014 Nov;141(22):4385-94. doi: 10.1242/dev.114165.


The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.

Hale MA, Swift GH, Hoang CQ, Deering TG, Masui T, Lee YK, Xue J, MacDonald RJ.

Development. 2014 Aug;141(16):3123-33. doi: 10.1242/dev.109405. Epub 2014 Jul 25.


The Parahox gene Pdx1 is required to maintain positional identity in the adult foregut.

Holland AM, Garcia S, Naselli G, Macdonald RJ, Harrison LC.

Int J Dev Biol. 2013;57(5):391-8. doi: 10.1387/ijdb.120048ah.


Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility.

Meredith DM, Borromeo MD, Deering TG, Casey BH, Savage TK, Mayer PR, Hoang C, Tung KC, Kumar M, Shen C, Swift GH, Macdonald RJ, Johnson JE.

Mol Cell Biol. 2013 Aug;33(16):3166-79. doi: 10.1128/MCB.00364-13. Epub 2013 Jun 10.


Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis.

Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L.

J Clin Invest. 2012 Oct;122(10):3516-28. doi: 10.1172/JCI63352. Epub 2012 Sep 24.


Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice.

Serup P, Gustavsen C, Klein T, Potter LA, Lin R, Mullapudi N, Wandzioch E, Hines A, Davis A, Bruun C, Engberg N, Petersen DR, Peterslund JM, Macdonald RJ, Grapin-Botton A, Magnuson MA, Zaret KS.

Dis Model Mech. 2012 Nov;5(6):956-66. doi: 10.1242/dmm.009696. Epub 2012 Aug 10.


Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells.

Direnzo D, Hess DA, Damsz B, Hallett JE, Marshall B, Goswami C, Liu Y, Deering T, Macdonald RJ, Konieczny SF.

Gastroenterology. 2012 Aug;143(2):469-80. doi: 10.1053/j.gastro.2012.04.011. Epub 2012 Apr 14.


Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.

Afelik S, Qu X, Hasrouni E, Bukys MA, Deering T, Nieuwoudt S, Rogers W, Macdonald RJ, Jensen J.

Development. 2012 May;139(10):1744-53. doi: 10.1242/dev.075804. Epub 2012 Mar 29.


Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.

Ahnfelt-Rønne J, Jørgensen MC, Klinck R, Jensen JN, Füchtbauer EM, Deering T, MacDonald RJ, Wright CV, Madsen OD, Serup P.

Development. 2012 Jan;139(1):33-45. doi: 10.1242/dev.071761. Epub 2011 Nov 17.


Notch-independent functions of CSL.

Johnson JE, Macdonald RJ.

Curr Top Dev Biol. 2011;97:55-74. doi: 10.1016/B978-0-12-385975-4.00009-7. Review.


LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.

Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, MacDonald RJ.

Genes Dev. 2011 Aug 15;25(16):1674-9. doi: 10.1101/gad.16860911.


The formation and characterisation of redox active and luminescent materials from the electrooxidation of indolizine.

Henry JB, MacDonald RJ, Gibbad HS, McNab H, Mount AR.

Phys Chem Chem Phys. 2011 Mar 28;13(12):5235-41. doi: 10.1039/c0cp02645j. Epub 2011 Feb 25.


Frequency of cardiovascular events in women with a congenitally bicuspid aortic valve in a single community and effect of pregnancy on events.

McKellar SH, MacDonald RJ, Michelena HI, Connolly HM, Sundt TM 3rd.

Am J Cardiol. 2011 Jan;107(1):96-9. doi: 10.1016/j.amjcard.2010.08.061.


Transcriptional control of acinar development and homeostasis.

MacDonald RJ, Swift GH, Real FX.

Prog Mol Biol Transl Sci. 2010;97:1-40. doi: 10.1016/B978-0-12-385233-5.00001-5. Review.


Papillary fibroelastomas in 19 patients with hypertrophic cardiomyopathy undergoing septal myectomy.

Kumar G, Macdonald RJ, Sorajja P, Edwards WD, Ommen SR, Klarich KW.

J Am Soc Echocardiogr. 2010 Jun;23(6):595-8. doi: 10.1016/j.echo.2010.03.030.


Location of coronary culprit lesions at autopsy in 41 nondiabetic patients with acute myocardial infarction.

Geske JB, Edwards WD, MacDonald RJ, Holmes DR Jr.

Am J Forensic Med Pathol. 2010 Sep;31(3):213-7. doi: 10.1097/PAF.0b013e3181dd7949.


Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.

Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ.

Gastroenterology. 2010 Jul;139(1):270-80. doi: 10.1053/j.gastro.2010.04.003. Epub 2010 Apr 14.


