Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 95

1.

A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets.

Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V, MacDonald PE.

Physiol Rep. 2019 Oct;7(19):e14250. doi: 10.14814/phy2.14250.

2.

A glucose-dependent spatial patterning of exocytosis in human β-cells is disrupted in type 2 diabetes.

Fu J, Githaka JM, Dai X, Plummer G, Suzuki K, Spigelman AF, Bautista A, Kim R, Greitzer-Antes D, Fox JEM, Gaisano HY, MacDonald PE.

JCI Insight. 2019 May 14;5. pii: 127896. doi: 10.1172/jci.insight.127896.

3.

β Cell tone is defined by proglucagon peptides through cAMP signaling.

Capozzi ME, Svendsen B, Encisco SE, Lewandowski SL, Martin MD, Lin H, Jaffe JL, Coch RW, Haldeman JM, MacDonald PE, Merrins MJ, D'Alessio DA, Campbell JE.

JCI Insight. 2019 Mar 7;4(5). pii: 126742. doi: 10.1172/jci.insight.126742. eCollection 2019 Mar 7.

4.

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.

Thomsen SK, Raimondo A, Hastoy B, Sengupta S, Dai XQ, Bautista A, Censin J, Payne AJ, Umapathysivam MM, Spigelman AF, Barrett A, Groves CJ, Beer NL, Manning Fox JE, McCarthy MI, Clark A, Mahajan A, Rorsman P, MacDonald PE, Gloyn AL.

Nat Genet. 2018 Aug;50(8):1122-1131. doi: 10.1038/s41588-018-0173-1. Epub 2018 Jul 27.

5.

Cystic fibrosis-related diabetes is caused by islet loss and inflammation.

Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC.

JCI Insight. 2018 Apr 19;3(8). pii: 98240. doi: 10.1172/jci.insight.98240. eCollection 2018 Apr 19.

6.

The cell biology of systemic insulin function.

Tokarz VL, MacDonald PE, Klip A.

J Cell Biol. 2018 Jul 2;217(7):2273-2289. doi: 10.1083/jcb.201802095. Epub 2018 Apr 5. Review.

7.

A post-translational balancing act: the good and the bad of SUMOylation in pancreatic islets.

MacDonald PE.

Diabetologia. 2018 Apr;61(4):775-779. doi: 10.1007/s00125-017-4543-5. Epub 2018 Jan 12.

PMID:
29330559
8.

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E.

J Clin Invest. 2017 Dec 1;127(12):4379-4393. doi: 10.1172/JCI90004. Epub 2017 Nov 6.

9.

Metabolomics applied to islet nutrient sensing mechanisms.

Jensen MV, Gooding JR, Ferdaoussi M, Dai XQ, Peterson BS, MacDonald PE, Newgard CB.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:90-94. doi: 10.1111/dom.13010. Review.

10.

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.

Fu J, Dai X, Plummer G, Suzuki K, Bautista A, Githaka JM, Senior L, Jensen M, Greitzer-Antes D, Manning Fox JE, Gaisano HY, Newgard CB, Touret N, MacDonald PE.

Diabetes. 2017 Jul;66(7):1890-1900. doi: 10.2337/db16-1170. Epub 2017 Jun 12.

11.

Transplantation of Human Pancreatic Endoderm Cells Reverses Diabetes Post Transplantation in a Prevascularized Subcutaneous Site.

Pepper AR, Pawlick R, Bruni A, Wink J, Rafiei Y, O'Gorman D, Yan-Do R, Gala-Lopez B, Kin T, MacDonald PE, Shapiro AMJ.

Stem Cell Reports. 2017 Jun 6;8(6):1689-1700. doi: 10.1016/j.stemcr.2017.05.004.

12.

N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes.

Aichler M, Borgmann D, Krumsiek J, Buck A, MacDonald PE, Fox JEM, Lyon J, Light PE, Keipert S, Jastroch M, Feuchtinger A, Mueller NS, Sun N, Palmer A, Alexandrov T, Hrabe de Angelis M, Neschen S, Tschöp MH, Walch A.

Cell Metab. 2017 Jun 6;25(6):1334-1347.e4. doi: 10.1016/j.cmet.2017.04.012.

13.

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.

Gordon HM, Majithia N, MacDonald PE, Fox JEM, Sharma PR, Byrne FL, Hoehn KL, Evans-Molina C, Langman L, Brayman KL, Nunemaker CS.

