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Synaptic Proteome Alterations in the Primary Auditory Cortex of Individuals With Schizophrenia.

MacDonald ML, Garver M, Newman J, Sun Z, Kannarkat J, Salisbury R, Glausier J, Ding Y, Lewis DA, Yates N, Sweet RA.

JAMA Psychiatry. 2019 Oct 23:1-10. doi: 10.1001/jamapsychiatry.2019.2974. [Epub ahead of print]


Increased Protein Insolubility in Brains From a Subset of Patients With Schizophrenia.

Nucifora LG, MacDonald ML, Lee BJ, Peters ME, Norris AL, Orsburn BC, Yang K, Gleason K, Margolis RL, Pevsner J, Tamminga CA, Sweet RA, Ross CA, Sawa A, Nucifora FC Jr.

Am J Psychiatry. 2019 Sep 1;176(9):730-743. doi: 10.1176/appi.ajp.2019.18070864. Epub 2019 May 6.


Bioinformatic analysis of Chinese hamster ovary host cell protein lipases.

MacDonald ML, Hamaker N, Lee KH.

AIChE J. 2018 Dec;64(12):4247-4254. doi: 10.1002/aic.16378. Epub 2018 Aug 9.


Density of small dendritic spines and microtubule-associated-protein-2 immunoreactivity in the primary auditory cortex of subjects with schizophrenia.

McKinney BC, MacDonald ML, Newman JT, Shelton MA, DeGiosio RA, Kelly RM, Fish KN, Sampson AR, Lewis DA, Sweet RA.

Neuropsychopharmacology. 2019 May;44(6):1055-1061. doi: 10.1038/s41386-019-0350-7. Epub 2019 Feb 22.


Laser capture microdissection-targeted mass spectrometry: a method for multiplexed protein quantification within individual layers of the cerebral cortex.

MacDonald ML, Favo D, Garver M, Sun Z, Arion D, Ding Y, Yates N, Sweet RA, Lewis DA.

Neuropsychopharmacology. 2019 Mar;44(4):743-748. doi: 10.1038/s41386-018-0260-0. Epub 2018 Nov 2.


mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia.

Wang HY, MacDonald ML, Borgmann-Winter KE, Banerjee A, Sleiman P, Tom A, Khan A, Lee KC, Roussos P, Siegel SJ, Hemby SE, Bilker WB, Gur RE, Hahn CG.

Mol Psychiatry. 2018 Sep 13. doi: 10.1038/s41380-018-0234-y. [Epub ahead of print]


Synaptic Proteome Compensation and Resilience to Psychosis in Alzheimer's Disease.

Krivinko JM, Erickson SL, Ding Y, Sun Z, Penzes P, MacDonald ML, Yates NA, Ikonomovic MD, Lopez OL, Sweet RA, Kofler J.

Am J Psychiatry. 2018 Oct 1;175(10):999-1009. doi: 10.1176/appi.ajp.2018.17080858. Epub 2018 Jul 19.


A reference genome of the Chinese hamster based on a hybrid assembly strategy.

Rupp O, MacDonald ML, Li S, Dhiman H, Polson S, Griep S, Heffner K, Hernandez I, Brinkrolf K, Jadhav V, Samoudi M, Hao H, Kingham B, Goesmann A, Betenbaugh MJ, Lewis NE, Borth N, Lee KH.

Biotechnol Bioeng. 2018 Aug;115(8):2087-2100. doi: 10.1002/bit.26722. Epub 2018 May 29.


Selective Loss of Smaller Spines in Schizophrenia.

MacDonald ML, Alhassan J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA, Sweet RA.

Am J Psychiatry. 2017 Jun 1;174(6):586-594. doi: 10.1176/appi.ajp.2017.16070814. Epub 2017 Mar 31.


Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease.

Sweet RA, MacDonald ML, Kirkwood CM, Ding Y, Schempf T, Jones-Laughner J, Kofler J, Ikonomovic MD, Lopez OL, Garver ME, Fitz NF, Koldamova R, Yates NA.

Mol Cell Proteomics. 2016 Jul;15(7):2252-62. doi: 10.1074/mcp.M115.056580. Epub 2016 Apr 21.


FastGGM: An Efficient Algorithm for the Inference of Gaussian Graphical Model in Biological Networks.

Wang T, Ren Z, Ding Y, Fang Z, Sun Z, MacDonald ML, Sweet RA, Wang J, Chen W.