Reactions of 2-(pyrrol-1-yl)benzyl radicals and related species under flash vacuum pyrolysis conditions.

Cadogan JI, Clark BA, Ford D, Macdonald RJ, Macpherson AD, McNab H, Nicolson IS, Reed D, Sommerville CC.

Org Biomol Chem. 2009 Dec 21;7(24):5173-83. doi: 10.1039/b914965a. Epub 2009 Oct 21.


Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by Fgf10.

Kobberup S, Schmerr M, Dang ML, Nyeng P, Jensen JN, MacDonald RJ, Jensen J.

Mech Dev. 2010 Apr;127(3-4):220-34. doi: 10.1016/j.mod.2009.11.005. Epub 2009 Dec 5.


Artificial muscle actuators in biorobotic fish fins.

Phelan CT, Macdonald RJ, Tangorra JL.

Conf Proc IEEE Eng Med Biol Soc. 2009;2009:6822-5. doi: 10.1109/IEMBS.2009.5334484.


Teaching Video NeuroImages: Wernicke encephalopathy without mental status changes.

MacDonald RJ, Stanich PP, Monrad PA, Mateen FJ.

Neurology. 2009 Nov 17;73(20):e97. doi: 10.1212/WNL.0b013e3181c1de31. No abstract available.


Multiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex.

Meredith DM, Masui T, Swift GH, MacDonald RJ, Johnson JE.

J Neurosci. 2009 Sep 9;29(36):11139-48. doi: 10.1523/JNEUROSCI.2303-09.2009.


PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression.

Gauthier BR, Wiederkehr A, Baquié M, Dai C, Powers AC, Kerr-Conte J, Pattou F, MacDonald RJ, Ferrer J, Wollheim CB.

Cell Metab. 2009 Aug;10(2):110-8. doi: 10.1016/j.cmet.2009.07.002.


Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord.

Henke RM, Savage TK, Meredith DM, Glasgow SM, Hori K, Dumas J, MacDonald RJ, Johnson JE.

Development. 2009 Sep;136(17):2945-54. doi: 10.1242/dev.035352. Epub 2009 Jul 29.


Short- and long-term efficacy of aspirin and clopidogrel for thromboprophylaxis for mechanical heart valves: an in vivo study in swine.

McKellar SH, Thompson JL 3rd, Garcia-Rinaldi RF, Macdonald RJ, Sundt TM 3rd, Schaff HV.

J Thorac Cardiovasc Surg. 2008 Oct;136(4):908-14. doi: 10.1016/j.jtcvs.2008.01.045. Epub 2008 Jun 30.


Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood.

Masui T, Swift GH, Hale MA, Meredith DM, Johnson JE, Macdonald RJ.

Mol Cell Biol. 2008 Sep;28(17):5458-68. doi: 10.1128/MCB.00549-08. Epub 2008 Jul 7.


A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.

Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE.

Genes Dev. 2008 Jan 15;22(2):166-78. doi: 10.1101/gad.1628008.


Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.

Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ.

Genes Dev. 2007 Oct 15;21(20):2629-43.


The transcriptional regulatory strategy of the rat tissue kallikrein gene family.

Kroon E, MacDonald RJ, Hammer RE.

Genes Funct. 1997 Dec;1(5-6):309-19.


Ptf1a determines horizontal and amacrine cell fates during mouse retinal development.

Fujitani Y, Fujitani S, Luo H, Qiu F, Burlison J, Long Q, Kawaguchi Y, Edlund H, MacDonald RJ, Furukawa T, Fujikado T, Magnuson MA, Xiang M, Wright CV.

Development. 2006 Nov;133(22):4439-50.


A comprehensive survey of DNA-binding transcription factor gene expression in human fetal and adult organs.

Kong YM, Macdonald RJ, Wen X, Yang P, Barbera VM, Swift GH.

Gene Expr Patterns. 2006 Oct;6(7):678-86. Epub 2006 Feb 17.


Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.

Smart NG, Apelqvist AA, Gu X, Harmon EB, Topper JN, MacDonald RJ, Kim SK.

PLoS Biol. 2006 Feb;4(2):e39. Epub 2006 Jan 31.


Ptf1a determines GABAergic over glutamatergic neuronal cell fate in the spinal cord dorsal horn.

Glasgow SM, Henke RM, Macdonald RJ, Wright CV, Johnson JE.

Development. 2005 Dec;132(24):5461-9. Epub 2005 Nov 16.


The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas.

Hale MA, Kagami H, Shi L, Holland AM, Elsässer HP, Hammer RE, MacDonald RJ.

Dev Biol. 2005 Oct 1;286(1):225-37.

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