Endocrine. 2017 Jun;56(3):528-537. doi: 10.1007/s12020-017-1297-2. Epub 2017 Apr 12.

14.

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells.

Ferdaoussi M, Fu J, Dai X, Manning Fox JE, Suzuki K, Smith N, Plummer G, MacDonald PE.

Sci Rep. 2017 Mar 21;7(1):248. doi: 10.1038/s41598-017-00344-z.

15.

Impaired "Glycine"-mia in Type 2 Diabetes and Potential Mechanisms Contributing to Glucose Homeostasis.

Yan-Do R, MacDonald PE.

Endocrinology. 2017 May 1;158(5):1064-1073. doi: 10.1210/en.2017-00148. Review.

PMID:
28323968
16.

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

Chakravarthy H, Gu X, Enge M, Dai X, Wang Y, Damond N, Downie C, Liu K, Wang J, Xing Y, Chera S, Thorel F, Quake S, Oberholzer J, MacDonald PE, Herrera PL, Kim SK.

Cell Metab. 2017 Mar 7;25(3):622-634. doi: 10.1016/j.cmet.2017.01.009. Epub 2017 Feb 16.

17.

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice.

Carrat GR, Hu M, Nguyen-Tu MS, Chabosseau P, Gaulton KJ, van de Bunt M, Siddiq A, Falchi M, Thurner M, Canouil M, Pattou F, Leclerc I, Pullen TJ, Cane MC, Prabhala P, Greenwald W, Schulte A, Marchetti P, Ibberson M, MacDonald PE, Manning Fox JE, Gloyn AL, Froguel P, Solimena M, McCarthy MI, Rutter GA.

Am J Hum Genet. 2017 Feb 2;100(2):238-256. doi: 10.1016/j.ajhg.2017.01.011. Epub 2017 Jan 26.

18.

Toward Connecting Metabolism to the Exocytotic Site.

Ferdaoussi M, MacDonald PE.

Trends Cell Biol. 2017 Mar;27(3):163-171. doi: 10.1016/j.tcb.2016.10.003. Epub 2016 Dec 5. Review.

PMID:
27932063
19.

Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats.

Hamza SM, Sung MM, Gao F, Soltys CM, Smith NP, MacDonald PE, Light PE, Dyck JR.

Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):313-322. doi: 10.1016/j.bbagen.2016.11.029. Epub 2016 Nov 19.

PMID:
27871838
20.

Interleukin-1 signaling contributes to acute islet compensation.

Hajmrle C, Smith N, Spigelman AF, Dai X, Senior L, Bautista A, Ferdaoussi M, MacDonald PE.

JCI Insight. 2016 Apr 7;1(4):e86055. doi: 10.1172/jci.insight.86055.

21.

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease.

Koppe L, Nyam E, Vivot K, Manning Fox JE, Dai XQ, Nguyen BN, Trudel D, Attané C, Moullé VS, MacDonald PE, Ghislain J, Poitout V.

J Clin Invest. 2016 Sep 1;126(9):3598-612. doi: 10.1172/JCI86181. Epub 2016 Aug 15.

22.

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.

Kolic J, Manning Fox JE, Chepurny OG, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE.

Mol Metab. 2016 May 11;5(7):459-471. doi: 10.1016/j.molmet.2016.05.003. eCollection 2016 Jul.

23.

A Glycine-Insulin Autocrine Feedback Loop Enhances Insulin Secretion From Human β-Cells and Is Impaired in Type 2 Diabetes.

Yan-Do R, Duong E, Manning Fox JE, Dai X, Suzuki K, Khan S, Bautista A, Ferdaoussi M, Lyon J, Wu X, Cheley S, MacDonald PE, Braun M.

Diabetes. 2016 Aug;65(8):2311-21. doi: 10.2337/db15-1272. Epub 2016 May 3.

24.

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore.

Lyon J, Manning Fox JE, Spigelman AF, Kim R, Smith N, O'Gorman D, Kin T, Shapiro AM, Rajotte RV, MacDonald PE.

Endocrinology. 2016 Feb;157(2):560-9. doi: 10.1210/en.2015-1562. Epub 2015 Dec 11.

PMID:
26653569
25.

TCF1 links GIPR signaling to the control of beta cell function and survival.

Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ.

Nat Med. 2016 Jan;22(1):84-90. doi: 10.1038/nm.3997. Epub 2015 Dec 7.