PLoS Comput Biol. 2016 Feb 12;12(2):e1004755. doi: 10.1371/journal.pcbi.1004755. eCollection 2016 Feb.


Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration.

Kirkwood CM, MacDonald ML, Schempf TA, Vatsavayi AV, Ikonomovic MD, Koppel JL, Ding Y, Sun M, Kofler JK, Lopez OL, Yates NA, Sweet RA.

J Neuropathol Exp Neurol. 2016 Feb;75(2):175-82.


Polygenic inheritance of cryptorchidism susceptibility in the LE/orl rat.

Barthold JS, Pugarelli J, MacDonald ML, Ren J, Adetunji MO, Polson SW, Mateson A, Wang Y, Sol-Church K, McCahan SM, Akins RE Jr, Devoto M, Robbins AK.

Mol Hum Reprod. 2016 Jan;22(1):18-34. doi: 10.1093/molehr/gav060. Epub 2015 Oct 26.


Crossing boundaries: the design of an interdisciplinary training program to improve care for the frail elderly.

Kolomitro K, Stockley D, Egan R, MacDonald ML.

Gerontol Geriatr Educ. 2015;36(3):302-17. doi: 10.1080/02701960.2015.1031894. Epub 2015 May 7.

15. 2.0: Genome resources and website updates.

Kremkow BG, Baik JY, MacDonald ML, Lee KH.

Biotechnol J. 2015 Jul;10(7):931-8. doi: 10.1002/biot.201400646. Epub 2015 Apr 28. Review.


Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia.

Shelton MA, Newman JT, Gu H, Sampson AR, Fish KN, MacDonald ML, Moyer CE, DiBitetto JV, Dorph-Petersen KA, Penzes P, Lewis DA, Sweet RA.

Biol Psychiatry. 2015 Sep 15;78(6):374-85. doi: 10.1016/j.biopsych.2014.12.029. Epub 2015 Jan 30.


Large-scale generation of human iPSC-derived neural stem cells/early neural progenitor cells and their neuronal differentiation.

D'Aiuto L, Zhi Y, Kumar Das D, Wilcox MR, Johnson JW, McClain L, MacDonald ML, Di Maio R, Schurdak ME, Piazza P, Viggiano L, Sweet R, Kinchington PR, Bhattacharjee AG, Yolken R, Nimgaonkar VL.

Organogenesis. 2014;10(4):365-77. doi: 10.1080/15476278.2015.1011921. Erratum in: Organogenesis. 2015;11(2):93. Nimgaonka, Vishwajit L [Corrected to Nimgaonkar, Vishwajit L].


Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.

MacDonald ML, Ding Y, Newman J, Hemby S, Penzes P, Lewis DA, Yates NA, Sweet RA.

Biol Psychiatry. 2015 Jun 1;77(11):959-68. doi: 10.1016/j.biopsych.2014.09.006. Epub 2014 Nov 26.


Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia.

Banerjee A, Wang HY, Borgmann-Winter KE, MacDonald ML, Kaprielian H, Stucky A, Kvasic J, Egbujo C, Ray R, Talbot K, Hemby SE, Siegel SJ, Arnold SE, Sleiman P, Chang X, Hakonarson H, Gur RE, Hahn CG.

Mol Psychiatry. 2015 Sep;20(9):1091-100. doi: 10.1038/mp.2014.115. Epub 2014 Oct 21.


The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies.

Hu W, MacDonald ML, Elswick DE, Sweet RA.

Ann N Y Acad Sci. 2015 Mar;1338:38-57. doi: 10.1111/nyas.12547. Epub 2014 Oct 14. Review.


Estimation of protein function using template-based alignment of enzyme active sites.

Hanson B, Westin C, Rosa M, Grier A, Osipovitch M, MacDonald ML, Dodge G, Boli PM, Corwin CW, Kessler H, McKay T, Bernstein HJ, Craig PA.

BMC Bioinformatics. 2014 Mar 27;15:87. doi: 10.1186/1471-2105-15-87.


Rapid evolutionary dynamics of structural disorder as a potential driving force for biological divergence in flaviviruses.

Ortiz JF, MacDonald ML, Masterson P, Uversky VN, Siltberg-Liberles J.

Genome Biol Evol. 2013;5(3):504-13. doi: 10.1093/gbe/evt026.