PMID:
26642437
26.

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.

van de Bunt M, Manning Fox JE, Dai X, Barrett A, Grey C, Li L, Bennett AJ, Johnson PR, Rajotte RV, Gaulton KJ, Dermitzakis ET, MacDonald PE, McCarthy MI, Gloyn AL.

PLoS Genet. 2015 Dec 1;11(12):e1005694. doi: 10.1371/journal.pgen.1005694. eCollection 2015 Dec.

27.

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice.

Gala-Lopez BL, Pepper AR, Pawlick RL, O'Gorman D, Kin T, Bruni A, Abualhassan N, Bral M, Bautista A, Manning Fox JE, Young LG, MacDonald PE, Shapiro AM.

Diabetes. 2016 Feb;65(2):451-62. doi: 10.2337/db15-0764. Epub 2015 Nov 18.

28.

cAMP-independent effects of GLP-1 on β cells.

Kolic J, MacDonald PE.

J Clin Invest. 2015 Dec;125(12):4327-30. doi: 10.1172/JCI85004. Epub 2015 Nov 16.

29.

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.

Gooding JR, Jensen MV, Dai X, Wenner BR, Lu D, Arumugam R, Ferdaoussi M, MacDonald PE, Newgard CB.

Cell Rep. 2015 Oct 6;13(1):157-167. doi: 10.1016/j.celrep.2015.08.072. Epub 2015 Sep 24.

30.

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE.

J Clin Invest. 2015 Oct 1;125(10):3847-60. doi: 10.1172/JCI82498. Epub 2015 Sep 21.

31.

Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.

Schwede F, Chepurny OG, Kaufholz M, Bertinetti D, Leech CA, Cabrera O, Zhu Y, Mei F, Cheng X, Manning Fox JE, MacDonald PE, Genieser HG, Herberg FW, Holz GG.

Mol Endocrinol. 2015 Jul;29(7):988-1005. doi: 10.1210/me.2014-1330. Epub 2015 Jun 10.

32.

Human islet function following 20 years of cryogenic biobanking.

Manning Fox JE, Lyon J, Dai XQ, Wright RC, Hayward J, van de Bunt M, Kin T, Shapiro AM, McCarthy MI, Gloyn AL, Ungrin MD, Lakey JR, Kneteman NM, Warnock GL, Korbutt GS, Rajotte RV, MacDonald PE.

Diabetologia. 2015 Jul;58(7):1503-12. doi: 10.1007/s00125-015-3598-4. Epub 2015 May 1.

33.

LKB1 couples glucose metabolism to insulin secretion in mice.

Fu A, Robitaille K, Faubert B, Reeks C, Dai XQ, Hardy AB, Sankar KS, Ogrel S, Al-Dirbashi OY, Rocheleau JV, Wheeler MB, MacDonald PE, Jones R, Screaton RA.

Diabetologia. 2015 Jul;58(7):1513-22. doi: 10.1007/s00125-015-3579-7. Epub 2015 Apr 16.

PMID:
25874445
34.

Stem cells to insulin secreting cells: two steps forward and now a time to pause?

Kushner JA, MacDonald PE, Atkinson MA.

Cell Stem Cell. 2014 Nov 6;15(5):535-6. doi: 10.1016/j.stem.2014.10.012. Epub 2014 Nov 6.

35.

Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells.

Kolic J, Spigelman AF, Smith AM, Manning Fox JE, MacDonald PE.

J Biol Chem. 2014 Nov 14;289(46):32109-20. doi: 10.1074/jbc.M114.577510. Epub 2014 Oct 6.

36.

Controlling insulin secretion: an exciting TASK.

MacDonald PE.

Endocrinology. 2014 Oct;155(10):3729-31. doi: 10.1210/en.2014-1667. No abstract available.

PMID:
25238133
37.

Autocrine activation of P2Y1 receptors couples Ca (2+) influx to Ca (2+) release in human pancreatic beta cells.

Khan S, Yan-Do R, Duong E, Wu X, Bautista A, Cheley S, MacDonald PE, Braun M.

Diabetologia. 2014 Dec;57(12):2535-45. doi: 10.1007/s00125-014-3368-8. Epub 2014 Sep 11.

PMID:
25208758
38.

SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.

Hajmrle C, Ferdaoussi M, Plummer G, Spigelman AF, Lai K, Manning Fox JE, MacDonald PE.

Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E664-73. doi: 10.1152/ajpendo.00168.2014. Epub 2014 Aug 19.

39.

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions.

Wang L, Luk CT, Schroer SA, Smith AM, Li X, Cai EP, Gaisano H, MacDonald PE, Hao Z, Mak TW, Woo M.

Diabetologia. 2014 Sep;57(9):1889-98. doi: 10.1007/s00125-014-3295-8. Epub 2014 Jul 1.

PMID:
24981769
40.

SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells.

Dai XQ, Spigelman AF, Khan S, Braun M, Manning Fox JE, MacDonald PE.

J Physiol. 2014 Sep 1;592(17):3715-26. doi: 10.1113/jphysiol.2014.274084. Epub 2014 Jun 6.

41.

Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated insulin secretion.

Patterson JN, Cousteils K, Lou JW, Manning Fox JE, MacDonald PE, Joseph JW.

J Biol Chem. 2014 May 9;289(19):13335-46. doi: 10.1074/jbc.M113.521666. Epub 2014 Mar 27.

42.

The role of the transcription factor ETV5 in insulin exocytosis.

Gutierrez-Aguilar R, Kim DH, Casimir M, Dai XQ, Pfluger PT, Park J, Haller A, Donelan E, Park J, D'Alessio D, Woods SC, MacDonald PE, Seeley RJ.

Diabetologia. 2014 Feb;57(2):383-91. doi: 10.1007/s00125-013-3096-5. Epub 2013 Nov 5.

43.

Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.

Yang YH, Manning Fox JE, Zhang KL, MacDonald PE, Johnson JD.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16480-5. doi: 10.1073/pnas.1214312110. Epub 2013 Sep 24.

44.

Triton X-100 inhibits L-type voltage-operated calcium channels.

Narang D, Kerr PM, Baserman J, Tam R, Yang W, Searle G, Manning-Fox JE, Paulsen IM, Kozuska JL, MacDonald PE, Light PE, Holt A, Plane F.

Can J Physiol Pharmacol. 2013 Apr;91(4):316-24. doi: 10.1139/cjpp-2012-0257. Epub 2013 Jan 15.

PMID:
23627843
45.

Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells.

Kolic J, Spigelman AF, Plummer G, Leung E, Hajmrle C, Kin T, Shapiro AM, Manning Fox JE, MacDonald PE.

Diabetologia. 2013 Jun;56(6):1339-49. doi: 10.1007/s00125-013-2882-4. Epub 2013 Apr 9.

PMID:
23568272
46.

Functional plasticity of the human infant β-cell exocytotic phenotype.

Fox JE, Seeberger K, Dai XQ, Lyon J, Spigelman AF, Kolic J, Hajmrle C, Joseph JW, Kin T, Shapiro AM, Korbutt G, MacDonald PE.

Endocrinology. 2013 Apr;154(4):1392-9. doi: 10.1210/en.2012-1934. Epub 2013 Feb 28.

PMID:
23449893
47.

Glucagon secretion and signaling in the development of diabetes.

Gaisano HY, Macdonald PE, Vranic M.

Front Physiol. 2012 Sep 4;3:349. doi: 10.3389/fphys.2012.00349. eCollection 2012.

48.

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells.

Kailey B, van de Bunt M, Cheley S, Johnson PR, MacDonald PE, Gloyn AL, Rorsman P, Braun M.

Am J Physiol Endocrinol Metab. 2012 Nov 1;303(9):E1107-16. doi: 10.1152/ajpendo.00207.2012. Epub 2012 Aug 28.

49.

G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.

Ferdaoussi M, Bergeron V, Zarrouki B, Kolic J, Cantley J, Fielitz J, Olson EN, Prentki M, Biden T, MacDonald PE, Poitout V.

Diabetologia. 2012 Oct;55(10):2682-2692. doi: 10.1007/s00125-012-2650-x. Epub 2012 Jul 22.

50.

In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking.

Cai EP, Casimir M, Schroer SA, Luk CT, Shi SY, Choi D, Dai XQ, Hajmrle C, Spigelman AF, Zhu D, Gaisano HY, MacDonald PE, Woo M.

Diabetes. 2012 Jul;61(7):1708-18. doi: 10.2337/db11-1344. Epub 2012 Apr 12.

Supplemental Content

Loading ...
Support Center