Biochemical fractionation and stable isotope dilution liquid chromatography-mass spectrometry for targeted and microdomain-specific protein quantification in human postmortem brain tissue.

MacDonald ML, Ciccimaro E, Prakash A, Banerjee A, Seeholzer SH, Blair IA, Hahn CG.

Mol Cell Proteomics. 2012 Dec;11(12):1670-81. doi: 10.1074/mcp.M112.021766. Epub 2012 Aug 31.


The PRISMA Symposium 2: lessons from beyond Europe. reflections on the evolution of palliative care research and policy in Canada.

Carstairs S, MacDonald ML.

J Pain Symptom Manage. 2011 Oct;42(4):501-4. doi: 10.1016/j.jpainsymman.2011.06.009. Epub 2011 Aug 27.


Tunable dual growth factor delivery from polyelectrolyte multilayer films.

Shah NJ, Macdonald ML, Beben YM, Padera RF, Samuel RE, Hammond PT.

Biomaterials. 2011 Sep;32(26):6183-93. doi: 10.1016/j.biomaterials.2011.04.036. Epub 2011 Jun 8.


Politics of a policy for aging in Canada.

Carstairs S, Macdonald ML.

Healthc Pap. 2011;11(1):30-5; discussion 86-91.


Tissue integration of growth factor-eluting layer-by-layer polyelectrolyte multilayer coated implants.

Macdonald ML, Samuel RE, Shah NJ, Padera RF, Beben YM, Hammond PT.

Biomaterials. 2011 Feb;32(5):1446-53. doi: 10.1016/j.biomaterials.2010.10.052. Epub 2010 Nov 16.


Characterization of tunable FGF-2 releasing polyelectrolyte multilayers.

Macdonald ML, Rodriguez NM, Shah NJ, Hammond PT.

Biomacromolecules. 2010 Aug 9;11(8):2053-9. doi: 10.1021/bm100413w.


Neuregulin 1-erbB4 pathway in schizophrenia: From genes to an interactome.

Banerjee A, Macdonald ML, Borgmann-Winter KE, Hahn CG.

Brain Res Bull. 2010 Sep 30;83(3-4):132-9. doi: 10.1016/j.brainresbull.2010.04.011. Epub 2010 Apr 28. Review.


The metabolic phenotype of SCD1-deficient mice is independent of melanin-concentrating hormone.

Glier MB, Pissios P, Babich SL, Macdonald ML, Hayden MR, Maratos-Flier E, Gibson WT.

Peptides. 2010 Jan;31(1):123-9. doi: 10.1016/j.peptides.2009.10.018. Epub 2009 Oct 31.


Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis.

Macdonald ML, Bissada N, Vallance BA, Hayden MR.

Biochim Biophys Acta. 2009 Dec;1791(12):1166-72. doi: 10.1016/j.bbalip.2009.08.001. Epub 2009 Aug 17.


The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses.

Hahn CG, Banerjee A, Macdonald ML, Cho DS, Kamins J, Nie Z, Borgmann-Winter KE, Grosser T, Pizarro A, Ciccimaro E, Arnold SE, Wang HY, Blair IA.

PLoS One. 2009;4(4):e5251. doi: 10.1371/journal.pone.0005251. Epub 2009 Apr 16.


Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue.

Chartoff EH, Papadopoulou M, MacDonald ML, Parsegian A, Potter D, Konradi C, Carlezon WA Jr.

Mol Pharmacol. 2009 Mar;75(3):704-12. doi: 10.1124/mol.108.051417. Epub 2008 Dec 23.


Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis.

MacDonald ML, van Eck M, Hildebrand RB, Wong BW, Bissada N, Ruddle P, Kontush A, Hussein H, Pouladi MA, Chapman MJ, Fievet C, van Berkel TJ, Staels B, McManus BM, Hayden MR.

Arterioscler Thromb Vasc Biol. 2009 Mar;29(3):341-7. doi: 10.1161/ATVBAHA.108.181099. Epub 2008 Dec 18.


Human olfactory epithelial cells generated in vitro express diverse neuronal characteristics.

Borgmann-Winter KE, Rawson NE, Wang HY, Wang H, Macdonald ML, Ozdener MH, Yee KK, Gomez G, Xu J, Bryant B, Adamek G, Mirza N, Pribitkin E, Hahn CG.

Neuroscience. 2009 Jan 23;158(2):642-53. doi: 10.1016/j.neuroscience.2008.09.059. Epub 2008 Oct 17.


Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice.

MacDonald ML, Singaraja RR, Bissada N, Ruddle P, Watts R, Karasinska JM, Gibson WT, Fievet C, Vance JE, Staels B, Hayden MR.

J Lipid Res. 2008 Jan;49(1):217-29. Epub 2007 Oct 24.


Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations.

Goldberg YP, MacFarlane J, MacDonald ML, Thompson J, Dube MP, Mattice M, Fraser R, Young C, Hossain S, Pape T, Payne B, Radomski C, Donaldson G, Ives E, Cox J, Younghusband HB, Green R, Duff A, Boltshauser E, Grinspan GA, Dimon JH, Sibley BG, Andria G, Toscano E, Kerdraon J, Bowsher D, Pimstone SN, Samuels ME, Sherrington R, Hayden MR.

Clin Genet. 2007 Apr;71(4):311-9.


Mass spectrometric analysis demonstrates that BODIPY 581/591 C11 overestimates and inhibits oxidative lipid damage.

MacDonald ML, Murray IV, Axelsen PH.

Free Radic Biol Med. 2007 May 1;42(9):1392-7. Epub 2007 Jan 30.


Isolation rearing and hyperlocomotion are associated with reduced immediate early gene expression levels in the medial prefrontal cortex.

Levine JB, Youngs RM, MacDonald ML, Chu M, Leeder AD, Berthiaume F, Konradi C.

Neuroscience. 2007 Mar 2;145(1):42-55. Epub 2007 Jan 17.


Chemical genetic strategies to delineate MAP kinase signaling pathways using protein-fragment complementation assays (PCA).

Michnick SW, MacDonald ML, Westwick JK.

Methods. 2006 Nov;40(3):287-93. Review.


Exploiting network biology to improve drug discovery.

MacDonald ML, Westwick JK.

Methods Mol Biol. 2007;356:221-32.


Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder.

MacDonald ML, Naydenov A, Chu M, Matzilevich D, Konradi C.

Bipolar Disord. 2006 Jun;8(3):255-64.


Identifying off-target effects and hidden phenotypes of drugs in human cells.

MacDonald ML, Lamerdin J, Owens S, Keon BH, Bilter GK, Shang Z, Huang Z, Yu H, Dias J, Minami T, Michnick SW, Westwick JK.

Nat Chem Biol. 2006 Jun;2(6):329-37. Epub 2006 May 7.


Antipsychotic drugs elevate mRNA levels of presynaptic proteins in the frontal cortex of the rat.

MacDonald ML, Eaton ME, Dudman JT, Konradi C.

Biol Psychiatry. 2005 May 1;57(9):1041-51.


Genetic variants of frizzled-4 gene in familial exudative vitreoretinopathy and advanced retinopathy of prematurity.

MacDonald ML, Goldberg YP, Macfarlane J, Samuels ME, Trese MT, Shastry BS.

Clin Genet. 2005 Apr;67(4):363-6. No abstract available.


Discovery of novel phenolic antioxidants as inhibitors of vascular cell adhesion molecule-1 expression for use in chronic inflammatory diseases.

Meng CQ, Somers PK, Hoong LK, Zheng XS, Ye Z, Worsencroft KJ, Simpson JE, Hotema MR, Weingarten MD, MacDOnald ML, Hill RR, Marino EM, Suen KL, Luchoomun J, Kunsch C, Landers LK, Stefanopoulos D, Howard RB, Sundell CL, Saxena U, Wasserman MA, Sikorski JA.

J Med Chem. 2004 Dec 2;47(25):6420-32.


Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates.

Lafreniere RG, MacDonald ML, Dube MP, MacFarlane J, O'Driscoll M, Brais B, Meilleur S, Brinkman RR, Dadivas O, Pape T, Platon C, Radomski C, Risler J, Thompson J, Guerra-Escobio AM, Davar G, Breakefield XO, Pimstone SN, Green R, Pryse-Phillips W, Goldberg YP, Younghusband HB, Hayden MR, Sherrington R, Rouleau GA, Samuels ME.

Am J Hum Genet. 2004 May;74(5):1064-73. Epub 2004 Apr 1.


Molecular evidence for mitochondrial dysfunction in bipolar disorder.

Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, Heckers S.

Arch Gen Psychiatry. 2004 Mar;61(3):300-8. Erratum in: Arch Gen Psychiatry. 2004 Jun;61(6):538.


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